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The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions.

Longerich S, Tanaka A, Bozek G, Nicolae D, Storb U. The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions. J Exp Med. 2005 Nov 21; 202(10):1443-54.

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