 Lymphocyte Culture Test, Mixed
"Lymphocyte Culture Test, Mixed" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Measure of histocompatibility at the HL-A locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way MLC test, the lymphocytes from one of the individuals are inactivated (usually by treatment with MITOMYCIN or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.
| Descriptor ID |
D007959
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| MeSH Number(s) |
E01.370.225.812.385.475 E05.200.812.385.475 E05.478.594.385.429
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| Concept/Terms |
Lymphocyte Culture Test, Mixed- Lymphocyte Culture Test, Mixed
- Mixed Lymphocyte Reaction
- Lymphocyte Reaction, Mixed
- Lymphocyte Reactions, Mixed
- Mixed Lymphocyte Reactions
- Mixed Lymphocyte Culture Test
- Mixed Leukocyte Reaction
- Leukocyte Reaction, Mixed
- Leukocyte Reactions, Mixed
- Mixed Leukocyte Reactions
- Mixed Leukocyte Culture Test
- Leukocyte Culture Test, Mixed
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Below are MeSH descriptors whose meaning is more general than "Lymphocyte Culture Test, Mixed".
Below are MeSH descriptors whose meaning is more specific than "Lymphocyte Culture Test, Mixed".
This graph shows the total number of publications written about "Lymphocyte Culture Test, Mixed" by people in this website by year, and whether "Lymphocyte Culture Test, Mixed" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1980 | 0 | 3 | 3 | | 1981 | 0 | 3 | 3 | | 1982 | 0 | 3 | 3 | | 1983 | 0 | 2 | 2 | | 1984 | 0 | 4 | 4 | | 1987 | 1 | 1 | 2 | | 1990 | 0 | 4 | 4 | | 1991 | 0 | 1 | 1 | | 1992 | 0 | 1 | 1 | | 1993 | 0 | 5 | 5 | | 1994 | 0 | 2 | 2 | | 1995 | 0 | 3 | 3 | | 1996 | 0 | 4 | 4 | | 1997 | 0 | 5 | 5 | | 1999 | 0 | 9 | 9 | | 2000 | 0 | 4 | 4 | | 2001 | 0 | 1 | 1 | | 2003 | 0 | 4 | 4 | | 2004 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2009 | 0 | 2 | 2 | | 2010 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Lymphocyte Culture Test, Mixed" by people in Profiles.
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Locke FL, Zha YY, Zheng Y, Driessens G, Gajewski TF. Conditional deletion of PTEN in peripheral T cells augments TCR-mediated activation but does not abrogate CD28 dependency or prevent anergy induction. J Immunol. 2013 Aug 15; 191(4):1677-85.
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Sonobe Y, Li H, Jin S, Kishida S, Kadomatsu K, Takeuchi H, Mizuno T, Suzumura A. Midkine inhibits inducible regulatory T cell differentiation by suppressing the development of tolerogenic dendritic cells. J Immunol. 2012 Mar 15; 188(6):2602-11.
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Hsieh CC, Chou HS, Fung JJ, Qian S, Lu L. The role of liver stromal cells in dendritic cells development in mice. Transplant Proc. 2010 Dec; 42(10):4279-81.
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Barth RN, Nam AJ, Stanwix MG, Kukuruga D, Drachenberg CI, Bluebond-Langner R, Hui-Chou H, Shipley ST, Bartlett ST, Rodriguez ED. Prolonged survival of composite facial allografts in non-human primates associated with posttransplant lymphoproliferative disorder. Transplantation. 2009 Dec 15; 88(11):1242-50.
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Wang L, Xiang Z, Ma LL, Chen Z, Gao X, Sun Z, Williams P, Chari RS, Yin DP. Deficiency of protein kinase C-theta facilitates tolerance induction. Transplantation. 2009 Feb 27; 87(4):507-16.
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Manicassamy S, Yin D, Zhang Z, Molinero LL, Alegre ML, Sun Z. A critical role for protein kinase C-theta-mediated T cell survival in cardiac allograft rejection. J Immunol. 2008 Jul 01; 181(1):513-20.
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Tiao MM, Lu L, Huang LT, Liang CD, Chen CL, Tao R, Fung JJ, Qian S. Cross-tolerance of recipient-derived transforming growth factor-beta dendritic cells. Transplant Proc. 2007 Jan-Feb; 39(1):281-2.
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Tao R, Wang L, Chen CH, Wang SH, Demarco RA, Lotze MT, Thai NL, Fung JJ, Lu L, Qian S. Mechanistic insights into achievement of cardiac allograft long-term survival by treatment with immature dendritic cells and sub-dose sirolimus. J Heart Lung Transplant. 2006 Mar; 25(3):310-9.
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Lesniak MS, Kelleher E, Pardoll D, Cui Y. Targeted gene therapy to antigen-presenting cells in the central nervous system using hematopoietic stem cells. Neurol Res. 2005 Dec; 27(8):820-6.
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Chiang PH, Wang L, Bonham CA, Liang X, Fung JJ, Lu L, Qian S. Mechanistic insights into impaired dendritic cell function by rapamycin: inhibition of Jak2/Stat4 signaling pathway. J Immunol. 2004 Feb 01; 172(3):1355-63.
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