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Romuald Girard

TitleResearch Assistant Professor
InstitutionUniversity of Chicago
DepartmentNeurological Surgery
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Alcazar-Felix RJ, Srinath A, Hage S, Bindal A, Ressler A, Pytel P, Allaw S, Girard R, Marchuk DA, Awad IA, Polster SP. Pathologic Features of Brain Hemorrhage After Radiation Treatment: Case Series with Somatic Mutation Analysis. J Stroke Cerebrovasc Dis. 2024 Mar 27; 107699. PMID: 38552890.
      Citations:    Fields:    
    2. Li Y, Girard R, Srinath A, Cruz DV, Ciszewski C, Chen C, Lightle R, Romanos S, Sone JY, Moore T, DeBiasse D, Stadnik A, Lee JJ, Shenkar R, Koskimäki J, Lopez-Ramirez MA, Marchuk DA, Ginsberg MH, Kahn ML, Shi C, Awad IA. Transcriptomic signatures of individual cell types in cerebral cavernous malformation. Cell Commun Signal. 2024 01 09; 22(1):23. PMID: 38195510; PMCID: PMC10775676.
      Citations:    Fields:    Translation:HumansCells
    3. Hellström S, Sajanti A, Srinath A, Bennett C, Girard R, Cao Y, Frantzén J, Koskimäki F, Falter J, Lyne SB, Rantamäki T, Takala R, Posti JP, Roine S, Puolitaival J, Jänkälä M, Kolehmainen S, Rahi M, Rinne J, Castrén E, Koskimäki J. Brain Plasticity Modulator p75 Neurotrophin Receptor in Human Urine after Different Acute Brain Injuries-A Prospective Cohort Study. Biomedicines. 2024 Jan 05; 12(1). PMID: 38255217; PMCID: PMC10813252.
      Citations:    
    4. Hage S, Kinkade S, Girard R, Flemming KD, Kim H, Torbey MT, Huang J, Huston J, Shu Y, Selwyn RG, Hart BL, Mabray MC, Feghali J, Sair HI, Narvid J, Lupo JM, Lee J, Stadnik A, Alcazar-Felix RJ, Shenkar R, Hobson N, DeBiasse D, Lane K, McBee NA, Treine K, Ostapkovich N, Wang Y, Thompson RE, Koenig JI, Carroll T, Hanley DF, Awad IA. Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part II: Biomarkers and Trial Modeling. Stroke. 2024 01; 55(1):31-39. PMID: 38134265; PMCID: PMC10752356.
      Citations:    Fields:    Translation:Humans
    5. Flemming KD, Kim H, Hage S, Mandrekar J, Kinkade S, Girard R, Torbey M, Huang J, Huston J, Shu Y, Lanzino G, Selwyn R, Hart B, Mabray M, Feghali J, Sair HI, Narvid J, Lupo JM, Lee J, Stadnik A, Alcazar-Felix RJ, Shenkar R, Lane K, McBee N, Treine K, Ostapkovich N, Wang Y, Thompson R, Koenig JI, Carroll T, Hanley D, Awad I. Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part I: Event Rates and Clinical Outcome. Stroke. 2024 01; 55(1):22-30. PMID: 38134268; PMCID: PMC10752254.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    6. Heino I, Sajanti A, Lyne SB, Frantzén J, Girard R, Cao Y, Ritala JF, Katila AJ, Takala RSK, Posti JP, Saarinen AJ, Hellström S, Laukka D, Saarenpää I, Rahi M, Tenovuo O, Rinne J, Koskimäki J. Outcome and survival of surgically treated acute subdural hematomas and postcraniotomy hematomas - A retrospective cohort study. Brain Spine. 2023; 3:102714. PMID: 38105801; PMCID: PMC10724206.
      Citations:    
    7. Ressler AK, Snellings DA, Girard R, Gallione CJ, Lightle R, Allen AS, Awad IA, Marchuk DA. Single-nucleus DNA sequencing reveals hidden somatic loss-of-heterozygosity in Cerebral Cavernous Malformations. Nat Commun. 2023 11 02; 14(1):7009. PMID: 37919320; PMCID: PMC10622526.
      Citations:    Fields:    Translation:Humans
    8. Zhang D, Kinloch AJ, Srinath A, Shenkar R, Girard R, Lightle R, Moore T, Koskimäki J, Mohsin A, Carrión-Penagos J, Romanos S, Shen L, Clark MR, Shi C, Awad IA. Corrigendum to "Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu" [J. Autoimmun. 113 (2020) 102469]. J Autoimmun. 2023 Sep 23; 103116. PMID: 37748978; PMCID: PMC10959760.
