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Mark Sheffield

TitleAssistant Professor
InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    We use optical techniques to measure and manipulate the activity of cells and circuits in the brain involved in the formation and recall of complex memories. We use mice as our animal model, and virtual reality as a platform for learning and memory related tasks. Our goal is to understand how the brain forms and recalls memories at the scale of synapses and dendrites through to the level of large ensembles of neurons and across brain regions.

    Collapse Biography 
    Collapse education and training
    University of Nottingham, Nottingham, EnglandBSc/Msc06/2006Neuroscience
    Northwestern University, Evanston, USAPh. D.08/2011Neurobiology
    Northwestern University, Evanston, USA04/2017Postdoc - Neurobiology
    Collapse awards and honors
    2017 - 2020Whitehall Foundation
    2018 - 2020Sloan
    2018 - 2021Searle scholars program
    2018 - 2023DP2 - New Innovator Award, NIH

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Heer CM, Sheffield MEJ. Distinct catecholaminergic pathways projecting to hippocampal CA1 transmit contrasting signals during behavior and learning. bioRxiv. 2024 Jan 08. PMID: 38076843; PMCID: PMC10705417.
    2. Krishnan S, Sheffield MEJ. Reward Expectation Reduces Representational Drift in the Hippocampus. bioRxiv. 2023 Dec 21. PMID: 38187677; PMCID: PMC10769341.
    3. Chiu Y, Dong C, Krishnan S, Sheffield MEJ. The Precision of Place Fields Governs Their Fate across Epochs of Experience. eNeuro. 2023 Dec; 10(12). PMID: 37973379; PMCID: PMC10706252.
      Citations: 1     Fields:    Translation:AnimalsCells
    4. Ratigan HC, Krishnan S, Smith S, Sheffield MEJ. A thalamic-hippocampal CA1 signal for contextual fear memory suppression, extinction, and discrimination. Nat Commun. 2023 10 24; 14(1):6758. PMID: 37875465; PMCID: PMC10598272.
      Citations: 3     Fields:    Translation:Animals
    5. Ratigan HC, Krishnan S, Smith S, Sheffield MEJ. Direct Thalamic Inputs to Hippocampal CA1 Transmit a Signal That Suppresses Ongoing Contextual Fear Memory Retrieval. Res Sq. 2023 Mar 27. PMID: 37034716; PMCID: PMC10081386.
    6. Ratigan HC, Krishnan S, Smith S, Sheffield MEJ. Direct Thalamic Inputs to Hippocampal CA1 Transmit a Signal That Suppresses Ongoing Contextual Fear Memory Retrieval. bioRxiv. 2023 Mar 27. PMID: 37034812; PMCID: PMC10081195.
    7. Krishnan S, Heer C, Cherian C, Sheffield MEJ. Reward expectation extinction restructures and degrades CA1 spatial maps through loss of a dopaminergic reward proximity signal. Nat Commun. 2022 11 04; 13(1):6662. PMID: 36333323; PMCID: PMC9636178.
      Citations: 9     Fields:    Translation:AnimalsCells
    8. Wildenberg G, Sorokina A, Koranda J, Monical A, Heer C, Sheffield M, Zhuang X, McGehee D, Kasthuri B. Partial connectomes of labeled dopaminergic circuits reveal non-synaptic communication and axonal remodeling after exposure to cocaine. Elife. 2021 12 29; 10. PMID: 34965204; PMCID: PMC8716107.
      Citations: 9     Fields:    Translation:AnimalsCells
    9. Dong C, Madar AD, Sheffield MEJ. Distinct place cell dynamics in CA1 and CA3 encode experience in new environments. Nat Commun. 2021 05 20; 12(1):2977. PMID: 34016996; PMCID: PMC8137926.
      Citations: 34     Fields:    Translation:AnimalsCells
    10. Sheffield ME, Dombeck DA. Dendritic mechanisms of hippocampal place field formation. Curr Opin Neurobiol. 2019 02; 54:1-11. PMID: 30036841.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    11. Sheffield MEJ, Adoff MD, Dombeck DA. Increased Prevalence of Calcium Transients across the Dendritic Arbor during Place Field Formation. Neuron. 2017 Oct 11; 96(2):490-504.e5. PMID: 29024668; PMCID: PMC5642299.
      Citations: 78     Fields:    Translation:AnimalsCells
    12. Sheffield ME, Dombeck DA. The binding solution? Nat Neurosci. 2015 Aug; 18(8):1060-2. PMID: 26216459.
      Citations: 4     Fields:    Translation:AnimalsCells
    13. Sheffield ME, Dombeck DA. Calcium transient prevalence across the dendritic arbour predicts place field properties. Nature. 2015 Jan 08; 517(7533):200-4. PMID: 25363782; PMCID: PMC4289090.
      Citations: 113     Fields:    Translation:AnimalsCells
    14. Sheffield ME, Edgerton GB, Heuermann RJ, Deemyad T, Mensh BD, Spruston N. Mechanisms of retroaxonal barrage firing in hippocampal interneurons. J Physiol. 2013 Oct 01; 591(19):4793-805. PMID: 23878372; PMCID: PMC3800455.
      Citations: 17     Fields:    Translation:AnimalsCells
    15. Sheffield ME, Best TK, Mensh BD, Kath WL, Spruston N. Slow integration leads to persistent action potential firing in distal axons of coupled interneurons. Nat Neurosci. 2011 Feb; 14(2):200-7. PMID: 21150916; PMCID: PMC3030701.
      Citations: 59     Fields:    Translation:AnimalsCells
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