 Lysergic Acid Diethylamide
"Lysergic Acid Diethylamide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is a potent hallucinogen, but the mechanisms of that effect are not well understood.
| Descriptor ID |
D008238
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| MeSH Number(s) |
D03.132.327.287.572.522 D03.549.439.572.522
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| Concept/Terms |
Lysergic Acid Diethylamide- Lysergic Acid Diethylamide
- Acid Diethylamide, Lysergic
- Diethylamide, Lysergic Acid
- LSD-25
- LSD 25
- Lysergide
- LSD
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Below are MeSH descriptors whose meaning is more general than "Lysergic Acid Diethylamide".
Below are MeSH descriptors whose meaning is more specific than "Lysergic Acid Diethylamide".
This graph shows the total number of publications written about "Lysergic Acid Diethylamide" by people in this website by year, and whether "Lysergic Acid Diethylamide" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 | | 2005 | 1 | 0 | 1 | | 2010 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2019 | 2 | 0 | 2 | | 2021 | 1 | 0 | 1 | | 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Lysergic Acid Diethylamide" by people in Profiles.
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de Wit H, Molla HM, Bershad A, Bremmer M, Lee R. Repeated low doses of LSD in healthy adults: A placebo-controlled, dose-response study. Addict Biol. 2022 03; 27(2):e13143.
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Murray CH, Tare I, Perry CM, Malina M, Lee R, de Wit H. Low doses of LSD reduce broadband oscillatory power and modulate event-related potentials in healthy adults. Psychopharmacology (Berl). 2022 Jun; 239(6):1735-1747.
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Bershad AK, Preller KH, Lee R, Keedy S, Wren-Jarvis J, Bremmer MP, de Wit H. Preliminary Report on the Effects of a Low Dose of LSD on Resting-State Amygdala Functional Connectivity. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 04; 5(4):461-467.
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Bershad AK, Schepers ST, Bremmer MP, Lee R, de Wit H. Acute Subjective and Behavioral Effects of Microdoses of Lysergic Acid Diethylamide in Healthy Human Volunteers. Biol Psychiatry. 2019 11 15; 86(10):792-800.
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Marseille R, Lee R, Coccaro EF. Inter-relationship between different platelet measures of 5-HT and their relationship to aggression in human subjects. Prog Neuropsychopharmacol Biol Psychiatry. 2012 Mar 30; 36(2):277-81.
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Baggott MJ, Coyle JR, Erowid E, Erowid F, Robertson LC. Abnormal visual experiences in individuals with histories of hallucinogen use: a Web-based questionnaire. Drug Alcohol Depend. 2011 Mar 01; 114(1):61-7.
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Marona-Lewicka D, Thisted RA, Nichols DE. Distinct temporal phases in the behavioral pharmacology of LSD: dopamine D2 receptor-mediated effects in the rat and implications for psychosis. Psychopharmacology (Berl). 2005 Jul; 180(3):427-35.
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Zacny JP, Goldman RE. Characterizing the subjective, psychomotor, and physiological effects of oral propoxyphene in non-drug-abusing volunteers. Drug Alcohol Depend. 2004 Feb 07; 73(2):133-40.
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Grailhe R, Waeber C, Dulawa SC, Hornung JP, Zhuang X, Brunner D, Geyer MA, Hen R. Increased exploratory activity and altered response to LSD in mice lacking the 5-HT(5A) receptor. Neuron. 1999 Mar; 22(3):581-91.
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Craig JC, Dinner A, Mulligan PJ. Simplified analogs of lysergic acid. V. Derivatives of N,N-diethyl-1-methyl-9H-indeno-1,2,3,9a-tetrahydro(2,1-b)pyridine-3-carboxamide. J Org Chem. 1974 Jun 14; 39(12):1669-76.
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