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Francis J. Alenghat

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Cardiology
AddressChicago IL 60637
Phone+1 (773) 8340705
Email
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    Collapse Overview 
    Collapse overview
    Dr. Alenghat's laboratory focuses on macrophage biology and the inflammatory component of atherosclerosis. His clinical interests and academic pursuits lie within the fields of cardiovascular physiology and pathophysiology, with a special focus on vascular biology and inflammatory pathways in atherosclerosis. He also has experience in integrin biology, mechanotransduction, and extracellular matrix biology. He seeks to discover basic mechanisms of physiology and pathophysiology that govern cardiovascular health and disease. One of the laboratory’s main projects is to elucidate how a signaling pathway that is activated downstream of integrins in macrophages governs atherogenesis and macrophage polarization. His laboratory has expertise in mouse husbandry, tissue sample preparation, immunohistochemistry, and quantitative confocal microscopy. He is highly motivated to mentor future physicians and scientists in an overarching aim to promote health by understanding and reducing cardiovascular disease.
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    Collapse Biography 
    Collapse education and training
    Harvard CollegeS.B.Engineering
    Harvard Graduate School of Arts & SciencesPh.D.Biophysics
    Harvard Medical SchoolM.D.Medicine
    Brigham & Women's HospitalInternal Medicine
    Brigham & Women's HospitalCardiovascular Medicine
    Collapse awards and honors
    1994Detur Prize, Harvard College
    1996Phi Beta Kappa, Harvard College
    1997Tau Beta Pi for Excellence in Engineering, Harvard College
    1999Howard Hughes Predoctoral Fellowship, Howard Hughes Medical Institute
    2005James Tolbert Shipley Prize, Harvard Medical School
    2009Laennec Young Clinician Award Finalist, American Heart Association
    2010Future Leaders in CV Medical Research Award, Leadership Council for Improving Cardiovascular Care
    2011AHA/ATVB Travel Award for Young Investigators, American Heart Association
    2012Thomas W. Smith Fellowship , Brigham & Women's Hospital
    2013William F. Keating Award for Hypertension & Peripheral Vascular Disease, American College of Cardiology
    2015ATVB Young Investigator Travel Award, Council on Arteriosclerosis, Thrombosis, and Vascular Biology
    2017Fellow of the American College of Cardiology (FACC), American College of Cardiology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Belkin MN, Alenghat FJ, Besser SA, Pinney SP, Grinstein J. Improved Prognostic Performance of Cardiac Power Output With Right Atrial Pressure: A Subanalysis of the ESCAPE Trial. J Card Fail. 2022 05; 28(5):866-869. PMID: 34774746.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    2. Pulipati VP, Alenghat FJ. The impact of lipid-lowering medications on coronary artery plaque characteristics. Am J Prev Cardiol. 2021 Dec; 8:100294. PMID: 34877559.
      Citations:    
    3. Kanelidis AJ, Miller P, Prabhu N, Dela Cruz MJ, Alenghat FJ, McMullen P, Sarswat N, Derman BA, Polonsky TS, DeCara JM. ATTR Cardiomyopathy Meets Multiple?Myeloma: The Importance of Cardiac Biopsy. JACC CardioOncol. 2021 Oct; 3(4):598-601. PMID: 34729534.
      Citations:    
    4. Belkin MN, Blair JE, Shah SJ, Alenghat FJ. A composite metric for predicting benefit from spironolactone in heart failure with preserved ejection fraction. ESC Heart Fail. 2021 10; 8(5):3495-3503. PMID: 34369088.
      Citations: 3     Fields:    Translation:Humans
    5. Attia ZI, Kapa S, Dugan J, Pereira N, Noseworthy PA, Jimenez FL, Cruz J, Carter RE, DeSimone DC, Signorino J, Halamka J, Chennaiah Gari NR, Madathala RS, Platonov PG, Gul F, Janssens SP, Narayan S, Upadhyay GA, Alenghat FJ, Lahiri MK, Dujardin K, Hermel M, Dominic P, Turk-Adawi K, Asaad N, Svensson A, Fernandez-Aviles F, Esakof DD, Bartunek J, Noheria A, Sridhar AR, Lanza GA, Cohoon K, Padmanabhan D, Pardo Gutierrez JA, Sinagra G, Merlo M, Zagari D, Rodriguez Escenaro BD, Pahlajani DB, Loncar G, Vukomanovic V, Jensen HK, Farkouh ME, Luescher TF, Su Ping CL, Peters NS, Friedman PA. Rapid Exclusion of COVID Infection With the Artificial Intelligence Electrocardiogram. Mayo Clin Proc. 2021 08; 96(8):2081-2094. PMID: 34353468.
