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Jonathan Grinstein

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Cardiology
AddressChicago IL 60637
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    Collapse Biography 
    Collapse education and training
    McGill University, Montreal, QC2006Physiology
    University of Chicago, Chicago, IL2010Medicine
    Brigham and Women's Hospital (Harvard), Boston, MA2013Internal Medicine
    University of Chicago, Chicago, IL2016Cardiovascular Medicine
    University of Chicago, Chicago, IL2017Advanced Heart Failure and Cardiac Transplantation
    Collapse awards and honors
    Alpha Omega Alpha
    Gold Humanism Honors Society
    Finalist, Jay N Cohn Award, Heart Failure Society of America
    Member of the Future Leaders in the Growth of Heart Failure Therapies (FLIGHT) Program
    MedStar New Investigator Grant
    Morton Arnsdorf Award for Best Research
    American Society for Clincal Pathology Award for Academic Excellence and Achievement
    Dean’s Scholarship for Outstanding Promise in Medicine
    Dr. Kathleen Terroux Prize in Physiology

    Collapse ORNG Applications 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Nishida H, Song T, Onsager D, Nguyen A, Grinstein J, Chung B, Smith B, Kalantari S, Sarswat N, Kim G, Pinney S, Jeevanandam V, Milner R, Ota T. Significant vascular complications in percutaneous axillary intra-aortic balloon pump. Ann Vasc Surg. 2022 Jan 05. PMID: 34995740.
      View in: PubMed
    2. Belkin MN, Kagan V, Labuhn C, Pinney SP, Grinstein J. Physiology and Clinical Utility of HeartMate Pump Parameters. J Card Fail. 2021 Dec 31. PMID: 34980564.
      View in: PubMed
    3. Nishida H, Ota T, Onsager D, Grinstein J, Jeevanandam V, Song T. Ten-year, single center experience of ambulatory axillary intra-aortic balloon pump support for heart failure. J Cardiol. 2021 Dec 08. PMID: 34895789.
      View in: PubMed
    4. Belkin MN, Alenghat FJ, Besser SA, Pinney SP, Grinstein J. Improved Prognostic Performance of Cardiac Power Output With Right Atrial Pressure: A Subanalysis of the ESCAPE Trial. J Card Fail. 2021 Nov 10. PMID: 34774746.
      View in: PubMed
    5. Nishida H, Song T, Onsager D, Nguyen A, Grinstein J, Chung B, Smith B, Kalantari S, Sarswat N, Kim G, Pinney S, Jeevanandam V, Ota T. Proximal ascending aorta size is associated with the incidence of de novo aortic insufficiency with left ventricular assist device. Heart Vessels. 2021 Sep 28. PMID: 34585275.
      View in: PubMed
    6. Grinstein J, Torii R, Bourantas CV, Garcia-Garcia HM. Left Ventricular Assist Device Flow Pattern Analysis Using a Novel Model Incorporating Left Ventricular Pulsatility. ASAIO J. 2021 07 01; 67(7):724-732. PMID: 33528162.
      View in: PubMed
    7. Chung BB, Grinstein JS, Imamura T, Kruse E, Nguyen AB, Narang N, Holzhauser LH, Burkhoff D, Lang RM, Sayer GT, Uriel NY. Biventricular Pacing Versus Right Ventricular Pacing in Patients Supported With LVAD. JACC Clin Electrophysiol. 2021 08; 7(8):1003-1009. PMID: 34217657.
      View in: PubMed
    8. Grinstein J, Molina EJ, Sheikh FH. Successful HeartMate 3 LVAD implantation in a patient with active heparin-induced thrombocytopaenia with thrombosis using pre-implantation plasmapheresis and intraoperative continuous prostacyclin. Interact Cardiovasc Thorac Surg. 2021 06 28; 33(1):161-162. PMID: 33575742.
      View in: PubMed
    9. Almousa SW, Belkin MN, Allan T, Stephens A, Kern J, Cisneros M, Friant J, Arevalo C, Nathan S, Shah AP, Paul J, Kalathiya R, Grinstein J, Blair JEA. Left Ventricular Pressure Ratio Predicts In-Hospital Outcomes in Hospitalized Heart Failure With Reduced Ejection Fraction. J Invasive Cardiol. 2021 Jul; 33(7):E507-E515. PMID: 34148868.
