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Alain J. Labro

InstitutionUniversity of Chicago
AddressChicago IL 60637
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gubic Š, Montalbano A, Sala C, Becchetti A, Hendrickx LA, Van Theemsche KM, Pinheiro-Junior EL, Altadonna GC, Peigneur S, Ilaš J, Labro AJ, Pardo LA, Tytgat J, Tomašic T, Arcangeli A, Peterlin Mašic L. Immunosuppressive effects of new thiophene-based KV1.3 inhibitors. Eur J Med Chem. 2023 Nov 05; 259:115561. PMID: 37454520.
      Citations: 1     Fields:    Translation:AnimalsCells
    2. Gubic Š, Hendrickx LA, Shi X, Toplak Ž, Možina Š, Theemsche KMV, Pinheiro-Junior EL, Peigneur S, Labro AJ, Pardo LA, Tytgat J, Tomašic T, Peterlin Mašic L. Correction: Gubic et al. Design of New Potent and Selective Thiophene-Based KV1.3 Inhibitors and Their Potential for Anticancer Activity. Cancers 2022, 14, 2595. Cancers (Basel). 2023 May 26; 15(11). PMID: 37297027; PMCID: PMC10252048.
    3. Sieliwonczyk E, Alaerts M, Simons E, Snyders D, Nijak A, Vandendriessche B, Schepers D, Akdeniz D, Van Craenenbroeck E, Knaepen K, Rabaut L, Heidbuchel H, Van Laer L, Saenen J, Labro AJ, Loeys B. Clinical and functional characterisation of a recurrent KCNQ1 variant in the Belgian population. Orphanet J Rare Dis. 2023 01 31; 18(1):23. PMID: 36721196; PMCID: PMC9887867.
      Citations: 2     Fields:    Translation:HumansAnimals
    4. Jost N, Labro AJ, Déri S, Hartai T, Virág L, Varró A, Baczkó I, Nattel S, Ördög B. A Possible Explanation for the Low Penetrance of Pathogenic KCNE1 Variants in Long QT Syndrome Type 5. Pharmaceuticals (Basel). 2022 Dec 13; 15(12). PMID: 36559002; PMCID: PMC9782992.
    5. Coonen L, Martinez-Morales E, Van De Sande DV, Snyders DJ, Cortes DM, Cuello LG, Labro AJ. The nonconducting W434F mutant adopts upon membrane depolarization an inactivated-like state that differs from wild-type Shaker-IR potassium channels. Sci Adv. 2022 Sep 16; 8(37):eabn1731. PMID: 36112676; PMCID: PMC9481120.
      Citations: 2     Fields:    
    6. Hendrickx LA, Theemsche KMV, Pinheiro-Junior EL, Peigneur S, Labro AJ, Tytgat J, Gubic Š, Shi X, Toplak Ž, Možina Š, Pardo LA, Tomašic T, Mašic LP. Design of New Potent and Selective Thiophene-Based KV1.3 Inhibitors and Their Potential for Anticancer Activity. Cancers (Basel). 2022 May 24; 14(11). PMID: 35681571; PMCID: PMC9179341.
      Citations: 3     
    7. Nijak A, Simons E, Vandendriessche B, Van de Sande D, Fransen E, Sieliwonczyk E, Van Gucht I, Van Craenenbroeck E, Saenen J, Heidbuchel H, Ponsaerts P, Labro AJ, Snyders D, De Vos W, Schepers D, Alaerts M, Loeys BL. Morpho-functional comparison of differentiation protocols to create iPSC-derived cardiomyocytes. Biol Open. 2022 02 15; 11(2). PMID: 35195246; PMCID: PMC8890088.
      Citations: 2     Fields:    Translation:HumansCells
    8. Arora R, Van Theemsche KM, Van Remoortel S, Snyders DJ, Labro AJ, Timmermans JP. Constitutive, Basal, and ß-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled Receptor D Induces Release of the Inflammatory Cytokine IL-6 and Is Dependent on NF-?B Signaling. Int J Mol Sci. 2021 Dec 09; 22(24). PMID: 34948051; PMCID: PMC8703779.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    9. Van de Sande DV, Kopljar I, Maaike A, Teisman A, Gallacher DJ, Bart L, Snyders DJ, Leybaert L, Lu HR, Labro AJ. The resting membrane potential of hSC-CM in a syncytium is more hyperpolarised than that of isolated cells. Channels (Austin). 2021 12; 15(1):239-252. PMID: 33465001; PMCID: PMC7817136.
