"Estrogen Receptor alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the ESTROGEN RECEPTORS that has marked affinity for ESTRADIOL. Its expression and function differs from, and in some ways opposes, ESTROGEN RECEPTOR BETA.
| Descriptor ID |
D047628
|
| MeSH Number(s) |
D12.776.826.750.350.174
|
| Concept/Terms |
Estrogen Receptor alpha- Estrogen Receptor alpha
- Estradiol Receptor alpha
- Receptor alpha, Estradiol
- alpha, Estradiol Receptor
- Receptor alpha, Estrogen
- ERalpha
- Estrogen Receptors alpha
|
Below are MeSH descriptors whose meaning is more general than "Estrogen Receptor alpha".
Below are MeSH descriptors whose meaning is more specific than "Estrogen Receptor alpha".
This graph shows the total number of publications written about "Estrogen Receptor alpha" by people in this website by year, and whether "Estrogen Receptor alpha" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 1 | 2 | 3 |
| 2004 | 1 | 2 | 3 |
| 2005 | 2 | 0 | 2 |
| 2006 | 2 | 0 | 2 |
| 2007 | 5 | 1 | 6 |
| 2008 | 4 | 1 | 5 |
| 2009 | 5 | 1 | 6 |
| 2010 | 1 | 1 | 2 |
| 2011 | 2 | 1 | 3 |
| 2012 | 3 | 3 | 6 |
| 2013 | 6 | 5 | 11 |
| 2014 | 6 | 0 | 6 |
| 2015 | 1 | 2 | 3 |
| 2016 | 5 | 0 | 5 |
| 2017 | 2 | 5 | 7 |
| 2018 | 4 | 3 | 7 |
| 2019 | 1 | 1 | 2 |
| 2020 | 4 | 0 | 4 |
| 2021 | 2 | 2 | 4 |
| 2022 | 1 | 1 | 2 |
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Below are the most recent publications written about "Estrogen Receptor alpha" by people in Profiles.
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Labeling of a mutant estrogen receptor with an Affimer in a breast cancer cell line. Biophys J. 2022 10 04; 121(19):3651-3662.
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Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells. Elife. 2022 05 16; 11.
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ESR1 hotspot mutations in endometrial stromal sarcoma with high-grade transformation and endocrine treatment. Mod Pathol. 2022 07; 35(7):972-978.
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Simvastatin modulates estrogen signaling in uterine leiomyoma via regulating receptor palmitoylation, trafficking and degradation. Pharmacol Res. 2021 10; 172:105856.
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A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice. Sci Transl Med. 2021 07 21; 13(603).
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Lasofoxifene as a potential treatment for therapy-resistant ER-positive metastatic breast cancer. Breast Cancer Res. 2021 05 12; 23(1):54.
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Hormonal modulation of ESR1 mutant metastasis. Oncogene. 2021 02; 40(5):997-1011.
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The Structure-Function Relationship of Angular Estrogens and Estrogen Receptor Alpha to Initiate Estrogen-Induced Apoptosis in Breast Cancer Cells. Mol Pharmacol. 2020 07; 98(1):24-37.
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The NF-?B Pathway Promotes Tamoxifen Tolerance and Disease Recurrence in Estrogen Receptor-Positive Breast Cancers. Mol Cancer Res. 2020 07; 18(7):1018-1027.
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Clinical significance of gene mutation in ctDNA analysis for hormone receptor-positive metastatic breast cancer. Breast Cancer Res Treat. 2020 Apr; 180(2):331-341.