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Kevin Hellman

TitleAssistant Professor, Part-Time
InstitutionUniversity of Chicago
DepartmentObstetrics & Gynecology
AddressChicago IL 60637
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    I am the principal investigator of an NIH funded grant that studies the physiology and treatment of women's health conditions. Dysmenorrhea, period pain, is the leading cause of school/work absence and foremost risk factor for chronic visceral pain in reproductive aged women. Our laboratory has developed new animal models, investigated novel diagnostic methods, and conducted treatment studies. My goal is to systematically define the pathophysiology of dysmenorrhea and develop new treatments, while simultaneously training a cadre of future investigators to revolutionize the study of visceral pain. Our research is essential because there are few other laboratories dedicated to eradicating dysmenorrhea, one of the most frequent causes of suffering and gender disparity worldwide. Our recent review article on dysmenorrhea http://doi.org/10.1016/j.ajog.2017.08.108 was reading material for board recertification and provides a roadmap for developing effective treatments for menstrual pain.


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    R21HD081709     (HELLMAN, KEVIN)Aug 6, 2014 - Jul 31, 2017
    NIH
    Neurophysiological Diagnostics for Menstrual Pain
    Role: Principal Investigator

    R21HD091502     (HELLMAN, KEVIN)Aug 2, 2017 - Jan 31, 2021
    NIH
    Noninvasive imaging of uterine physiology to improve treatment for dysmenorrhea
    Role: Principal Investigator

    R01HD098193     (HELLMAN, KEVIN)Sep 6, 2019 - Aug 31, 2024
    NIH
    Mechanistic Characterization of Uterine Pain (M-CUP) to improve diagnosis and treatment for dysmenorrhea
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Oh H, Ehrenpreis ED, Tu FF, Dillane KE, Garrison EF, Leloudas N, Prasad PV, Hellman KM. Menstrual Cycle Variation in MRI-Based Quantification of Intraluminal Gas in Women With and Without Dysmenorrhea. Front Pain Res (Lausanne). 2022; 3:720141. PMID: 35634451.
      View in: PubMed
    2. Schrepf A, Hellman KM, Bohnert AM, Williams DA, Tu FF. Generalized sensory sensitivity is associated with comorbid pain symptoms: a replication study in women with dysmenorrhea. Pain. 2023 01 01; 164(1):142-148. PMID: 35543649.
      View in: PubMed
    3. Tu FF, Hellman KM, Roth GE, Dillane KE, Walker LS. Noninvasive bladder testing of adolescent females to assess visceral hypersensitivity. Pain. 2022 Jan 01; 163(1):100-109. PMID: 34086630.
      View in: PubMed
    4. Kmiecik MJ, Tu FF, Silton RL, Dillane KE, Roth GE, Harte SE, Hellman KM. Cortical mechanisms of visual hypersensitivity in women at risk for chronic pelvic pain. Pain. 2022 06 01; 163(6):1035-1048. PMID: 34510138.
      View in: PubMed
    5. Tu F, Hellman K. Primary Dysmenorrhea: Diagnosis and Therapy. Obstet Gynecol. 2021 04 01; 137(4):752. PMID: 33759824.
      View in: PubMed
    6. Wilson SH, Hellman KM, James D, Adler AC, Chandrakantan A. Mechanisms, diagnosis, prevention?and management of perioperative opioid-induced hyperalgesia. Pain Manag. 2021 Apr; 11(4):405-417. PMID: 33779215.
      View in: PubMed
    7. Brito KS, Madueke-Laveaux OS, Glass D, Hellman KM, Gao G, Iyer S. Racial Distribution and Characterization of Pelvic Organ Prolapse in a Hospital-Based Subspecialty Clinic. Female Pelvic Med Reconstr Surg. 2021 03 01; 27(3):147-150. PMID: 33620896.
      View in: PubMed
    8. Kantarovich D, Dillane KE, Garrison EF, Oladosu FA, Schroer MS, Roth GE, Tu FF, Hellman KM. Development and validation of a real-time method characterizing spontaneous pain in women with dysmenorrhea. J Obstet Gynaecol Res. 2021 Apr; 47(4):1472-1480. PMID: 33590541.
      View in: PubMed
    9. Kmiecik MJ, Tu FF, Silton RL, Dillane KE, Roth GE, Harte SE, Hellman KM. Cortical Mechanisms of Visual Hypersensitivity in Women at Risk for Chronic Pelvic Pain. medRxiv. 2021 Jan 18. PMID: 33501463.
      View in: PubMed
    10. Hellman KM, Oladosu FA, Garrison EF, Roth GE, Dillane KE, Tu FF. Circulating sex steroids and bladder pain sensitivity in dysmenorrhea. Mol Pain. 2021 Jan-Dec; 17:17448069211035217. PMID: 34689649.
      View in: PubMed
    11. Oladosu FA, Tu FF, Garrison EF, Dillane KE, Roth GE, Hellman KM. Low Serum Naproxen Concentrations Are Associated with Minimal Pain Relief: A Preliminary Study in Women with Dysmenorrhea. Pain Med. 2020 11 01; 21(11):3102-3108. PMID: 32488234.
      View in: PubMed
    12. Kantarovich D, Vollbrecht HB, Cruz SA, Castillo H, Lee CS, Kushner J, Leng JX, Morgan VK, Hellman KM. Wikipedia: A Medical Student Educational Project to Edit Wikipedia in Preparation for Practicing Evidence-Based Pain Medicine. J Med Educ Curric Dev. 2020 Jan-Dec; 7:2382120520959691. PMID: 33015367.
      View in: PubMed
    13. Hellman KM, Roth GE, Dillane KE, Garrison EF, Oladosu FA, Clauw DJ, Tu FF. Dysmenorrhea subtypes exhibit differential quantitative sensory assessment profiles. Pain. 2020 06; 161(6):1227-1236. PMID: 32168005.
      View in: PubMed
    14. Oladosu FA, Tu FF, Garfield LB, Garrison EF, Steiner ND, Roth GE, Hellman KM. Low Serum Oxytocin Concentrations Are Associated with Painful Menstruation. Reprod Sci. 2020 02; 27(2):668-674. PMID: 32046441.
      View in: PubMed
    15. Tu FF, Datta A, Atashroo D, Senapati S, Roth G, Clauw DJ, Hellman KM. Clinical profile of comorbid dysmenorrhea and bladder sensitivity: a?cross-sectional analysis. Am J Obstet Gynecol. 2020 06; 222(6):594.e1-594.e11. PMID: 31870730.
      View in: PubMed
    16. Oladosu FA, Hellman KM, Ham PJ, Kochlefl LE, Datta A, Garrison EF, Steiner ND, Roth GE, Tu FF. Persistent autonomic dysfunction and bladder sensitivity in primary dysmenorrhea. Sci Rep. 2019 02 18; 9(1):2194. PMID: 30778114.
      View in: PubMed
    17. Oladosu FA, Tu FF, Farhan S, Garrison EF, Steiner ND, Roth GE, Hellman KM. Abdominal skeletal muscle activity precedes spontaneous menstrual cramping pain in primary dysmenorrhea. Am J Obstet Gynecol. 2018 07; 219(1):91.e1-91.e7. PMID: 29733841.
      View in: PubMed
    18. Hellman KM, Datta A, Steiner ND, Kane Morlock JN, Garrison EF, Clauw DJ, Tu FF. Identification of experimental bladder sensitivity among dysmenorrhea sufferers. Am J Obstet Gynecol. 2018 07; 219(1):84.e1-84.e8. PMID: 29704486.
      View in: PubMed
    19. Zuckerman RM, Silton RL, Tu FF, Eng JS, Hellman KM. Somatic symptoms in women with dysmenorrhea and noncyclic pelvic pain. Arch Womens Ment Health. 2018 10; 21(5):533-541. PMID: 29525829.
      View in: PubMed
    20. Hellman KM, Kuhn CS, Tu FF, Dillane KE, Shlobin NA, Senapati S, Zhou X, Li W, Prasad PV. Cine MRI during spontaneous cramps in women with menstrual pain. Am J Obstet Gynecol. 2018 05; 218(5):506.e1-506.e8. PMID: 29409786.
      View in: PubMed
    21. Oladosu FA, Tu FF, Hellman KM. Nonsteroidal antiinflammatory drug resistance in?dysmenorrhea: epidemiology, causes, and?treatment. Am J Obstet Gynecol. 2018 04; 218(4):390-400. PMID: 28888592.
      View in: PubMed
    22. Hellman KM, Yu PY, Oladosu FA, Segel C, Han A, Prasad PV, Jilling T, Tu FF. The Effects of Platelet-Activating Factor on Uterine Contractility, Perfusion, Hypoxia, and Pain in Mice. Reprod Sci. 2018 03; 25(3):384-394. PMID: 28631554.