      Citations:    Fields:    
    9. Li Y, Srinath A, Alcazar-Felix RJ, Hage S, Bindal A, Lightle R, Shenkar R, Shi C, Girard R, Awad IA. Inflammatory Mechanisms in a Neurovascular Disease: Cerebral Cavernous Malformation. Brain Sci. 2023 Sep 17; 13(9). PMID: 37759937; PMCID: PMC10526329.
      Citations:    
    10. Hage S, Kinkade S, Girard R, Flemming KD, Kim H, Torbey MT, Huang J, Huston J, Shu Y, Selwyn RG, Hart BL, Mabray MC, Feghali J, Sair HI, Narvid J, Lupo JM, Lee J, Stadnik A, Alcazar R, Shenkar R, Hobson N, DeBiasse D, Lane K, McBee N, Treine K, Ostapkovich N, Wang Y, Thompson RE, Mendoza-Puccini C, Koenig J, Carroll T, Hanley DF, Awad IA. Cavernous Angioma Symptomatic Hemorrhage (CASH) Trial Readiness II: Imaging Biomarkers and Trial Modeling. medRxiv. 2023 Jun 05. PMID: 37333396; PMCID: PMC10275015.
      Citations:    
    11. Hage S, Hagan M, Bi D, Stadnik A, Lee J, Romanos S, Srinath A, Shenkar R, Lee C, Horowitz PM, Girard R, Awad IA. Impact of socioeconomics and race on clinical follow-up and trial enrollment and adherence in cerebral cavernous malformation. J Stroke Cerebrovasc Dis. 2023 Jul; 32(7):107167. PMID: 37146402; PMCID: PMC10201538.
      Citations:    Fields:    Translation:Humans
    12. Sone JY, Girard R, Koskimäki J. Editorial for "The Consistence of Dynamic-Contrast-Enhanced MRI and Filter-Exchange Imaging in Measuring Water Exchange Across the Blood-Brain Barrier in High-Grade Glioma". J Magn Reson Imaging. 2023 12; 58(6):1861-1862. PMID: 37052208.
      Citations:    Fields:    Translation:Humans
    13. Srinath A, Xie B, Li Y, Sone JY, Romanos S, Chen C, Sharma A, Polster S, Dorrestein PC, Weldon KC, DeBiasse D, Moore T, Lightle R, Zhang D, Stadnik A, Piedad K, Hagan M, Shkoukani A, Bi D, Shen L, Shenkar R, Ji Y, Sidebottom A, Pamer E, Gilbert JA, Kahn ML, D'Souza M, Sulakhe D, Awad IA, Girard R, Koskimäki J, Carrión-Penagos J. Plasma metabolites with mechanistic and clinical links to the neurovascular disease cavernous angioma. Commun Med (Lond). 2023 Mar 03; 3(1):35. PMID: 36869161; PMCID: PMC9984539.
      Citations:    
    14. Romanos SG, Srinath A, Li Y, Xie B, Chen C, Li Y, Moore T, Bi D, Sone JY, Lightle R, Hobson N, Zhang D, Shen L, McCurdy S, Lai CC, Stadnik A, Piedad K, Shkoukani A, Snellings D, Shenkar R, Sulakhe D, Ji Y, Lopez-Ramirez MA, Kahn ML, Marchuk DA, Ginsberg MH, Girard R, Awad IA, Koskimäki J, Carrión-Penagos J. Circulating Plasma miRNA Homologs in Mice and Humans Reflect Familial Cerebral Cavernous Malformation Disease. Transl Stroke Res. 2023 08; 14(4):513-529. PMID: 35715588; PMCID: PMC9758276.
      Citations:    Fields:    Translation:HumansAnimals
    15. Hagan MJ, Shenkar R, Srinath A, Romanos SG, Stadnik A, Kahn ML, Marchuk DA, Girard R, Awad IA. Rapamycin in Cerebral Cavernous Malformations: What Doses to Test in Mice and Humans. ACS Pharmacol Transl Sci. 2022 May 13; 5(5):266-277. PMID: 35592432; PMCID: PMC9112291.
      Citations: 2     
    16. Magid-Bernstein J, Girard R, Polster S, Srinath A, Romanos S, Awad IA, Sansing LH. Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions. Circ Res. 2022 04 15; 130(8):1204-1229. PMID: 35420918; PMCID: PMC10032582.
      Citations: 55     Fields:    Translation:Humans
    17. Shenkar R, Moore T, Benavides C, Lightle R, Detter MR, Hobson N, Girard R, DeBiasse D, Patrucco M, Gallione C, Zabramski JM, Marchuk DA, Awad IA. Propranolol as therapy for cerebral cavernous malformations: a cautionary note. J Transl Med. 2022 04 05; 20(1):160. PMID: 35382850; PMCID: PMC8981698.
