"Chromosome Walking" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A technique with which an unknown region of a chromosome can be explored. It is generally used to isolate a locus of interest for which no probe is available but that is known to be linked to a gene which has been identified and cloned. A fragment containing a known gene is selected and used as a probe to identify other overlapping fragments which contain the same gene. The nucleotide sequences of these fragments can then be characterized. This process continues for the length of the chromosome.
| Descriptor ID |
D016386
|
| MeSH Number(s) |
E05.393.183.250
|
| Concept/Terms |
Chromosome Walking- Chromosome Walking
- Chromosome Walkings
- Walking, Chromosome
- Walkings, Chromosome
|
Below are MeSH descriptors whose meaning is more general than "Chromosome Walking".
Below are MeSH descriptors whose meaning is more specific than "Chromosome Walking".
This graph shows the total number of publications written about "Chromosome Walking" by people in this website by year, and whether "Chromosome Walking" was a major or minor topic of these publications.
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Below are the most recent publications written about "Chromosome Walking" by people in Profiles.
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Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis. Blood. 1993 May 15; 81(10):2728-34.
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Molecular genetics of the Drosophila melanogaster ovo locus, a gene required for sex determination of germline cells. Genetics. 1992 Apr; 130(4):791-803.