Anthony Kossiakoff to Models, Molecular
This is a "connection" page, showing publications Anthony Kossiakoff has written about Models, Molecular.
Connection Strength
3.489
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Engineered synthetic antibodies as probes to quantify the energetic contributions of ligand binding to conformational changes in proteins. J Biol Chem. 2018 02 23; 293(8):2815-2828.
Score: 0.401
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Cryo-EM structures of Clostridium perfringens enterotoxin bound to its human receptor, claudin-4. Structure. 2024 11 07; 32(11):1936-1951.e5.
Score: 0.160
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Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins. Nat Commun. 2020 03 27; 11(1):1598.
Score: 0.117
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An engineered ultra-high affinity Fab-Protein G pair enables a modular antibody platform with multifunctional capability. Protein Sci. 2020 01; 29(1):141-156.
Score: 0.114
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Development of "Plug and Play" Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM. Structure. 2019 12 03; 27(12):1862-1874.e7.
Score: 0.114
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Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination. J Mol Biol. 2018 02 02; 430(3):337-347.
Score: 0.100
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A polar ring endows improved specificity to an antibody fragment. Protein Sci. 2016 07; 25(7):1290-8.
Score: 0.088
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Conformational Chaperones for Structural Studies of Membrane Proteins Using Antibody Phage Display with Nanodiscs. Structure. 2016 Feb 02; 24(2):300-9.
Score: 0.087
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Engineering Synthetic Antibody Inhibitors Specific for LD2 or LD4 Motifs of Paxillin. J Mol Biol. 2015 Jul 31; 427(15):2532-2547.
Score: 0.084
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Phage display selections for affinity reagents to membrane proteins in nanodiscs. Methods Enzymol. 2015; 557:219-45.
Score: 0.083
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Visualization of arrestin recruitment by a G-protein-coupled receptor. Nature. 2014 08 14; 512(7513):218-222.
Score: 0.078
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Mechanism of activation gating in the full-length KcsA K+ channel. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11896-9.
Score: 0.064
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Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins. Nat Struct Mol Biol. 2011 Apr; 18(4):437-42.
Score: 0.062
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Principal determinants leading to transition state formation of a protein-protein complex, orientation trumps side-chain interactions. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2559-64.
Score: 0.054
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Understanding mechanisms governing protein-protein interactions from synthetic binding interfaces. Curr Opin Struct Biol. 2008 Aug; 18(4):499-506.
Score: 0.052
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The 1.38 A crystal structure of DmsD protein from Salmonella typhimurium, a proofreading chaperone on the Tat pathway. Proteins. 2008 May 01; 71(2):525-33.
Score: 0.051
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Exploring and designing protein function with restricted diversity. Curr Opin Chem Biol. 2007 Jun; 11(3):347-54.
Score: 0.048
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Comprehensive and quantitative mapping of energy landscapes for protein-protein interactions by rapid combinatorial scanning. J Biol Chem. 2006 Aug 04; 281(31):22378-22385.
Score: 0.045
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Crystal structure and site 1 binding energetics of human placental lactogen. J Mol Biol. 2006 May 05; 358(3):773-84.
Score: 0.044
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Characterization of the OMP biogenesis machinery in Fusobacterium nucleatum. Structure. 2025 Nov 06; 33(11):1878-1892.e5.
Score: 0.043
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Effect of phosphorylation barcodes on arrestin binding to a chemokine receptor. Nature. 2025 Jul; 643(8070):280-287.
Score: 0.042
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Structural insights into terminal arabinosylation of mycobacterial cell wall arabinan. Nat Commun. 2025 Apr 29; 16(1):3973.
Score: 0.042
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Mechanistic studies of mycobacterial glycolipid biosynthesis by the mannosyltransferase PimE. Nat Commun. 2025 Apr 29; 16(1):3974.
Score: 0.042
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Structural basis for nucleolin recognition of MYC promoter G-quadruplex. Science. 2025 04 18; 388(6744):eadr1752.
Score: 0.042
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Structural basis of BAK sequestration by MCL-1 in apoptosis. Mol Cell. 2025 Apr 17; 85(8):1606-1623.e10.
Score: 0.041
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The crystal structure of a quercetin 2,3-dioxygenase from Bacillus subtilis suggests modulation of enzyme activity by a change in the metal ion at the active site(s). Biochemistry. 2005 Jan 11; 44(1):193-201.
Score: 0.041
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Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function. Nat Commun. 2024 12 04; 15(1):10545.
Score: 0.040
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Structural insights into translocation and tailored synthesis of hyaluronan. Nat Struct Mol Biol. 2025 Jan; 32(1):161-171.
Score: 0.040
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Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment. Commun Biol. 2024 06 17; 7(1):733.
Score: 0.039
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Structural and molecular basis of choline uptake into the brain by FLVCR2. Nature. 2024 May; 629(8012):704-709.
