SAM Domain and HD Domain-Containing Protein 1
"SAM Domain and HD Domain-Containing Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A host restriction triphosphorylhydrolase and dNTPase that contains an N-terminal STERILE ALPHA MOTIF and central, conserved ASPARTATE and HISTIDINE (HD) domain. It acts on single-stranded RNA, yielding deoxynucleosides and triphosphate, and functions in anti-viral defense through its dNTPase activity, reducing cellular dNTP levels below what is required for retroviral reverse transcription in DENDRITIC CELLS and MYELOID CELLS. It also has RIBONUCLEASE activity which blocks early replication of retroviruses such as HIV-1. Mutations in the SAMHD1 gene are associated with type 5 Aicardi-Goutieres syndrome (AGS5) and type 2 chilblain LUPUS (CHBL2).
| Descriptor ID |
D000076106
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| MeSH Number(s) |
D08.811.277.040.725 D08.811.277.352.700.843
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "SAM Domain and HD Domain-Containing Protein 1".
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Below are the most recent publications written about "SAM Domain and HD Domain-Containing Protein 1" by people in Profiles.
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Inhibition of CUL4A Neddylation causes a reversible block to SAMHD1-mediated restriction of HIV-1. J Virol. 2013 Nov; 87(21):11741-50.