An autosomal recessive metabolic disorder caused by a deficiency of GALACTOSYLCERAMIDASE leading to intralysosomal accumulation of galactolipids such as GALACTOSYLCERAMIDES and PSYCHOSINE. It is characterized by demyelination associated with large multinucleated globoid cells, predominantly involving the white matter of the central nervous system. The loss of MYELIN disrupts normal conduction of nerve impulses.

Descriptor ID	D007965
MeSH Number(s)	C10.228.140.163.100.362.500 C10.228.140.163.100.435.825.590 C10.228.140.695.625.500 C10.228.518.625.500 C10.314.400.500 C16.320.565.189.362.500 C16.320.565.189.435.825.590 C16.320.565.398.641.803.585 C16.320.565.595.554.825.590 C18.452.132.100.362.500 C18.452.132.100.435.825.590 C18.452.584.687.803.585 C18.452.648.189.362.500 C18.452.648.189.435.825.590 C18.452.648.398.641.803.585 C18.452.648.595.554.825.590
Concept/Terms	Leukodystrophy, Globoid Cell Leukodystrophy, Globoid Cell Cell Leukodystrophies, Globoid Cell Leukodystrophy, Globoid Globoid Cell Leukodystrophies Leukodystrophies, Globoid Cell Galactosylceramidase Deficiency Disease Deficiency Disease, Galactosylceramidase Deficiency Diseases, Galactosylceramidase Disease, Galactosylceramidase Deficiency Diseases, Galactosylceramidase Deficiency Galactosylceramidase Deficiency Diseases Galactosylceramide-beta-Galactosidase Deficiency Disease Deficiency Disease, Galactosylceramide-beta-Galactosidase Deficiency Diseases, Galactosylceramide-beta-Galactosidase Disease, Galactosylceramide-beta-Galactosidase Deficiency Diseases, Galactosylceramide-beta-Galactosidase Deficiency Galactosylceramide beta Galactosidase Deficiency Disease Galactosylceramide-beta-Galactosidase Deficiency Diseases Globoid Body Sclerosis, Diffuse Krabbe's Leukodystrophy Krabbes Leukodystrophy Leukodystrophy, Krabbe's Globoid Cell Leukoencephalopathy Cell Leukoencephalopathies, Globoid Cell Leukoencephalopathy, Globoid Globoid Cell Leukoencephalopathies Leukoencephalopathies, Globoid Cell Leukoencephalopathy, Globoid Cell Globoid Leukodystrophy Globoid Leukodystrophies Leukodystrophies, Globoid Leukodystrophy, Globoid Krabbe Disease Krabbe Leukodystrophy Leukodystrophy, Krabbe Krabbe's Disease Krabbes Disease Diffuse Globoid Body Sclerosis Globoid Cell Leukodystrophy Late-Onset Globoid Cell Leukodystrophy Late-Onset Globoid Cell Leukodystrophy Late Onset Globoid Cell Leukodystrophy Leukodystrophy, Globoid Cell, Late-Onset Early-Onset Globoid Cell Leukodystrophy Early-Onset Globoid Cell Leukodystrophy Early Onset Globoid Cell Leukodystrophy Leukodystrophy, Globoid Cell, Infantile Leukodystrophy, Globoid Cell, Classic Leukodystrophy, Globoid Cell, Early-Onset Classic Globoid Cell Leukodystrophy Infantile Globoid Cell Leukodystrophy

Below are MeSH descriptors whose meaning is more general than "Leukodystrophy, Globoid Cell".

Below are MeSH descriptors whose meaning is related to "Leukodystrophy, Globoid Cell".

Below are MeSH descriptors whose meaning is more specific than "Leukodystrophy, Globoid Cell".