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Bryce Weir

TitleMaurice Goldblatt Professor, Emeritus
InstitutionUniversity of Chicago
DepartmentNeurology
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Weir B. Vasospasm: does it cause infarction and poor outcome? J Neurosurg. 2020 Oct 30; 134(3):1006-1011. PMID: 33126209.
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    2. Weir B. Vasospasm: A Personal Odyssey. Acta Neurochir Suppl. 2020; 127:1-10. PMID: 31407055.
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    3. Weir B. A history of neurosurgery in Canada. Can J Neurol Sci. 2011 Mar; 38(2):203-19. PMID: 21320822.
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    4. Weir B. Multiple sclerosis - a vascular etiology? Can J Neurol Sci. 2010 Nov; 37(6):745-57. PMID: 21059535.
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    5. Weir B. Patients with small, asymptomatic, unruptured intracranial aneurysms and no history of subarachnoid hemorrhage should be treated conservatively: against. Stroke. 2005 Feb; 36(2):410-1. PMID: 15618442.
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    6. Weir B, Amidei C, Kongable G, Findlay JM, Kassell NF, Kelly J, Dai L, Karrison TG. The aspect ratio (dome/neck) of ruptured and unruptured aneurysms. J Neurosurg. 2003 Sep; 99(3):447-51. PMID: 12959428.
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    7. Macdonald RL, Amidei C, Baron J, Weir B, Brown F, Erickson RK, Hekmatpanah J, Frim D. Randomized, pilot study of intermittent pneumatic compression devices plus dalteparin versus intermittent pneumatic compression devices plus heparin for prevention of venous thromboembolism in patients undergoing craniotomy. Surg Neurol. 2003 May; 59(5):363-72; discussion 372-4. PMID: 12765806.
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    8. Maroun F, Squarey K, Jacob J, Murray G, Cramer B, Barron J, Weir B. Rupture of middle cerebral artery aneurysm in a neonate: case report and review of the literature. Surg Neurol. 2003 Feb; 59(2):114-9. PMID: 12648910.
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    9. Weir B. Unruptured aneurysms. J Neurosurg. 2002 Nov; 97(5):1011-2; discussion 1012-3. PMID: 12450019.
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    10. Weir B. Non-atherosclerotic fusiform aneurysms. Can J Neurol Sci. 2002 Feb; 29(1):5. PMID: 11858535.
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    11. Weir B. Unruptured intracranial aneurysms: a review. J Neurosurg. 2002 Jan; 96(1):3-42. PMID: 11794601.
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    12. Weir B, Disney L, Karrison T. Sizes of ruptured and unruptured aneurysms in relation to their sites and the ages of patients. J Neurosurg. 2002 Jan; 96(1):64-70. PMID: 11794606.
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    13. Komuro T, Borsody MK, Ono S, Marton LS, Weir BK, Zhang ZD, Paik E, Macdonald RL. The vasorelaxation of cerebral arteries by carbon monoxide. Exp Biol Med (Maywood). 2001 Oct; 226(9):860-5. PMID: 11568310.
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    14. Macdonald RL, Weir BK, Marton LS, Zhang ZD, Sajdak M, Johns LM, Kowalczuk A, Borsody M. Role of adenosine 5'-triphosphate in vasospasm after subarachnoid hemorrhage: human investigations. Neurosurgery. 2001 Apr; 48(4):854-62; discussion 862-3. PMID: 11322446.
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    15. Lin G, Macdonald RL, Marton LS, Kowalczuk A, Solenski NJ, Weir BK. Hemoglobin increases endothelin-1 in endothelial cells by decreasing nitric oxide. Biochem Biophys Res Commun. 2001 Jan 26; 280(3):824-30. PMID: 11162595.
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    16. Jahromi BS, Komuro T, Macdonald RL, Marton LS, Weir BK. Phosphatidylcholine peroxidized by hemoglobin increases intracellular calcium in dog basilar artery smooth muscle cells. Acta Neurochir Suppl. 2001; 77:45-7. PMID: 11563307.
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    17. Stoodley MA, Foroohar M, Macdonald RL, Weir BK. Multimedia computer database for neurosurgery. Neurosurgery. 2000 Jul; 47(1):178-86; discussion 186-8. PMID: 10917361.
