The University of Chicago Header Logo
Last Name

Sam Light

TitleAssistant Professor
InstitutionUniversity of Chicago
AddressChicago IL 60637
vCardDownload vCard

    Collapse Overview 
    Collapse overview
    Microbes exhibit variable forms of cellular metabolism, the distinctive properties of which reflect critical features of relevant microbial ecosystems. In the context of the gut microbiota, these metabolic processes generate numerous small molecules that influence host biology in a myriad of ways. Our research seeks to develop a fundamental understanding of the relationship between microbial metabolism and healthy/diseased states of the gut microbiota and, eventually, to exploit these insights in the development of targeted therapies.

    Collapse Biography 
    Collapse education and training
    University of California, BerkeleyPostdoctoral Fellow2019
    Northwestern UniversityPostdoctoral Associate2016
    Northwestern UniversityPhD2013
    Bard CollegeBA2008

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Cahoon LA, Alejandro-Navarreto X, Gururaja AN, Light SH, Alonzo F, Anderson WF, Freitag NE. Listeria monocytogenes two component system PieRS regulates secretion chaperones PrsA1 and PrsA2 and enhances bacterial translocation across the intestine. Mol Microbiol. 2022 09; 118(3):278-293. PMID: 35943959.
      View in: PubMed
    2. Little AS, Light SH. Stickland metabolism in the gut. Nat Microbiol. 2022 05; 7(5):603-604. PMID: 35505246.
      View in: PubMed
    3. Smith KP, Lee W, Tonelli M, Lee Y, Light SH, Cornilescu G, Chakravarthy S. Solution structure and dynamics of the mitochondrial-targeted GTPase-activating protein (GAP) VopE by an integrated NMR/SAXS approach. Protein Sci. 2022 05; 31(5):e4282. PMID: 35137487.
      View in: PubMed
    4. Rivera-Lugo R, Deng D, Anaya-Sanchez A, Tejedor-Sanz S, Tang E, Reyes Ruiz VM, Smith HB, Titov DV, Sauer JD, Skaar EP, Ajo-Franklin CM, Portnoy DA, Light SH. Listeria monocytogenes requires cellular respiration for NAD+ regeneration and pathogenesis. Elife. 2022 04 05; 11. PMID: 35380108.
      View in: PubMed
    5. Rivera-Lugo R, Light SH, Garelis NE, Portnoy DA. RibU is an essential determinant of Listeria pathogenesis that mediates acquisition of FMN and FAD during intracellular growth. Proc Natl Acad Sci U S A. 2022 03 29; 119(13):e2122173119. PMID: 35316134.
      View in: PubMed
    6. Tejedor-Sanz S, Stevens ET, Li S, Finnegan P, Nelson J, Knoesen A, Light SH, Ajo-Franklin CM, Marco ML. Extracellular electron transfer increases fermentation in lactic acid bacteria via a hybrid metabolism. Elife. 2022 02 11; 11. PMID: 35147079.
      View in: PubMed
    7. Pfister CA, Light SH, Bohannan B, Schmidt T, Martiny A, Hynson NA, Devkota S, David L, Whiteson K. Conceptual Exchanges for Understanding Free-Living and Host-Associated Microbiomes. mSystems. 2022 02 22; 7(1):e0137421. PMID: 35014872.
      View in: PubMed
    8. M?heust R, Huang S, Rivera-Lugo R, Banfield JF, Light SH. Post-translational flavinylation is associated with diverse extracytosolic redox functionalities throughout bacterial life. Elife. 2021 05 25; 10. PMID: 34032212.
      View in: PubMed
    9. Zeng Z, Boeren S, Bhandula V, Light SH, Smid EJ, Notebaart RA, Abee T. Bacterial Microcompartments Coupled with Extracellular Electron Transfer Drive the Anaerobic Utilization of Ethanolamine in Listeria monocytogenes. mSystems. 2021 Apr 13; 6(2). PMID: 33850044.
      View in: PubMed
    10. Light SH, M?heust R, Ferrell JL, Cho J, Deng D, Agostoni M, Iavarone AT, Banfield JF, D'Orazio SEF, Portnoy DA. Extracellular electron transfer powers flavinylated extracellular reductases in Gram-positive bacteria. Proc Natl Acad Sci U S A. 2019 Dec 26; 116(52):26892-26899. PMID: 31818955.
      View in: PubMed
    11. Light SH, Su L, Rivera-Lugo R, Cornejo JA, Louie A, Iavarone AT, Ajo-Franklin CM, Portnoy DA. A flavin-based extracellular electron transfer mechanism in diverse Gram-positive bacteria. Nature. 2018 10; 562(7725):140-144. PMID: 30209391.
      View in: PubMed
    12. Light SH, Cahoon LA, Mahasenan KV, Lee M, Boggess B, Halavaty AS, Mobashery S, Freitag NE, Anderson WF. Transferase Versus Hydrolase: The Role of Conformational Flexibility in Reaction Specificity. Structure. 2017 02 07; 25(2):295-304. PMID: 28089449.
      View in: PubMed
    13. Light SH, Cahoon LA, Halavaty AS, Freitag NE, Anderson WF. Structure to function of an a-glucan metabolic pathway that promotes Listeria monocytogenes pathogenesis. Nat Microbiol. 2016 Nov 07; 2:16202. PMID: 27819654.
      View in: PubMed
    14. Light SH, Minasov G, Shuvalova L, Duban ME, Caffrey M, Anderson WF, Lavie A. Insights into the mechanism of type I dehydroquinate dehydratases from structures of reaction intermediates. J Biol Chem. 2015 Jul 31; 290(31):19008. PMID: 26232400.
      View in: PubMed
    15. Shaw KE, Bondi CO, Light SH, Massimino LA, McAloon RL, Monaco CM, Kline AE. Donepezil is ineffective in promoting motor and cognitive benefits after controlled cortical impact injury in male rats. J Neurotrauma. 2013 Apr 01; 30(7):557-64. PMID: 23227953.
      View in: PubMed
    Light's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    Co-Authors Expand Description
    Similar People Expand Description
    Same Department Expand Description
    Physical Neighbors Expand Description