"Isocoumarins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds that differ from COUMARINS in having the positions of the ring and ketone oxygens reversed so the keto oxygen is at the 1-position of the molecule.
| Descriptor ID |
D049934
|
| MeSH Number(s) |
D03.383.663.283.446.598 D03.633.100.150.446.598
|
| Concept/Terms |
Isocoumarins- Isocoumarins
- 1H-2-Benzopyran-1-ones
- 1-Isochromen-1-ones
|
Below are MeSH descriptors whose meaning is more general than "Isocoumarins".
Below are MeSH descriptors whose meaning is more specific than "Isocoumarins".
This graph shows the total number of publications written about "Isocoumarins" by people in this website by year, and whether "Isocoumarins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
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Below are the most recent publications written about "Isocoumarins" by people in Profiles.
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Epitope-specific antibody-induced cleavage of angiotensin-converting enzyme from the cell surface. Biochem J. 2002 Mar 15; 362(Pt 3):585-95.
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The novel isocoumarin 2-(8-hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl) propionic acid (NM-3) induces lethality of human carcinoma cells by generation of reactive oxygen species. Mol Cancer Ther. 2001 Nov; 1(1):43-8.
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NM-3, an isocoumarin, increases the antitumor effects of radiotherapy without toxicity. Cancer Res. 2000 Dec 15; 60(24):6958-63.
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Granzyme B independently of perforin mediates noncytolytic intracellular inactivation of vesicular stomatitis virus. Cell Immunol. 1997 Aug 25; 180(1):1-9.
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Human granzyme B is essential for DNA fragmentation of susceptible target cells. Eur J Immunol. 1994 Sep; 24(9):2073-80.