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Xander Van Wijk

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentPathology
AddressChicago IL 60637
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    Collapse Biography 
    Collapse education and training
    Maastricht University, Maastricht, The NetherlandsB.Sc.08/2006Molecular Life Sciences
    Hasselt University, Hasselt, BelgiumM.Sc.07/2007Biomedical Sciences
    Radboud University Nijmegen, Nijmegen, The NetherlandsPh.D.05/2013Biochemistry
    University of California, San Diego, San Diego, CAPostdoctoral07/2015Biomedical Sciences
    University of California, San Francisco, San Francisco, CADABCC07/2017Clinical Chemistry

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Damen SAJ, Cramer GE, Dieker HJ, Gehlmann H, Ophuis TJMO, Aengevaeren WRM, Fokkert M, Verheugt FWA, Suryapranata H, Wu AH, van Wijk XMR, Brouwer MA. Cardiac Troponin Composition Characterization after Non ST-Elevation Myocardial Infarction: Relation with Culprit Artery, Ischemic Time Window, and Severity of Injury. Clin Chem. 2021 Jan 08; 67(1):227-236. PMID: 33418572.
      View in: PubMed
    2. van Wijk XMR, Yun C, Lynch KL. Evaluation of Biomarkers in Sepsis: High Dimethylarginine (ADMA and SDMA) Concentrations Are Associated with Mortality. J Appl Lab Med. 2020 Dec 31. PMID: 33382901.
      View in: PubMed
    3. Reizine N, Vokes EE, Liu P, Truong TM, Nanda R, Fleming GF, Catenacci DVT, Pearson AT, Parsad S, Danahey K, van Wijk XMR, Yeo KJ, Ratain MJ, O'Donnell PH. Implementation of pharmacogenomic testing in oncology care (PhOCus): study protocol of a pragmatic, randomized clinical trial. Ther Adv Med Oncol. 2020; 12:1758835920974118. PMID: 33414846.
      View in: PubMed
    4. Chan CW, Parker K, Tesic V, Baldwin A, Tang NY, van Wijk XMR, Yeo KJ. Analytical and Clinical Evaluation of the Automated Elecsys Anti-SARS-CoV-2 Antibody Assay on the Roche cobas e602 Analyzer. Am J Clin Pathol. 2020 10 13; 154(5):620-626. PMID: 32814955.
      View in: PubMed
    5. Tang NY, Leanse JH, Tesic V, van Wijk XMR. A comparison of venous blood gas analysis with paired specimens collected in syringes and evacuated blood collection tubes. Clin Chim Acta. 2020 Nov; 510:671-674. PMID: 32818493.
      View in: PubMed
    6. Tang NY, Yeo KJ, van Wijk XMR. Evaluation of interference effects from hemolysis, icterus and lipemia on the Roche Elecsys® Anti-SARS-CoV-2 assay. Clin Chim Acta. 2020 Oct; 509:293-294. PMID: 32598879.
      View in: PubMed
    7. Christian C, Borden BA, Danahey K, Yeo KJ, van Wijk XMR, Ratain MJ, O'Donnell PH. Pharmacogenomic-Based Decision Support to Predict Adherence to Medications. Clin Pharmacol Ther. 2020 Aug; 108(2):368-376. PMID: 32236960.
      View in: PubMed
    8. Marin MJ, van Wijk XMR. Can We Improve Current Cancer Screening Programs? Clin Chem. 2020 May 01; 66(5):746. PMID: 32353138.
      View in: PubMed
    9. Tang NY, Groboske SE, Baldwin AD, Yeo KJ, van Wijk XMR. False-Positive Hepatitis B Surface Antibody Results: An Example of Reagent Carryover. J Appl Lab Med. 2020 03 01; 5(2):429-431. PMID: 32445392.
      View in: PubMed
    10. van Wijk XMR, Leanse JH, Poinier A, Uriel N, O'Connor MF, Weber SG, Tesic V, Staneva I. A root cause analysis of 'falsely elevated' oxygen saturation: investigation of pneumatic tube transport and differences between estimated and measured saturation in a critical patient population. Clin Chem Lab Med. 2020 02 25; 58(3):e72-e74. PMID: 31525163.
      View in: PubMed
    11. Truong TM, Apfelbaum J, Shahul S, Anitescu M, Danahey K, Knoebel RW, Liebovitz D, Karrison T, van Wijk XMR, Yeo KJ, Meltzer D, Ratain MJ, O'Donnell PH. The ImPreSS Trial: Implementation of Point-of-Care Pharmacogenomic Decision Support in Perioperative Care. Clin Pharmacol Ther. 2019 12; 106(6):1179-1183. PMID: 31433489.
