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Francis J. Alenghat

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Cardiology
AddressChicago IL 60637
Phone+1 (773) 8340705
Email
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    Collapse Overview 
    Collapse overview
    Dr. Alenghat's laboratory focuses on macrophage biology and the inflammatory component of atherosclerosis. His clinical interests and academic pursuits lie within the fields of cardiovascular physiology and pathophysiology, with a special focus on vascular biology and inflammatory pathways in atherosclerosis. He also has experience in integrin biology, mechanotransduction, and extracellular matrix biology. He seeks to discover basic mechanisms of physiology and pathophysiology that govern cardiovascular health and disease. One of the laboratory’s main projects is to elucidate how a signaling pathway that is activated downstream of integrins in macrophages governs atherogenesis and macrophage polarization. His laboratory has expertise in mouse husbandry, tissue sample preparation, immunohistochemistry, and quantitative confocal microscopy. He is highly motivated to mentor future physicians and scientists in an overarching aim to promote health by understanding and reducing cardiovascular disease.


    Collapse Biography 
    Collapse education and training
    Harvard CollegeS.B.Engineering
    Harvard Graduate School of Arts & SciencesPh.D.Biophysics
    Harvard Medical SchoolM.D.Medicine
    Brigham & Women's HospitalInternal Medicine
    Brigham & Women's HospitalCardiovascular Medicine
    Collapse awards and honors
    1994Detur Prize, Harvard College
    1996Phi Beta Kappa, Harvard College
    1997Tau Beta Pi for Excellence in Engineering, Harvard College
    1999Howard Hughes Predoctoral Fellowship, Howard Hughes Medical Institute
    2005James Tolbert Shipley Prize, Harvard Medical School
    2009Laennec Young Clinician Award Finalist, American Heart Association
    2010Future Leaders in CV Medical Research Award, Leadership Council for Improving Cardiovascular Care
    2011AHA/ATVB Travel Award for Young Investigators, American Heart Association
    2012Thomas W. Smith Fellowship , Brigham & Women's Hospital
    2013William F. Keating Award for Hypertension & Peripheral Vascular Disease, American College of Cardiology
    2015ATVB Young Investigator Travel Award, Council on Arteriosclerosis, Thrombosis, and Vascular Biology
    2017Fellow of the American College of Cardiology (FACC), American College of Cardiology

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Belkin MN, Alenghat FJ, Besser SA, Pinney SP, Grinstein J. Improved Prognostic Performance of Cardiac Power Output With Right Atrial Pressure: A Subanalysis of the ESCAPE Trial. J Card Fail. 2022 05; 28(5):866-869. PMID: 34774746.
      View in: PubMed
    2. Pulipati VP, Alenghat FJ. The impact of lipid-lowering medications on coronary artery plaque characteristics. Am J Prev Cardiol. 2021 Dec; 8:100294. PMID: 34877559.
      View in: PubMed
    3. Kanelidis AJ, Miller P, Prabhu N, Dela Cruz MJ, Alenghat FJ, McMullen P, Sarswat N, Derman BA, Polonsky TS, DeCara JM. ATTR Cardiomyopathy Meets Multiple Myeloma: The Importance of Cardiac Biopsy. JACC CardioOncol. 2021 Oct; 3(4):598-601. PMID: 34729534.
      View in: PubMed
    4. Belkin MN, Blair JE, Shah SJ, Alenghat FJ. A composite metric for predicting benefit from spironolactone in heart failure with preserved ejection fraction. ESC Heart Fail. 2021 10; 8(5):3495-3503. PMID: 34369088.
      View in: PubMed
    5. Attia ZI, Kapa S, Dugan J, Pereira N, Noseworthy PA, Jimenez FL, Cruz J, Carter RE, DeSimone DC, Signorino J, Halamka J, Chennaiah Gari NR, Madathala RS, Platonov PG, Gul F, Janssens SP, Narayan S, Upadhyay GA, Alenghat FJ, Lahiri MK, Dujardin K, Hermel M, Dominic P, Turk-Adawi K, Asaad N, Svensson A, Fernandez-Aviles F, Esakof DD, Bartunek J, Noheria A, Sridhar AR, Lanza GA, Cohoon K, Padmanabhan D, Pardo Gutierrez JA, Sinagra G, Merlo M, Zagari D, Rodriguez Escenaro BD, Pahlajani DB, Loncar G, Vukomanovic V, Jensen HK, Farkouh ME, Luescher TF, Su Ping CL, Peters NS, Friedman PA. Rapid Exclusion of COVID Infection With the Artificial Intelligence Electrocardiogram. Mayo Clin Proc. 2021 08; 96(8):2081-2094. PMID: 34353468.
