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Alain J. Labro

AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Van de Sande DV, Kopljar I, Maaike A, Teisman A, Gallacher DJ, Bart L, Snyders DJ, Leybaert L, Lu HR, Labro AJ. The resting membrane potential of hSC-CM in a syncytium is more hyperpolarised than that of isolated cells. Channels (Austin). 2021 12; 15(1):239-252. PMID: 33465001.
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    2. Simons E, Labro A, Saenen J, Nijak A, Sieliwonczyk E, Vandendriessche B, Dabrowska M, Van Craenenbroeck EM, Schepers D, Van Laer L, Loeys BL, Alaerts M. Molecular autopsy and subsequent functional analysis reveal de novo DSG2 mutation as cause of sudden death. Eur J Med Genet. 2021 Aug 23; 64(11):104322. PMID: 34438094.
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    3. Déri S, Borbás J, Hartai T, Hategan L, Csányi B, Visnyovszki Á, Madácsy T, Maléth J, Hegedus Z, Nagy I, Arora R, Labro AJ, Környei L, Varró A, Sepp R, Ördög B. Impaired cytoplasmic domain interactions cause co-assembly defect and loss of function in the p.Glu293Lys KNCJ2 variant isolated from an Andersen-Tawil syndrome patient. Cardiovasc Res. 2021 Jul 07; 117(8):1923-1934. PMID: 32810216.
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    4. Nijak A, Saenen J, Labro AJ, Schepers D, Loeys BL, Alaerts M. iPSC-Cardiomyocyte Models of Brugada Syndrome-Achievements, Challenges and Future Perspectives. Int J Mol Sci. 2021 Mar 10; 22(6). PMID: 33802229.
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    5. Möller L, Regnier G, Labro AJ, Snyders DJ, Blunck R. Reply to Pisupati et al.: Evaluating single subunit counting data to find the correct stoichiometry. Proc Natl Acad Sci U S A. 2020 11 24; 117(47):29290-29291. PMID: 33082223.
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    6. Nijak A, Labro AJ, De Wilde H, Dewals W, Peigneur S, Tytgat J, Snyders D, Sieliwonczyk E, Simons E, Van Craenenbroeck E, Schepers D, Van Laer L, Saenen J, Loeys B, Alaerts M. Compound Heterozygous SCN5A Mutations in Severe Sodium Channelopathy With Brugada Syndrome: A Case Report. Front Cardiovasc Med. 2020; 7:117. PMID: 32850980.
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    7. Van Theemsche KM, Van de Sande DV, Snyders DJ, Labro AJ. Hydrophobic Drug/Toxin Binding Sites in Voltage-Dependent K+ and Na+ Channels. Front Pharmacol. 2020; 11:735. PMID: 32499709.
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    8. Coonen L, Mayeur E, De Neuter N, Snyders DJ, Cuello LG, Labro AJ. The Selectivity Filter Is Involved in the U-Type Inactivation Process of Kv2.1 and Kv3.1 Channels. Biophys J. 2020 05 19; 118(10):2612-2620. PMID: 32365329.
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    9. Möller L, Regnier G, Labro AJ, Blunck R, Snyders DJ. Determining the correct stoichiometry of Kv2.1/Kv6.4 heterotetramers, functional in multiple stoichiometrical configurations. Proc Natl Acad Sci U S A. 2020 04 28; 117(17):9365-9376. PMID: 32284408.
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    10. Van de Sande DV, Kopljar I, Teisman A, Gallacher DJ, Snyders DJ, Lu HR, Labro AJ. Pharmacological Profile of the Sodium Current in Human Stem Cell-Derived Cardiomyocytes Compares to Heterologous Nav1.5+ß1 Model. Front Pharmacol. 2019; 10:1374. PMID: 31920633.
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    11. Labro AJ, Cortes DM, Tilegenova C, Cuello LG. Inverted allosteric coupling between activation and inactivation gates in K+ channels. Proc Natl Acad Sci U S A. 2018 05 22; 115(21):5426-5431. PMID: 29735651.
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    12. Martínez-Morales E, Kopljar I, Rainier JD, Tytgat J, Snyders DJ, Labro AJ. Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K(+) pore. Toxicon. 2016 Sep 15; 120:57-60. PMID: 27475861.
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    13. Hassiki R, Labro AJ, Benlasfar Z, Vincke C, Somia M, El Ayeb M, Muyldermans S, Snyders DJ, Bouhaouala-Zahar B. Dromedary immune response and specific Kv2.1 antibody generation using a specific immunization approach. Int J Biol Macromol. 2016 Dec; 93(Pt A):167-171. PMID: 27320844.
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    14. Kopljar I, Grottesi A, de Block T, Rainier JD, Tytgat J, Labro AJ, Snyders DJ. Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels. Neuropharmacology. 2016 08; 107:160-167. PMID: 26956727.
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    15. Labro AJ, Priest MF, Lacroix JJ, Snyders DJ, Bezanilla F. Kv3.1 uses a timely resurgent K(+) current to secure action potential repolarization. Nat Commun. 2015 Dec 17; 6:10173. PMID: 26673941.
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    16. Martínez-Morales E, Kopljar I, Snyders DJ, Labro AJ. Alkanols inhibit voltage-gated K(+) channels via a distinct gating modifying mechanism that prevents gate opening. Sci Rep. 2015 Nov 30; 5:17402. PMID: 26616025.
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    17. Stas JI, Bocksteins E, Labro AJ, Snyders DJ. Modulation of Closed-State Inactivation in Kv2.1/Kv6.4 Heterotetramers as Mechanism for 4-AP Induced Potentiation. PLoS One. 2015; 10(10):e0141349. PMID: 26505474.