      Citations: 8     Fields:    Translation:Cells
    10. Hoyberghs J, Valenzuela A, Buyssens L, Ayuso M, Van Ginneken C, Labro AJ, Foubert K, Van Cruchten SJ, Bars C. Developmental Toxicity and Biotransformation of Two Anti-Epileptics in Zebrafish Embryos and Early Larvae. Int J Mol Sci. 2021 Nov 24; 22(23). PMID: 34884510; PMCID: PMC8657848.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    11. Simons E, Labro A, Saenen J, Nijak A, Sieliwonczyk E, Vandendriessche B, Dabrowska M, Van Craenenbroeck EM, Schepers D, Van Laer L, Loeys BL, Alaerts M. Molecular autopsy and subsequent functional analysis reveal de novo DSG2 mutation as cause of sudden death. Eur J Med Genet. 2021 Nov; 64(11):104322. PMID: 34438094.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    12. Hategan L, Arora R, Labro AJ, Déri S, Borbás J, Hartai T, Csányi B, Visnyovszki Á, Madácsy T, Maléth J, Hegedus Z, Nagy I, Környei L, Varró A, Sepp R, Ördög B. Impaired cytoplasmic domain interactions cause co-assembly defect and loss of function in the p.Glu293Lys KNCJ2 variant isolated from an Andersen-Tawil syndrome patient. Cardiovasc Res. 2021 07 07; 117(8):1923-1934. PMID: 32810216.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    13. Nijak A, Saenen J, Labro AJ, Schepers D, Loeys BL, Alaerts M. iPSC-Cardiomyocyte Models of Brugada Syndrome-Achievements, Challenges and Future Perspectives. Int J Mol Sci. 2021 Mar 10; 22(6). PMID: 33802229; PMCID: PMC8001521.
      Citations: 9     Fields:    Translation:HumansCells
    14. Regnier G, Labro AJ, Snyders DJ, Möller L, Blunck R. Reply to Pisupati et al.: Evaluating single subunit counting data to find the correct stoichiometry. Proc Natl Acad Sci U S A. 2020 11 24; 117(47):29290-29291. PMID: 33082223; PMCID: PMC7703587.
      Citations:    Fields:    Translation:Animals
    15. Nijak A, Labro AJ, De Wilde H, Dewals W, Peigneur S, Tytgat J, Snyders D, Sieliwonczyk E, Simons E, Van Craenenbroeck E, Schepers D, Van Laer L, Saenen J, Loeys B, Alaerts M. Compound Heterozygous SCN5A Mutations in Severe Sodium Channelopathy With Brugada Syndrome: A Case Report. Front Cardiovasc Med. 2020; 7:117. PMID: 32850980; PMCID: PMC7396896.
      Citations: 2     
    16. Van Theemsche KM, Van de Sande DV, Snyders DJ, Labro AJ. Hydrophobic Drug/Toxin Binding Sites in Voltage-Dependent K+ and Na+ Channels. Front Pharmacol. 2020; 11:735. PMID: 32499709; PMCID: PMC7243439.
      Citations: 8     
    17. Coonen L, Mayeur E, De Neuter N, Snyders DJ, Cuello LG, Labro AJ. The Selectivity Filter Is Involved in the U-Type Inactivation Process of Kv2.1 and Kv3.1 Channels. Biophys J. 2020 05 19; 118(10):2612-2620. PMID: 32365329; PMCID: PMC7231921.
      Citations: 6     Fields:    Translation:Cells
    18. Regnier G, Labro AJ, Snyders DJ, Möller L, Blunck R. Determining the correct stoichiometry of Kv2.1/Kv6.4 heterotetramers, functional in multiple stoichiometrical configurations. Proc Natl Acad Sci U S A. 2020 04 28; 117(17):9365-9376. PMID: 32284408; PMCID: PMC7196910.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    19. Van de Sande DV, Kopljar I, Teisman A, Gallacher DJ, Snyders DJ, Lu HR, Labro AJ. Pharmacological Profile of the Sodium Current in Human Stem Cell-Derived Cardiomyocytes Compares to Heterologous Nav1.5+ß1 Model. Front Pharmacol. 2019; 10:1374. PMID: 31920633; PMCID: PMC6917651.
      Citations: 4     
    20. Labro AJ, Cortes DM, Tilegenova C, Cuello LG. Inverted allosteric coupling between activation and inactivation gates in K+ channels. Proc Natl Acad Sci U S A. 2018 05 22; 115(21):5426-5431. PMID: 29735651; PMCID: PMC6003467.