      View in: PubMed
    10. Belkin MN, Kalantari S, Kanelidis AJ, Miller T, Smith BA, Besser SA, Tehrani D, Chung BB, Nguyen A, Sarswat N, Blair JEA, Burkhoff D, Sayer G, Pinney SP, Uriel N, Kim G, Grinstein J. Aortic Pulsatility Index: A Novel Hemodynamic Variable for Evaluation of Decompensated Heart Failure. J Card Fail. 2021 10; 27(10):1045-1052. PMID: 34048919.
      View in: PubMed
    11. Grinstein J, Sawalha Y, Medvedofsky DA, Ahmad S, Hofmeyer M, Rodrigo M, Kadakkal A, Barnett C, Kalantari S, Talati I, Zaghol R, Molina EJ, Sheikh FH, Najjar SS. VE/VCO2 slope predicts RV dysfunction and mortality after left ventricular assist device: a fresh look at cardiopulmonary stress testing for prognostication. J Artif Organs. 2021 Dec; 24(4):425-432. PMID: 33792816.
      View in: PubMed
    12. Nathan S, Grinstein J. Future Devices for Percutaneous Mechanical Circulatory Support. Interv Cardiol Clin. 2021 04; 10(2S):e1-e12. PMID: 34362554.
      View in: PubMed
    13. Kostick KM, Trejo M, Bhimaraj A, Civitello A, Grinstein J, Horstmanshof D, Jorde UP, Loebe M, Mehra MR, Sulemanjee NZ, Thohan V, Trachtenberg BH, Uriel N, Volk RJ, Estep JD, Blumenthal-Barby JS. A principal components analysis of factors associated with successful implementation of an LVAD decision support tool. BMC Med Inform Decis Mak. 2021 03 20; 21(1):106. PMID: 33743685.
      View in: PubMed
    14. Belkin MN, Alenghat FJ, Besser SA, Nguyen AB, Chung BB, Smith BA, Kalantari S, Sarswat N, Blair JEA, Kim GH, Pinney SP, Grinstein J. Aortic pulsatility index predicts clinical outcomes in heart failure: a sub-analysis of the ESCAPE trial. ESC Heart Fail. 2021 04; 8(2):1522-1530. PMID: 33595923.
      View in: PubMed
    15. Grinstein J, Kalantari S. Palliative Care Reform in Acute Heart Failure: Are We Ready for a Systematic Shift from Quantity to Quality? Cardiovasc Revasc Med. 2021 02; 23:57-58. PMID: 33234473.
      View in: PubMed
    16. Grinstein J, Garan AR, Oesterle A, Fried J, Imamura T, Mai X, Kalantari S, Sayer G, Kim GH, Sarswat N, Raikhelkar J, Adatya S, Jeevanandam V, Flatley E, Moss J, Uriel N. Increased Rate of Pump Thrombosis and Cardioembolic Events Following Ventricular Tachycardia Ablation in Patients Supported With Left Ventricular Assist Devices. ASAIO J. 2020 Nov/Dec; 66(10):1127-1136. PMID: 33136600.
      View in: PubMed
    17. Imamura T, Narang N, Kim G, Nitta D, Fujino T, Nguyen A, Grinstein J, Rodgers D, Ota T, Raikhelkar J, Jeevanandam V, Sayer G, Uriel N. Impact of worsening of aortic insufficiency during HeartMate 3 LVAD support. Artif Organs. 2021 Mar; 45(3):297-302. PMID: 33098153.
      View in: PubMed
    18. Nishida H, Koda Y, Kalantari S, Nguyen A, Chung B, Grinstein J, Kim G, Sarswat N, Smith B, Song T, Onsager D, Jeevanandam V, Ota T. Outcomes of Ambulatory Axillary Intraaortic Balloon Pump as a Bridge to Heart Transplantation. Ann Thorac Surg. 2021 04; 111(4):1264-1270. PMID: 32882197.
