"Kernicterus" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613)
| Descriptor ID |
D007647
|
| MeSH Number(s) |
C10.228.140.163.480 C15.378.295.502 C16.614.304.502 C18.452.132.480 C20.306.502 C23.550.429.750
|
| Concept/Terms |
Kernicterus- Kernicterus
- Encephalopathy, Bilirubin
- Bilirubin Encephalopathy
- Bilirubin Encephalopathies
- Encephalopathies, Bilirubin
- Hyperbilirubinemic Encephalopathy
- Encephalopathies, Hyperbilirubinemic
- Hyperbilirubinemic Encephalopathies
- Encephalopathy, Hyperbilirubinemic
|
Below are MeSH descriptors whose meaning is more general than "Kernicterus".
- Diseases [C]
- Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
- Brain Diseases [C10.228.140]
- Brain Diseases, Metabolic [C10.228.140.163]
- Kernicterus [C10.228.140.163.480]
- Hemic and Lymphatic Diseases [C15]
- Hematologic Diseases [C15.378]
- Erythroblastosis, Fetal [C15.378.295]
- Kernicterus [C15.378.295.502]
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Infant, Newborn, Diseases [C16.614]
- Erythroblastosis, Fetal [C16.614.304]
- Kernicterus [C16.614.304.502]
- Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
- Brain Diseases, Metabolic [C18.452.132]
- Kernicterus [C18.452.132.480]
- Immune System Diseases [C20]
- Erythroblastosis, Fetal [C20.306]
- Kernicterus [C20.306.502]
- Pathological Conditions, Signs and Symptoms [C23]
- Pathologic Processes [C23.550]
- Hyperbilirubinemia [C23.550.429]
- Kernicterus [C23.550.429.750]
Below are MeSH descriptors whose meaning is more specific than "Kernicterus".
This graph shows the total number of publications written about "Kernicterus" by people in this website by year, and whether "Kernicterus" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
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Below are the most recent publications written about "Kernicterus" by people in Profiles.
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Neonatal bilirubin workshop. Pediatrics. 1994 Oct; 94(4 Pt 1):537-40.
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Management of jaundice in the well baby. Pediatrics. 1992 May; 89(5 Pt 1):826-7.
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Neonatal and infant mortality in relation to phototherapy. Pediatrics. 1985 Feb; 75(2 Pt 2):422-6.
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Effect of phototherapy on albumin binding of bilirubin. Pediatrics. 1985 Feb; 75(2 Pt 2):401-6.
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The association of kernicterus with bacterial infection in the newborn. Pediatrics. 1980 Jan; 65(1):26-9.
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Clinical application of neonatal bilirubin-binding determinations: current status. J Pediatr. 1978 Nov; 93(5):827-33.
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Absence of kernicterus in low-birth weight infants from 1971 through 1976: comparison with findings in 1966 and 1967. Pediatrics. 1978 Oct; 62(4):460-4.
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Commentary: the bronze baby syndrome. J Pediatr. 1976 Mar; 88(3):465-6.
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Bilirubin binding, free fatty acids and a new concept for the pathogenesis of kernicterus. Birth Defects Orig Artic Ser. 1976; 12(2):264-74.
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Kernicterus: high incidence in premature infants with low serum bilirubin concentrations. Pediatrics. 1970 Jun; 45(6):906-17.