      Citations: 4     Fields:    Translation:Humans
    6. Lowisz J, Alenghat FJ, Li Y, Roberson D, Penk J, Gandhi R. Comparison of semi-automated versus manual quantitative right ventricular assessment in tetralogy of Fallot. Cardiol Young. 2021 Nov; 31(11):1781-1787. PMID: 33685532.
      Citations:    Fields:    Translation:Humans
    7. Belkin MN, Alenghat FJ, Besser SA, Nguyen AB, Chung BB, Smith BA, Kalantari S, Sarswat N, Blair JEA, Kim GH, Pinney SP, Grinstein J. Aortic pulsatility index predicts clinical outcomes in heart failure: a sub-analysis of the ESCAPE trial. ESC Heart Fail. 2021 04; 8(2):1522-1530. PMID: 33595923.
      Citations: 4     Fields:    Translation:Humans
    8. Holzhauser L, Clerkin KJ, Fujino T, Alenghat FJ, Raikhelkar J, Kim G, Sayer G, Uriel N. Donor-derived cell-free DNA is associated with cardiac allograft vasculopathy. Clin Transplant. 2021 03; 35(3):e14206. PMID: 33368611.
      Citations: 4     Fields:    Translation:Humans
    9. Singh N, Anchan RK, Besser SA, Belkin MN, Cruz MD, Lee L, Yu D, Mehta N, Nguyen AB, Alenghat FJ. High sensitivity Troponin-T for prediction of adverse events in patients with COVID-19. Biomarkers. 2020 Dec; 25(8):626-633. PMID: 32981387.
      Citations: 11     Fields:    Translation:HumansCellsPHPublic Health
    10. Karunakaran D, Nguyen MA, Geoffrion M, Vreeken D, Lister Z, Cheng HS, Otte N, Essebier P, Wyatt H, Kandiah JW, Jung R, Alenghat FJ, Mompeon A, Lee R, Pan C, Gordon E, Rasheed A, Lusis AJ, Liu P, Matic LP, Hedin U, Fish JE, Guo L, Kolodgie F, Virmani R, van Gils JM, Rayner KJ. RIPK1 Expression Associates With Inflammation in Early Atherosclerosis in Humans and Can Be Therapeutically Silenced to Reduce NF-?B Activation and Atherogenesis in Mice. Circulation. 2021 01 12; 143(2):163-177. PMID: 33222501.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    11. Holzhauser L, Fujino T, Alenghat F, Raikhelkar J, Kim G, Sayer G, Uriel N. Donor-Derived Cell-Free DNA is Associated with Cardiac Allograft Vasculopathy. J Heart Lung Transplant. 2020 Apr; 39(4S):S63. PMID: 32465994.
      Citations:    
    12. Holzhauser L, Fujino T, Nguyen A, Alenghat F, Raikhelkar J, Kim G, Sayer G, Uriel N. Donor-Derived Cell-Free DNA Does Not Correlate with Levels of Inflammation or Angiogenesis in a Stable Post Transplant Population. J Heart Lung Transplant. 2020 Apr; 39(4S):S287. PMID: 32465303.
      Citations:    
    13. Upadhyay GA, Alenghat FJ. Catheter Ablation for Atrial Fibrillation in 2019. JAMA. 2019 08 20; 322(7):686-687. PMID: 31429886.
      Citations: 3     Fields:    Translation:Humans
    14. Arnold KA, Blair JE, Paul JD, Shah AP, Nathan S, Alenghat FJ. Monocyte and macrophage subtypes as paired cell biomarkers for coronary artery disease. Exp Physiol. 2019 09; 104(9):1343-1352. PMID: 31264265.
      Citations: 7     Fields:    Translation:HumansCells
    15. Laffin LJ, Alenghat FJ. The SPRINT Trial Score web calculator. Eur J Prev Cardiol. 2019 12; 26(18):2016. PMID: 31189381.
      Citations:    Fields:    Translation:Humans
    16. Arnold KA, Treister AD, Lio PA, Alenghat FJ. Association of Atherosclerosis Prevalence With Age, Race, and Traditional Risk Factors in Patients With Psoriasis. JAMA Dermatol. 2019 05 01; 155(5):622-623. PMID: 30785601.
      Citations: 4     Fields:    Translation:Humans
    17. Alenghat FJ, Davis AM. Management of Blood Cholesterol. JAMA. 2019 02 26; 321(8):800-801. PMID: 30715135.
      Citations: 9     Fields:    Translation:Humans
    18. Laffin LJ, Besser SA, Alenghat FJ. A data-zone scoring system to assess the generalizability of clinical trial results to individual patients. Eur J Prev Cardiol. 2019 04; 26(6):569-575. PMID: 30477321.
      Citations: 7     Fields:    Translation:Humans
    19. Poon C, Chowdhuri S, Kuo CH, Fang Y, Alenghat FJ, Hyatt D, Kani K, Gross ME, Chung EJ. Protein Mimetic and Anticancer Properties of Monocyte-Targeting Peptide Amphiphile Micelles. ACS Biomater Sci Eng. 2017 Dec 11; 3(12):3273-3282. PMID: 29302619.
