 Apoenzymes
"Apoenzymes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The protein components of enzyme complexes (HOLOENZYMES). An apoenzyme is the holoenzyme minus any cofactors (ENZYME COFACTORS) or prosthetic groups required for the enzymatic function.
| Descriptor ID |
D001051
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| MeSH Number(s) |
D08.811.255.500 D12.776.070.290
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Apoenzymes".
Below are MeSH descriptors whose meaning is more specific than "Apoenzymes".
This graph shows the total number of publications written about "Apoenzymes" by people in this website by year, and whether "Apoenzymes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1986 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Apoenzymes" by people in Profiles.
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Makowska-Grzyska M, Kim Y, Wu R, Wilton R, Gollapalli DR, Wang XK, Zhang R, Jedrzejczak R, Mack JC, Maltseva N, Mulligan R, Binkowski TA, Gornicki P, Kuhn ML, Anderson WF, Hedstrom L, Joachimiak A. Bacillus anthracis inosine 5'-monophosphate dehydrogenase in action: the first bacterial series of structures of phosphate ion-, substrate-, and product-bound complexes. Biochemistry. 2012 Aug 07; 51(31):6148-63.
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Gleghorn ML, Davydova EK, Rothman-Denes LB, Murakami KS. Structural basis for DNA-hairpin promoter recognition by the bacteriophage N4 virion RNA polymerase. Mol Cell. 2008 Dec 05; 32(5):707-17.
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Muench SP, Prigge ST, McLeod R, Rafferty JB, Kirisits MJ, Roberts CW, Mui EJ, Rice DW. Studies of Toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents. Acta Crystallogr D Biol Crystallogr. 2007 Mar; 63(Pt 3):328-38.
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Bortolato M, Besson F, Roux B. Role of metal ions on the secondary and quaternary structure of alkaline phosphatase from bovine intestinal mucosa. Proteins. 1999 Nov 01; 37(2):310-8.
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Schroeder HR, Johnson PK, Dean CL, Morris DL, Smith D, Refetoff S. Homogeneous apoenzyme reactivation immunoassay for thyroxin-binding globulin in serum. Clin Chem. 1986 May; 32(5):826-30.
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Willard HF, Rosenberg LE. Inherited methylmalonyl CoA mutase apoenzyme deficiency in human fibroblasts: evidence for allelic heterogeneity, genetic compounds, and codominant expression. J Clin Invest. 1980 Mar; 65(3):690-8.
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Mellman I, Willard HF, Rosenberg LE. Cobalamin binding and cobalamin-dependent enzyme activity in normal and mutant human fibroblasts. J Clin Invest. 1978 Nov; 62(5):952-60.
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Willard HF, Rosenberg LE. Inherited deficiencies of human methylmalonyl CaA mutase activity: reduced affinity of mutant apoenzyme for adenosylcobalamin. Biochem Biophys Res Commun. 1977 Oct 10; 78(3):927-34.
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Mellman IS, Youngdahl-Turner P, Willard HF, Rosenberg LE. Intracellular binding of radioactive hydroxocobalamin to cobalamin-dependent apoenzymes in rat liver. Proc Natl Acad Sci U S A. 1977 Mar; 74(3):916-20.
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Niepomniszcze H, Rosenbloom AL, Degroot LJ, Shimaoka K, Refetoff S, Yamamoto K. Differentiation of two abnormalities in thyroid peroxidase causing organification defect and goitrous hypothyroidism. Metabolism. 1975 Jan; 24(1):57-67.
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