 Polymerase Chain Reaction
"Polymerase Chain Reaction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
| Descriptor ID |
D016133
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| MeSH Number(s) |
E05.393.620.500
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| Concept/Terms |
Polymerase Chain Reaction- Polymerase Chain Reaction
- Polymerase Chain Reactions
- Reaction, Polymerase Chain
- Reactions, Polymerase Chain
- PCR
Inverse PCR- Inverse PCR
- PCR, Inverse
- Inverse Polymerase Chain Reaction
Anchored PCR- Anchored PCR
- PCR, Anchored
- Anchored Polymerase Chain Reaction
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Below are MeSH descriptors whose meaning is more general than "Polymerase Chain Reaction".
Below are MeSH descriptors whose meaning is more specific than "Polymerase Chain Reaction".
This graph shows the total number of publications written about "Polymerase Chain Reaction" by people in this website by year, and whether "Polymerase Chain Reaction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1990 | 2 | 12 | 14 | | 1991 | 0 | 26 | 26 | | 1992 | 2 | 36 | 38 | | 1993 | 1 | 53 | 54 | | 1994 | 1 | 42 | 43 | | 1995 | 3 | 41 | 44 | | 1996 | 7 | 34 | 41 | | 1997 | 4 | 40 | 44 | | 1998 | 2 | 31 | 33 | | 1999 | 1 | 19 | 20 | | 2000 | 1 | 28 | 29 | | 2001 | 0 | 22 | 22 | | 2002 | 3 | 30 | 33 | | 2003 | 1 | 19 | 20 | | 2004 | 1 | 25 | 26 | | 2005 | 2 | 16 | 18 | | 2006 | 0 | 20 | 20 | | 2007 | 3 | 28 | 31 | | 2008 | 4 | 30 | 34 | | 2009 | 5 | 26 | 31 | | 2010 | 4 | 18 | 22 | | 2011 | 4 | 31 | 35 | | 2012 | 1 | 17 | 18 | | 2013 | 0 | 17 | 17 | | 2014 | 3 | 9 | 12 | | 2015 | 1 | 18 | 19 | | 2016 | 2 | 13 | 15 | | 2017 | 2 | 12 | 14 | | 2018 | 1 | 6 | 7 | | 2019 | 1 | 2 | 3 | | 2020 | 1 | 3 | 4 | | 2021 | 0 | 2 | 2 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Polymerase Chain Reaction" by people in Profiles.
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Lin J, Tay S. Ultra-Sensitive Quantification of Protein and mRNA in Single Mammalian Cells with Digital PLA. Methods Mol Biol. 2022; 2386:157-169.
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Pilishvili T, Gierke R, Fleming-Dutra KE, Farrar JL, Mohr NM, Talan DA, Krishnadasan A, Harland KK, Smithline HA, Hou PC, Lee LC, Lim SC, Moran GJ, Krebs E, Steele MT, Beiser DG, Faine B, Haran JP, Nandi U, Schrading WA, Chinnock B, Henning DJ, Lovecchio F, Lee J, Barter D, Brackney M, Fridkin SK, Marceaux-Galli K, Lim S, Phipps EC, Dumyati G, Pierce R, Markus TM, Anderson DJ, Debes AK, Lin MY, Mayer J, Kwon JH, Safdar N, Fischer M, Singleton R, Chea N, Magill SS, Verani JR, Schrag SJ. Effectiveness of mRNA Covid-19 Vaccine among U.S. Health Care Personnel. N Engl J Med. 2021 12 16; 385(25):e90.
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Wang J, Kaperak C, Sato T, Sakuraba A. COVID-19 reinfection: a rapid systematic review of case reports and case series. J Investig Med. 2021 08; 69(6):1253-1255.
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Gudbjartsson DF, Norddahl GL, Melsted P, Gunnarsdottir K, Holm H, Eythorsson E, Arnthorsson AO, Helgason D, Bjarnadottir K, Ingvarsson RF, Thorsteinsdottir B, Kristjansdottir S, Birgisdottir K, Kristinsdottir AM, Sigurdsson MI, Arnadottir GA, Ivarsdottir EV, Andresdottir M, Jonsson F, Agustsdottir AB, Berglund J, Eiriksdottir B, Fridriksdottir R, Gardarsdottir EE, Gottfredsson M, Gretarsdottir OS, Gudmundsdottir S, Gudmundsson KR, Gunnarsdottir TR, Gylfason A, Helgason A, Jensson BO, Jonasdottir A, Jonsson H, Kristjansson T, Kristinsson KG, Magnusdottir DN, Magnusson OT, Olafsdottir LB, Rognvaldsson S, le Roux L, Sigmundsdottir G, Sigurdsson A, Sveinbjornsson G, Sveinsdottir KE, Sveinsdottir M, Thorarensen EA, Thorbjornsson B, Thordardottir M, Saemundsdottir J, Kristjansson SH, Josefsdottir KS, Masson G, Georgsson G, Kristjansson M, Moller A, Palsson R, Gudnason T, Thorsteinsdottir U, Jonsdottir I, Sulem P, Stefansson K. Humoral Immune Response to SARS-CoV-2 in Iceland. N Engl J Med. 2020 10 29; 383(18):1724-1734.
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Das S, Mangold KA, Shah NS, Peterson LR, Thomson RB, Kaul KL. Performance and Utilization of a Laboratory-Developed Nucleic Acid Amplification Test (NAAT) for the Diagnosis of Pulmonary and Extrapulmonary Tuberculosis in a Low-Prevalence Area. Am J Clin Pathol. 2020 06 08; 154(1):115-123.
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Luchins KR, Mailhiot D, Theriault BR, Langan GP. Detection of Lactate Dehydrogenase Elevating Virus in a Mouse Vivarium Using an Exhaust Air Dust Health Monitoring Program. J Am Assoc Lab Anim Sci. 2020 05 01; 59(3):328-333.
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Shah AA, Wang D, Hirsch E. Nucleic Acid-Based Screening of Maternal Serum to Detect Viruses in Women with Labor or PROM. Reprod Sci. 2020 02; 27(2):537-544.
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Weinstein JA, Regev A, Zhang F. DNA Microscopy: Optics-free Spatio-genetic Imaging by a Stand-Alone Chemical Reaction. Cell. 2019 06 27; 178(1):229-241.e16.
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Marotz C, Sharma A, Humphrey G, Gottel N, Daum C, Gilbert JA, Eloe-Fadrosh E, Knight R. Triplicate PCR reactions for 16S rRNA gene amplicon sequencing are unnecessary. Biotechniques. 2019 07; 67(1):29-32.
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Quan SC, Skondra D. Case Report: Varicella-zoster Encephalitis with Acute Retinal Necrosis and Oculomotor Nerve Palsy. Optom Vis Sci. 2019 05; 96(5):367-371.
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