      Citations: 29     Fields:    Translation:HumansCells
    21. Kopljar I, Rainier JD, Tytgat J, Snyders DJ, Labro AJ, Martínez-Morales E. Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K(+) pore. Toxicon. 2016 Sep 15; 120:57-60. PMID: 27475861; PMCID: PMC7008702.
      Citations: 1     Fields:    Translation:Cells
    22. Labro AJ, Muyldermans S, Snyders DJ, Hassiki R, Benlasfar Z, Vincke C, Somia M, El Ayeb M, Bouhaouala-Zahar B. Dromedary immune response and specific Kv2.1 antibody generation using a specific immunization approach. Int J Biol Macromol. 2016 Dec; 93(Pt A):167-171. PMID: 27320844.
      Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    23. Kopljar I, Grottesi A, de Block T, Rainier JD, Tytgat J, Labro AJ, Snyders DJ. Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels. Neuropharmacology. 2016 08; 107:160-167. PMID: 26956727; PMCID: PMC7134334.
      Citations: 3     Fields:    Translation:AnimalsCells
    24. Labro AJ, Priest MF, Snyders DJ, Bezanilla F, Lacroix JJ. Kv3.1 uses a timely resurgent K(+) current to secure action potential repolarization. Nat Commun. 2015 Dec 17; 6:10173. PMID: 26673941; PMCID: PMC4703866.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    25. Kopljar I, Snyders DJ, Labro AJ, Martínez-Morales E. Alkanols inhibit voltage-gated K(+) channels via a distinct gating modifying mechanism that prevents gate opening. Sci Rep. 2015 Nov 30; 5:17402. PMID: 26616025; PMCID: PMC4663795.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    26. Stas JI, Bocksteins E, Labro AJ, Snyders DJ. Modulation of Closed-State Inactivation in Kv2.1/Kv6.4 Heterotetramers as Mechanism for 4-AP Induced Potentiation. PLoS One. 2015; 10(10):e0141349. PMID: 26505474; PMCID: PMC4623978.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    27. Martinez-Morales E, Snyders DJ, Labro AJ. Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel. Biophys J. 2014 Jan 07; 106(1):134-44. PMID: 24411245; PMCID: PMC3907211.
      Citations: 6     Fields:    Translation:HumansCells
    28. Kopljar I, Labro AJ, de Block T, Rainier JD, Tytgat J, Snyders DJ. The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state. J Gen Physiol. 2013 Mar; 141(3):359-69. PMID: 23401573; PMCID: PMC3581691.
      Citations: 14     Fields:    Translation:AnimalsCells
    29. Labro AJ, Lacroix JJ, Villalba-Galea CA, Snyders DJ, Bezanilla F. Molecular mechanism for depolarization-induced modulation of Kv channel closure. J Gen Physiol. 2012 Nov; 140(5):481-93. PMID: 23071266; PMCID: PMC3483114.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    30. Labro AJ, Snyders DJ. Being flexible: the voltage-controllable activation gate of kv channels. Front Pharmacol. 2012; 3:168. PMID: 22993508; PMCID: PMC3440756.
      Citations: 35     
    31. Abderemane-Ali F, Es-Salah-Lamoureux Z, Delemotte L, Kasimova MA, Labro AJ, Snyders DJ, Fedida D, Tarek M, Loussouarn G, Baró I. Dual effect of phosphatidylinositol (4,5)-bisphosphate PIP(2) on Shaker K(+) [corrected] channels. J Biol Chem. 2012 Oct 19; 287(43):36158-67. PMID: 22932893; PMCID: PMC3476283.
      Citations: 27     Fields:    Translation:AnimalsCells
    32. Veys K, Labro AJ, De Schutter E, Snyders DJ. Quantitative single-cell ion-channel gene expression profiling through an improved qRT-PCR technique combined with whole cell patch clamp. J Neurosci Methods. 2012 Jul 30; 209(1):227-34. PMID: 22728251.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    33. Bocksteins E, Labro AJ, Snyders DJ, Mohapatra DP. The electrically silent Kv6.4 subunit confers hyperpolarized gating charge movement in Kv2.1/Kv6.4 heterotetrameric channels. PLoS One. 2012; 7(5):e37143. PMID: 22615922; PMCID: PMC3355112.
      Citations: 12     Fields:    Translation:HumansCells
    34. Bocksteins E, Ottschytsch N, Timmermans JP, Labro AJ, Snyders DJ. Functional interactions between residues in the S1, S4, and S5 domains of Kv2.1. Eur Biophys J. 2011 Jun; 40(6):783-93. PMID: 21455829.
