 Chlorpromazine
"Chlorpromazine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
| Descriptor ID |
D002746
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| MeSH Number(s) |
D02.886.369.198 D03.494.741.198
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Chlorpromazine".
Below are MeSH descriptors whose meaning is more specific than "Chlorpromazine".
This graph shows the total number of publications written about "Chlorpromazine" by people in this website by year, and whether "Chlorpromazine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1980 | 0 | 1 | 1 | | 1982 | 0 | 2 | 2 | | 1984 | 1 | 1 | 2 | | 1989 | 0 | 1 | 1 | | 2003 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Chlorpromazine" by people in Profiles.
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Lui S, Yao L, Xiao Y, Keedy SK, Reilly JL, Keefe RS, Tamminga CA, Keshavan MS, Pearlson GD, Gong Q, Sweeney JA. Resting-state brain function in schizophrenia and psychotic bipolar probands and their first-degree relatives. Psychol Med. 2015 Jan; 45(1):97-108.
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Wobrock T, Falkai P, Schneider-Axmann T, Hasan A, Galderisi S, Davidson M, Kahn RS, Derks EM, Boter H, Rybakowski JK, Libiger J, Dollfus S, López-Ibor JJ, Peuskens J, Hranov LG, Gaebel W, Fleischhacker WW. Comorbid substance abuse in first-episode schizophrenia: effects on cognition and psychopathology in the EUFEST study. Schizophr Res. 2013 Jun; 147(1):132-139.
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Lange Y, Ye J, Steck TL. Activation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cells. PLoS One. 2012; 7(1):e30051.
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Bourseau-Guilmain E, Griveau A, Benoit JP, Garcion E. The importance of the stem cell marker prominin-1/CD133 in the uptake of transferrin and in iron metabolism in human colon cancer Caco-2 cells. PLoS One. 2011; 6(9):e25515.
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Homer JR, Davies JM, Amundsen LB. Persistent hiccups after attempted interscalene brachial plexus block. Reg Anesth Pain Med. 2005 Nov-Dec; 30(6):574-6.
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Nashiki K, Taketani Y, Takeichi T, Sawada N, Yamamoto H, Ichikawa M, Arai H, Miyamoto K, Takeda E. Role of membrane microdomains in PTH-mediated down-regulation of NaPi-IIa in opossum kidney cells. Kidney Int. 2005 Sep; 68(3):1137-47.
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Tsutsui S, Itagaki S, Kawamura S, Harada K, Karaki H, Doi K, Yoshikawa Y. D-galactosamine induced hepatocyte apoptosis is inhibited in vivo and in cell culture by a calcium calmodulin antagonist, chlorpromazine, and a calcium channel blocker, verapamil. Exp Anim. 2003 Jan; 52(1):43-52.
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Khodadad JK, Weinstein RS, Marsh LW, Steck TL. Shape determinants of McLeod acanthocytes. J Membr Biol. 1989 Mar; 107(3):213-8.
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Szanto P, Ehrenpreis E, Krakow M, Rubinstein O, Ehrenpreis S. Histologic changes in the guinea pig gastrointestinal tract following 1 weeks' administration of chlorpromazine, haloperidol or atropine. Psychopharmacology (Berl). 1988; 95(3):351-5.
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Lieber MR, Lange Y, Weinstein RS, Steck TL. Interaction of chlorpromazine with the human erythrocyte membrane. J Biol Chem. 1984 Jul 25; 259(14):9225-34.
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