      Citations: 2     Fields:    Translation:Humans
    18. Ritala JF, Sajanti A, Girard R, Lyne SB, Koskimäki J. Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain. Neural Regen Res. 2022 Apr; 17(4):701-704. PMID: 34472454; PMCID: PMC8530109.
      Citations: 6     
    19. Snellings DA, Girard R, Lightle R, Srinath A, Romanos S, Li Y, Chen C, Ren AA, Kahn ML, Awad IA, Marchuk DA. Developmental venous anomalies are a genetic primer for cerebral cavernous malformations. Nat Cardiovasc Res. 2022 Mar; 1:246-252. PMID: 35355835; PMCID: PMC8958845.
      Citations: 12     
    20. Li W, Shenkar R, Detter MR, Moore T, Benavides C, Lightle R, Girard R, Hobson N, Cao Y, Li Y, Griffin E, Gallione C, Zabramski JM, Ginsberg MH, Marchuk DA, Awad IA. Propranolol inhibits cavernous vascular malformations by ß1 adrenergic receptor antagonism in animal models. J Clin Invest. 2021 10 01; 131(19). PMID: 34596055; PMCID: PMC8483741.
      Citations: 7     Fields:    
    21. Sone JY, Hobson N, Srinath A, Romanos SG, Li Y, Shkoukani A, Stadnik A, Piedad K, Lightle R, Moore T, DeBiasse D, Bi D, Shenkar R, Carroll T, Ji Y, Girard R, Awad IA, Carrión-Penagos J. Perfusion and Permeability MRI Predicts Future Cavernous Angioma Hemorrhage and Growth. J Magn Reson Imaging. 2022 05; 55(5):1440-1449. PMID: 34558140; PMCID: PMC8942875.
      Citations: 3     Fields:    Translation:Humans
    22. Shkoukani A, Srinath A, Stadnik A, Girard R, Shenkar R, Sheline A, Dahlem K, Lee C, Flemming K, Awad IA. COVID-19 in a Hemorrhagic Neurovascular Disease, Cerebral Cavernous Malformation. J Stroke Cerebrovasc Dis. 2021 Nov; 30(11):106101. PMID: 34520969; PMCID: PMC8424017.
      Citations: 1     Fields:    Translation:Humans
    23. Lopez-Ramirez MA, Lai CC, Soliman SI, Hale P, Pham A, Estrada EJ, McCurdy S, Girard R, Verma R, Moore T, Lightle R, Hobson N, Shenkar R, Poulsen O, Haddad GG, Daneman R, Gongol B, Sun H, Lagarrigue F, Awad IA, Ginsberg MH. Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation. J Clin Invest. 2021 07 01; 131(13). PMID: 34043589; PMCID: PMC8245174.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    24. Snellings DA, Hong CC, Ren AA, Lopez-Ramirez MA, Girard R, Srinath A, Marchuk DA, Ginsberg MH, Awad IA, Kahn ML. Cerebral Cavernous Malformation: From Mechanism to Therapy. Circ Res. 2021 06 25; 129(1):195-215. PMID: 34166073; PMCID: PMC8922476.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    25. Sone JY, Li Y, Hobson N, Romanos SG, Srinath A, Shkoukani A, Stadnik A, Piedad K, Lightle R, Moore T, Li Y, Bi D, Shenkar R, Carroll T, Ji Y, Girard R, Awad IA, Lyne SB, Carrión-Penagos J. Perfusion and permeability as diagnostic biomarkers of cavernous angioma with symptomatic hemorrhage. J Cereb Blood Flow Metab. 2021 11; 41(11):2944-2956. PMID: 34039038; PMCID: PMC8756480.
      Citations: 4     Fields:    Translation:Humans
    26. Ren AA, Snellings DA, Su YS, Hong CC, Castro M, Tang AT, Detter MR, Hobson N, Girard R, Romanos S, Lightle R, Moore T, Shenkar R, Benavides C, Beaman MM, Chen M, Mericko P, Yang J, Sung DC, Lawton MT, Ruppert JM, Potente M, Awad IA, Marchuk DA, Kahn ML, Müller-Fielitz H, Schwaninger M, Körbelin J. PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism. Nature. 2021 06; 594(7862):271-276. PMID: 33910229; PMCID: PMC8626098.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    27. Polster SP, Gregson BA, Cao Y, Thompson RE, Stadnik A, Girard R, Money PL, Lane K, McBee N, Ziai W, Mould WA, Iqbal A, Metcalfe S, Hao Y, Dodd R, Carlson AP, Camarata PJ, Caron JL, Harrigan MR, Zuccarello M, Mendelow AD, Hanley DF, Awad IA, Carrión-Penagos J, Lyne SB. Intracerebral Hemorrhage Volume Reduction and Timing of Intervention Versus Functional Benefit and Survival in the MISTIE III and STICH Trials. Neurosurgery. 2021 04 15; 88(5):961-970. PMID: 33475732; PMCID: PMC8190461.