      View in: PubMed
    19. Belkin MN, Venturini J, Nathan S, Grinstein J. Left Ventricular Assist Device Performance Under Pressure: Troubleshooting Outflow Graft Dysfunction. Circ Heart Fail. 2020 07; 13(7):e007098. PMID: 32605386.
      View in: PubMed
    20. Belkin MN, Dela Cruz M, Nadeem U, Patel AR, Kim G, Grinstein J. Massive Myocardial Calcium Deposition: Hardened Heart. JACC Case Rep. 2020 Jun 17; 2(7):996-1003. PMID: 34317401.
      View in: PubMed
    21. Imamura T, Narang N, Kim G, Nitta D, Fujino T, Nguyen A, Grinstein J, Rodgers D, Ota T, Jeevanandam V, Sayer G, Uriel N. Aortic Insufficiency During HeartMate 3 Left Ventricular Assist Device Support. J Card Fail. 2020 Oct; 26(10):863-869. PMID: 32473380.
      View in: PubMed
    22. Uriel N, Jeevanandam V, Imamura T, Onsager D, Song T, Ota T, Juricek C, Combs P, Lammy T, Patel-Raman S, Woolley JR, Sayer G, Milano C, Schroder J, Molina E, Grinstein J, Suarez E, Estep JD, Aggarwal S, Silvestry S, Raval N. Clinical Outcomes and Quality of Life With an Ambulatory Counterpulsation Pump in Advanced Heart Failure Patients: Results of the Multicenter Feasibility Trial. Circ Heart Fail. 2020 04; 13(4):e006666. PMID: 32264715.
      View in: PubMed
    23. Nishida H, Jeevanandam V, Koda Y, Song T, Onsager D, Nguyen A, Grinstein J, Chung B, Smith B, Kalantari S, Sarswat N, Kim G, Ota T. Impact of Prophylactic Donor Heart Tricuspid Valve Annuloplasty in Long-Term Clinical Outcomes of Heart Transplantation. J Heart Lung Transplant. 2020 Apr; 39(4S):S44. PMID: 32465743.
      View in: PubMed
    24. Grinstein J, Onsager D, Rodgers D, Symalla T, Ota T, Labuhn C, Combs P, Kagan V, Lammy T, Kalantari S, Smith B, Sarswat N, Nguyen A, Chung B, Kim GH, Jeevanandam V. Cardiac Reserve as Assessed by Augmentation in Cardiac Power Efficiency Predicts Response to Intravascular Ventricular Assist System Support. J Heart Lung Transplant. 2020 Apr; 39(4S):S350-S351. PMID: 32465488.
      View in: PubMed
    25. Yu D, Kruse E, Rodgers D, Holzhauser H, Sarswat N, Smith B, Kalantari S, Chung B, Nguyen AB, Mehta N, Raikhelkar J, Sayer G, Uriel N, Song T, Ota T, Jeevanandam V, Kim G, Grinstein J. Outflow Cannula Systolic Slope as a Predictor of Myocardial Recovery Leading to Successful LVAD Decommission: A Case Series. J Heart Lung Transplant. 2020 Apr; 39(4S):S345. PMID: 32465473.
      View in: PubMed
    26. Karagodin I, Hackett I, Kim G, Lang RM, Grinstein J. Effects of Various Left Ventricular Assist Device Models on Echocardiographic Markers of Aortic Compliance. J Heart Lung Transplant. 2020 Apr; 39(4S):S349. PMID: 32465482.
      View in: PubMed
    27. Dela Cruz M, Besser S, Sarswat N, Smith B, Grinstein J, Nguyen A, Chung B, Kalantari S, Kim G. Immune Function Testing and Donor-Specific Antibody Production among Heart Transplant Patients. J Heart Lung Transplant. 2020 Apr; 39(4S):S278. PMID: 32465276.
      View in: PubMed
    28. Hackett IS, Lang RM, Sun D, Kim G, Grinstein J. Redefining Normal Outflow Cannula Velocity Reference Values for Each Left Ventricular Assist Device. J Heart Lung Transplant. 2020 Apr; 39(4S):S416. PMID: 32465677.
