 Polymerase Chain Reaction
"Polymerase Chain Reaction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
| Descriptor ID |
D016133
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| MeSH Number(s) |
E05.393.620.500
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| Concept/Terms |
Polymerase Chain Reaction- Polymerase Chain Reaction
- Polymerase Chain Reactions
- Reaction, Polymerase Chain
- Reactions, Polymerase Chain
- PCR
Inverse PCR- Inverse PCR
- PCR, Inverse
- Inverse Polymerase Chain Reaction
Anchored PCR- Anchored PCR
- PCR, Anchored
- Anchored Polymerase Chain Reaction
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Below are MeSH descriptors whose meaning is more general than "Polymerase Chain Reaction".
Below are MeSH descriptors whose meaning is more specific than "Polymerase Chain Reaction".
This graph shows the total number of publications written about "Polymerase Chain Reaction" by people in this website by year, and whether "Polymerase Chain Reaction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1990 | 2 | 9 | 11 | | 1991 | 0 | 24 | 24 | | 1992 | 2 | 35 | 37 | | 1993 | 1 | 51 | 52 | | 1994 | 1 | 37 | 38 | | 1995 | 5 | 37 | 42 | | 1996 | 6 | 30 | 36 | | 1997 | 4 | 35 | 39 | | 1998 | 2 | 32 | 34 | | 1999 | 0 | 16 | 16 | | 2000 | 1 | 25 | 26 | | 2001 | 0 | 20 | 20 | | 2002 | 4 | 30 | 34 | | 2003 | 2 | 16 | 18 | | 2004 | 0 | 28 | 28 | | 2005 | 2 | 15 | 17 | | 2006 | 0 | 15 | 15 | | 2007 | 3 | 23 | 26 | | 2008 | 4 | 29 | 33 | | 2009 | 5 | 24 | 29 | | 2010 | 3 | 18 | 21 | | 2011 | 5 | 30 | 35 | | 2012 | 1 | 17 | 18 | | 2013 | 0 | 14 | 14 | | 2014 | 2 | 8 | 10 | | 2015 | 1 | 17 | 18 | | 2016 | 2 | 11 | 13 | | 2017 | 1 | 11 | 12 | | 2018 | 0 | 5 | 5 | | 2019 | 0 | 3 | 3 | | 2020 | 1 | 2 | 3 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Polymerase Chain Reaction" by people in Profiles.
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Wang J, Kaperak C, Sato T, Sakuraba A. COVID-19 reinfection: a rapid systematic review of case reports and case series. J Investig Med. 2021 08; 69(6):1253-1255.
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Gudbjartsson DF, Norddahl GL, Melsted P, Gunnarsdottir K, Holm H, Eythorsson E, Arnthorsson AO, Helgason D, Bjarnadottir K, Ingvarsson RF, Thorsteinsdottir B, Kristjansdottir S, Birgisdottir K, Kristinsdottir AM, Sigurdsson MI, Arnadottir GA, Ivarsdottir EV, Andresdottir M, Jonsson F, Agustsdottir AB, Berglund J, Eiriksdottir B, Fridriksdottir R, Gardarsdottir EE, Gottfredsson M, Gretarsdottir OS, Gudmundsdottir S, Gudmundsson KR, Gunnarsdottir TR, Gylfason A, Helgason A, Jensson BO, Jonasdottir A, Jonsson H, Kristjansson T, Kristinsson KG, Magnusdottir DN, Magnusson OT, Olafsdottir LB, Rognvaldsson S, le Roux L, Sigmundsdottir G, Sigurdsson A, Sveinbjornsson G, Sveinsdottir KE, Sveinsdottir M, Thorarensen EA, Thorbjornsson B, Thordardottir M, Saemundsdottir J, Kristjansson SH, Josefsdottir KS, Masson G, Georgsson G, Kristjansson M, Moller A, Palsson R, Gudnason T, Thorsteinsdottir U, Jonsdottir I, Sulem P, Stefansson K. Humoral Immune Response to SARS-CoV-2 in Iceland. N Engl J Med. 2020 10 29; 383(18):1724-1734.
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Das S, Mangold KA, Shah NS, Peterson LR, Thomson RB, Kaul KL. Performance and Utilization of a Laboratory-Developed Nucleic Acid Amplification Test (NAAT) for the Diagnosis of Pulmonary and Extrapulmonary Tuberculosis in a Low-Prevalence Area. Am J Clin Pathol. 2020 06 08; 154(1):115-123.
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Luchins KR, Mailhiot D, Theriault BR, Langan GP. Detection of Lactate Dehydrogenase Elevating Virus in a Mouse Vivarium Using an Exhaust Air Dust Health Monitoring Program. J Am Assoc Lab Anim Sci. 2020 05 01; 59(3):328-333.
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Quan SC, Skondra D. Case Report: Varicella-zoster Encephalitis with Acute Retinal Necrosis and Oculomotor Nerve Palsy. Optom Vis Sci. 2019 05; 96(5):367-371.
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Taxy JB, Goldin HM, Dickie S, Cibull T. Cutaneous Leishmaniasis: Contribution of Routine Histopathology in Unexpected Encounters. Am J Surg Pathol. 2019 02; 43(2):195-200.
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Guthmiller JJ, Dugan HL, Neu KE, Lan LY, Wilson PC. An Efficient Method to Generate Monoclonal Antibodies from Human B Cells. Methods Mol Biol. 2019; 1904:109-145.
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Cai Y, Xue F, Quan C, Qu M, Liu N, Zhang Y, Fleming C, Hu X, Zhang HG, Weichselbaum R, Fu YX, Tieri D, Rouchka EC, Zheng J, Yan J. A Critical Role of the IL-1ß-IL-1R Signaling Pathway in Skin Inflammation and Psoriasis Pathogenesis. J Invest Dermatol. 2019 01; 139(1):146-156.
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Hujoel IA, Johnson DH, Lebwohl B, Leffler D, Kupfer S, Wu TT, Murray JA, Rubio-Tapia A. Tropheryma whipplei Infection (Whipple Disease) in the USA. Dig Dis Sci. 2019 01; 64(1):213-223.
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Nashat MA, Ricart Arbona RJ, Riedel ER, Francino O, Ferrer L, Luchins KR, Lipman NS. Comparison of Diagnostic Methods and Sampling Sites for the Detection of Demodex musculi. J Am Assoc Lab Anim Sci. 2018 03 01; 57(2):173-185.
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