A disorder of sexual development transmitted as an X-linked recessive trait. These patients have a karyotype of 46,XY with end-organ resistance to androgen due to mutations in the androgen receptor (RECEPTORS, ANDROGEN) gene. Severity of the defect in receptor quantity or quality correlates with their phenotypes. In these genetic males, the phenotypic spectrum ranges from those with normal female external genitalia, through those with genital ambiguity as in Reifenstein Syndrome, to that of a normal male with INFERTILITY.

Descriptor ID	D013734
MeSH Number(s)	C12.706.316.096.500 C13.351.875.253.096.500 C16.131.939.316.096.500 C16.320.322.061 C19.391.119.096.500
Concept/Terms	Androgen-Insensitivity Syndrome Androgen-Insensitivity Syndrome Androgen Insensitivity Syndrome Androgen-Insensitivity Syndromes Syndrome, Androgen-Insensitivity Syndromes, Androgen-Insensitivity Androgen Resistance Syndrome Androgen Resistance Syndromes Resistance Syndrome, Androgen Resistance Syndromes, Androgen Syndrome, Androgen Resistance Syndromes, Androgen Resistance Male Pseudohermaphroditism Due to Androgen Insensitivity Testicular Feminization Testicular Feminization Feminization, Testicular Feminizations, Testicular Testicular Feminizations Testicular Feminization Syndrome Feminization Syndrome, Testicular Feminization Syndromes, Testicular Syndrome, Testicular Feminization Syndromes, Testicular Feminization Testicular Feminization Syndromes Androgen-Insensitivity Syndrome, Complete Androgen Insensitivity Syndrome, Complete Androgen-Insensitivity Syndromes, Complete Complete Androgen-Insensitivity Syndrome Complete Androgen-Insensitivity Syndromes Syndrome, Complete Androgen-Insensitivity Syndromes, Complete Androgen-Insensitivity Androgen Receptor Deficiency Androgen Receptor Deficiency Androgen Receptor Deficiencies Deficiencies, Androgen Receptor Deficiency, Androgen Receptor Receptor Deficiencies, Androgen Receptor Deficiency, Androgen Reifenstein Syndrome Reifenstein Syndrome Syndrome, Reifenstein Reifenstein's Syndrome Reifensteins Syndrome Syndrome, Reifenstein's Androgen-Insensitivity Syndrome, Partial Androgen Insensitivity Syndrome, Partial Androgen-Insensitivity Syndromes, Partial Partial Androgen-Insensitivity Syndrome Partial Androgen-Insensitivity Syndromes Syndrome, Partial Androgen-Insensitivity Syndromes, Partial Androgen-Insensitivity

Below are MeSH descriptors whose meaning is more general than "Androgen-Insensitivity Syndrome".

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