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    18. Munshi I, Frim D, Stine-Reyes R, Weir BK, Hekmatpanah J, Brown F. Effects of posterior fossa decompression with and without duraplasty on Chiari malformation-associated hydromyelia. Neurosurgery. 2000 Jun; 46(6):1384-9; discussion 1389-90. PMID: 10834643.
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    19. Munshi I, Macdonald RL, Weir BK. Intraoperative angiography of brain arteriovenous malformations. Neurosurgery. 1999 Sep; 45(3):491-7; discussion 497-9. PMID: 10493371.
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    20. Macdonald RL, Amidei C, Lin G, Munshi I, Baron J, Weir BK, Brown F, Erickson RK, Hekmatpanah J. Safety of perioperative subcutaneous heparin for prophylaxis of venous thromboembolism in patients undergoing craniotomy. Neurosurgery. 1999 Aug; 45(2):245-51; discussion 251-2. PMID: 10449068.
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    21. Wang X, Marton LS, Weir BK, Macdonald RL. Immediate early gene expression in vascular smooth-muscle cells synergistically induced by hemolysate components. J Neurosurg. 1999 Jun; 90(6):1083-90. PMID: 10350256.
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    22. Tsuji T, Cook DA, Weir BK, Handa Y, Chiba S, Kobayashi S. Cerebrovascular contractility after clot removal in monkey subarachnoid haemorrhage. Clin Exp Pharmacol Physiol. 1999 May-Jun; 26(5-6):485-8. PMID: 10386244.
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    23. Guan YY, Weir BK, Marton LS, Macdonald RL, Zhang H. Effects of erythrocyte lysate of different incubation times on intracellular free calcium in rat basilar artery smooth-muscle cells. J Neurosurg. 1998 Dec; 89(6):1007-14. PMID: 9833828.
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    24. Stoodley MA, Macdonald RL, Weir BK. Surgical treatment of middle cerebral artery aneurysms. Neurosurg Clin N Am. 1998 Oct; 9(4):823-34. PMID: 9738109.
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    25. Weir BK, Kongable GL, Kassell NF, Schultz JR, Truskowski LL, Sigrest A. Cigarette smoking as a cause of aneurysmal subarachnoid hemorrhage and risk for vasospasm: a report of the Cooperative Aneurysm Study. J Neurosurg. 1998 Sep; 89(3):405-11. PMID: 9724114.
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    26. Stoodley MA, Macdonald RL, Weir BK. Pregnancy and intracranial aneurysms. Neurosurg Clin N Am. 1998 Jul; 9(3):549-56. PMID: 9668186.
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    27. Macdonald RL, Bassiouny M, Johns L, Sajdak M, Marton LS, Weir BK, Hall ED, Andrus PK. U74389G prevents vasospasm after subarachnoid hemorrhage in dogs. Neurosurgery. 1998 Jun; 42(6):1339-45; discussion 1345-6. PMID: 9632194.
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    28. Kim CJ, Weir BK, Macdonald RL, Zhang H. Erythrocyte lysate releases Ca2+ from IP3-sensitive stores and activates Ca(2+)-dependent K+ channels in rat basilar smooth muscle cells. Neurol Res. 1998 Jan; 20(1):23-30. PMID: 9471099.
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    29. Zhang H, Weir BK, Marton LS, Lee KS, Macdonald RL. P2 purinoceptors in cultured bovine middle cerebral artery endothelial cells. J Cardiovasc Pharmacol. 1997 Dec; 30(6):767-74. PMID: 9436816.
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    30. Kowalczuk A, Macdonald RL, Amidei C, Dohrmann G, Erickson RK, Hekmatpanah J, Krauss S, Krishnasamy S, Masters G, Mullan SF, Mundt AJ, Sweeney P, Vokes EE, Weir BK, Wollman RL. Quantitative imaging study of extent of surgical resection and prognosis of malignant astrocytomas. Neurosurgery. 1997 Nov; 41(5):1028-36; discussion 1036-8. PMID: 9361056.
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    31. Sima B, Weir BK, Macdonald RL, Zhang H. Extracellular nucleotide-induced [Ca2+]i elevation in rat basilar smooth muscle cells. Stroke. 1997 Oct; 28(10):2053-8; discussion 2059. PMID: 9341718.