      Citations: 10     Fields:    Translation:Humans
    28. Girard R, Li Y, Stadnik A, Shenkar R, Hobson N, Romanos S, Srinath A, Moore T, Lightle R, Shkoukani A, Akers A, Carroll T, Christoforidis GA, Koenig JI, Lee C, Piedad K, Greenberg SM, Kim H, Flemming KD, Ji Y, Awad IA. A Roadmap for Developing Plasma Diagnostic and Prognostic Biomarkers of Cerebral Cavernous Angioma With Symptomatic Hemorrhage (CASH). Neurosurgery. 2021 02 16; 88(3):686-697. PMID: 33469662; PMCID: PMC7884145.
      Citations: 12     Fields:    Translation:HumansCells
    29. Li W, Shenkar R, Detter MR, Moore T, Benavides C, Lightle R, Girard R, Hobson N, Cao Y, Li Y, Griffin E, Gallione C, Zabramski JM, Ginsberg MH, Marchuk DA, Awad IA. Propranolol inhibits cavernous vascular malformations by ß1 adrenergic receptor antagonism in animal models. J Clin Invest. 2021 02 01; 131(3). PMID: 33301422; PMCID: PMC7843213.
      Citations: 11     Fields:    Translation:Animals
    30. Hong CC, Tang AT, Detter MR, Choi JP, Wang R, Yang X, Guerrero AA, Wittig CF, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Goddard LM, Ren AA, Leu NA, Sterling S, Yang J, Li L, Chen M, Mericko-Ishizuka P, Dow LE, Watanabe H, Schwaninger M, Min W, Marchuk DA, Zheng X, Awad IA, Kahn ML. Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican. J Exp Med. 2020 10 05; 217(10). PMID: 32648916; PMCID: PMC7537394.
      Citations: 22     Fields:    Translation:AnimalsCells
    31. Girard R, Cao Y, Diniz C, Umemori J, Li Y, Takala R, Sajanti A, Lyne SB, Frantzén J, Rantamäki T, Heino I, Posti JP, Roine S, Koskimäki F, Rahi M, Rinne J, Castrén E, Koskimäki J. A comprehensive p75 neurotrophin receptor gene network and pathway analyses identifying new target genes. Sci Rep. 2020 09 11; 10(1):14984. PMID: 32917932; PMCID: PMC7486379.
      Citations: 6     Fields:    Translation:HumansCells
    32. Detter MR, Shenkar R, Benavides CR, Neilson CA, Moore T, Lightle R, Hobson N, Shen L, Cao Y, Girard R, Zhang D, Griffin E, Gallione CJ, Awad IA, Marchuk DA. Novel Murine Models of Cerebral Cavernous Malformations. Angiogenesis. 2020 11; 23(4):651-666. PMID: 32710309; PMCID: PMC7530029.
      Citations: 23     Fields:    Translation:Animals
    33. Polster SP, Li Y, Romanos S, Srinath A, Zhang D, Lightle R, Moore T, Stadnik A, Piedad K, Cao Y, Shenkar R, Dimov AV, Hobson N, Christoforidis GA, Carroll T, Girard R, Awad IA, Koskimäki J, Carrión-Penagos J, Lyne SB. Common transcriptome, plasma molecules, and imaging signatures in the aging brain and a Mendelian neurovascular disease, cerebral cavernous malformation. Geroscience. 2020 10; 42(5):1351-1363. PMID: 32556941; PMCID: PMC7525636.
      Citations: 7     Fields:    Translation:HumansCells
    34. Polster SP, Sharma A, Tanes C, Tang AT, Mericko P, Cao Y, Girard R, Zhang D, Stadnik A, Romanos SG, Shenkar R, Yan K, Lee C, Akers A, Morrison L, Robinson M, Zafar A, Bittinger K, Kim H, Gilbert JA, Kahn ML, Shen L, Awad IA, Carrión-Penagos J, Koskimäki J, Lyne SB. Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma. Nat Commun. 2020 05 27; 11(1):2659. PMID: 32461638; PMCID: PMC7253448.
