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Last Name

Mark Sheffield

TitleAssistant Professor
InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    We use optical techniques to measure and manipulate the activity of cells and circuits in the brain involved in the formation and recall of complex memories. We use mice as our animal model, and virtual reality as a platform for learning and memory related tasks. Our goal is to understand how the brain forms and recalls memories at the scale of synapses and dendrites through to the level of large ensembles of neurons and across brain regions.

    Collapse Biography 
    Collapse education and training
    University of Nottingham, Nottingham, EnglandBSc/Msc06/2006Neuroscience
    Northwestern University, Evanston, USAPh. D.08/2011Neurobiology
    Northwestern University, Evanston, USA04/2017Postdoc - Neurobiology
    Collapse awards and honors
    2017 - 2020Whitehall Foundation
    2018 - 2020Sloan
    2018 - 2021Searle scholars program
    2018 - 2023DP2 - New Innovator Award, NIH

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wildenberg G, Sorokina A, Koranda J, Monical A, Heer C, Sheffield M, Zhuang X, McGehee D, Kasthuri B. Partial connectomes of labeled dopaminergic circuits reveal non-synaptic communication and axonal remodeling after exposure to cocaine. Elife. 2021 12 29; 10. PMID: 34965204.
      View in: PubMed
    2. Dong C, Madar AD, Sheffield MEJ. Distinct place cell dynamics in CA1 and CA3 encode experience in new environments. Nat Commun. 2021 05 20; 12(1):2977. PMID: 34016996.
      View in: PubMed
    3. Sheffield ME, Dombeck DA. Dendritic mechanisms of hippocampal place field formation. Curr Opin Neurobiol. 2019 02; 54:1-11. PMID: 30036841.
      View in: PubMed
    4. Sheffield MEJ, Adoff MD, Dombeck DA. Increased Prevalence of Calcium Transients across the Dendritic Arbor during Place Field Formation. Neuron. 2017 Oct 11; 96(2):490-504.e5. PMID: 29024668.
      View in: PubMed
    5. Sheffield ME, Dombeck DA. The binding solution? Nat Neurosci. 2015 Aug; 18(8):1060-2. PMID: 26216459.
      View in: PubMed
    6. Sheffield ME, Dombeck DA. Calcium transient prevalence across the dendritic arbour predicts place field properties. Nature. 2015 Jan 08; 517(7533):200-4. PMID: 25363782.
      View in: PubMed
    7. Sheffield ME, Edgerton GB, Heuermann RJ, Deemyad T, Mensh BD, Spruston N. Mechanisms of retroaxonal barrage firing in hippocampal interneurons. J Physiol. 2013 Oct 01; 591(19):4793-805. PMID: 23878372.
      View in: PubMed
    8. Sheffield ME, Best TK, Mensh BD, Kath WL, Spruston N. Slow integration leads to persistent action potential firing in distal axons of coupled interneurons. Nat Neurosci. 2011 Feb; 14(2):200-7. PMID: 21150916.
      View in: PubMed
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