1-Alkyl-2-acetylglycerophosphocholine Esterase
"1-Alkyl-2-acetylglycerophosphocholine Esterase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.
Descriptor ID |
D043203
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MeSH Number(s) |
D08.811.277.352.100.680.750.937.249
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Concept/Terms |
1-Alkyl-2-acetylglycerophosphocholine Esterase- 1-Alkyl-2-acetylglycerophosphocholine Esterase
- 1 Alkyl 2 acetylglycerophosphocholine Esterase
- Esterase, 1-Alkyl-2-acetylglycerophosphocholine
- PAF Acetylhydrolase II
- Acetylhydrolase II, PAF
- Platelet-Activating Factor Hydrolase
- Factor Hydrolase, Platelet-Activating
- Hydrolase, Platelet-Activating Factor
- Platelet Activating Factor Hydrolase
- PAF 2-Acylhydrolase
- PAF 2 Acylhydrolase
- Lipoprotein-Associated Phospholipase A2
- Lipoprotein Associated Phospholipase A2
- Phospholipase A2, Lipoprotein-Associated
- Lp-PLA(2)
- Lp-PLA2
- Lp PLA2
- PAF 2-Acetylhydrolase
- 2-Acetylhydrolase, PAF
- PAF 2 Acetylhydrolase
- PAF Acetylhydrolase
- Acetylhydrolase, PAF
- Lipoprotein-Associated Phospholipase A(2)
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Below are MeSH descriptors whose meaning is more general than "1-Alkyl-2-acetylglycerophosphocholine Esterase".
Below are MeSH descriptors whose meaning is more specific than "1-Alkyl-2-acetylglycerophosphocholine Esterase".
This graph shows the total number of publications written about "1-Alkyl-2-acetylglycerophosphocholine Esterase" by people in this website by year, and whether "1-Alkyl-2-acetylglycerophosphocholine Esterase" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1997 | 0 | 2 | 2 |
1998 | 0 | 2 | 2 |
1999 | 0 | 1 | 1 |
2000 | 0 | 3 | 3 |
2001 | 0 | 3 | 3 |
2002 | 0 | 2 | 2 |
2003 | 0 | 4 | 4 |
2005 | 0 | 1 | 1 |
2008 | 4 | 0 | 4 |
2009 | 1 | 0 | 1 |
2010 | 2 | 1 | 3 |
2011 | 0 | 1 | 1 |
2013 | 1 | 0 | 1 |
2014 | 0 | 1 | 1 |
2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "1-Alkyl-2-acetylglycerophosphocholine Esterase" by people in Profiles.
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Lissencephaly: Expanded imaging and clinical classification. Am J Med Genet A. 2017 Jun; 173(6):1473-1488.
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Endothelial Dysfunction in Children With Obstructive Sleep Apnea Is Associated With Elevated Lipoprotein-Associated Phospholipase A2 Plasma Activity Levels. J Am Heart Assoc. 2017 02 09; 6(2).
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Platelet-activating factor: a role in preterm delivery and an essential interaction with Toll-like receptor signaling in mice. Biol Reprod. 2014 Nov; 91(5):119.
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The duplication 17p13.3 phenotype: analysis of 21 families delineates developmental, behavioral and brain abnormalities, and rare variant phenotypes. Am J Med Genet A. 2013 Aug; 161A(8):1833-52.
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Spatially dependent dynamic MAPK modulation by the Nde1-Lis1-Brap complex patterns mammalian CNS. Dev Cell. 2013 May 13; 25(3):241-55.
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Lipoprotein-associated phospholipase A2 measurements: mass, activity, but little productivity. Clin Chem. 2012 May; 58(5):814-7.
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Peripheral artery disease, biomarkers, and darapladib. Am Heart J. 2011 May; 161(5):972-8.
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Mouse plasminogen has oxidized phosphatidylcholine adducts that are not metabolized by lipoprotein-associated phospholipase A2under basal conditions. Int J Mol Sci. 2010; 11(12):5339-47.
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Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis. Pediatr Res. 2010 Sep; 68(3):225-30.
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Naturally occurring human plasminogen, like genetically related apolipoprotein(a), contains oxidized phosphatidylcholine adducts. Biochim Biophys Acta. 2010 Jul; 1801(7):738-45.