"Dihydroxyphenylalanine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
| Descriptor ID |
D004295
|
| MeSH Number(s) |
D02.092.311.200 D12.125.072.050.685.400 D12.125.072.050.875.130
|
| Concept/Terms |
Dihydroxyphenylalanine- Dihydroxyphenylalanine
- beta-Hydroxytyrosine
- beta Hydroxytyrosine
- 3-Hydroxy-DL-tyrosine
- 3 Hydroxy DL tyrosine
- 3,4-Dihydroxyphenylalanine
- 3,4 Dihydroxyphenylalanine
- Dopa
|
Below are MeSH descriptors whose meaning is more general than "Dihydroxyphenylalanine".
Below are MeSH descriptors whose meaning is more specific than "Dihydroxyphenylalanine".
This graph shows the total number of publications written about "Dihydroxyphenylalanine" by people in this website by year, and whether "Dihydroxyphenylalanine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 0 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dihydroxyphenylalanine" by people in Profiles.
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In Vivo Delivery and Therapeutic Effects of a MicroRNA on Colorectal Liver Metastases. Mol Ther. 2017 07 05; 25(7):1588-1595.
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Effects of VMAT2 inhibitors lobeline and GZ-793A on methamphetamine-induced changes in dopamine release, metabolism and synthesis in vivo. J Neurochem. 2013 Oct; 127(2):187-98.
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Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors. Nat Neurosci. 2011 Jul 10; 14(8):1033-8.
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The first global screening of protein substrates bearing protein-bound 3,4-Dihydroxyphenylalanine in Escherichia coli and human mitochondria. J Proteome Res. 2010 Nov 05; 9(11):5705-14.
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D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD. Neurobiol Dis. 2010 Jan; 37(1):228-36.
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Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease. Ann Neurol. 2006 Mar; 59(3):459-66.
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Striatal tyrosine hydroxylase immunoreactive neurons are induced by L-dihydroxyphenylalanine and nerve growth factor treatment in 6-hydroxydopamine lesioned rats. Neurosci Lett. 2004 May 20; 362(2):79-82.
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Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science. 2000 Oct 27; 290(5492):767-73.
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The role of inheritance in sporadic Parkinson's disease: evidence from a longitudinal study of dopaminergic function in twins. Ann Neurol. 1999 May; 45(5):577-82.
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Efficacy of hydroquinone in the treatment of cutaneous hyperpigmentation in hairless descendants of Mexican hairless dogs (Xoloitzcuintli). Lab Anim Sci. 1998 Oct; 48(5):469-75.