"Globosides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Glycosphingolipids containing N-acetylglucosamine (paragloboside) or N-acetylgalactosamine (globoside). Globoside is the P antigen on erythrocytes and paragloboside is an intermediate in the biosynthesis of erythrocyte blood group ABH and P 1 glycosphingolipid antigens. The accumulation of globoside in tissue, due to a defect in hexosaminidases A and B, is the cause of Sandhoff disease.
- Lacto N tetraosylceramide
- Lacto N neotetraosylceramide
Below are MeSH descriptors whose meaning is more general than "Globosides".
Below are MeSH descriptors whose meaning is more specific than "Globosides".
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Below are the most recent publications written about "Globosides" by people in Profiles.
Alpha anomers of iGb3 and Gb3 stimulate cytokine production by natural killer T cells. ACS Chem Biol. 2009 Mar 20; 4(3):199-208.
Crystal structures of mouse CD1d-iGb3 complex and its cognate Valpha14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids. J Mol Biol. 2008 Apr 04; 377(4):1104-16.
Sensitive detection of isoglobo and globo series tetraglycosylceramides in human thymus by ion trap mass spectrometry. Glycobiology. 2008 Feb; 18(2):158-65.
The Niemann-Pick type C2 protein loads isoglobotrihexosylceramide onto CD1d molecules and contributes to the thymic selection of NKT cells. J Exp Med. 2007 Apr 16; 204(4):841-52.
The biology of NKT cells. Annu Rev Immunol. 2007; 25:297-336.
Lysosomal glycosphingolipid recognition by NKT cells. Science. 2004 Dec 03; 306(5702):1786-9.
Neutral glycosphingolipids of murine myeloma cells and helper, cytolytic, and suppressor T lymphocytes. Biochemistry. 1983 Jan 18; 22(2):251-5.