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    18. Martinez-Morales E, Snyders DJ, Labro AJ. Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel. Biophys J. 2014 Jan 07; 106(1):134-44. PMID: 24411245.
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    19. Kopljar I, Labro AJ, de Block T, Rainier JD, Tytgat J, Snyders DJ. The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state. J Gen Physiol. 2013 Mar; 141(3):359-69. PMID: 23401573.
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    20. Labro AJ, Lacroix JJ, Villalba-Galea CA, Snyders DJ, Bezanilla F. Molecular mechanism for depolarization-induced modulation of Kv channel closure. J Gen Physiol. 2012 Nov; 140(5):481-93. PMID: 23071266.
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    21. Labro AJ, Snyders DJ. Being flexible: the voltage-controllable activation gate of kv channels. Front Pharmacol. 2012; 3:168. PMID: 22993508.
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    22. Abderemane-Ali F, Es-Salah-Lamoureux Z, Delemotte L, Kasimova MA, Labro AJ, Snyders DJ, Fedida D, Tarek M, Baró I, Loussouarn G. Dual effect of phosphatidylinositol (4,5)-bisphosphate PIP(2) on Shaker K(+) [corrected] channels. J Biol Chem. 2012 Oct 19; 287(43):36158-67. PMID: 22932893.
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    23. Veys K, Labro AJ, De Schutter E, Snyders DJ. Quantitative single-cell ion-channel gene expression profiling through an improved qRT-PCR technique combined with whole cell patch clamp. J Neurosci Methods. 2012 Jul 30; 209(1):227-34. PMID: 22728251.
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    24. Bocksteins E, Labro AJ, Snyders DJ, Mohapatra DP. The electrically silent Kv6.4 subunit confers hyperpolarized gating charge movement in Kv2.1/Kv6.4 heterotetrameric channels. PLoS One. 2012; 7(5):e37143. PMID: 22615922.
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    25. Bocksteins E, Ottschytsch N, Timmermans JP, Labro AJ, Snyders DJ. Functional interactions between residues in the S1, S4, and S5 domains of Kv2.1. Eur Biophys J. 2011 Jun; 40(6):783-93. PMID: 21455829.
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    26. Lacroix JJ, Labro AJ, Bezanilla F. Properties of deactivation gating currents in Shaker channels. Biophys J. 2011 Mar 02; 100(5):L28-30. PMID: 21354387.
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    27. Labro AJ, Boulet IR, Choveau FS, Mayeur E, Bruyns T, Loussouarn G, Raes AL, Snyders DJ. The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure. J Biol Chem. 2011 Jan 07; 286(1):717-25. PMID: 21059661.
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    28. Choveau FS, Rodriguez N, Abderemane Ali F, Labro AJ, Rose T, Dahimène S, Boudin H, Le Hénaff C, Escande D, Snyders DJ, Charpentier F, Mérot J, Baró I, Loussouarn G. KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain. J Biol Chem. 2011 Jan 07; 286(1):707-16. PMID: 20940310.
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    29. Rodriguez N, Amarouch MY, Montnach J, Piron J, Labro AJ, Charpentier F, Mérot J, Baró I, Loussouarn G. Phosphatidylinositol-4,5-bisphosphate (PIP(2)) stabilizes the open pore conformation of the Kv11.1 (hERG) channel. Biophys J. 2010 Aug 09; 99(4):1110-8. PMID: 20712994.
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    30. Labro AJ, Boulet IR, Timmermans JP, Ottschytsch N, Snyders DJ. The rate-dependent biophysical properties of the LQT1 H258R mutant are counteracted by a dominant negative effect on channel trafficking. J Mol Cell Cardiol. 2010 Jun; 48(6):1096-104. PMID: 19913547.
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    31. Bocksteins E, Labro AJ, Mayeur E, Bruyns T, Timmermans JP, Adriaensen D, Snyders DJ. Conserved negative charges in the N-terminal tetramerization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels. J Biol Chem. 2009 Nov 13; 284(46):31625-34. PMID: 19717558.
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    32. Kopljar I, Labro AJ, Cuypers E, Johnson HW, Rainier JD, Tytgat J, Snyders DJ. A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol. Proc Natl Acad Sci U S A. 2009 Jun 16; 106(24):9896-901. PMID: 19482941.
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    33. Labro AJ, Raes AL, Grottesi A, Van Hoorick D, Sansom MS, Snyders DJ. Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues. J Gen Physiol. 2008 Dec; 132(6):667-80. PMID: 19029374.
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    34. Labro AJ, Grottesi A, Sansom MS, Raes AL, Snyders DJ. A Kv channel with an altered activation gate sequence displays both "fast" and "slow" activation kinetics. . 2008 Jun; 294(6):C1476-84. PMID: 18385285.
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    35. Boulet IR, Labro AJ, Raes AL, Snyders DJ. Role of the S6 C-terminus in KCNQ1 channel gating. J Physiol. 2007 Dec 01; 585(Pt 2):325-37. PMID: 17932138.
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    36. Saenen JB, Labro AJ, Raes A, Snyders DJ. Modulation of HERG gating by a charge cluster in the N-terminal proximal domain. Biophys J. 2006 Dec 15; 91(12):4381-91. PMID: 16997865.
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    37. Labro AJ, Raes AL, Snyders DJ. Coupling of voltage sensing to channel opening reflects intrasubunit interactions in kv channels. J Gen Physiol. 2005 Jan; 125(1):71-80. PMID: 15623896.
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    38. