 Muscarinic Antagonists
"Muscarinic Antagonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system.
| Descriptor ID |
D018727
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| MeSH Number(s) |
D27.505.519.625.120.200.500 D27.505.696.577.120.200.500
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| Concept/Terms |
Muscarinic Antagonists- Muscarinic Antagonists
- Antagonists, Muscarinic
- Antimuscarinic Agents
- Agents, Antimuscarinic
- Antimuscarinics
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Below are MeSH descriptors whose meaning is more general than "Muscarinic Antagonists".
Below are MeSH descriptors whose meaning is more specific than "Muscarinic Antagonists".
This graph shows the total number of publications written about "Muscarinic Antagonists" by people in this website by year, and whether "Muscarinic Antagonists" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 | | 1996 | 1 | 0 | 1 | | 1997 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2001 | 1 | 0 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 1 | 1 | 2 | | 2004 | 2 | 0 | 2 | | 2005 | 1 | 0 | 1 | | 2006 | 3 | 0 | 3 | | 2007 | 2 | 1 | 3 | | 2008 | 0 | 1 | 1 | | 2009 | 7 | 0 | 7 | | 2010 | 3 | 1 | 4 | | 2011 | 4 | 0 | 4 | | 2012 | 2 | 0 | 2 | | 2013 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 0 | 1 | 1 | | 2018 | 2 | 1 | 3 |
To return to the timeline, click here.
Below are the most recent publications written about "Muscarinic Antagonists" by people in Profiles.
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Osinski BL, Kim A, Xiao W, Mehta NM, Kay LM. Pharmacological manipulation of the olfactory bulb modulates beta oscillations: testing model predictions. J Neurophysiol. 2018 09 01; 120(3):1090-1106.
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Krishnan JA, Au DH. Time to Converge FDA Decisions and Evidence Syntheses for Long-Acting Muscarinic Antagonists and SMART in Guidelines for the Treatment of Asthma. JAMA. 2018 04 10; 319(14):1441-1443.
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Kim Y, Bravo E, Thirnbeck CK, Smith-Mellecker LA, Kim SH, Gehlbach BK, Laux LC, Zhou X, Nordli DR, Richerson GB. Severe peri-ictal respiratory dysfunction is common in Dravet syndrome. J Clin Invest. 2018 03 01; 128(3):1141-1153.
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Wedzicha JA, Calverley PMA, Albert RK, Anzueto A, Criner GJ, Hurst JR, Miravitlles M, Papi A, Rabe KF, Rigau D, Sliwinski P, Tonia T, Vestbo J, Wilson KC, Krishnan JA. Prevention of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline. Eur Respir J. 2017 09; 50(3).
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Pediani JD, Ward RJ, Godin AG, Marsango S, Milligan G. Dynamic Regulation of Quaternary Organization of the M1 Muscarinic Receptor by Subtype-selective Antagonist Drugs. J Biol Chem. 2016 Jun 17; 291(25):13132-46.
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Liste MJ, Caltabiano G, Ward RJ, Alvarez-Curto E, Marsango S, Milligan G. The molecular basis of oligomeric organization of the human M3 muscarinic acetylcholine receptor. Mol Pharmacol. 2015 Jun; 87(6):936-53.
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Rinaldo L, Hansel C. Muscarinic acetylcholine receptor activation blocks long-term potentiation at cerebellar parallel fiber-Purkinje cell synapses via cannabinoid signaling. Proc Natl Acad Sci U S A. 2013 Jul 02; 110(27):11181-6.
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Jirschele K, Sand PK. Oxybutynin: past, present, and future. Int Urogynecol J. 2013 Apr; 24(4):595-604.
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Sand PK, Heesakkers J, Kraus SR, Carlsson M, Guan Z, Berriman S. Long-term safety, tolerability and efficacy of fesoterodine in subjects with overactive bladder symptoms stratified by age: pooled analysis of two open-label extension studies. Drugs Aging. 2012 Feb 01; 29(2):119-31.
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Dang MT, Yokoi F, Cheetham CC, Lu J, Vo V, Lovinger DM, Li Y. An anticholinergic reverses motor control and corticostriatal LTD deficits in Dyt1 ?GAG knock-in mice. Behav Brain Res. 2012 Jan 15; 226(2):465-72.
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