      Citations: 11     Fields:    Translation:HumansCells
    35. Labro AJ, Bezanilla F, Lacroix JJ. Properties of deactivation gating currents in Shaker channels. Biophys J. 2011 Mar 02; 100(5):L28-30. PMID: 21354387; PMCID: PMC3043211.
      Citations: 36     Fields:    Translation:AnimalsCells
    36. Labro AJ, Boulet IR, Choveau FS, Mayeur E, Bruyns T, Loussouarn G, Raes AL, Snyders DJ. The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure. J Biol Chem. 2011 Jan 07; 286(1):717-25. PMID: 21059661; PMCID: PMC3013030.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    37. Choveau FS, Rodriguez N, Abderemane Ali F, Labro AJ, Rose T, Escande D, Snyders DJ, Charpentier F, Loussouarn G, Dahimène S, Boudin H, Le Hénaff C, Mérot J, Baró I. KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain. J Biol Chem. 2011 Jan 07; 286(1):707-16. PMID: 20940310; PMCID: PMC3013029.
      Citations: 34     Fields:    Translation:AnimalsCells
    38. Amarouch MY, Piron J, Labro AJ, Charpentier F, Loussouarn G, Rodriguez N, Montnach J, Mérot J, Baró I. Phosphatidylinositol-4,5-bisphosphate (PIP(2)) stabilizes the open pore conformation of the Kv11.1 (hERG) channel. Biophys J. 2010 Aug 09; 99(4):1110-8. PMID: 20712994; PMCID: PMC2920645.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    39. Labro AJ, Boulet IR, Timmermans JP, Ottschytsch N, Snyders DJ. The rate-dependent biophysical properties of the LQT1 H258R mutant are counteracted by a dominant negative effect on channel trafficking. J Mol Cell Cardiol. 2010 Jun; 48(6):1096-104. PMID: 19913547.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    40. Bocksteins E, Labro AJ, Mayeur E, Bruyns T, Timmermans JP, Adriaensen D, Snyders DJ. Conserved negative charges in the N-terminal tetramerization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels. J Biol Chem. 2009 Nov 13; 284(46):31625-34. PMID: 19717558; PMCID: PMC2797233.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    41. Kopljar I, Labro AJ, Cuypers E, Johnson HW, Rainier JD, Tytgat J, Snyders DJ. A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol. Proc Natl Acad Sci U S A. 2009 Jun 16; 106(24):9896-901. PMID: 19482941; PMCID: PMC2688436.
      Citations: 14     Fields:    Translation:Cells
    42. Labro AJ, Raes AL, Grottesi A, Van Hoorick D, Sansom MS, Snyders DJ. Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues. J Gen Physiol. 2008 Dec; 132(6):667-80. PMID: 19029374; PMCID: PMC2585865.
      Citations: 54     Fields:    Translation:HumansCells
    43. Labro AJ, Grottesi A, Sansom MS, Raes AL, Snyders DJ. A Kv channel with an altered activation gate sequence displays both "fast" and "slow" activation kinetics. Am J Physiol Cell Physiol. 2008 Jun; 294(6):C1476-84. PMID: 18385285.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    44. Boulet IR, Labro AJ, Raes AL, Snyders DJ. Role of the S6 C-terminus in KCNQ1 channel gating. J Physiol. 2007 Dec 01; 585(Pt 2):325-37. PMID: 17932138; PMCID: PMC2375480.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    45. Saenen JB, Labro AJ, Raes A, Snyders DJ. Modulation of HERG gating by a charge cluster in the N-terminal proximal domain. Biophys J. 2006 Dec 15; 91(12):4381-91. PMID: 16997865; PMCID: PMC1779935.
      Citations: 16     Fields:    Translation:HumansCells
    46. Labro AJ, Raes AL, Snyders DJ. Coupling of voltage sensing to channel opening reflects intrasubunit interactions in kv channels. J Gen Physiol. 2005 Jan; 125(1):71-80. PMID: 15623896; PMCID: PMC2217479.
      Citations: 10     Fields:    Translation:HumansCells
    47. Labro AJ, Raes AL, Bellens I, Ottschytsch N, Snyders DJ. Gating of shaker-type channels requires the flexibility of S6 caused by prolines. J Biol Chem. 2003 Dec 12; 278(50):50724-31. PMID: 13679372.
      Citations: 37     Fields:    Translation:HumansCells
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