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    32. Marton LS, Weir BK, Zhang H. Tyrosine phosphorylation and [Ca2+]i elevation induced by hemolysate in bovine endothelial cells: implications for cerebral vasospasm. Neurol Res. 1996 Aug; 18(4):349-53. PMID: 8875455.
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    33. Zhang H, Weir BK, Macdonald RL, Marton LS, Solenski NJ, Kwan AL, Lee KS. Mechanisms of [Ca++]i elevation induced by erythrocyte components in endothelial cells. J Pharmacol Exp Ther. 1996 Jun; 277(3):1501-9. PMID: 8667216.
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    34. Tsuji T, Cook DA, Weir BK, Handa Y. Effect of clot removal on cerebrovascular contraction after subarachnoid hemorrhage in the monkey: pharmacological study. Heart Vessels. 1996; 11(2):69-79. PMID: 8836754.
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    35. Hino A, Weir BK, Macdonald RL, Thisted RA, Kim CJ, Johns LM. Prospective, randomized, double-blind trial of BQ-123 and bosentan for prevention of vasospasm following subarachnoid hemorrhage in monkeys. J Neurosurg. 1995 Sep; 83(3):503-9. PMID: 7666230.
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    36. Findlay JM, Kassell NF, Weir BK, Haley EC, Kongable G, Germanson T, Truskowski L, Alves WM, Holness RO, Knuckey NW, et al. A randomized trial of intraoperative, intracisternal tissue plasminogen activator for the prevention of vasospasm. Neurosurgery. 1995 Jul; 37(1):168-76; discussion 177-8. PMID: 8587685.
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    37. Haley EC, Kassell NF, Alves WM, Weir BK, Hansen CA. Phase II trial of tirilazad in aneurysmal subarachnoid hemorrhage. A report of the Cooperative Aneurysm Study. J Neurosurg. 1995 May; 82(5):786-90. PMID: 7714603.
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    38. Kasuya H, Weir BK, Nakane M, Pollock JS, Johns L, Marton LS, Stefansson K. Nitric oxide synthase and guanylate cyclase levels in canine basilar artery after subarachnoid hemorrhage. J Neurosurg. 1995 Feb; 82(2):250-5. PMID: 7529302.
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    39. Kasuya H, Weir BK, Shen YJ, Tredget EE, Ghahary A. Insulin-like growth factor-1 in the arterial wall after exposure to periarterial blood. Neurosurgery. 1994 Jul; 35(1):99-105. PMID: 7936160.
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    40. Macdonald RL, Weir BK. Cerebral vasospasm and free radicals. Free Radic Biol Med. 1994 May; 16(5):633-43. PMID: 8026807.
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    41. Vollrath BA, Weir BK, Macdonald RL, Cook DA. Intracellular mechanisms involved in the responses of cerebrovascular smooth-muscle cells to hemoglobin. J Neurosurg. 1994 Feb; 80(2):261-8. PMID: 8283265.
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    42. Kasuya H, Weir BK, White DM, Stefansson K. Mechanism of oxyhemoglobin-induced release of endothelin-1 from cultured vascular endothelial cells and smooth-muscle cells. J Neurosurg. 1993 Dec; 79(6):892-8. PMID: 7504096.
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    43. Hariton GB, Findlay JM, Weir BK, Kasuya H, Grace MG, Mielke BW. Comparison of intrathecal administration of urokinase and tissue plasminogen activator on subarachnoid clot and chronic vasospasm in a primate model. Neurosurgery. 1993 Oct; 33(4):691-6; discussion 696-7. PMID: 8232810.
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    44. Findlay JM, Grace MG, Weir BK. Treatment of intraventricular hemorrhage with tissue plasminogen activator. Neurosurgery. 1993 Jun; 32(6):941-7; discussion 947. PMID: 8327096.
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    45. Macdonald RL, Weir BK, Grace MG, Chen MH, Martin TP, Young JD. Mechanism of cerebral vasospasm following subarachnoid hemorrhage in monkeys. Can J Neurol Sci. 1992 Nov; 19(4):419-27. PMID: 1423039.