      View in: PubMed
    23. Tu FF, Kane JN, Hellman KM. Noninvasive experimental bladder pain assessment in painful bladder syndrome. BJOG. 2017 01; 124(2):283-291. PMID: 28012262.
      View in: PubMed
    24. Hellman KM, Tu FF. Reply. Am J Obstet Gynecol. 2016 07; 215(1):132-3. PMID: 26945607.
      View in: PubMed
    25. Rosenbaum J, Kuhn C, Tu FF, Hellman KM. Ultrasonographic Investigation of the Mechanisms Involved in Menstrual Cramps. J Minim Invasive Gynecol. 2015 Nov-Dec; 22(6S):S16. PMID: 27678901.
      View in: PubMed
    26. Hellman KM, Patanwala IY, Pozolo KE, Tu FF. Multimodal nociceptive mechanisms underlying chronic pelvic pain. Am J Obstet Gynecol. 2015 Dec; 213(6):827.e1-9. PMID: 26299416.
      View in: PubMed
    27. Tu FF, Epstein AE, Pozolo KE, Sexton DL, Melnyk AI, Hellman KM. A noninvasive bladder sensory test supports a role for dysmenorrhea increasing bladder noxious mechanosensitivity. Clin J Pain. 2013 Oct; 29(10):883-90. PMID: 23370073.
      View in: PubMed
    28. Westling AM, Tu FF, Griffith JW, Hellman KM. The association of dysmenorrhea with noncyclic pelvic pain accounting for psychological factors. Am J Obstet Gynecol. 2013 Nov; 209(5):422.e1-422.e10. PMID: 23973396.
      View in: PubMed
    29. Hellman KM, Mason P. Opioids disrupt pro-nociceptive modulation mediated by raphe magnus. J Neurosci. 2012 Oct 03; 32(40):13668-78. PMID: 23035079.
      View in: PubMed
    30. Tu FF, Hellman KM, Backonja MM. Gynecologic management of neuropathic pain. Am J Obstet Gynecol. 2011 Nov; 205(5):435-43. PMID: 21777899.
      View in: PubMed
    31. Hellman K, Hernandez P, Park A, Abel T. Genetic evidence for a role for protein kinase A in the maintenance of sleep and thalamocortical oscillations. Sleep. 2010 Jan; 33(1):19-28. PMID: 20120617.
      View in: PubMed
    32. Hellman KM, Mendelson SJ, Mendez-Duarte MA, Russell JL, Mason P. Opioid microinjection into raphe magnus modulates cardiorespiratory function in mice and rats. Am J Physiol Regul Integr Comp Physiol. 2009 Nov; 297(5):R1400-8. PMID: 19710394.
      View in: PubMed
    33. Hellman KM, Brink TS, Mason P. Activity of murine raphe magnus cells predicts tachypnea and on-going nociceptive responsiveness. J Neurophysiol. 2007 Dec; 98(6):3121-33. PMID: 17913977.
      View in: PubMed
    34. Hellman K, Abel T. Fear conditioning increases NREM sleep. Behav Neurosci. 2007 Apr; 121(2):310-23. PMID: 17469920.
      View in: PubMed
    35. Brink TS, Hellman KM, Lambert AM, Mason P. Raphe magnus neurons help protect reactions to visceral pain from interruption by cutaneous pain. J Neurophysiol. 2006 Dec; 96(6):3423-32. PMID: 16928792.
      View in: PubMed
    36. Keeley MB, Wood MA, Isiegas C, Stein J, Hellman K, Hannenhalli S, Abel T. Differential transcriptional response to nonassociative and associative components of classical fear conditioning in the amygdala and hippocampus. Learn Mem. 2006 Mar-Apr; 13(2):135-42. PMID: 16547164.
      View in: PubMed
    37. Ouyang M, Hellman K, Abel T, Thomas SA. Adrenergic signaling plays a critical role in the maintenance of waking and in the regulation of REM sleep. J Neurophysiol. 2004 Oct; 92(4):2071-82. PMID: 15190089.
      View in: PubMed
    38. Graves LA, Hellman K, Veasey S, Blendy JA, Pack AI, Abel T. Genetic evidence for a role of CREB in sustained cortical arousal. J Neurophysiol. 2003 Aug; 90(2):1152-9. PMID: 12711709.
      View in: PubMed
    39. Lytton WW, Hellman KM, Sutula TP. Computer models of hippocampal circuit changes of the kindling model of epilepsy. Artif Intell Med. 1998 May; 13(1-2):81-97. PMID: 9654380.
      View in: PubMed
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