      Citations: 15     Fields:    Translation:Humans
    35. Zhang D, Kinloch AJ, Srinath A, Shenkar R, Girard R, Lightle R, Moore T, Mohsin A, Romanos S, Shen L, Clark MR, Shi C, Awad IA, Koskimäki J, Carrión-Penagos J. Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu. J Autoimmun. 2020 09; 113:102469. PMID: 32362501; PMCID: PMC7483292.
      Citations: 4     Fields:    Translation:HumansCells
    36. Zeineddine HA, Polster SP, Girard R, Romanos S, Srinath A, Zhang D, Cao Y, Stadnik A, Piedad K, Shenkar R, Awad IA, Carrión-Penagos J, Lyne SB, Koskimäki J. Subclinical imaging changes in cerebral cavernous angiomas during prospective surveillance. J Neurosurg. 2020 Apr 03; 134(3):1147-1154. PMID: 32244216; PMCID: PMC7541547.
      Citations: 6     Fields:    Translation:Humans
    37. Srinath A, Romanos S, Girard R, Lyne SB, Leporq B, Koskimäki J. Editorial for "Ensemble Learning for Early-Response Prediction of Antidepressant Treatment in Major Depressive Disorder". J Magn Reson Imaging. 2020 07; 52(1):172-173. PMID: 32034809.
      Citations:    Fields:    Translation:Humans
    38. Zhang D, Girard R, Piedad K, Polster SP, Stadnik A, Awad IA, Koskimäki J, Carrión-Penagos J, Lyne S. Symptomatic Brain Hemorrhages from Cavernous Angioma After Botulinum Toxin Injections, a Role of TLR/MEKK3 Mechanism? Case Report and Review of the Literature. World Neurosurg. 2020 Apr; 136:7-11. PMID: 31917316.
      Citations: 4     Fields:    Translation:Humans
    39. Polster SP, Stadnik A, Akers AL, Cao Y, Christoforidis GA, Fam MD, Flemming KD, Girard R, Hobson N, Koenig JI, Lane K, Liao JK, Lee C, McBee N, Morrison L, Piedad K, Shenkar R, Sorrentino M, Thompson RE, Whitehead KJ, Zeineddine HA, Hanley DF, Awad IA, Koskimäki J, Lyne SB. Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial. Neurosurgery. 2019 12 01; 85(6):843-853. PMID: 30476251; PMCID: PMC7054711.
      Citations: 32     Fields:    Translation:HumansCTClinical Trials
    40. Tang AT, Sullivan KR, Hong CC, Goddard LM, Mahadevan A, Ren A, Pardo H, Peiper A, Griffin E, Tanes C, Mattei LM, Yang J, Li L, Mericko-Ishizuka P, Shen L, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Li N, Zhu Q, Whitehead KJ, Zheng X, Akers A, Morrison L, Kim H, Bittinger K, Lengner CJ, Velcich A, Augenlicht L, Abdelilah-Seyfried S, Min W, Marchuk DA, Awad IA, Kahn ML, Schwaninger M, Rödel CJ. Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation. Sci Transl Med. 2019 11 27; 11(520). PMID: 31776290; PMCID: PMC6937779.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    41. Hobson N, Polster SP, Cao Y, Flemming K, Shu Y, Huston J, Gerrard CY, Selwyn R, Mabray M, Zafar A, Girard R, Chen YF, Parrish T, Zhou XJ, Koenig JI, Shenkar R, Stadnik A, Dimov A, Turley D, Carroll T, Awad IA, Carrión-Penagos J, Koskimäki J. Phantom validation of quantitative susceptibility and dynamic contrast-enhanced permeability MR sequences across instruments and sites. J Magn Reson Imaging. 2020 04; 51(4):1192-1199. PMID: 31515878; PMCID: PMC7065930.
      Citations: 8     Fields:    
    42. McKerracher L, Shenkar R, Abbinanti M, Cao Y, Peiper A, Liao JK, Lightle R, Moore T, Hobson N, Gallione C, Ruschel J, Girard R, Rosen K, Marchuk DA, Awad IA, Koskimäki J. A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease. Transl Stroke Res. 2020 06; 11(3):365-376. PMID: 31446620; PMCID: PMC7036327.
      Citations: 13     Fields:    Translation:Animals
    43. Zhang D, Li Y, Saadat L, Moore T, Lightle R, Polster SP, Zeineddine HA, Shi C, Shenkar R, Romanos S, Avner K, Srinath A, Shen L, Detter MR, Snellings D, Cao Y, Lopez-Ramirez MA, Fonseca G, Tang AT, Faber P, Andrade J, Ginsberg M, Kahn ML, Marchuk DA, Girard R, Awad IA, Koskimäki J, Carrión-Penagos J, Lyne SB. Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations. Acta Neuropathol Commun. 2019 08 19; 7(1):132. PMID: 31426861; PMCID: PMC6699077.