      View in: PubMed
    29. Mehta N, Fujino T, Belkin M, DelaCruz M, Yu D, Holzhauser L, Rodgers D, Smith B, Kalantari S, Sarswat N, Chung B, Nguyen A, Uriel N, Raikhelkar J, Sayer G, Song T, Ota T, Jeevanandam V, Kim G, Grinstein J. Prognostication of Residual Mitral Regurgitation or Aortic Insufficiency after Invasive Hemodynamic Ramp Optimization. J Heart Lung Transplant. 2020 Apr; 39(4S):S117. PMID: 32464824.
      View in: PubMed
    30. Mehta N, Fujino T, Dela Cruz M, Holzhauser L, Rodgers D, Kalantari S, Smith B, Sarswat N, Nguyen A, Chung B, Uriel N, Raikhelkar J, Sayer G, Ota T, Song T, Jeevanandam V, Kim G, Grinstein J. Absence of Aortic Valve Opening after Hemodynamic Ramp Optimization Study Does Not Impact LVAD Morbidity of Mortality. J Heart Lung Transplant. 2020 Apr; 39(4S):S351. PMID: 32465490.
      View in: PubMed
    31. Sheikh FH, Ahmed S, Rodrigo ME, Hofmeyer M, Kadakkal A, Grinstein J, Mohammed SF, Kitahara H, Molina EJ, Najjar SS. Long Term Outcomes of African-American LVAD Recipients. J Heart Lung Transplant. 2020 Apr; 39(4S):S338-S339. PMID: 32465451.
      View in: PubMed
    32. Grinstein J, Torii R, Bourantas C, Garcia HMG. Left Ventricular Assist Device Shear Stress Quantification Utilizing Computational Fluid Dynamics: Using Physics and Physiology to Optimize Programmable Flow Algorithms. J Heart Lung Transplant. 2020 Apr; 39(4S):S344. PMID: 32465470.
      View in: PubMed
    33. Nishida H, Ota T, Koda Y, Onsager D, Nguyen A, Grinstein J, Chung B, Smith B, Kalantari S, Sarswat N, Kim G, Jeevanandam V, Song T. Long Term Survival after Heart Transplantation is Not Affected by Axillary Intra Aortic Balloon Pump Support as a Bridge to Heart Transplantation. J Heart Lung Transplant. 2020 Apr; 39(4S):S281-S282. PMID: 32465289.
      View in: PubMed
    34. Koda Y, Nishida H, Kagan V, Meehan K, Okray J, Creighton S, Labuhn C, Nguyen A, Kalantari S, Chung B, Kim G, Sarswat N, Smith B, Grinstein J, Onsager D, Song T, Jeevanandam V, Ota T. Clinical Outcomes of Left Ventricular Assist Device Implantation for Patients Refusing Blood Transfusion. J Heart Lung Transplant. 2020 Apr; 39(4S):S427. PMID: 32465709.
      View in: PubMed
    35. LaBuhn C, Kagan V, Meehan K, Creighton S, Okray J, Chinco A, Ota T, Song T, Onsager D, Kim G, Kalantari S, Smith B, Sarswat N, Chung B, Grinstein J, Nyugen A, Rodgers D, Jeevanandam V. Prophylactic Use for Driveline Infections: Can we Prevent Infection Resulting from Trauma? J Heart Lung Transplant. 2020 Apr; 39(4S):S489. PMID: 32465889.
      View in: PubMed
    36. Belkin MN, Kalantari S, Tehrani D, Besser S, Nguyen A, Chung BB, Smith B, Sarswat N, Uriel N, Kim G, Grinstein J. The Novel Hemodynamic Variable Aortic Pulsatility Index Predicts Freedom from Advanced Heart Failure Therapies and Death. J Heart Lung Transplant. 2020 Apr; 39(4S):S35. PMID: 32465486.
      View in: PubMed
    37. Sheikh FH, Peters LM, Grinstein J, Ahmed S, Rodrigo ME, Hofmeyer M, Kadakkal A, Mohammed SF, Kitahara H, Najjar SS, Molina EJ. Feasibility of Delayed Parenteral Heparin Initiation after HM3 Implantation. J Heart Lung Transplant. 2020 Apr; 39(4S):S450. PMID: 32465773.
