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Christopher Lehmann

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Infectious Diseases
AddressChicago IL 60637
ORCID ORCID Icon0000-0002-1111-2169 Additional info
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    Collapse Overview 
    Collapse overview
    Shortly after the discovery of antibiotics in the early to mid 20th century, bacteria have developed resistance to them. Now, antibiotics that were once considered medical miracles have been relegated to obscurity by wide spread resistance. Even the most advanced broad spectrum antibiotics are failing because of resistance. Our current path of new drug discovery followed by development of resistant bacteria is resulting in ever increasing antibiotic resistance, meanwhile infections and deaths caused by drug resistant pathogens only rises.
    Before humans learned to use antibiotics, the healthy bacteria living with us (our microbiome) were in a constant state of competition and cooperation. In this state, healthy bacteria competed against harmful ones and prevented infection. When antibiotics are introduced, the healthy bacteria are killed, drug resistant harmful bacteria bloom, and they cause deadly infections.
    Guided by an ever growing understanding of the human microbiome, I am working to restore and defend the beneficial bacteria of the microbiome. This strategy will restore the microbiome back to health and add to the arsenal in our fight against antibiotic resistant infections.

    Collapse Biography 
    Collapse education and training
    University of Chicago, Chicago, IL06/2023Adult and Pediatric Infectious Disease Fellowship
    Indiana University, Indianapolis, IN2019Internal Medicine and Pediatrics Residency
    Indiana University, Indianapolis, INMD06/2015Medicine
    Colorado State University, Fort Collins, COBS05/2011Microbiology/Biochemistry
    Collapse awards and honors
    2014Alpha Omega Alpha
    2022Fellow, American Academy of Pediatrics

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lehmann CJ, Dylla NP, Odenwald M, Nayak R, Khalid M, Boissiere J, Cantoral J, Adler E, Stutz MR, Dela Cruz M, Moran A, Lin H, Ramaswamy R, Sundararajan A, Sidebottom AM, Little J, Pamer EG, Aronsohn A, Fung J, Baker TB, Kacha A. Fecal metabolite profiling identifies liver transplant recipients at risk for postoperative infection. Cell Host Microbe. 2024 Jan 10; 32(1):117-130.e4. PMID: 38103544.
      Citations: 1     Fields:    Translation:Humans
    2. Odenwald MA, Lin H, Lehmann C, Dylla NP, Cole CG, Mostad JD, Pappas TE, Ramaswamy R, Moran A, Hutchison AL, Stutz MR, Dela Cruz M, Adler E, Boissiere J, Khalid M, Cantoral J, Haro F, Oliveira RA, Waligurski E, Cotter TG, Light SH, Beavis KG, Sundararajan A, Sidebottom AM, Reddy KG, Paul S, Pillai A, Te HS, Rinella ME, Charlton MR, Pamer EG, Aronsohn AI. Bifidobacteria metabolize lactulose to optimize gut metabolites and prevent systemic infection in patients with liver disease. Nat Microbiol. 2023 Nov; 8(11):2033-2049. PMID: 37845315; PMCID: PMC11059310.
      Citations: 2     Fields:    Translation:HumansAnimals
    3. Stutz MR, Dylla NP, Pearson SD, Lecompte-Osorio P, Nayak R, Khalid M, Adler E, Boissiere J, Lin H, Leiter W, Little J, Rose A, Moran D, Mullowney MW, Wolfe KS, Lehmann C, Odenwald M, De La Cruz M, Giurcanu M, Pohlman AS, Hall JB, Chaubard JL, Sundararajan A, Sidebottom A, Kress JP, Pamer EG, Patel BK. Immunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure. Nat Commun. 2022 11 03; 13(1):6615. PMID: 36329015; PMCID: PMC9633022.
      Citations: 16     Fields:    Translation:HumansCells
    4. Zhang ZJ, Lehmann CJ, Cole CG, Pamer EG. Translating Microbiome Research From and To the Clinic. Annu Rev Microbiol. 2022 09 08; 76:435-460. PMID: 35655344.
      Citations: 8     Fields:    Translation:Humans
    5. Krasnow MR, Litt HK, Lehmann CJ, Lio J, Zhu M, Sherer R. Cancer, transplant, and immunocompromising conditions were not significantly associated with severe illness or death in hospitalized COVID-19 patients. J Clin Virol. 2021 07; 140:104850. PMID: 34022753; PMCID: PMC8106963.
      Citations: 3     Fields:    Translation:HumansCells
    6. Lehmann CJ, Pho MT, Pitrak D, Ridgway JP, Pettit NN. Community-acquired Coinfection in Coronavirus Disease 2019: A Retrospective Observational Experience. Clin Infect Dis. 2021 04 26; 72(8):1450-1452. PMID: 32604413; PMCID: PMC7337635.
      Citations: 34     Fields:    Translation:HumansCells
    7. Sundararajan M, Enane LA, Kidwell LA, Gentry R, Danao S, Bhumbra S, Lehmann C, Teachout M, Yeadon-Fagbohun J, Krombach P, Schroeder B, Martin H, Winkjer J, Waltz T, Strysko J, Cope JR. Notes from the Field: Cronobacter sakazakii Meningitis in a Full-Term Neonate Fed Exclusively with Breast Milk - Indiana, 2018. MMWR Morb Mortal Wkly Rep. 2018 Nov 09; 67(44):1248-1249. PMID: 30408018; PMCID: PMC6223960.
      Citations: 5     Fields:    Translation:HumansCellsPHPublic Health
    8. Lehmann CJ, Daftary AS, Machogu EM. Apical Lung Herniation Associated with Continuous Positive Airway Pressure in a 4-Year-Old Girl. J Clin Sleep Med. 2016 11 15; 12(11):1565-1566. PMID: 27397657; PMCID: PMC5078713.
      Citations: 2     Fields:    Translation:Humans
    9. Lecher SL, Hollis N, Lehmann C, Hoover KW, Jones A, Belcher L. Evaluation of the Impact of National HIV Testing Day - United States, 2011-2014. MMWR Morb Mortal Wkly Rep. 2016 Jun 24; 65(24):613-8. PMID: 27336946.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    10. Campbell CL, Lehmann CJ, Gill SS, Dunn WA, James AA, Foy BD. A role for endosomal proteins in alphavirus dissemination in mosquitoes. Insect Mol Biol. 2011 Aug; 20(4):429-36. PMID: 21496127; PMCID: PMC3138809.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
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