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    46. Macdonald RL, Weir BK, Runzer TD, Grace MG. Malondialdehyde, glutathione peroxidase, and superoxide dismutase in cerebrospinal fluid during cerebral vasospasm in monkeys. Can J Neurol Sci. 1992 Aug; 19(3):326-32. PMID: 1393841.
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    47. Macdonald RL, Weir BK, Runzer TD, Grace MG, Poznansky MJ. Effect of intrathecal superoxide dismutase and catalase on oxyhemoglobin-induced vasospasm in monkeys. Neurosurgery. 1992 Apr; 30(4):529-39. PMID: 1584351.
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    48. Takanashi Y, Weir BK, Vollrath B, Kasuya H, Macdonald RL, Cook D. Time course of changes in concentration of intracellular free calcium in cultured cerebrovascular smooth muscle cells exposed to oxyhemoglobin. Neurosurgery. 1992 Mar; 30(3):346-50. PMID: 1620296.
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    49. Weir BK. [Cerebral vasospasm. Experimental study]. Neurochirurgie. 1992; 38(3):129-33. PMID: 1461328.
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    50. Macdonald RL, Weir BK, Young JD, Grace MG. Cytoskeletal and extracellular matrix proteins in cerebral arteries following subarachnoid hemorrhage in monkeys. J Neurosurg. 1992 Jan; 76(1):81-90. PMID: 1727173.
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    51. Weir BK, Drake CG. Rapid growth of residual aneurysmal neck during pregnancy. Case report. J Neurosurg. 1991 Nov; 75(5):780-2. PMID: 1919702.
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    52. Macdonald RL, Weir BK, Chen MH, Grace MG. Scanning electron microscopy of normal and vasospastic monkey cerebrovascular smooth muscle cells. Neurosurgery. 1991 Oct; 29(4):544-50. PMID: 1944834.
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    53. Findlay JM, Macdonald RL, Weir BK, Grace MG. Surgical manipulation of primate cerebral arteries in established vasospasm. J Neurosurg. 1991 Sep; 75(3):425-32. PMID: 1869944.
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    54. Macdonald RL, Weir BK, Runzer TD, Grace MG, Findlay JM, Saito K, Cook DA, Mielke BW, Kanamaru K. Etiology of cerebral vasospasm in primates. J Neurosurg. 1991 Sep; 75(3):415-24. PMID: 1869943.
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    55. Macdonald RL, Weir BK. A review of hemoglobin and the pathogenesis of cerebral vasospasm. Stroke. 1991 Aug; 22(8):971-82. PMID: 1866764.
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    56. Findlay JM, Weir BK, Kassell NF, Disney LB, Grace MG. Intracisternal recombinant tissue plasminogen activator after aneurysmal subarachnoid hemorrhage. J Neurosurg. 1991 Aug; 75(2):181-8. PMID: 1906533.
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    57. Findlay JM, Weir BK, Stollery DE. Lysis of intraventricular hematoma with tissue plasminogen activator. Case report. J Neurosurg. 1991 May; 74(5):803-7. PMID: 1901601.
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    58. Kanamaru K, Weir BK, Simpson I, Witbeck T, Grace M. Effect of 21-aminosteroid U-74006F on lipid peroxidation in subarachnoid clot. J Neurosurg. 1991 Mar; 74(3):454-9. PMID: 1993911.
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    59. Findlay JM, Macdonald RL, Weir BK. Current concepts of pathophysiology and management of cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Cerebrovasc Brain Metab Rev. 1991; 3(4):336-61. PMID: 1772740.
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    60. Macdonald RL, Weir BK, Grace MG, Martin TP, Doi M, Cook DA. Morphometric analysis of monkey cerebral arteries exposed in vivo to whole blood, oxyhemoglobin, methemoglobin, and bilirubin. Blood Vessels. 1991; 28(6):498-510. PMID: 1782405.
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    61. Maroun FB, Jacob JC, Weir BK, Mangan MA. Hemifacial spasm and craniovertebral anomaly. Can J Neurol Sci. 1990 Nov; 17(4):424-6. PMID: 2276101.
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    62. Vollrath B, Weir BK, Cook DA. Hemoglobin causes release of inositol trisphosphate from vascular smooth muscle. Biochem Biophys Res Commun. 1990 Aug 31; 171(1):506-11. PMID: 2393405.