      View in: PubMed
    12. Asif M, Groboske SE, Leung EKY, Yeo KJ, van Wijk XMR. Evaluation of a New Generation Automated Assay for 25-Hydroxy Vitamin D Based on Competitive Protein Binding. J Appl Lab Med. 2019 09; 4(2):247-253. PMID: 31639671.
      View in: PubMed
    13. van Wijk XMR, Claassen S, Enea NS, Li P, Yang S, Brouwer MA, Cramer GE, Zuk R, Lynch KL, Wu AHB. Cardiac troponin I is present in plasma of type 1 myocardial infarction patients and patients with troponin I elevations due to other etiologies as complex with little free I. Clin Biochem. 2019 Nov; 73:35-43. PMID: 31247187.
      View in: PubMed
    14. van Wijk XMR, Yun C, Hooshfar S, Arens AM, Lung D, Wu AHB, Lynch KL. A Liquid-Chromatography High-Resolution Mass Spectrometry Method for Non-FDA Approved Benzodiazepines. J Anal Toxicol. 2019 May 01; 43(4):316-320. PMID: 30462225.
      View in: PubMed
    15. Van Wijk XMR, Goodnough R, Colby JM. Mass spectrometry in emergency toxicology: Current state and future applications. Crit Rev Clin Lab Sci. 2019 06; 56(4):225-238. PMID: 30931660.
      View in: PubMed
    16. Marin MJ, van Wijk XMR, Yeo KJ. Losing sight of the Forest for the trees: Why clinical laboratories need to perform their own interference studies. Clin Chim Acta. 2018 08; 483:239-240. PMID: 29750966.
      View in: PubMed
    17. Ihse E, Yamakado H, van Wijk XM, Lawrence R, Esko JD, Masliah E. Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type. Sci Rep. 2017 08 21; 7(1):9008. PMID: 28827536.
      View in: PubMed
    18. Li K, van Wijk XMR, Hayashi S, Lynch KL, Wu AHB, Smollin CG. Anticholinergic toxicity associated with ingestion of water containing lupini bean extract. Clin Toxicol (Phila). 2017 08; 55(7):687-688. PMID: 28443353.
      View in: PubMed
    19. van Wijk XMR, Vittinghoff E, Wu AHB, Lynch KL, Riley ED. Cocaine use is associated with a higher prevalence of elevated ST2 concentrations. Clin Biochem. 2017 Sep; 50(13-14):791-793. PMID: 28442257.
      View in: PubMed
    20. van Wijk XM, Döhrmann S, Hallström BM, Li S, Voldborg BG, Meng BX, McKee KK, van Kuppevelt TH, Yurchenco PD, Palsson BO, Lewis NE, Nizet V, Esko JD. Whole-Genome Sequencing of Invasion-Resistant Cells Identifies Laminin a2 as a Host Factor for Bacterial Invasion. mBio. 2017 01 10; 8(1). PMID: 28074024.
      View in: PubMed
    21. Vo KT, van Wijk XM, Wu AH, Lynch KL, Ho RY. Synthetic agents off the darknet: a case of U-47700 and phenazepam abuse. Clin Toxicol (Phila). 2017 Jan; 55(1):71-72. PMID: 27736261.
      View in: PubMed
    22. van Wijk XMR, Magee CA, Wu AHB, Tana MM, Lynch KL. A comparison of methods for evaluation of a case of suspected macro-aspartate aminotransferase. Clin Chim Acta. 2016 Dec 01; 463:1-3. PMID: 27732874.
      View in: PubMed
    23. Arens AM, van Wijk XM, Vo KT, Lynch KL, Wu AH, Smollin CG. Adverse Effects From Counterfeit Alprazolam Tablets. JAMA Intern Med. 2016 10 01; 176(10):1554-1555. PMID: 27532131.
      View in: PubMed
    24. Vo KT, van Wijk XM, Lynch KL, Wu AH, Smollin CG. Counterfeit Norco Poisoning Outbreak - San Francisco Bay Area, California, March 25-April 5, 2016. MMWR Morb Mortal Wkly Rep. 2016 Apr 29; 65(16):420-3. PMID: 27123589.
      View in: PubMed
    25. Xu D, Olson J, Cole JN, van Wijk XM, Brinkmann V, Zychlinsky A, Nizet V, Esko JD, Chang YC. Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity. Infect Immun. 2015 Sep; 83(9):3648-56. PMID: 26150541.