      View in: PubMed
    6. Lowisz J, Alenghat FJ, Li Y, Roberson D, Penk J, Gandhi R. Comparison of semi-automated versus manual quantitative right ventricular assessment in tetralogy of Fallot. Cardiol Young. 2021 Nov; 31(11):1781-1787. PMID: 33685532.
      View in: PubMed
    7. Belkin MN, Alenghat FJ, Besser SA, Nguyen AB, Chung BB, Smith BA, Kalantari S, Sarswat N, Blair JEA, Kim GH, Pinney SP, Grinstein J. Aortic pulsatility index predicts clinical outcomes in heart failure: a sub-analysis of the ESCAPE trial. ESC Heart Fail. 2021 04; 8(2):1522-1530. PMID: 33595923.
      View in: PubMed
    8. Holzhauser L, Clerkin KJ, Fujino T, Alenghat FJ, Raikhelkar J, Kim G, Sayer G, Uriel N. Donor-derived cell-free DNA is associated with cardiac allograft vasculopathy. Clin Transplant. 2021 03; 35(3):e14206. PMID: 33368611.
      View in: PubMed
    9. Singh N, Anchan RK, Besser SA, Belkin MN, Cruz MD, Lee L, Yu D, Mehta N, Nguyen AB, Alenghat FJ. High sensitivity Troponin-T for prediction of adverse events in patients with COVID-19. Biomarkers. 2020 Dec; 25(8):626-633. PMID: 32981387.
      View in: PubMed
    10. Karunakaran D, Nguyen MA, Geoffrion M, Vreeken D, Lister Z, Cheng HS, Otte N, Essebier P, Wyatt H, Kandiah JW, Jung R, Alenghat FJ, Mompeon A, Lee R, Pan C, Gordon E, Rasheed A, Lusis AJ, Liu P, Matic LP, Hedin U, Fish JE, Guo L, Kolodgie F, Virmani R, van Gils JM, Rayner KJ. RIPK1 Expression Associates With Inflammation in Early Atherosclerosis in Humans and Can Be Therapeutically Silenced to Reduce NF-?B Activation and Atherogenesis in Mice. Circulation. 2021 01 12; 143(2):163-177. PMID: 33222501.
      View in: PubMed
    11. Holzhauser L, Fujino T, Alenghat F, Raikhelkar J, Kim G, Sayer G, Uriel N. Donor-Derived Cell-Free DNA is Associated with Cardiac Allograft Vasculopathy. J Heart Lung Transplant. 2020 Apr; 39(4S):S63. PMID: 32465994.
      View in: PubMed
    12. Holzhauser L, Fujino T, Nguyen A, Alenghat F, Raikhelkar J, Kim G, Sayer G, Uriel N. Donor-Derived Cell-Free DNA Does Not Correlate with Levels of Inflammation or Angiogenesis in a Stable Post Transplant Population. J Heart Lung Transplant. 2020 Apr; 39(4S):S287. PMID: 32465303.
      View in: PubMed
    13. Upadhyay GA, Alenghat FJ. Catheter Ablation for Atrial Fibrillation in 2019. JAMA. 2019 08 20; 322(7):686-687. PMID: 31429886.
      View in: PubMed
    14. Arnold KA, Blair JE, Paul JD, Shah AP, Nathan S, Alenghat FJ. Monocyte and macrophage subtypes as paired cell biomarkers for coronary artery disease. Exp Physiol. 2019 09; 104(9):1343-1352. PMID: 31264265.
      View in: PubMed
    15. Laffin LJ, Alenghat FJ. The SPRINT Trial Score web calculator. Eur J Prev Cardiol. 2019 12; 26(18):2016. PMID: 31189381.
      View in: PubMed
    16. Arnold KA, Treister AD, Lio PA, Alenghat FJ. Association of Atherosclerosis Prevalence With Age, Race, and Traditional Risk Factors in Patients With Psoriasis. JAMA Dermatol. 2019 05 01; 155(5):622-623. PMID: 30785601.
      View in: PubMed
    17. Alenghat FJ, Davis AM. Management of Blood Cholesterol. JAMA. 2019 02 26; 321(8):800-801. PMID: 30715135.
      View in: PubMed
    18. Laffin LJ, Besser SA, Alenghat FJ. A data-zone scoring system to assess the generalizability of clinical trial results to individual patients. Eur J Prev Cardiol. 2019 04; 26(6):569-575. PMID: 30477321.