Score: 0.039
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The structural basis for biological signaling, regulation, and specificity in the growth hormone-prolactin system of hormones and receptors. Adv Protein Chem. 2004; 68:147-69.
Score: 0.038
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Site2 binding energetics of the regulatory step of growth hormone-induced receptor homodimerization. Protein Sci. 2003 Sep; 12(9):1960-70.
Score: 0.037
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Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):952-7.
Score: 0.036
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Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites. J Mol Biol. 2002 Feb 15; 316(2):277-89.
Score: 0.033
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Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins. Proc Natl Acad Sci U S A. 2021 11 23; 118(47).
Score: 0.033
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High affinity RNase S-peptide variants obtained by phage display have a novel "hot-spot" of binding energy. Biochemistry. 2001 Nov 13; 40(45):13491-500.
Score: 0.033
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Structures of ABCB4 provide insight into phosphatidylcholine translocation. Proc Natl Acad Sci U S A. 2021 08 17; 118(33).
Score: 0.032
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Structure of an AMPK complex in an inactive, ATP-bound state. Science. 2021 07 23; 373(6553):413-419.
Score: 0.032
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K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle. Nat Chem Biol. 2021 08; 17(8):896-905.
Score: 0.032
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Structural basis of omega-3 fatty acid transport across the blood-brain barrier. Nature. 2021 07; 595(7866):315-319.
Score: 0.032
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The structure and activity of a monomeric interferon-gamma:alpha-chain receptor signaling complex. Structure. 2001 Feb 07; 9(2):155-63.
Score: 0.031
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Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor. Nat Struct Biol. 2000 Sep; 7(9):808-15.
Score: 0.030
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Recognition of an a-helical hairpin in P22 large terminase by a synthetic antibody fragment. Acta Crystallogr D Struct Biol. 2020 Sep 01; 76(Pt 9):876-888.
Score: 0.030
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Biosynthetic phage display: a novel protein engineering tool combining chemical and genetic diversity. Chem Biol. 2000 Apr; 7(4):263-74.
Score: 0.029
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Structure and mechanism of the ER-based glucosyltransferase ALG6. Nature. 2020 03; 579(7799):443-447.
Score: 0.029
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The 2.0 A structure of bovine interferon-gamma; assessment of the structural differences between species. Acta Crystallogr D Biol Crystallogr. 2000 Jan; 56(Pt 1):14-24.
Score: 0.029
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Structure and drug resistance of the Plasmodium falciparum transporter PfCRT. Nature. 2019 12; 576(7786):315-320.
Score: 0.029
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Cryo-EM structure of human rhodopsin bound to an inhibitory G protein. Nature. 2018 06; 558(7711):553-558.
Score: 0.026
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Crystallization and preliminary X-ray analysis of a 1:1 complex between a designed monomeric interferon-gamma and its soluble receptor. Protein Sci. 1998 Apr; 7(4):1057-60.
Score: 0.025
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Structural basis for cytokine hormone-receptor recognition and receptor activation. Adv Protein Chem. 1998; 52:67-108.
Score: 0.025
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Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities. Protein Sci. 1997 Sep; 6(9):1806-24.
Score: 0.024
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The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical. Structure. 2016 11 01; 24(11):1936-1946.
Score: 0.023
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Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment. J Mol Biol. 2016 10 09; 428(20):4100-4114.
Score: 0.023
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Hydroxyl and water molecule orientations in trypsin: comparison to molecular dynamic structures. Basic Life Sci. 1996; 64:273-87.
Score: 0.022
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A YidC-like Protein in the Archaeal Plasma Membrane. Structure. 2015 Sep 01; 23(9):1715-1724.
Score: 0.021
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Structure of the growth hormone-receptor complex and mechanism of receptor signaling. J Nucl Med. 1995 Jun; 36(6 Suppl):14S-16S.
Score: 0.021
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The X-ray structure of a growth hormone-prolactin receptor complex. Nature. 1994 Dec 01; 372(6505):478-81.
Score: 0.020
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Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain. Nat Struct Mol Biol. 2014 Mar; 21(3):244-52.
Score: 0.019
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Molecular recognition in biological systems: from activation to inhibition. Biochem Soc Trans. 1993 Aug; 21 ( Pt 3)(3):614-8.
Score: 0.018
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Structure of active ß-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature. 2013 May 02; 497(7447):137-41.
Score: 0.018
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X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling. J Mol Biol. 1993 Feb 20; 229(4):969-95.
Score: 0.018
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Structural effects induced by mutagenesis affected by crystal packing factors: the structure of a 30-51 disulfide mutant of basic pancreatic trypsin inhibitor. Proteins. 1992 Sep; 14(1):75-87.
Score: 0.017
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Analysis of solvent structure in proteins using neutron D2O-H2O solvent maps: pattern of primary and secondary hydration of trypsin. Proteins. 1992 Mar; 12(3):223-36.
