Christopher Froelich to Humans
This is a "connection" page, showing publications Christopher Froelich has written about Humans.
Connection Strength
0.285
-
Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes. Cell Death Differ. 2015 Jan; 22(1):74-85.
Score: 0.016
-
Perforin rapidly induces plasma membrane phospholipid flip-flop. PLoS One. 2011; 6(9):e24286.
Score: 0.013
-
Granule-associated serine proteases: granzymes might not just be killer proteases. Trends Immunol. 2009 Mar; 30(3):117-23.
Score: 0.011
-
Human and mouse granzyme A induce a proinflammatory cytokine response. Immunity. 2008 Nov 14; 29(5):720-33.
Score: 0.011
-
Detection of functional cell surface perforin by flow cytometry. J Immunol Methods. 2005 Apr; 299(1-2):117-27.
Score: 0.008
-
Human neutrophils lack granzyme A, granzyme B, and perforin. Blood. 2004 Aug 01; 104(3):905-6; author reply 907-8.
Score: 0.008
-
Right place, right time. Nat Immunol. 2004 Feb; 5(2):124-5.
Score: 0.008
-
Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism. Curr Opin Immunol. 2003 Oct; 15(5):528-32.
Score: 0.007
-
Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis. J Cell Biol. 2003 Mar 17; 160(6):875-85.
Score: 0.007
-
Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin. J Biol Chem. 2002 Dec 20; 277(51):49523-30.
Score: 0.007
-
Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation. Immunity. 2002 Mar; 16(3):417-28.
Score: 0.007
-
Flow cytometry cannot assess surface binding of perforin to target cells. Blood. 2001 Apr 01; 97(7):2181-3.
Score: 0.006
-
Apoptosis induced by granzyme B-glycosaminoglycan complexes: implications for granule-mediated apoptosis in vivo. J Immunol. 1999 May 01; 162(9):5345-50.
Score: 0.005
-
Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases. Immunol Today. 1998 Jan; 19(1):30-6.
Score: 0.005
-
Granule-mediated killing: pathways for granzyme B-initiated apoptosis. J Exp Med. 1997 Oct 20; 186(8):1323-31.
Score: 0.005
-
Human perforin: rapid enrichment by immobilized metal affinity chromatography (IMAC) for whole cell cytotoxicity assays. Biochem Biophys Res Commun. 1996 Dec 04; 229(1):44-9.
Score: 0.005
-
New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis. J Biol Chem. 1996 Nov 15; 271(46):29073-9.
Score: 0.005
-
Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment. Biochem Biophys Res Commun. 1996 Oct 23; 227(3):658-65.
Score: 0.005
-
Extracellular activities of human granzymes. I. Granzyme A induces IL6 and IL8 production in fibroblast and epithelial cell lines. Cell Immunol. 1996 Jul 10; 171(1):159-63.
Score: 0.004
-
Dominant chymotrypsin-like esterase activity in human lymphocyte granules is mediated by the serine carboxypeptidase called cathepsin A-like protective protein. J Immunol. 1994 Nov 15; 153(10):4663-72.
Score: 0.004
-
Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes. J Immunol. 1993 Dec 15; 151(12):7161-71.
Score: 0.004
-
Rapid purification of cationic granule proteases: application to human granzymes. Protein Expr Purif. 1993 Oct; 4(5):398-404.
Score: 0.004
-
Granzyme A produced by ?(9)d(2) T cells induces human macrophages to inhibit growth of an intracellular pathogen. PLoS Pathog. 2013 Jan; 9(1):e1003119.
Score: 0.004
-
Sustained delivery of interleukin-2 from a poloxamer 407 gel matrix following intraperitoneal injection in mice. Pharm Res. 1992 Mar; 9(3):425-34.
Score: 0.003
-
Perforin activity at membranes leads to invaginations and vesicle formation. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21016-21.
Score: 0.003
-
Human perforin employs different avenues to damage membranes. J Biol Chem. 2011 Jan 28; 286(4):2946-55.
Score: 0.003
-
Human perforin permeabilizing activity, but not binding to lipid membranes, is affected by pH. Mol Immunol. 2010 Sep; 47(15):2492-504.
Score: 0.003
-
Deregulation of mitochondrial membrane potential by mitochondrial insertion of granzyme B and direct Hax-1 cleavage. J Biol Chem. 2010 Jul 16; 285(29):22461-72.
