Hydroxymethylglutaryl CoA Reductases
"Hydroxymethylglutaryl CoA Reductases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzymes that catalyze the reversible reduction of alpha-carboxyl group of 3-hydroxy-3-methylglutaryl-coenzyme A to yield MEVALONIC ACID.
| Descriptor ID |
D006903
|
| MeSH Number(s) |
D08.811.682.047.820.150.415
|
| Concept/Terms |
Hydroxymethylglutaryl CoA Reductases- Hydroxymethylglutaryl CoA Reductases
- Hydroxymethylglutaryl CoA Reductase
- HMG CoA Reductases
- 3-Hydroxy-3-methylglutaryl CoA Reductase
- 3 Hydroxy 3 methylglutaryl CoA Reductase
- CoA Reductase, 3-Hydroxy-3-methylglutaryl
- Reductase, 3-Hydroxy-3-methylglutaryl CoA
- HMG CoA Reductase
|
Below are MeSH descriptors whose meaning is more general than "Hydroxymethylglutaryl CoA Reductases".
Below are MeSH descriptors whose meaning is more specific than "Hydroxymethylglutaryl CoA Reductases".
This graph shows the total number of publications written about "Hydroxymethylglutaryl CoA Reductases" by people in this website by year, and whether "Hydroxymethylglutaryl CoA Reductases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1997 | 1 | 0 | 1 |
| 1998 | 0 | 1 | 1 |
| 2001 | 1 | 0 | 1 |
| 2002 | 2 | 0 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Hydroxymethylglutaryl CoA Reductases" by people in Profiles.
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Body mass index and the association between low-density lipoprotein cholesterol as predicted by HMGCR genetic variants and breast cancer risk. Int J Epidemiol. 2019 10 01; 48(5):1727-1730.
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Zebrafish Prickle1b mediates facial branchiomotor neuron migration via a farnesylation-dependent nuclear activity. Development. 2011 May; 138(10):2121-32.
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Regulation of fibroblast mitochondrial 27-hydroxycholesterol production by active plasma membrane cholesterol. J Lipid Res. 2009 Sep; 50(9):1881-8.
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Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase. J Biol Chem. 2008 Jan 18; 283(3):1445-1455.
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Activation of membrane cholesterol by displacement from phospholipids. J Biol Chem. 2005 Oct 28; 280(43):36126-31.
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How cholesterol homeostasis is regulated by plasma membrane cholesterol in excess of phospholipids. Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11664-7.
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Isoprenoids as mediators of the biological effects of statins. J Clin Invest. 2002 Aug; 110(3):285-8.
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A multiple-dose pharmacodynamic, safety, and pharmacokinetic comparison of extended- and immediate-release formulations of lovastatin. Clin Ther. 2002 Jan; 24(1):112-25.
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Treatment of the elderly with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors: focus on drug interactions. J Cardiovasc Pharmacol Ther. 2001 Jul; 6(3):219-29.
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Aggressive treatment of dyslipidemia: a review of supporting evidence. Cleve Clin J Med. 2001 Feb; 68(2):130-1, 135-6, 137-8, 141-2.