      Citations: 12     Fields:    
    20. Poon C, Chowdhuri S, Kuo CH, Fang Y, Alenghat FJ, Hyatt D, Kani K, Gross ME, Chung EJ. Protein Mimetic and Anticancer Properties of Monocyte-Targeting Peptide Amphiphile Micelles. ACS Biomaterials Science & Engineering. 2017. View Publication.
    21. Alenghat FJ. The Prevalence of Atherosclerosis in Those with Inflammatory Connective Tissue Disease by Race, Age, and Traditional Risk Factors. Sci Rep. 2016 Feb 04; 6:20303. PMID: 26842423.
      Citations: 17     Fields:    Translation:Humans
    22. Chung EJ, Mlinar LB, Nord K, Sugimoto MJ, Wonder E, Alenghat FJ, Fang Y, Tirrell M. Monocyte-targeting supramolecular micellar assemblies: a molecular diagnostic tool for atherosclerosis. Adv Healthc Mater. 2015 Feb 18; 4(3):367-76. PMID: 25156590.
      Citations: 27     Fields:    Translation:AnimalsCells
    23. Alenghat FJ, Golan DE. Membrane protein dynamics and functional implications in mammalian cells. Curr Top Membr. 2013; 72:89-120. PMID: 24210428.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    24. Alenghat FJ, Couper GS, Givertz MM. Giant left ventricular aneurysm as a late complication of inferior myocardial infarction. Eur Heart J. 2013 Feb; 34(5):344. PMID: 23095983.
      Citations: 2     Fields:    Translation:Humans
    25. Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, Golan DE, Neel BG, Swanson KD. Macrophages require Skap2 and Sirpa for integrin-stimulated cytoskeletal rearrangement. J Cell Sci. 2012 Nov 15; 125(Pt 22):5535-45. PMID: 22976304.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    26. Alenghat FJ, Tytell JD, Thodeti CK, Derrien A, Ingber DE. Mechanical control of cAMP signaling through integrins is mediated by the heterotrimeric Galphas protein. J Cell Biochem. 2009 Mar 01; 106(4):529-38. PMID: 19170051.
      Citations: 29     Fields:    Translation:HumansCells
    27. Nauli SM, Rossetti S, Kolb RJ, Alenghat FJ, Consugar MB, Harris PC, Ingber DE, Loghman-Adham M, Zhou J. Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction. J Am Soc Nephrol. 2006 Apr; 17(4):1015-25. PMID: 16565258.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    28. Alenghat FJ, Nauli SM, Kolb R, Zhou J, Ingber DE. Global cytoskeletal control of mechanotransduction in kidney epithelial cells. Exp Cell Res. 2004 Nov 15; 301(1):23-30. PMID: 15501441.
      Citations: 59     Fields:    Translation:AnimalsCells
    29. Matthews BD, Overby DR, Alenghat FJ, Karavitis J, Numaguchi Y, Allen PG, Ingber DE. Mechanical properties of individual focal adhesions probed with a magnetic microneedle. Biochem Biophys Res Commun. 2004 Jan 16; 313(3):758-64. PMID: 14697256.
      Citations: 35     Fields:    Translation:AnimalsCells
    30. Overby DR, Alenghat FJ, Montoya-Zavala M, Bei H, Oh P, Karavitis J, Ingber DE. Magnetic Cellular Switches. IEEE Trans Magn. 2004; 40(4):2958-2960. PMID: 23097592.
      Citations: 2     
    31. Nauli SM, Alenghat FJ, Luo Y, Williams E, Vassilev P, Li X, Elia AE, Lu W, Brown EM, Quinn SJ, Ingber DE, Zhou J. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet. 2003 Feb; 33(2):129-37. PMID: 12514735.
      Citations: 831     Fields:    Translation:HumansAnimalsCells
    32. Alenghat FJ, Ingber DE. Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins. Sci STKE. 2002 Feb 12; 2002(119):pe6. PMID: 11842240.
      Citations: 133     Fields:    Translation:HumansAnimalsCells
    33. Alenghat FJ, Fabry B, Tsai KY, Goldmann WH, Ingber DE. Analysis of cell mechanics in single vinculin-deficient cells using a magnetic tweezer. Biochem Biophys Res Commun. 2000 Oct 14; 277(1):93-9. PMID: 11027646.
      Citations: 44     Fields:    Translation:AnimalsCells
    34. Meyer CJ, Alenghat FJ, Rim P, Fong JH, Fabry B, Ingber DE. Mechanical control of cyclic AMP signalling and gene transcription through integrins. Nat Cell Biol. 2000 Sep; 2(9):666-8. PMID: 10980709.
      Citations: 77     Fields:    Translation:AnimalsCells
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