"Pinacidil" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
| Descriptor ID |
D020110
|
| MeSH Number(s) |
D02.078.370.729
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Pinacidil".
Below are MeSH descriptors whose meaning is more specific than "Pinacidil".
This graph shows the total number of publications written about "Pinacidil" by people in this website by year, and whether "Pinacidil" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pinacidil" by people in Profiles.
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Evidence against a systemic arterial defect in patients with inflammatory bowel disease. J Surg Res. 2014 Oct; 191(2):318-22.
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Vasodilation induced by oxygen/glucose deprivation is attenuated in cerebral arteries of SUR2 null mice. Am J Physiol Heart Circ Physiol. 2011 Oct; 301(4):H1360-8.
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Hydrogen sulfide dilates cerebral arterioles by activating smooth muscle cell plasma membrane KATP channels. Am J Physiol Heart Circ Physiol. 2011 Jun; 300(6):H2088-95.
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Sulfonylurea receptor-dependent and -independent pathways mediate vasodilation induced by ATP-sensitive K+ channel openers. Mol Pharmacol. 2008 Sep; 74(3):736-43.
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Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion. Circ Res. 2000 Mar 17; 86(5):541-8.
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Preconditioning reduces tissue complement gene expression in the rabbit isolated heart. Am J Physiol. 1999 12; 277(6):H2373-80.
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Effects of tedisamil (KC-8857) on cardiac electrophysiology and ventricular fibrillation in the rabbit isolated heart. Br J Pharmacol. 1996 Mar; 117(6):1261-9.