 Mecamylamine
"Mecamylamine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
| Descriptor ID |
D008464
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| MeSH Number(s) |
D02.455.849.575.781.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Mecamylamine".
Below are MeSH descriptors whose meaning is more specific than "Mecamylamine".
This graph shows the total number of publications written about "Mecamylamine" by people in this website by year, and whether "Mecamylamine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 | | 2005 | 1 | 0 | 1 | | 2007 | 0 | 2 | 2 | | 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mecamylamine" by people in Profiles.
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Miyauchi M, Neugebauer NM, Oyamada Y, Meltzer HY. Nicotinic receptors and lurasidone-mediated reversal of phencyclidine-induced deficit in novel object recognition. Behav Brain Res. 2016 Mar 15; 301:204-12.
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Chen J, Brunzell DH, Jackson K, van der Vaart A, Ma JZ, Payne TJ, Sherva R, Farrer LA, Gejman P, Levinson DF, Holmans P, Aggen SH, Damaj I, Kuo PH, Webb BT, Anton R, Kranzler HR, Gelernter J, Li MD, Kendler KS, Chen X. ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure. PLoS One. 2011; 6(12):e28790.
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Stairs DJ, Neugebauer NM, Bardo MT. Nicotine and cocaine self-administration using a multiple schedule of intravenous drug and sucrose reinforcement in rats. Behav Pharmacol. 2010 May; 21(3):182-93.
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Drisdel RC, Sharp D, Henderson T, Hales TG, Green WN. High affinity binding of epibatidine to serotonin type 3 receptors. J Biol Chem. 2008 Apr 11; 283(15):9659-65.
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Miller DK, Lever JR, Rodvelt KR, Baskett JA, Will MJ, Kracke GR. Lobeline, a potential pharmacotherapy for drug addiction, binds to mu opioid receptors and diminishes the effects of opioid receptor agonists. Drug Alcohol Depend. 2007 Jul 10; 89(2-3):282-91.
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Neugebauer NM, Zhang Z, Crooks PA, Dwoskin LP, Bardo MT. Effect of a novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide, on nicotine self-administration and hyperactivity in rats. Psychopharmacology (Berl). 2006 Mar; 184(3-4):426-34.
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Young EM, Mahler S, Chi H, de Wit H. Mecamylamine and ethanol preference in healthy volunteers. Alcohol Clin Exp Res. 2005 Jan; 29(1):58-65.
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Chi H, de Wit H. Mecamylamine attenuates the subjective stimulant-like effects of alcohol in social drinkers. Alcohol Clin Exp Res. 2003 May; 27(5):780-6.
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