"Alarmins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A structurally diverse group of endogenous molecules that are multifunctional, having physiological functions inside the cell, but when released from dying cells or from cells under stress or certain immune cells, they function to activate INNATE IMMUNITY. Uncontrolled and excessive release of alarmins may contribute to INFLAMMATION; CARCINOGENESIS, and NEOPLASM METASTASIS. Alarmins are also critical for heart and nerve tissue homeostasis.
- Damage-Associated Molecular Pattern Molecules
- Damage Associated Molecular Pattern Molecules
- Danger-Associated Molecular Pattern Molecules
- Danger Associated Molecular Pattern Molecules
- Alarmin Proteins
Below are MeSH descriptors whose meaning is more general than "Alarmins".
Below are MeSH descriptors whose meaning is more specific than "Alarmins".
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Below are the most recent publications written about "Alarmins" by people in Profiles.
Intracellular immune sensing promotes inflammation via gasdermin D-driven release of a lectin alarmin. Nat Immunol. 2021 02; 22(2):154-165.
Tissue alarmins and adaptive cytokine induce dynamic and distinct transcriptional responses in tissue-resident intraepithelial cytotoxic T lymphocytes. J Autoimmun. 2020 03; 108:102422.
Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses. Immunity. 2019 10 15; 51(4):709-723.e6.
Intracellular RNA Sensing in Mammalian Cells: Role in Stress Response and Cancer Therapies. Int Rev Cell Mol Biol. 2019; 344:31-89.
Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity. J Histochem Cytochem. 2018 04; 66(4):213-227.