Iron Regulatory Protein 1
"Iron Regulatory Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its RNA binding ability and its aconitate hydrolase activity are dependent upon availability of IRON.
| Descriptor ID |
D035941
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| MeSH Number(s) |
D08.811.520.241.300.050.500 D12.776.157.427.374.375.960 D12.776.157.725.374 D12.776.494.500 D12.776.556.579.374.375.960 D12.776.664.962.374
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| Concept/Terms |
Iron Regulatory Protein 1- Iron Regulatory Protein 1
- IRP-1 Protein
- IRP 1 Protein
- IRP1 Protein
- ACO1 Protein
- Aconitase 1, Soluble
- Soluble Aconitase 1
- IRE-BP1
- IRE BP1
- Ferritin Repressor Protein
- Repressor Protein, Ferritin
|
Below are MeSH descriptors whose meaning is more general than "Iron Regulatory Protein 1".
Below are MeSH descriptors whose meaning is more specific than "Iron Regulatory Protein 1".
This graph shows the total number of publications written about "Iron Regulatory Protein 1" by people in this website by year, and whether "Iron Regulatory Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Iron Regulatory Protein 1" by people in Profiles.
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Regulation of iron homeostasis by the p53-ISCU pathway. Sci Rep. 2015 Nov 12; 5:16497.
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Abnormal body iron distribution and erythropoiesis in a novel mouse model with inducible gain of iron regulatory protein (IRP)-1 function. J Mol Med (Berl). 2013 Jul; 91(7):871-81.
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Evidence that phosphorylation of iron regulatory protein 1 at Serine 138 destabilizes the [4Fe-4S] cluster in cytosolic aconitase by enhancing 4Fe-3Fe cycling. J Biol Chem. 2009 May 08; 284(19):12701-9.
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Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster. EMBO J. 2006 Feb 08; 25(3):544-53.
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Selective inhibition of the citrate-to-isocitrate reaction of cytosolic aconitase by phosphomimetic mutation of serine-711. Proc Natl Acad Sci U S A. 2004 Jul 27; 101(30):10907-12.