Score: 0.003
-
Clinical value of an integrated ELISA system for the detection of 6 autoantibodies (ssDNA, dsDNA, Sm, RNP/Sm, SSA, and SSB). J Rheumatol. 1990 Feb; 17(2):192-200.
Score: 0.003
-
Granzyme A is a proinflammatory protease. Blood. 2009 Oct 29; 114(18):3968; author reply 3969-70.
Score: 0.003
-
Deficient interleukin-2-activated killer cell cytotoxicity in patients with systemic lupus erythematosus. Clin Immunol Immunopathol. 1989 Jan; 50(1 Pt 1):132-45.
Score: 0.003
-
Mcl-1 is a key regulator of apoptosis resistance in Chlamydia trachomatis-infected cells. PLoS One. 2008 Sep 01; 3(9):e3102.
Score: 0.003
-
NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network. J Immunol. 2008 Jun 15; 180(12):8184-91.
Score: 0.003
-
Modulation of the tumor cell phenotype by IFN-gamma results in resistance of uveal melanoma cells to granule-mediated lysis by cytotoxic lymphocytes. J Immunol. 2008 Mar 15; 180(6):3766-74.
Score: 0.003
-
Phytohemagglutinin induced proliferation by aged lymphocytes: reduced expression of high affinity interleukin-2 receptors and interleukin-2 secretion. Life Sci. 1988; 43(20):1583-90.
Score: 0.002
-
Modulation of the autologous mixed lymphocyte reaction by beta-endorphin. J Neuroimmunol. 1987 Dec; 17(1):1-10.
Score: 0.002
-
Lysis of human T cell leukemia virus infected T and B lymphoid cells by interleukin 2-activated killer cells. J Immunol. 1987 Dec 01; 139(11):3637-43.
Score: 0.002
-
Natural killer cells do not lyse resting or mitogen-stimulated B cells. Nat Immun Cell Growth Regul. 1987; 6(1):12-8.
Score: 0.002
-
Serine and cysteine proteases are translocated to similar extents upon formation of covalent complexes with serpins. Fluorescence perturbation and fluorescence resonance energy transfer mapping of the protease binding site in CrmA complexes with granzyme B and caspase-1. J Biol Chem. 2007 Jan 26; 282(4):2305-13.
Score: 0.002
-
Induction of lymphokine activated killer cells in serum-free medium. J Immunol Methods. 1986 Feb 12; 86(2):205-11.
Score: 0.002
-
Detection of human perforin by ELISpot and ELISA: ex vivo identification of virus-specific cells. J Immunol Methods. 2005 Jul; 302(1-2):13-25.
Score: 0.002
-
Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin. J Biol Chem. 2005 Jun 24; 280(25):23549-58.
Score: 0.002
-
A novel mechanism for protein delivery: granzyme B undergoes electrostatic exchange from serglycin to target cells. J Biol Chem. 2005 May 27; 280(21):20752-61.
Score: 0.002
-
Myeloma cells are highly sensitive to the granule exocytosis pathway mediated by WT1-specific cytotoxic T lymphocytes. Clin Cancer Res. 2004 Nov 01; 10(21):7402-12.
Score: 0.002
-
A role for the granzyme B inhibitor serine protease inhibitor 6 in CD8+ memory cell homeostasis. J Immunol. 2004 Sep 15; 173(6):3801-9.
Score: 0.002
-
The effect of beta-endorphin on natural cytotoxicity and antibody dependent cellular cytotoxicity. Life Sci. 1984 Jul 16; 35(3):261-5.
Score: 0.002
-
Reconstitution of caspase-3 confers low glucose-enhanced tumor necrosis factor-related apoptosis-inducing ligand cytotoxicity and Akt cleavage. Clin Cancer Res. 2004 Mar 15; 10(6):1894-900.
Score: 0.002
-
Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events. J Biol Chem. 2004 May 21; 279(21):22020-9.
Score: 0.002
-
Separation of natural and antibody-dependent cytotoxicity by differential reactivity of human mononuclear cell Fc receptors with IgG. Clin Exp Immunol. 1984 Mar; 55(3):664-70.