      Citations: 23     Fields:    Translation:AnimalsCells
    44. Girard R, Zeineddine HA, Zhang D, Cao Y, Li Y, Stadnik A, Moore T, Lightle R, Shi C, Shenkar R, Polster SP, Romanos S, Akers A, Lopez-Ramirez M, Whitehead KJ, Kahn ML, Ginsberg MH, Marchuk DA, Awad IA, Lyne SB, Koskimäki J, Carrión-Penagos J. Biomarkers of cavernous angioma with symptomatic hemorrhage. JCI Insight. 2019 06 20; 4(12). PMID: 31217347; PMCID: PMC6629090.
      Citations: 16     Fields:    Translation:HumansCells
    45. Awad IA, Polster SP, Thompson RE, Cao Y, Stadnik A, Money PL, Fam MD, Girard R, Lane K, McBee N, Ziai W, Hao Y, Dodd R, Carlson AP, Camarata PJ, Caron JL, Harrigan MR, Gregson BA, Mendelow AD, Zuccarello M, Hanley DF, MISTIE III Trial Investigators, Carrión-Penagos J, Koskimäki J. Surgical Performance Determines Functional Outcome Benefit in the Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation (MISTIE) Procedure. Neurosurgery. 2019 06 01; 84(6):1157-1168. PMID: 30891610; PMCID: PMC6537634.
      Citations: 40     Fields:    Translation:HumansCTClinical Trials
    46. Chapman EM, Lant B, Ohashi Y, Yu B, Schertzberg M, Go C, Dogra D, Girard R, Li Y, Fraser AG, Awad IA, Abdelilah-Seyfried S, Gingras AC, Derry WB, Koskimäki J. A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis. Nat Commun. 2019 04 17; 10(1):1791. PMID: 30996251; PMCID: PMC6470173.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    47. Polster SP, Cao Y, Carroll T, Flemming K, Girard R, Hanley D, Hobson N, Kim H, Koenig J, Lane K, Majersik JJ, McBee N, Morrison L, Shenkar R, Stadnik A, Thompson RE, Zabramski J, Zeineddine HA, Awad IA, Koskimäki J. Trial Readiness in Cavernous Angiomas With Symptomatic Hemorrhage (CASH). Neurosurgery. 2019 04 01; 84(4):954-964. PMID: 29660039; PMCID: PMC6500884.
      Citations: 22     Fields:    Translation:Humans
    48. Shenkar R, Peiper A, Pardo H, Moore T, Lightle R, Girard R, Hobson N, Polster SP, Zhang D, Cao Y, Chaudagar K, Saadat L, Gallione C, Pytel P, Liao JK, Marchuk D, Awad IA, Koskimäki J, Lyne SB. Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease. Stroke. 2019 03; 50(3):738-744. PMID: 30744543; PMCID: PMC6389370.
      Citations: 19     Fields:    Translation:Animals
    49. Girard R, Li Y, Saadat L, Zeineddine HA, Lightle R, Moore T, Avner K, Shenkar R, Cao Y, Shi C, Polster SP, Zhang D, Romanos S, Fonseca G, Lopez-Ramirez MA, Chapman EM, Popiel E, Tang AT, Akers A, Faber P, Andrade J, Ginsberg M, Derry WB, Kahn ML, Marchuk DA, Awad IA, Koskimäki J, Lyne S, Carrión-Penagos J. Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes. JCI Insight. 2019 Feb 07; 4(3). PMID: 30728328; PMCID: PMC6413775.
      Citations: 28     Fields:    
    50. Heino I, Rinne J, Girard R, Cao Y, Sajanti A, Katila AJ, Posti JP, Takala RSK, Tenovuo O, Frantzén J, Koskimäki J. Risk Factors for Recurrent Hematoma After Surgery for Acute Traumatic Subdural Hematoma. World Neurosurg. 2019 Apr; 124:e563-e571. PMID: 30639489.
      Citations: 4     Fields:    
    51. Fam MD, Stadnik A, Zeineddine HA, Girard R, Mayo S, Dlugash R, McBee N, Lane K, Mould WA, Ziai W, Hanley D, Awad IA. Symptomatic Hemorrhagic Complications in Clot Lysis: Evaluation of Accelerated Resolution of Intraventricular Hemorrhage Phase III Clinical Trial (CLEAR III): A Posthoc Root-Cause Analysis. Neurosurgery. 2018 12 01; 83(6):1260-1268. PMID: 29294116; PMCID: PMC6454794.
