"Serotonin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
| Descriptor ID |
D012701
|
| MeSH Number(s) |
D02.092.211.215.801.852 D03.633.100.473.914.814 D23.469.050.650
|
| Concept/Terms |
Serotonin- Serotonin
- 5-Hydroxytryptamine
- 5 Hydroxytryptamine
- Hippophaine
- 3-(2-Aminoethyl)-1H-indol-5-ol
- Enteramine
- 5-HT
|
Below are MeSH descriptors whose meaning is more general than "Serotonin".
Below are MeSH descriptors whose meaning is more specific than "Serotonin".
This graph shows the total number of publications written about "Serotonin" by people in this website by year, and whether "Serotonin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 2 | 1 | 3 |
| 1995 | 2 | 4 | 6 |
| 1996 | 1 | 1 | 2 |
| 1997 | 3 | 2 | 5 |
| 1998 | 4 | 4 | 8 |
| 1999 | 1 | 3 | 4 |
| 2000 | 1 | 0 | 1 |
| 2001 | 3 | 3 | 6 |
| 2002 | 1 | 4 | 5 |
| 2003 | 1 | 3 | 4 |
| 2004 | 5 | 2 | 7 |
| 2005 | 3 | 5 | 8 |
| 2006 | 4 | 4 | 8 |
| 2007 | 5 | 0 | 5 |
| 2008 | 3 | 1 | 4 |
| 2009 | 4 | 2 | 6 |
| 2010 | 2 | 1 | 3 |
| 2011 | 3 | 3 | 6 |
| 2012 | 4 | 3 | 7 |
| 2013 | 2 | 0 | 2 |
| 2014 | 2 | 0 | 2 |
| 2015 | 4 | 1 | 5 |
| 2016 | 1 | 1 | 2 |
| 2017 | 2 | 0 | 2 |
| 2018 | 2 | 1 | 3 |
| 2019 | 2 | 0 | 2 |
| 2020 | 1 | 2 | 3 |
| 2021 | 1 | 0 | 1 |
| 2023 | 1 | 1 | 2 |
| 2024 | 0 | 3 | 3 |
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Below are the most recent publications written about "Serotonin" by people in Profiles.
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Novel Benzofuran Derivatives Induce Monoamine Release and Substitute for the Discriminative Stimulus Effects of 3,4-Methylenedioxymethamphetamine. J Pharmacol Exp Ther. 2024 Sep 18; 391(1):22-29.
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A novel mechanism of idiopathic orthostatic hypotension and hypocatecholaminemia due to autoimmunity against aromatic l-Amino acid decarboxylase. Biochem Biophys Res Commun. 2024 06 25; 714:149940.
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Structural basis for partial agonism in 5-HT3A receptors. Nat Struct Mol Biol. 2024 Apr; 31(4):598-609.
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2023 updated MASCC/ESMO consensus recommendations: prevention of nausea and vomiting following multiple-day chemotherapy, high-dose chemotherapy, and breakthrough nausea and vomiting. Support Care Cancer. 2023 Dec 18; 32(1):36.
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Spinal motoneurons respond aberrantly to serotonin in a rabbit model of cerebral palsy. J Physiol. 2023 10; 601(19):4271-4289.
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Structure, Function and Physiology of 5-Hydroxytryptamine Receptors Subtype 3. Subcell Biochem. 2021; 96:373-408.
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Efficacy of intravenous NEPA, a fixed NK1/5-HT3 receptor antagonist combination, for the prevention of chemotherapy-induced nausea and vomiting (CINV) during cisplatin- and anthracycline cyclophosphamide (AC)-based chemotherapy: A review of phase 3 studies. Crit Rev Oncol Hematol. 2021 Jan; 157:103143.
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High-resolution structures of multiple 5-HT3AR-setron complexes reveal a novel mechanism of competitive inhibition. Elife. 2020 10 16; 9.
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Serum Serotonin Differentiates Between Disease Activity States in Crohn's Patients. Inflamm Bowel Dis. 2020 09 18; 26(10):1607-1618.
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Development of a Nonradioactive Platelet Serotonin Uptake and Release Assay by Micro-Liquid Chromatography Tandem Mass Spectrometry Using Minimal Blood Volume. Am J Clin Pathol. 2019 11 04; 152(6):718-724.