Score: 0.002
-
Enrichment of natural killer cells by negative selection: comparison to Percoll gradient separation method. J Immunol Methods. 1983 Nov 25; 64(3):327-33.
Score: 0.002
-
NF-kappaB protects from the lysosomal pathway of cell death. EMBO J. 2003 Oct 01; 22(19):5313-22.
Score: 0.002
-
Natural killing and antibody-dependent cellular cytotoxicity: characterization of effector cells by E-rosetting and monoclonal antibodies. Cell Immunol. 1983 May; 78(1):33-42.
Score: 0.002
-
The human cytomegalovirus protein UL16 mediates increased resistance to natural killer cell cytotoxicity through resistance to cytolytic proteins. J Virol. 2003 Apr; 77(8):4539-45.
Score: 0.002
-
Lack of the CD8+ cell anti-HIV factor in CD8+ cell granules. Blood. 2003 Jul 01; 102(1):180-3.
Score: 0.002
-
A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death. J Cell Biol. 2003 Jan 20; 160(2):223-33.
Score: 0.002
-
Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway. J Leukoc Biol. 2002 Oct; 72(4):668-76.
Score: 0.002
-
Characterization of E-rosette-positive Fc-receptor-bearing cells by flow cytometry. Clin Immunol Immunopathol. 1982 Jan; 22(1):105-17.
Score: 0.002
-
Human E-rosette-positive cells which bind monomeric IgG mediate natural cytotoxicity. Cell Immunol. 1982 Jan 01; 66(1):190-4.
Score: 0.002
-
HSV and glycoprotein J inhibit caspase activation and apoptosis induced by granzyme B or Fas. J Immunol. 2001 Oct 01; 167(7):3928-35.
Score: 0.002
-
The T cell death knell: immune-mediated tumor death in renal cell carcinoma. Clin Cancer Res. 2001 Oct; 7(10):3276-81.
Score: 0.002
-
A distinct pathway of cell-mediated apoptosis initiated by granulysin. J Immunol. 2001 Jul 01; 167(1):350-6.
Score: 0.002
-
Perforin and granzyme B induce apoptosis in FasL-resistant colon carcinoma cells. Cancer Immunol Immunother. 2001 Jun; 50(4):212-7.
Score: 0.002
-
Flow cytometry and cytoadherence studies of sera from children with juvenile rheumatoid arthritis and normal controls. Arthritis Rheum. 1981 Mar; 24(3):457-63.
Score: 0.002
-
P-glycoprotein does not protect cells against cytolysis induced by pore-forming proteins. J Biol Chem. 2001 May 18; 276(20):16667-73.
Score: 0.002
-
Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis. Rheumatology (Oxford). 2001 Jan; 40(1):55-61.
Score: 0.002
-
Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin- and etoposide-induced apoptosis. Cancer Res. 2001 Jan 01; 61(1):348-54.
Score: 0.002
-
A case of Guillain-Barré syndrome with immunologic abnormalities. Ann Intern Med. 1980 Oct; 93(4):563-5.
Score: 0.002
-
Pregnancy, a temporary fetal graft of suppressor cells in autoimmune disease? Am J Med. 1980 Sep; 69(3):329-31.
Score: 0.001
-
Activation of a cysteine protease in MCF-7 and T47D breast cancer cells during beta-lapachone-mediated apoptosis. Exp Cell Res. 2000 Mar 15; 255(2):144-55.
Score: 0.001
-
HIV virions and HIV infection in vitro are unaffected by human granzymes A and B. AIDS Res Hum Retroviruses. 2000 Mar 01; 16(4):367-72.
Score: 0.001
-
Extracellular granzyme A, complexed to proteoglycans, is protected against inactivation by protease inhibitors. Blood. 2000 Feb 15; 95(4):1465-72.
Score: 0.001
-
Purification and use of granzyme B. Methods Enzymol. 2000; 322:125-43.
Score: 0.001
-
Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin. Mol Cell Biol. 1999 Dec; 19(12):8604-15.
Score: 0.001
-
The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA). Clin Exp Immunol. 1999 May; 116(2):366-70.
Score: 0.001
-
D-penicillamine-induced myasthenia gravis in rheumatoid arthritis. J Rheumatol. 1979 Mar-Apr; 6(2):237-9.
Score: 0.001
-
Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7. J Biol Chem. 1998 Dec 18; 273(51):34278-83.