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    63. Kanamaru K, Weir BK, Findlay JM, Grace M, Macdonald RL. A dosage study of the effect of the 21-aminosteroid U74006F on chronic cerebral vasospasm in a primate model. Neurosurgery. 1990 Jul; 27(1):29-38. PMID: 2377279.
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    64. Findlay JM, Weir BK, Kanamaru K, Grace M, Baughman R. The effect of timing of intrathecal fibrinolytic therapy on cerebral vasospasm in a primate model of subarachnoid hemorrhage. Neurosurgery. 1990 Feb; 26(2):201-6. PMID: 2106630.
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    65. Kanamaru K, Weir BK, Findlay JM, Krueger CA, Cook DA. Pharmacological studies on relaxation of spastic primate cerebral arteries in subarachnoid hemorrhage. J Neurosurg. 1989 Dec; 71(6):909-15. PMID: 2511283.
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    66. Findlay JM, Weir BK, Kanamaru K, Espinosa F. Arterial wall changes in cerebral vasospasm. Neurosurgery. 1989 Nov; 25(5):736-45; discussion 745-6. PMID: 2586727.
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    67. Findlay JM, Weir BK, Gordon P, Grace M, Baughman R. Safety and efficacy of intrathecal thrombolytic therapy in a primate model of cerebral vasospasm. Neurosurgery. 1989 Apr; 24(4):491-8. PMID: 2496328.
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    68. Steinke DE, Weir BK, Findlay JM, Tanabe T, Grace M, Krushelnycky BW. A trial of the 21-aminosteroid U74006F in a primate model of chronic cerebral vasospasm. Neurosurgery. 1989 Feb; 24(2):179-86. PMID: 2918968.
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    69. Findlay JM, Weir BK, Kanamaru K, Grace M, Gordon P, Baughman R, Howarth A. Intrathecal fibrinolytic therapy after subarachnoid hemorrhage: dosage study in a primate model and review of the literature. Can J Neurol Sci. 1989 Feb; 16(1):28-40. PMID: 2493974.
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    70. Tsuji T, Weir BK, Cook DA. Time-dependent effects of extraluminally-applied oxyhemoglobin and endothelial removal on vasodilator responses in isolated, perfused canine basilar arteries. Pharmacology. 1989; 38(2):101-12. PMID: 2498911.
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    71. Findlay JM, Weir BK, Steinke D, Tanabe T, Gordon P, Grace M. Effect of intrathecal thrombolytic therapy on subarachnoid clot and chronic vasospasm in a primate model of SAH. J Neurosurg. 1988 Nov; 69(5):723-35. PMID: 3141595.
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    72. Petruk KC, West M, Mohr G, Weir BK, Benoit BG, Gentili F, Disney LB, Khan MI, Grace M, Holness RO, et al. Nimodipine treatment in poor-grade aneurysm patients. Results of a multicenter double-blind placebo-controlled trial. J Neurosurg. 1988 Apr; 68(4):505-17. PMID: 3280746.
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    73. Lewis PJ, Weir BK, Nosko MG, Tanabe T, Grace MG. Intrathecal nimodipine therapy in a primate model of chronic cerebral vasospasm. Neurosurgery. 1988 Mar; 22(3):492-500. PMID: 3362315.
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    74. Bornstein RA, Weir BK, Petruk KC, Disney LB. Neuropsychological function in patients after subarachnoid hemorrhage. Neurosurgery. 1987 Nov; 21(5):651-4. PMID: 3696396.
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    75. Handa Y, Weir BK, Nosko M, Mosewich R, Tsuji T, Grace M. The effect of timing of clot removal on chronic vasospasm in a primate model. J Neurosurg. 1987 Oct; 67(4):558-64. PMID: 3655894.
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    76. Nosko M, Weir BK, Lunt A, Grace M, Allen P, Mielke B. Effect of clot removal at 24 hours on chronic vasospasm after SAH in the primate model. J Neurosurg. 1987 Mar; 66(3):416-22. PMID: 3819837.
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    77. Nosko M, Krueger CA, Weir BK, Cook DA. Effects of nimodipine on in vitro contractility of cerebral arteries of dog, monkey, and man. J Neurosurg. 1986 Sep; 65(3):376-81. PMID: 3734887.
