 Trimethoprim
"Trimethoprim" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
| Descriptor ID |
D014295
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| MeSH Number(s) |
D03.383.742.906
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Trimethoprim".
Below are MeSH descriptors whose meaning is more specific than "Trimethoprim".
This graph shows the total number of publications written about "Trimethoprim" by people in this website by year, and whether "Trimethoprim" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1980 | 0 | 1 | 1 | | 1984 | 0 | 1 | 1 | | 1998 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 | | 2021 | 2 | 0 | 2 |
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Below are the most recent publications written about "Trimethoprim" by people in Profiles.
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Botros C, Lozo S, Iyer S, Warren A, Goldberg R, Tomezsko J, Sasso K, Sand P, Gafni-Kane A, Biener A, Botros-Brey S. Methenamine hippurate compared with trimethoprim for the prevention of recurrent urinary tract infections: a randomized clinical trial. Int Urogynecol J. 2022 Mar; 33(3):571-580.
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Pach NM, Luchins KR, Broman MT, Langan GP, Theriault BR. Long-Term Effects of Sulfadiazine-Trimethoprim Medicated Diet on Cardiac Function, Hematology, and Weight Gain in Hsd:ICR (CD1) and Tac:SW Mice. Comp Med. 2021 02 01; 71(1):66-75.
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Pach NM, Luchins KR, Kim GH, Langan GP, Theriault BR. Unexpected Cardiomyopathy and Cardiac Dysfunction after Administration of Sulfadiazine-trimethoprim Medicated Diet to ICR mice (Mus musculus). Comp Med. 2020 08 01; 70(4):384-389.
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Wilbur MB, Daum RS, Gold HS. CLINICAL DECISIONS. Skin Abscess. N Engl J Med. 2016 Mar 03; 374(9):882-4.
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Houppert AS, Kwiatkowski E, Glass EM, DeBord KL, Merritt PM, Schneewind O, Marketon MM. Identification of chromosomal genes in Yersinia pestis that influence type III secretion and delivery of Yops into target cells. PLoS One. 2012; 7(3):e34039.
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Kiernan DF, Chin EK, Sclafani LA, Saidel MA. Multiple drug-resistant Alcaligenes xylosoxidans keratitis in a sanitation worker. Eye Contact Lens. 2009 Jul; 35(4):212-4.
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Slavik RS, Rybak MJ, Lerner SA. Trimethoprim/sulfamethoxazole-induced tremor in a patient with AIDS. Ann Pharmacother. 1998 Feb; 32(2):189-92.
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Thompson EI, Callihan TR, Mauer AM. Prophylaxis in severe granulocytopenia. Adv Intern Med. 1984; 29:193-214.
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Daum RS, Glode MP, Ambrosino D, Halsey N, Goldmann DA, Mather FJ, Russell R, Kamon J, Murray M, Band JD, et al. Trimethoprim and rifampin in combination for chemoprophylaxis of household contacts of patients with invasive infections due to Haemophilus influenzae type b. Antimicrob Agents Chemother. 1983 Nov; 24(5):658-62.
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Glode MP, Daum RS, Halsey NA, Johansen TL, Goldmann DA, Ambrosino D, Boies E, Granoff DM. Rifampin alone and in combination with trimethoprim in chemoprophylaxis for infections due to Haemophilus influenzae type b. Rev Infect Dis. 1983 Jul-Aug; 5 Suppl 3:S549-55.
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