      View in: PubMed
    26. van Wijk XM, Lawrence R, Thijssen VL, van den Broek SA, Troost R, van Scherpenzeel M, Naidu N, Oosterhof A, Griffioen AW, Lefeber DJ, van Delft FL, van Kuppevelt TH. A common sugar-nucleotide-mediated mechanism of inhibition of (glycosamino)glycan biosynthesis, as evidenced by 6F-GalNAc (Ac3). FASEB J. 2015 Jul; 29(7):2993-3002. PMID: 25868729.
      View in: PubMed
    27. Aw TC, van Wijk XM, Wu AH, Jaffe AS. Release of cardiac troponin using a high sensitivity assay after exercise: Type 2 acute myocardial infarction? Clin Chim Acta. 2015 Jun 15; 446:6-8. PMID: 25862921.
      View in: PubMed
    28. Wu AH, van Wijk XM. A new ultra-high sensitivity troponin I assay for chest pain patients with no evidence of troponin I using a conventional assay. Clin Biochem. 2015 Mar; 48(4-5):358-9. PMID: 25482854.
      View in: PubMed
    29. van Wijk XM, Oosterhof A, Versteeg EM, van de Westerlo EM, van Kuppevelt TH. 'Immunosequencing' of heparan sulfate from human cell lines and rat kidney: the (GlcNS6S-IdoA2S)3 motif, recognized by antibody NS4F5, is located towards the non-reducing end. Biochem J. 2014 Aug 01; 461(3):461-8. PMID: 24819558.
      View in: PubMed
    30. Rops AL, Loeven MA, van Gemst JJ, Eversen I, Van Wijk XM, Dijkman HB, van Kuppevelt TH, Berden JH, Rabelink TJ, Esko JD, van der Vlag J. Modulation of heparan sulfate in the glomerular endothelial glycocalyx decreases leukocyte influx during experimental glomerulonephritis. Kidney Int. 2014 Nov; 86(5):932-42. PMID: 24759151.
      View in: PubMed
    31. van Wijk XM, van Kuppevelt TH. Heparan sulfate in angiogenesis: a target for therapy. Angiogenesis. 2014 Jul; 17(3):443-62. PMID: 24146040.
      View in: PubMed
    32. van Wijk XM, Thijssen VL, Lawrence R, van den Broek SA, Dona M, Naidu N, Oosterhof A, van de Westerlo EM, Kusters LJ, Khaled Y, Jokela TA, Nowak-Sliwinska P, Kremer H, Stringer SE, Griffioen AW, van Wijk E, van Delft FL, van Kuppevelt TH. Interfering with UDP-GlcNAc metabolism and heparan sulfate expression using a sugar analogue reduces angiogenesis. ACS Chem Biol. 2013 Oct 18; 8(10):2331-8. PMID: 23972127.
      View in: PubMed
    33. Janssen DA, van Wijk XM, Jansen KC, van Kuppevelt TH, Heesakkers JP, Schalken JA. The distribution and function of chondroitin sulfate and other sulfated glycosaminoglycans in the human bladder and their contribution to the protective bladder barrier. J Urol. 2013 Jan; 189(1):336-42. PMID: 23174248.
      View in: PubMed
    34. Houben AJ, van Wijk XM, van Meeteren LA, van Zeijl L, van de Westerlo EM, Hausmann J, Fish A, Perrakis A, van Kuppevelt TH, Moolenaar WH. The polybasic insertion in autotaxin a confers specific binding to heparin and cell surface heparan sulfate proteoglycans. J Biol Chem. 2013 Jan 04; 288(1):510-9. PMID: 23150666.
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    35. van Wijk XM, Vallen MJ, van de Westerlo EM, Oosterhof A, Hao W, Versteeg EM, Raben J, Wismans RG, Smetsers TF, Dijkman HB, Schalkwijk J, van Kuppevelt TH. Extraction and structural analysis of glycosaminoglycans from formalin-fixed, paraffin-embedded tissues. Glycobiology. 2012 Dec; 22(12):1666-72. PMID: 22859440.
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    36. Rijkers K, Mescheriakova J, Majoie M, Lemmens E, van Wijk X, Philippens M, Van Kranen-Mastenbroek V, Schijns O, Vles J, Hoogland G. Polymorphisms in CACNA1E and Camk2d are associated with seizure susceptibility of Sprague-Dawley rats. Epilepsy Res. 2010 Sep; 91(1):28-34. PMID: 20638246.
      View in: PubMed
    37. van Wijk XM, Oosterhof A, van den Broek SA, Griffioen AW, ten Dam GB, Rutjes FP, van Delft FL, van Kuppevelt TH. A 4-deoxy analogue of N-acetyl-D-glucosamine inhibits heparan sulphate expression and growth factor binding in vitro. Exp Cell Res. 2010 Sep 10; 316(15):2504-12. PMID: 20433828.
      View in: PubMed
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