"Trimetrexate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
Below are MeSH descriptors whose meaning is more general than "Trimetrexate".
Below are MeSH descriptors whose meaning is more specific than "Trimetrexate".
This graph shows the total number of publications written about "Trimetrexate" by people in this website by year, and whether "Trimetrexate" was a major or minor topic of these publications.
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Below are the most recent publications written about "Trimetrexate" by people in Profiles.
A double-blind placebo-controlled randomized phase III trial of 5-fluorouracil and leucovorin, plus or minus trimetrexate, in previously untreated patients with advanced colorectal cancer. Ann Oncol. 2002 Jan; 13(1):87-91.
Safety and efficacy of using a single agent or a phase II agent before instituting standard combination chemotherapy in previously untreated metastatic breast cancer patients: report of a randomized study--Cancer and Leukemia Group B 8642. J Clin Oncol. 1999 May; 17(5):1397-406.
Antifolates: the next generation. Semin Oncol. 1992 Dec; 19(6):707-19.