Score: 0.017
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Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science. 1992 Jan 17; 255(5042):306-12.
Score: 0.017
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Neutron structure of subtilisin BPN': effects of chemical environment on hydrogen-bonding geometries and the pattern of hydrogen-deuterium exchange in secondary structure elements. Biochemistry. 1991 Feb 05; 30(5):1211-21.
Score: 0.016
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A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination. Nat Struct Mol Biol. 2011 Jan; 18(1):100-6.
Score: 0.015
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X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor. Biochemistry. 1990 Oct 30; 29(43):10018-22.
Score: 0.015
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Structural effects induced by removal of a disulfide-bridge: the X-ray structure of the C30A/C51A mutant of basic pancreatic trypsin inhibitor at 1.6 A. Protein Eng. 1990 Jul; 3(7):591-8.
Score: 0.015
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Crystal structures of subtilisin BPN' variants containing disulfide bonds and cavities: concerted structural rearrangements induced by mutagenesis. Proteins. 1990; 7(4):343-57.
Score: 0.014
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Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods. Protein Sci. 2009 Jun; 18(6):1146-54.
Score: 0.014
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Role of a salt bridge in the model protein crambin explored by chemical protein synthesis: X-ray structure of a unique protein analogue, [V15A]crambin-alpha-carboxamide. Mol Biosyst. 2009 Jul; 5(7):750-6.
Score: 0.014
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Crystal structure of full-length KcsA in its closed conformation. Proc Natl Acad Sci U S A. 2009 Apr 21; 106(16):6644-9.
Score: 0.014
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X-ray structure of native scorpion toxin BmBKTx1 by racemic protein crystallography using direct methods. J Am Chem Soc. 2009 Feb 04; 131(4):1362-3.
Score: 0.014
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Tertiary structure is a principal determinant to protein deamidation. Science. 1988 Apr 08; 240(4849):191-4.
Score: 0.013
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Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope. J Mol Biol. 2007 Nov 02; 373(4):941-53.
Score: 0.012
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Time-controlled microfluidic seeding in nL-volume droplets to separate nucleation and growth stages of protein crystallization. Angew Chem Int Ed Engl. 2006 Dec 11; 45(48):8156-60.
Score: 0.012
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Structure of bistramide A-actin complex at a 1.35 angstroms resolution. J Am Chem Soc. 2006 Mar 29; 128(12):3882-3.
Score: 0.011
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Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis. Nat Chem Biol. 2006 Mar; 2(3):139-43.
Score: 0.011
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The crystal structure of Aq_328 from the hyperthermophilic bacteria Aquifex aeolicus shows an ancestral histone fold. Proteins. 2006 Jan 01; 62(1):8-16.
Score: 0.011
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Protein dynamics investigated by neutron diffraction. Methods Enzymol. 1986; 131:433-47.
Score: 0.011
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Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis. J Mol Biol. 2005 Apr 01; 347(3):489-94.
Score: 0.010
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The application of neutron crystallography to the study of dynamic and and hydration properties of proteins. Annu Rev Biochem. 1985; 54:1195-227.
Score: 0.010
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Use of the neutron diffraction--H/D exchange technique to determine the conformational dynamics of trypsin. Basic Life Sci. 1984; 27:281-304.
Score: 0.009
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The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity. J Mol Biol. 2003 Sep 05; 332(1):195-204.
Score: 0.009
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Protein dynamics investigated by the neutron diffraction-hydrogen exchange technique. Nature. 1982 Apr 22; 296(5859):713-21.
Score: 0.008
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Direct determination of the protonation states of aspartic acid-102 and histidine-57 in the tetrahedral intermediate of the serine proteases: neutron structure of trypsin. Biochemistry. 1981 Oct 27; 20(22):6462-74.
Score: 0.008
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Probing intermolecular backbone H-bonding in serine proteinase-protein inhibitor complexes. Chem Biol. 1999 Jul; 6(7):419-27.
Score: 0.007
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Structure of bovine trypsinogen at 1.9 A resolution. Biochemistry. 1977 Feb 22; 16(4):654-64.
Score: 0.006
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The crystal structure of affinity-matured human growth hormone at 2 A resolution. J Mol Biol. 1994 Feb 11; 236(1):286-99.
Score: 0.005
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Solvent structure in crystals of trypsin determined by X-ray and neutron diffraction. Proteins. 1992 Mar; 12(3):203-22.
Score: 0.004
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The three-dimensional structure of Bacillus amyloliquefaciens subtilisin at 1.8 A and an analysis of the structural consequences of peroxide inactivation. J Biol Chem. 1988 Jun 05; 263(16):7895-906.
Score: 0.003
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Mechanisms of zymogen activation. Annu Rev Biophys Bioeng. 1977; 6:177-93.
Score: 0.001