      Citations: 1     Fields:    Translation:Humans
    52. Lopez-Ramirez MA, Pham A, Girard R, Wyseure T, Hale P, Yamashita A, Polster S, Saadat L, Romero IA, Esmon CT, Lagarrigue F, Awad IA, Mosnier LO, Ginsberg MH, Koskimäki J. Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice. Blood. 2019 01 17; 133(3):193-204. PMID: 30442679; PMCID: PMC6337879.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    53. Zeineddine HA, Girard R, Saadat L, Shen L, Lightle R, Moore T, Cao Y, Hobson N, Shenkar R, Avner K, Chaudager K, Polster SP, Fam MD, Shi C, Lopez-Ramirez MA, Tang AT, Gallione C, Kahn ML, Ginsberg M, Marchuk DA, Awad IA, Koskimäki J. Phenotypic characterization of murine models of cerebral cavernous malformations. Lab Invest. 2019 03; 99(3):319-330. PMID: 29946133; PMCID: PMC6309944.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    54. Girard R, Zeineddine HA, Fam MD, Cao Y, Shi C, Moore T, Lightle R, Stadnik A, Chaudagar K, Polster S, Shenkar R, Duggan R, Leclerc D, Whitehead KJ, Li DY, Awad IA, Koskimäki J. Plasma Biomarkers of Inflammation and Angiogenesis Predict Cerebral Cavernous Malformation Symptomatic Hemorrhage or Lesional Growth. Circ Res. 2018 06 08; 122(12):1716-1721. PMID: 29720384; PMCID: PMC5993629.
      Citations: 30     Fields:    Translation:Humans
    55. Fam MD, Hanley D, Stadnik A, Zeineddine HA, Girard R, Jesselson M, Cao Y, Money L, McBee N, Bistran-Hall AJ, Mould WA, Lane K, Camarata PJ, Zuccarello M, Awad IA. Surgical Performance in Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation Phase III Clinical Trial. Neurosurgery. 2017 Nov 01; 81(5):860-866. PMID: 28402516; PMCID: PMC6257031.
      Citations: 18     Fields:    Translation:HumansCTClinical Trials
    56. Lopez-Ramirez MA, Fonseca G, Zeineddine HA, Girard R, Moore T, Pham A, Cao Y, Shenkar R, de Kreuk BJ, Lagarrigue F, Lawler J, Glass CK, Awad IA, Ginsberg MH. Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations. J Exp Med. 2017 Nov 06; 214(11):3331-3346. PMID: 28970240; PMCID: PMC5679163.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    57. Girard R, Zeineddine HA, Fam MD, Mayampurath A, Cao Y, Shi C, Shenkar R, Polster SP, Jesselson M, Duggan R, Mikati AG, Christoforidis G, Andrade J, Whitehead KJ, Li DY, Awad IA. Plasma Biomarkers of Inflammation Reflect Seizures and Hemorrhagic Activity of Cerebral Cavernous Malformations. Transl Stroke Res. 2018 02; 9(1):34-43. PMID: 28819935; PMCID: PMC5750099.
      Citations: 31     Fields:    Translation:Humans
    58. Zeineddine HA, Girard R, Cao Y, Hobson N, Fam MD, Stadnik A, Tan H, Shen J, Chaudagar K, Shenkar R, Thompson RE, McBee N, Hanley D, Carroll T, Christoforidis GA, Awad IA. Quantitative susceptibility mapping as a monitoring biomarker in cerebral cavernous malformations with recent hemorrhage. J Magn Reson Imaging. 2018 04; 47(4):1133-1138. PMID: 28791783; PMCID: PMC5807224.
      Citations: 14     Fields:    Translation:Humans
    59. Tang AT, Choi JP, Kotzin JJ, Yang Y, Hong CC, Hobson N, Girard R, Zeineddine HA, Lightle R, Moore T, Cao Y, Shenkar R, Chen M, Mericko P, Yang J, Li L, Tanes C, Kobuley D, Whitehead KJ, Li DY, Franke L, Hart B, Henao-Mejia J, Morrison L, Kim H, Awad IA, Zheng X, Kahn ML, Võsa U, Schwaninger M. Endothelial TLR4 and the microbiome drive cerebral cavernous malformations. Nature. 2017 05 18; 545(7654):305-310. PMID: 28489816; PMCID: PMC5757866.
      Citations: 137     Fields:    Translation:HumansAnimalsCells
    60. Ligneul R, Girard R, Dreher JC. Social brains and divides: the interplay between social dominance orientation and the neural sensitivity to hierarchical ranks. Sci Rep. 2017 04 05; 7:45920. PMID: 28378784; PMCID: PMC5381105.