      View in: PubMed
    38. Grinstein J, Garan AR, Oesterle A, Fried J, Imamura T, Mai X, Kalantari S, Sayer G, Kim GH, Sarswat N, Raikhelkar J, Adatya S, Jeevanandam V, Flatley E, Moss J, Uriel N. Increased Rate of Pump Thrombosis and Cardioembolic Events Following Ventricular Tachycardia Ablation in Patients Supported With Left Ventricular Assist Devices. ASAIO J. 2020 Mar 27. PMID: 32224787.
      View in: PubMed
    39. Imamura T, Narang N, Rodgers D, Nitta D, Grinstein J, Fujino T, Kim G, Nguyen A, Jeevanandam V, Sayer G, Uriel N. HVAD Flow Waveform Estimates Left Ventricular Filling Pressure. J Card Fail. 2020 Apr; 26(4):342-348. PMID: 31981696.
      View in: PubMed
    40. Imamura T, Kim G, Nitta D, Fujino T, Smith B, Kalantari S, Nguyen A, Narang N, Holzhauser L, Grinstein J, Juricek C, Rodgers D, Song T, Ota T, Jeevanandam V, Sayer G, Uriel N. Aortic Insufficiency and Hemocompatibility-related Adverse Events in Patients with Left Ventricular Assist Devices. J Card Fail. 2019 Oct; 25(10):787-794. PMID: 31419485.
      View in: PubMed
    41. Grinstein J, Imamura T, Uriel N. Authors' Reply to the Comments of Joshua Fogel and Abhinav Saxena on Our Paper. J Card Fail. 2019 05; 25(5):415. PMID: 30926394.
      View in: PubMed
    42. Grinstein J, Kruse E, Sayer G, Kim GH, Raikhelkar J, Kalantari S, Sarswat N, Adatya S, Ota T, Jeevanandam V, Mor-Avi V, Lang RM, Uriel N. Outflow Cannula Systolic Slope in Patients With Left Ventricular Assist Devices: A Novel Marker of Myocardial Contractility. ASAIO J. 2019 02; 65(2):160-166. PMID: 29677035.
      View in: PubMed
    43. Tehrani DM, Adatya S, Grinstein J, Rodgers D, Sarswat N, Kim GH, Raikhelkar J, Sayer G, Uriel N. Impact of Cardiac Resynchronization Therapy on Left Ventricular Unloading in Patients with Implanted Left Ventricular Assist Devices. ASAIO J. 2019 02; 65(2):117-122. PMID: 29608492.
      View in: PubMed
    44. Grinstein J, Imamura T, Kruse E, Kalantari S, Rodgers D, Adatya S, Sayer G, Kim GH, Sarswat N, Raihkelkar J, Ota T, Jeevanandam V, Burkhoff D, Lang R, Uriel N. Echocardiographic Predictors of Hemodynamics in Patients Supported With Left Ventricular Assist Devices. J Card Fail. 2018 Sep; 24(9):561-567. PMID: 30048771.
      View in: PubMed
    45. Grinstein J, Rodgers D, Kalantari S, Sayer G, Kim GH, Sarswat N, Adatya S, Ota T, Jeevanandam V, Burkhoff D, Uriel N. HVAD Waveform Analysis as a Noninvasive Marker of Pulmonary Capillary Wedge Pressure: A First Step Toward the Development of a Smart Left Ventricular Assist Device Pump. ASAIO J. 2018 Jan/Feb; 64(1):10-15. PMID: 28604571.
      View in: PubMed
    46. Tehrani DM, Grinstein J, Kalantari S, Kim G, Sarswat N, Adatya S, Sayer G, Uriel N. Cardiac Output Assessment in Patients Supported with Left Ventricular Assist Device: Discordance Between Thermodilution and Indirect Fick Cardiac Output Measurements. ASAIO J. 2017 Jul/Aug; 63(4):433-437. PMID: 28125464.
      View in: PubMed
    47. Grinstein J, Lourenco LM, Te HS, Renz JF, Jeevanandam V, Uriel N. Accepting Hearts From Hepatitis C-Positive Donor: Can We Expand the Donor Pool? J Card Fail. 2017 Oct; 23(10):762-764. PMID: 28627403.