Score: 0.001
-
FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation. J Immunol. 1998 Oct 15; 161(8):3936-42.
Score: 0.001
-
An antimicrobial activity of cytolytic T cells mediated by granulysin. Science. 1998 Oct 02; 282(5386):121-5.
Score: 0.001
-
Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis. Blood. 1998 Aug 01; 92(3):1044-54.
Score: 0.001
-
Synthesis and evaluation of diphenyl phosphonate esters as inhibitors of the trypsin-like granzymes A and K and mast cell tryptase. J Med Chem. 1998 Jun 18; 41(13):2289-301.
Score: 0.001
-
Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo. J Immunol. 1998 Apr 01; 160(7):3610-6.
Score: 0.001
-
The CD8+ granzyme B+ T-cell subset in peripheral blood from healthy individuals contains activated and apoptosis-prone cells. Immunology. 1998 Mar; 93(3):383-9.
Score: 0.001
-
Granzyme B independently of perforin mediates noncytolytic intracellular inactivation of vesicular stomatitis virus. Cell Immunol. 1997 Aug 25; 180(1):1-9.
Score: 0.001
-
Routine measurement of IgM, IgG, and IgA rheumatoid factors: high sensitivity, specificity, and predictive value for rheumatoid arthritis. J Rheumatol. 1997 Jun; 24(6):1037-44.
Score: 0.001
-
ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J Biol Chem. 1996 Jul 12; 271(28):16720-4.
Score: 0.001
-
The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A. J Biol Chem. 1996 Jul 12; 271(28):16443-6.
Score: 0.001
-
Extracellular activities of human granzyme A. Monocyte activation by granzyme A versus alpha-thrombin. J Immunol. 1996 Apr 01; 156(7):2585-90.
Score: 0.001
-
Thrombin induces IL-6 production in fibroblasts and epithelial cells. Evidence for the involvement of the seven-transmembrane domain (STD) receptor for alpha-thrombin. J Immunol. 1995 Jul 15; 155(2):895-901.
Score: 0.001
-
Human granzyme B is essential for DNA fragmentation of susceptible target cells. Eur J Immunol. 1994 Sep; 24(9):2073-80.
Score: 0.001
-
Detection of anticardiolipin antibody in patients with cocaine abuse. J Emerg Med. 1991; 9 Suppl 1:37-43.
Score: 0.001
-
Glomerulosclerosis in the sudden infant death syndrome. Pediatr Pathol. 1990; 10(1-2):273-9.
Score: 0.001
-
Retinal vein thrombosis in a patient with pernicious anemia and anticardiolipin antibodies. J Rheumatol. 1989 Aug; 16(8):1144-6.
Score: 0.001
-
Antiphospholipid antibodies associated with retinal vascular disease. Retina. 1987; 7(4):215-8.
Score: 0.001
-
Salmonella typhimurium mitogen induces proliferation of human B lymphocytes. Cell Immunol. 1985 Jun; 93(1):83-90.
Score: 0.001
-
Interferon-alpha regulation of lymphocyte function in systemic lupus erythematosus. Clin Immunol Immunopathol. 1984 Jul; 32(1):70-80.
Score: 0.000
-
High anion gap acidosis during intravenous infusion of protein hydrolysate. South Med J. 1984 May; 77(5):661-3.
Score: 0.000
-
Abnormal interferon modulation of natural cytotoxicity in systemic lupus erythematosus. Relation to suppressive serum factors. Arthritis Rheum. 1983 Dec; 26(12):1452-9.
Score: 0.000
-
Natural cytotoxicity in systemic lupus erythematosus: mechanisms of suppression by inhibitory serum factors. Clin Exp Immunol. 1983 Aug; 53(2):363-70.
Score: 0.000
-
Enhancement of natural cytotoxicity by beta-endorphin. J Immunol. 1983 Apr; 130(4):1658-62.
Score: 0.000
-
T gamma subset specificity of lymphocyte reactive factors in juvenile rheumatoid arthritis and systemic lupus erythematosus sera. Arthritis Rheum. 1981 Apr; 24(4):585-91.
Score: 0.000
-
Telltale mouth flora: a clue to the diagnosis of factitious recurrent thigh abscesses. South Med J. 1979 Feb; 72(2):225-6.
Score: 0.000