      Citations: 13     Fields:    Translation:Humans
    61. Shenkar R, Shi C, Austin C, Moore T, Lightle R, Cao Y, Zhang L, Wu M, Zeineddine HA, Girard R, McDonald DA, Rorrer A, Gallione C, Pytel P, Liao JK, Marchuk DA, Awad IA. RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations. Stroke. 2017 01; 48(1):187-194. PMID: 27879448; PMCID: PMC5183488.
      Citations: 49     Fields:    Translation:Animals
    62. Girard R, Fam MD, Zeineddine HA, Tan H, Mikati AG, Shi C, Jesselson M, Shenkar R, Wu M, Cao Y, Hobson N, Larsson HBW, Christoforidis GA, Awad IA. Vascular permeability and iron deposition biomarkers in longitudinal follow-up of cerebral cavernous malformations. J Neurosurg. 2017 Jul; 127(1):102-110. PMID: 27494817; PMCID: PMC6421857.
      Citations: 34     Fields:    Translation:Humans
    63. Girard R, Zeineddine HA, Orsbon C, Tan H, Moore T, Hobson N, Shenkar R, Lightle R, Shi C, Fam MD, Cao Y, Shen L, Neander AI, Rorrer A, Gallione C, Tang AT, Kahn ML, Marchuk DA, Luo ZX, Awad IA. Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease. J Neurosci Methods. 2016 09 15; 271:14-24. PMID: 27345427; PMCID: PMC5003657.
      Citations: 17     Fields:    Translation:Animals
    64. Shi C, Shenkar R, Zeineddine HA, Girard R, Fam MD, Austin C, Moore T, Lightle R, Zhang L, Wu M, Cao Y, Gunel M, Louvi A, Rorrer A, Gallione C, Marchuk DA, Awad IA. B-Cell Depletion Reduces the Maturation of Cerebral Cavernous Malformations in Murine Models. J Neuroimmune Pharmacol. 2016 06; 11(2):369-77. PMID: 27086141; PMCID: PMC6746226.
      Citations: 26     Fields:    Translation:AnimalsCells
    65. Tan H, Zhang L, Mikati AG, Girard R, Khanna O, Fam MD, Liu T, Wang Y, Edelman RR, Christoforidis G, Awad IA. Quantitative Susceptibility Mapping in Cerebral Cavernous Malformations: Clinical Correlations. AJNR Am J Neuroradiol. 2016 Jul; 37(7):1209-15. PMID: 26965464; PMCID: PMC4947004.
      Citations: 24     Fields:    Translation:Humans
    66. Girard R, Khanna O, Shenkar R, Zhang L, Wu M, Jesselson M, Zeineddine HA, Gangal A, Fam MD, Gibson CC, Whitehead KJ, Li DY, Liao JK, Shi C, Awad IA. Peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease. Biomark Med. 2016; 10(3):255-64. PMID: 26861901; PMCID: PMC4926533.
      Citations: 16     Fields:    Translation:HumansCells
    67. Mikati AG, Khanna O, Zhang L, Girard R, Shenkar R, Guo X, Shah A, Larsson HB, Tan H, Li L, Wishnoff MS, Shi C, Christoforidis GA, Awad IA. Vascular permeability in cerebral cavernous malformations. J Cereb Blood Flow Metab. 2015 Oct; 35(10):1632-9. PMID: 25966944; PMCID: PMC4640319.
      Citations: 38     Fields:    Translation:Humans
    68. Watts C, Mendenhall RC, Radecki SE, Girard RA. Neurosurgical manpower: the physician's viewpoint. J Neurosurg. 1982 May; 56(5):609-14. PMID: 7069471.
      Citations:    Fields:    
    69. Mendenhall RC, Watts C, Radecki SE, Girard RA. Neurosurgery in the United States: a log-diary study. Neurosurgery. 1981 Feb; 8(2):267-76. PMID: 7207795.
      Citations: 1     Fields:    
    70. Lloyd JS, Mendenhall RC, De Florio GP, Girard RA. A study of the practice of otorhinolaryngology in the United States. Initial findings. Arch Otolaryngol. 1979 Oct; 105(10):610-20. PMID: 485931.
      Citations:    Fields:    Translation:Humans
    71. Mendenhall RC, Ramsay DL, Girard RA, DeFlorio GP, Weary PE, Lloyd JS. A study of the practice of dermatology in the United States. Initial findings. Arch Dermatol. 1978 Oct; 114(10):1456-62. PMID: 718180.
      Citations: 5     Fields:    Translation:Humans
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