      View in: PubMed
    19. Poon C, Chowdhuri S, Kuo CH, Fang Y, Alenghat FJ, Hyatt D, Kani K, Gross ME, Chung EJ. Protein Mimetic and Anticancer Properties of Monocyte-Targeting Peptide Amphiphile Micelles. ACS Biomater Sci Eng. 2017 Dec 11; 3(12):3273-3282. PMID: 29302619.
      View in: PubMed
    20. Poon C, Chowdhuri S, Kuo CH, Fang Y, Alenghat FJ, Hyatt D, Kani K, Gross ME, Chung EJ. Protein Mimetic and Anticancer Properties of Monocyte-Targeting Peptide Amphiphile Micelles. ACS Biomaterials Science & Engineering. 2017.
      View Publication
    21. Alenghat FJ. The Prevalence of Atherosclerosis in Those with Inflammatory Connective Tissue Disease by Race, Age, and Traditional Risk Factors. Sci Rep. 2016 Feb 04; 6:20303. PMID: 26842423.
      View in: PubMed
    22. Chung EJ, Mlinar LB, Nord K, Sugimoto MJ, Wonder E, Alenghat FJ, Fang Y, Tirrell M. Monocyte-targeting supramolecular micellar assemblies: a molecular diagnostic tool for atherosclerosis. Adv Healthc Mater. 2015 Feb 18; 4(3):367-76. PMID: 25156590.
      View in: PubMed
    23. Alenghat FJ, Golan DE. Membrane protein dynamics and functional implications in mammalian cells. Curr Top Membr. 2013; 72:89-120. PMID: 24210428.
      View in: PubMed
    24. Alenghat FJ, Couper GS, Givertz MM. Giant left ventricular aneurysm as a late complication of inferior myocardial infarction. Eur Heart J. 2013 Feb; 34(5):344. PMID: 23095983.
      View in: PubMed
    25. Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, Golan DE, Neel BG, Swanson KD. Macrophages require Skap2 and Sirpa for integrin-stimulated cytoskeletal rearrangement. J Cell Sci. 2012 Nov 15; 125(Pt 22):5535-45. PMID: 22976304.
      View in: PubMed
    26. Alenghat FJ, Tytell JD, Thodeti CK, Derrien A, Ingber DE. Mechanical control of cAMP signaling through integrins is mediated by the heterotrimeric Galphas protein. J Cell Biochem. 2009 Mar 01; 106(4):529-38. PMID: 19170051.
      View in: PubMed
    27. Nauli SM, Rossetti S, Kolb RJ, Alenghat FJ, Consugar MB, Harris PC, Ingber DE, Loghman-Adham M, Zhou J. Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction. J Am Soc Nephrol. 2006 Apr; 17(4):1015-25. PMID: 16565258.
      View in: PubMed
    28. Alenghat FJ, Nauli SM, Kolb R, Zhou J, Ingber DE. Global cytoskeletal control of mechanotransduction in kidney epithelial cells. Exp Cell Res. 2004 Nov 15; 301(1):23-30. PMID: 15501441.
      View in: PubMed
    29. Matthews BD, Overby DR, Alenghat FJ, Karavitis J, Numaguchi Y, Allen PG, Ingber DE. Mechanical properties of individual focal adhesions probed with a magnetic microneedle. Biochem Biophys Res Commun. 2004 Jan 16; 313(3):758-64. PMID: 14697256.
      View in: PubMed
    30. Overby DR, Alenghat FJ, Montoya-Zavala M, Bei H, Oh P, Karavitis J, Ingber DE. Magnetic Cellular Switches. IEEE Trans Magn. 2004; 40(4):2958-2960. PMID: 23097592.
      View in: PubMed
    31. Nauli SM, Alenghat FJ, Luo Y, Williams E, Vassilev P, Li X, Elia AE, Lu W, Brown EM, Quinn SJ, Ingber DE, Zhou J. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet. 2003 Feb; 33(2):129-37. PMID: 12514735.
      View in: PubMed
    32. Alenghat FJ, Ingber DE. Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins. Sci STKE. 2002 Feb 12; 2002(119):pe6. PMID: 11842240.
      View in: PubMed
    33. Alenghat FJ, Fabry B, Tsai KY, Goldmann WH, Ingber DE. Analysis of cell mechanics in single vinculin-deficient cells using a magnetic tweezer. Biochem Biophys Res Commun. 2000 Oct 14; 277(1):93-9. PMID: 11027646.
      View in: PubMed
    34. Meyer CJ, Alenghat FJ, Rim P, Fong JH, Fabry B, Ingber DE. Mechanical control of cyclic AMP signalling and gene transcription through integrins. Nat Cell Biol. 2000 Sep; 2(9):666-8. PMID: 10980709.
      View in: PubMed
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