 Crigler-Najjar Syndrome
"Crigler-Najjar Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A familial form of congenital hyperbilirubinemia transmitted as an autosomal recessive trait. It is characterized by icterus and brain damage caused by a glucuronyl transferase deficiency in the liver and faulty bilirubin conjugation.
| Descriptor ID |
D003414
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| MeSH Number(s) |
C16.320.565.300.281 C18.452.648.300.281
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| Concept/Terms |
Crigler-Najjar Syndrome- Crigler-Najjar Syndrome
- Crigler Najjar Syndrome
- Syndrome, Crigler-Najjar
- Crigler-Najar Syndrome
- Crigler Najar Syndrome
- Syndrome, Crigler-Najar
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Below are MeSH descriptors whose meaning is more general than "Crigler-Najjar Syndrome".
Below are MeSH descriptors whose meaning is more specific than "Crigler-Najjar Syndrome".
This graph shows the total number of publications written about "Crigler-Najjar Syndrome" by people in this website by year, and whether "Crigler-Najjar Syndrome" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1983 | 0 | 1 | 1 | | 1993 | 1 | 0 | 1 | | 1998 | 0 | 1 | 1 |
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Below are the most recent publications written about "Crigler-Najjar Syndrome" by people in Profiles.
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Iyer L, King CD, Whitington PF, Green MD, Roy SK, Tephly TR, Coffman BL, Ratain MJ. Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes. J Clin Invest. 1998 Feb 15; 101(4):847-54.
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Whitington PF, Emond JC, Heffron T, Thistlethwaite JR. Orthotopic auxiliary liver transplantation for Crigler-Najjar syndrome type 1. Lancet. 1993 Sep 25; 342(8874):779-80.
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Lee KS, Gartner LM. Management of unconjugated hyperbilirubinemia in the newborn. Semin Liver Dis. 1983 Feb; 3(1):52-64.
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