"Globosides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Glycosphingolipids containing N-acetylglucosamine (paragloboside) or N-acetylgalactosamine (globoside). Globoside is the P antigen on erythrocytes and paragloboside is an intermediate in the biosynthesis of erythrocyte blood group ABH and P 1 glycosphingolipid antigens. The accumulation of globoside in tissue, due to a defect in hexosaminidases A and B, is the cause of Sandhoff disease.
| Descriptor ID |
D005915
|
| MeSH Number(s) |
D02.065.313.425 D09.400.410.420.525.200.425 D10.390.470.675.200.425 D10.570.877.360.612.200.425
|
| Concept/Terms |
Cytolipins- Cytolipins
- Lacto-N-tetraosylceramide
- Lacto N tetraosylceramide
- Lactoneotetraosylceramide
- Lacto-N-neotetraosylceramide
- Lacto N neotetraosylceramide
|
Below are MeSH descriptors whose meaning is more general than "Globosides".
Below are MeSH descriptors whose meaning is more specific than "Globosides".
This graph shows the total number of publications written about "Globosides" by people in this website by year, and whether "Globosides" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2007 | 2 | 1 | 3 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
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Below are the most recent publications written about "Globosides" by people in Profiles.
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Alpha anomers of iGb3 and Gb3 stimulate cytokine production by natural killer T cells. ACS Chem Biol. 2009 Mar 20; 4(3):199-208.
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Crystal structures of mouse CD1d-iGb3 complex and its cognate Valpha14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids. J Mol Biol. 2008 Apr 04; 377(4):1104-16.
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Sensitive detection of isoglobo and globo series tetraglycosylceramides in human thymus by ion trap mass spectrometry. Glycobiology. 2008 Feb; 18(2):158-65.
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The Niemann-Pick type C2 protein loads isoglobotrihexosylceramide onto CD1d molecules and contributes to the thymic selection of NKT cells. J Exp Med. 2007 Apr 16; 204(4):841-52.
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The biology of NKT cells. Annu Rev Immunol. 2007; 25:297-336.
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Lysosomal glycosphingolipid recognition by NKT cells. Science. 2004 Dec 03; 306(5702):1786-9.
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Neutral glycosphingolipids of murine myeloma cells and helper, cytolytic, and suppressor T lymphocytes. Biochemistry. 1983 Jan 18; 22(2):251-5.