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    78. Allen GS, Ahn HS, Preziosi TJ, Battye R, Boone SC, Boone SC, Chou SN, Kelly DL, Weir BK, Crabbe RA, Lavik PJ, Rosenbloom SB, Dorsey FC, Ingram CR, Mellits DE, Bertsch LA, Boisvert DP, Hundley MB, Johnson RK, Strom JA, Transou CR. Cerebral arterial spasm--a controlled trial of nimodipine in patients with subarachnoid hemorrhage. N Engl J Med. 1983 Mar 17; 308(11):619-24. PMID: 6338383.
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    79. Weir BK. Results of burr hole and open or closed suction drainage for chronic subdural hematomas in adults. Can J Neurol Sci. 1983 Feb; 10(1):22-6. PMID: 6839223.
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    80. Benoit BG, Cochrane DD, Durity F, Ferguson GG, Fewer D, Hunter KM, Khan MI, Mohr G, Watts AR, Weir BK, Wheelock WB. Clinical - radiological correlates in intracerebral hematomas due to aneurysmal rupture. Can J Neurol Sci. 1982 Nov; 9(4):409-14. PMID: 7151024.
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    81. Okwuasaba FK, Weir BK, Cook DA, Krueger CA. Effects of various intracranial fluids on smooth muscle. Neurosurgery. 1981 Oct; 9(4):402-6. PMID: 7301086.
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    82. Weir BK, Jacobs GA. Reoperation rate following lumbar discectomy. An analysis of 662 lumbar discectomies. Spine (Phila Pa 1976). 1980 Jul-Aug; 5(4):366-70. PMID: 7455766.
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    83. Okwuasaba FK, Weir BK, Cook DA. Effects of storage on vasospastic activity of canine blood and blood-CSF mixtures. Proc West Pharmacol Soc. 1980; 23:331-4. PMID: 7403154.
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    84. Boisvert DP, Weir BK, Overton TR, Reiffenstein RJ, Grace MG. Cerebrovascular responses to subarachnoid blood and serotonin in the monkey. J Neurosurg. 1979 Apr; 50(4):441-8. PMID: 106096.
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    85. Okawuasaba FK, Weir BK, Cook DA, Krueger CA. 5-Hydroxytryptamine and vasospasm induced by subarachnoid hemorrhage. Proc West Pharmacol Soc. 1979; 22:441-5. PMID: 515085.
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    86. Cook DA, Weir BK, Okawuasaba FK, Krueger CA. Effects of hemoglobin on smooth muscle. Proc West Pharmacol Soc. 1979; 22:429-34. PMID: 515082.
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    87. Weir BK. Pulmonary edema following fatal aneurysm rupture. J Neurosurg. 1978 Oct; 49(4):502-7. PMID: 690677.
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    88. Henderson RM, Biosvert DP, Weir BK. Intercellular contacts in primate cerebral arteries: acute effects of subarachnoid injection of artificial cerebrospinal fluids, serotonin, and blood. Adv Neurol. 1978; 20:25-34. PMID: 97923.
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    89. Petruk KC, Weir BK, Overton TR, Marriott MR, Grace MG. The effect of graded hypocapnia and hypercapnia on regional cerebral blood flow and cerebral vessel caliber in the rhesus monkey: study of cerebral hemodynamics following subarachnoid hemorrhage and traumatic internal carotid spasm. Stroke. 1974 Mar-Apr; 5(2):230-6. PMID: 4205814.
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    90. Petruk KC, Weir BK, Marriott MR, Overton TR. Clinical grade, egional cerebral blood flow and angiographical spasm in the monkey after subarachnoid and subdural hemorrhage. Stroke. 1973 May-Jun; 4(3):431-45. PMID: 4197313.
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    91. Weir BK, Allen PB, Miller JD. Excision of thrombosed vein of Galen aneurysm in an infant. Case report. J Neurosurg. 1968 Dec; 29(6):619-22. PMID: 5304310.
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    92. McCann WP, Weir BK, Elvidge AR. Long-term survival after removal of metastatic malignant melanoma of the brain. Report of two cases. J Neurosurg. 1968 May; 28(5):483-7. PMID: 5659576.
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