"Calgranulin A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 10.8-kDa member of the S-100 family of calcium-binding proteins that can form homo- or heterocomplexes with CALGRANULIN B and a variety of other proteins. The calgranulin A/B heterodimer is known as LEUKOCYTE L1 ANTIGEN COMPLEX. Calgranulin A is found in many cell types including GRANULOCYTES; KERATINOCYTES; and myelomonocytes, and has been shown to act as a chemotactic substance for NEUTROPHILS. Because it is present in acute inflammation but absent in chronic inflammation, it is a useful biological marker for a number of pathological conditions.
| Descriptor ID |
D040501
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| MeSH Number(s) |
D12.776.157.125.750.500.100 D12.776.631.655.500.100 D23.050.301.562.100
|
| Concept/Terms |
Calgranulin A- Calgranulin A
- 60B8-B Antigen
- 60B8 B Antigen
- Antigen, 60B8-B
- CABP-P8
- MRP8 Protein
- Leukocyte L1 Protein Light Chain
- Myeloid Calcium-Binding Protein P8
- Myeloid Calcium Binding Protein P8
- MRP-8 Protein
- MRP 8 Protein
- S100 A8 Protein
- A8 Protein, S100
- S100A8 Protein
- Cystic Fibrosis Antigen
- Antigen, Cystic Fibrosis
- Macrophage-Related Protein-8
- Macrophage Related Protein 8
|
Below are MeSH descriptors whose meaning is more general than "Calgranulin A".
Below are MeSH descriptors whose meaning is more specific than "Calgranulin A".
This graph shows the total number of publications written about "Calgranulin A" by people in this website by year, and whether "Calgranulin A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 2 | 0 | 2 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 1 | 2 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Calgranulin A" by people in Profiles.
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Elevated Level of Circulating but Not Urine S100A8/A9 Identifies Poor COVID-19 Outcomes. ACS Infect Dis. 2023 10 13; 9(10):1815-1820.
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Molecular Basis of Ca(II)-Induced Tetramerization and Transition-Metal Sequestration in Human Calprotectin. J Am Chem Soc. 2021 11 03; 143(43):18073-18090.
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S100A8/A9 in COVID-19 pathogenesis: Impact on clinical outcomes. Cytokine Growth Factor Rev. 2022 02; 63:90-97.
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S100A8/A9 regulates CD11b expression and neutrophil recruitment during chronic tuberculosis. J Clin Invest. 2020 06 01; 130(6):3098-3112.
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Serum S100A8/A9 and S100A12 Levels in Children With Polyarticular Forms of Juvenile Idiopathic Arthritis: Relationship to Maintenance of Clinically Inactive Disease During Anti-Tumor Necrosis Factor Therapy and Occurrence of Disease Flare After Discontinuation of Therapy. Arthritis Rheumatol. 2019 03; 71(3):451-459.
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Involvement of calprotectin (S100A8/A9) in molecular pathways associated with HNSCC. Oncotarget. 2016 Mar 22; 7(12):14029-47.
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Biomarkers associated with obstructive sleep apnea and morbidities: a scoping review. Sleep Med. 2015 Mar; 16(3):347-57.
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S100/Calgranulin-mediated inflammation accelerates left ventricular hypertrophy and aortic valve sclerosis in chronic kidney disease in a receptor for advanced glycation end products-dependent manner. Arterioscler Thromb Vasc Biol. 2014 Jul; 34(7):1399-411.
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IL-22 is induced by S100/calgranulin and impairs cholesterol efflux in macrophages by downregulating ABCG1. J Lipid Res. 2014 Mar; 55(3):443-54.
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S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis. Am J Respir Crit Care Med. 2013 Nov 01; 188(9):1137-46.