      View in: PubMed
    48. Kalathiya RJ, Grinstein J, Uriel N, Shah AP. Percutaneous Transcatheter Therapies for the Management of Left Ventricular Assist Device Complications. J Invasive Cardiol. 2017 May; 29(5):151-162. PMID: 28208117.
      View in: PubMed
    49. Grinstein J, Estrada J, Sayer G, Kim GH, Sarswat N, Adatya S, Nathan S, Paul JD, Blair JE, Jeevanandam V, Lang R, Uriel N, Shah AP. Left Ventricular Assist Device Deactivation via Percutaneous Closure of the Outflow Graft. J Card Fail. 2016 Aug; 22(8):653-5. PMID: 27291686.
      View in: PubMed
    50. Grinstein J, Kruse E, Collins K, Sayer G, Fedson S, Kim GH, Sarswat N, Adatya S, Ota T, Jeevanandam V, Mor-Avi V, Uriel N, Lang RM. Screening for Outflow Cannula Malfunction of Left Ventricular Assist Devices (LVADs) With the Use of Doppler Echocardiography: New LVAD-Specific Reference Values for Contemporary Devices. J Card Fail. 2016 Oct; 22(10):808-14. PMID: 27288845.
      View in: PubMed
    51. Grinstein J, Kruse E, Sayer G, Fedson S, Kim GH, Sarswat N, Adatya S, Ota T, Jeevanandam V, Mor-Avi V, Lang RM, Uriel N. Novel echocardiographic parameters of aortic insufficiency in continuous-flow left ventricular assist devices and clinical outcome. J Heart Lung Transplant. 2016 08; 35(8):976-85. PMID: 27373822.
      View in: PubMed
    52. Grinstein J, Kruse E, Sayer G, Fedson S, Kim GH, Jorde UP, Juricek C, Ota T, Jeevanandam V, Lang RM, Uriel N. Accurate Quantification Methods for Aortic Insufficiency Severity in Patients With LVAD: Role of Diastolic Flow Acceleration and Systolic-to-Diastolic Peak Velocity Ratio of Outflow Cannula. JACC Cardiovasc Imaging. 2016 06; 9(6):641-51. PMID: 26684975.
      View in: PubMed
    53. Grinstein J, Burkhoff D. Innovative devices for advanced heart failure: exploring the current state and future direction of device therapies. Curr Opin Cardiol. 2015 May; 30(3):267-76. PMID: 25807225.
      View in: PubMed
    54. Grinstein J, Gomberg-Maitland M. Management of pulmonary hypertension and right heart failure in the intensive care unit. Curr Hypertens Rep. 2015 May; 17(5):32. PMID: 25833459.
      View in: PubMed
    55. Grinstein J, Nathan S. Differential hemodynamic profile of high-capacity intraaortic balloon pumps: new promise for an antiquated technology? J Invasive Cardiol. 2015 Apr; 27(4):188-90. PMID: 25840401.
      View in: PubMed
    56. Grinstein J, Bonaca MP, Jarolim P, Conrad MJ, Bohula-May E, Deenadayalu N, Braunwald E, Giugliano RP, Newby LK, Sabatine MS, Morrow DA. Prognostic implications of low level cardiac troponin elevation using high-sensitivity cardiac troponin T. Clin Cardiol. 2015 Apr; 38(4):230-5. PMID: 25737394.
      View in: PubMed
    57. Grinstein J, Hofmann Bowman MA, Fedson S. Ventricular Assist Devices in Advanced Heart Failure: Exploring the Technology’s Current Utilization, Limitations and Future Directions. J Cardiobiol. 2014; S1:7.
    58. Grinstein J, Cannon CP. Aspirin resistance: current status and role of tailored therapy. Clin Cardiol. 2012 Nov; 35(11):673-81. PMID: 22740110.
      View in: PubMed
    59. Vaschetto R, Grinstein J, Del Sorbo L, Khine AA, Voglis S, Tullis E, Slutsky AS, Zhang H. Role of human neutrophil peptides in the initial interaction between lung epithelial cells and CD4+ lymphocytes. J Leukoc Biol. 2007 Apr; 81(4):1022-31. PMID: 17215524.
      View in: PubMed
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