 Potassium Channels, Tandem Pore Domain
"Potassium Channels, Tandem Pore Domain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Potassium channels that contain two pores in tandem. They are responsible for baseline or leak currents and may be the most numerous of all K channels.
| Descriptor ID |
D024683
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| MeSH Number(s) |
D12.776.157.530.400.600.850 D12.776.543.550.425.750.850 D12.776.543.585.400.750.850
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| Concept/Terms |
Potassium Channels, Tandem Pore Domain- Potassium Channels, Tandem Pore Domain
- Potassium Channels, Leak
- Leak Potassium Channels
- Potassium Channels, Baseline
- Baseline Potassium Channels
- K+ Channels, Tandem Pore Domain
- Potassium Channel, Baseline
- Baseline Potassium Channel
- Potassium Channel, Tandem Pore Domain
- Tandem Pore Domain Potassium Channel
- Potassium Channel, Leak
- Leak Potassium Channel
- Potassium Channel, Background
- Background Potassium Channel
- Potassium Channels, Background
- Background Potassium Channels
- Tandem Pore Domain Potassium Channels
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Below are MeSH descriptors whose meaning is more general than "Potassium Channels, Tandem Pore Domain".
Below are MeSH descriptors whose meaning is more specific than "Potassium Channels, Tandem Pore Domain".
This graph shows the total number of publications written about "Potassium Channels, Tandem Pore Domain" by people in this website by year, and whether "Potassium Channels, Tandem Pore Domain" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 2 | 0 | 2 | | 2005 | 2 | 0 | 2 | | 2008 | 2 | 0 | 2 | | 2010 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2017 | 1 | 1 | 2 |
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Below are the most recent publications written about "Potassium Channels, Tandem Pore Domain" by people in Profiles.
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Dookeran KA, Zhang W, Stayner L, Argos M. Associations of two-pore domain potassium channels and triple negative breast cancer subtype in The Cancer Genome Atlas: systematic evaluation of gene expression and methylation. BMC Res Notes. 2017 Sep 12; 10(1):475.
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Goldstein SA. Sodium leak through K2P potassium channels and cardiac arrhythmia, an emerging theme. EMBO Mol Med. 2017 04; 9(4):399-402.
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Plant LD, Zuniga L, Araki D, Marks JD, Goldstein SA. SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons. Sci Signal. 2012 Nov 20; 5(251):ra84.
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Plant LD, Dementieva IS, Kollewe A, Olikara S, Marks JD, Goldstein SA. One SUMO is sufficient to silence the dimeric potassium channel K2P1. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10743-8.
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Thomas D, Plant LD, Wilkens CM, McCrossan ZA, Goldstein SA. Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium. Neuron. 2008 Jun 26; 58(6):859-70.
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Perlis RH, Moorjani P, Fagerness J, Purcell S, Trivedi MH, Fava M, Rush AJ, Smoller JW. Pharmacogenetic analysis of genes implicated in rodent models of antidepressant response: association of TREK1 and treatment resistance in the STAR(*)D study. Neuropsychopharmacology. 2008 Nov; 33(12):2810-9.
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Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. Pharmacol Rev. 2005 Dec; 57(4):527-40.
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Rajan S, Plant LD, Rabin ML, Butler MH, Goldstein SA. Sumoylation silences the plasma membrane leak K+ channel K2P1. Cell. 2005 Apr 08; 121(1):37-47.
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Rajan S, Preisig-Müller R, Wischmeyer E, Nehring R, Hanley PJ, Renigunta V, Musset B, Schlichthörl G, Derst C, Karschin A, Daut J. Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3. J Physiol. 2002 11 15; 545(1):13-26.
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Kananura C, Sander T, Rajan S, Preisig-Müller R, Grzeschik KH, Daut J, Derst C, Steinlein OK. Tandem pore domain K(+)-channel TASK-3 (KCNK9) and idiopathic absence epilepsies. Am J Med Genet. 2002 Mar 08; 114(2):227-9.
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