"Intercalating Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA.
| Descriptor ID |
D007364
|
| MeSH Number(s) |
D27.720.470.410.360
|
| Concept/Terms |
Intercalating Agents- Intercalating Agents
- Agents, Intercalating
- Intercalating Ligands
- Ligands, Intercalating
- Intercalators
- Intercalative Compounds
- Compounds, Intercalative
|
Below are MeSH descriptors whose meaning is more general than "Intercalating Agents".
Below are MeSH descriptors whose meaning is more specific than "Intercalating Agents".
This graph shows the total number of publications written about "Intercalating Agents" by people in this website by year, and whether "Intercalating Agents" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 0 | 1 |
| 1996 | 0 | 1 | 1 |
| 1998 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
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Below are the most recent publications written about "Intercalating Agents" by people in Profiles.
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Activation of membrane cholesterol by 63 amphipaths. Biochemistry. 2009 Sep 15; 48(36):8505-15.
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Regulation of fibroblast mitochondrial 27-hydroxycholesterol production by active plasma membrane cholesterol. J Lipid Res. 2009 Sep; 50(9):1881-8.
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Visualizing superoxide production in normal and diabetic rat islets of Langerhans. J Biol Chem. 2003 Mar 14; 278(11):9796-801.
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DNA-drug interaction measurements using surface plasmon resonance. J Biomol Struct Dyn. 1998 Oct; 16(2):187-203.
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Crystal structure of an IHF-DNA complex: a protein-induced DNA U-turn. Cell. 1996 Dec 27; 87(7):1295-306.
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Phase I study of amonafide dosing based on acetylator phenotype. Cancer Res. 1993 May 15; 53(10 Suppl):2304-8.
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Limited sampling models for amonafide (NSC 308847) pharmacokinetics. Cancer Res. 1988 Jul 15; 48(14):4127-30.
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Mitoxantrone in malignant lymphomas. Cancer Treat Rev. 1983 Dec; 10 Suppl B:69-72.