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Sam Light

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMicrobiology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Microbes exhibit variable forms of cellular metabolism, the distinctive properties of which reflect critical features of relevant microbial ecosystems. In the context of the gut microbiota, these metabolic processes generate numerous small molecules that influence host biology in a myriad of ways. Our research seeks to develop a fundamental understanding of the relationship between microbial metabolism and healthy/diseased states of the gut microbiota and, eventually, to exploit these insights in the development of targeted therapies.


    Collapse Biography 
    Collapse education and training
    University of California, BerkeleyPostdoctoral Fellow2019
    Northwestern UniversityPostdoctoral Associate2016
    Northwestern UniversityPhD2013
    Bard CollegeBA2008

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Zeng Z, Boeren S, Bhandula V, Light SH, Smid EJ, Notebaart RA, Abee T. Bacterial Microcompartments Coupled with Extracellular Electron Transfer Drive the Anaerobic Utilization of Ethanolamine in Listeria monocytogenes. mSystems. 2021 Apr 13; 6(2). PMID: 33850044.
      View in: PubMed
    2. Light SH, Méheust R, Ferrell JL, Cho J, Deng D, Agostoni M, Iavarone AT, Banfield JF, D'Orazio SEF, Portnoy DA. Extracellular electron transfer powers flavinylated extracellular reductases in Gram-positive bacteria. Proc Natl Acad Sci U S A. 2019 Dec 09. PMID: 31818955.
      View in: PubMed
    3. Light SH, Su L, Rivera-Lugo R, Cornejo JA, Louie A, Iavarone AT, Ajo-Franklin CM, Portnoy DA. A flavin-based extracellular electron transfer mechanism in diverse Gram-positive bacteria. Nature. 2018 10; 562(7725):140-144. PMID: 30209391.
      View in: PubMed
    4. Light SH, Cahoon LA, Mahasenan KV, Lee M, Boggess B, Halavaty AS, Mobashery S, Freitag NE, Anderson WF. Transferase Versus Hydrolase: The Role of Conformational Flexibility in Reaction Specificity. Structure. 2017 02 07; 25(2):295-304. PMID: 28089449.
      View in: PubMed
    5. Light SH, Cahoon LA, Halavaty AS, Freitag NE, Anderson WF. Structure to function of an a-glucan metabolic pathway that promotes Listeria monocytogenes pathogenesis. Nat Microbiol. 2016 Nov 07; 2:16202. PMID: 27819654.
      View in: PubMed
    6. Reider B. Do We Care? Should We? Am J Sports Med. 2016 Apr; 44(4):835-7. PMID: 26232400.
      View in: PubMed
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