"Methylmalonyl-CoA Mutase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the conversion of methylmalonyl-CoA to succinyl-CoA by transfer of the carbonyl group. It requires a cobamide coenzyme. A block in this enzymatic conversion leads to the metabolic disease, methylmalonic aciduria. EC 5.4.99.2.
| Descriptor ID |
D008765
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| MeSH Number(s) |
D08.811.399.520.625
|
| Concept/Terms |
Methylmalonyl-CoA Mutase- Methylmalonyl-CoA Mutase
- Methylmalonyl CoA Mutase
- Mutase, Methylmalonyl-CoA
- Methylmalonyl-CoA Isomerase
- Isomerase, Methylmalonyl-CoA
- Methylmalonyl CoA Isomerase
|
Below are MeSH descriptors whose meaning is more general than "Methylmalonyl-CoA Mutase".
Below are MeSH descriptors whose meaning is more specific than "Methylmalonyl-CoA Mutase".
This graph shows the total number of publications written about "Methylmalonyl-CoA Mutase" by people in this website by year, and whether "Methylmalonyl-CoA Mutase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
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Below are the most recent publications written about "Methylmalonyl-CoA Mutase" by people in Profiles.
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Molecular basis for dysfunction of some mutant forms of methylmalonyl-CoA mutase: deductions from the structure of methionine synthase. Proc Natl Acad Sci U S A. 1996 May 28; 93(11):5550-5.
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Purification and properties of methylmalonyl coenzyme A mutase from human liver. Arch Biochem Biophys. 1982 Apr 01; 214(2):815-23.
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Interactions of methylmalonyl CoA mutase from normal human fibroblasts with adenosylcobalamin and methylmalonyl CoA: evidence for non-equivalent active sites. Arch Biochem Biophys. 1980 Mar; 200(1):130-9.
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Inherited methylmalonyl CoA mutase apoenzyme deficiency in human fibroblasts: evidence for allelic heterogeneity, genetic compounds, and codominant expression. J Clin Invest. 1980 Mar; 65(3):690-8.
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Inborn errors of cobalamin metabolism: effect of cobalamin supplementation in culture on methylmalonyl CoA mutase activity in normal and mutant human fibroblasts. Biochem Genet. 1979 Feb; 17(1-2):57-75.
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Cobalamin binding and cobalamin-dependent enzyme activity in normal and mutant human fibroblasts. J Clin Invest. 1978 Nov; 62(5):952-60.
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Genetic complementation among inherited deficiencies of methylmalonyl-CoA mutase activity: evidence for a new class of human cobalamin mutant. Am J Hum Genet. 1978 Jan; 30(1):1-13.
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Inherited deficiencies of human methylmalonyl CaA mutase activity: reduced affinity of mutant apoenzyme for adenosylcobalamin. Biochem Biophys Res Commun. 1977 Oct 10; 78(3):927-34.
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Intracellular binding of radioactive hydroxocobalamin to cobalamin-dependent apoenzymes in rat liver. Proc Natl Acad Sci U S A. 1977 Mar; 74(3):916-20.