Cyclin-Dependent Kinase 6
"Cyclin-Dependent Kinase 6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cyclin-dependent kinase 6 associates with CYCLIN D and phosphorylates RETINOBLASTOMA PROTEIN during G1 PHASE of the CELL CYCLE. It helps regulate the transition to S PHASE and its kinase activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P18.
| Descriptor ID |
D051361
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.646.500.937 D12.644.360.250.515 D12.776.167.200.515 D12.776.476.250.515
|
| Concept/Terms |
Cyclin-Dependent Kinase 6- Cyclin-Dependent Kinase 6
- Cyclin Dependent Kinase 6
- Cell Division Protein Kinase 6
- Cdk6 Protein Kinase
- Protein Kinase, Cdk6
- CDK6 Protein
- PLSTIRE Protein
|
Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinase 6".
Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinase 6".
This graph shows the total number of publications written about "Cyclin-Dependent Kinase 6" by people in this website by year, and whether "Cyclin-Dependent Kinase 6" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 2 | 2 |
| 2011 | 2 | 0 | 2 |
| 2012 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cyclin-Dependent Kinase 6" by people in Profiles.
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Serial circulating tumor DNA monitoring of CDK4/6 inhibitors response in metastatic breast cancer. Cancer Sci. 2022 May; 113(5):1808-1820.
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Transcriptional alterations in hereditary and sporadic nonfunctioning pancreatic neuroendocrine tumors according to genotype. Cancer. 2018 02 01; 124(3):636-647.
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Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia. Cancer Cell. 2012 Oct 16; 22(4):452-65.
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The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6. Cancer Prev Res (Phila). 2011 Dec; 4(12):2051-61.
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CDK6 kinase activity is required for thymocyte development. Blood. 2011 Jun 09; 117(23):6120-31.
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Interwoven roles of cyclin D3 and cdk4 recruited by ICP0 and ICP4 in the expression of herpes simplex virus genes. J Virol. 2010 Oct; 84(19):9709-17.
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Sansalvamide induces pancreatic cancer growth arrest through changes in the cell cycle. Anticancer Res. 2010 Jan; 30(1):73-8.
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A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis. Cancer Res. 2009 Feb 01; 69(3):810-8.
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Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators. Oncogene. 2006 May 25; 25(22):3123-38.
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A vitamin D3 analog induces a G1-phase arrest in CaCo-2 cells by inhibiting cdk2 and cdk6: roles of cyclin E, p21Waf1, and p27Kip1. Endocrinology. 2000 Nov; 141(11):3931-9.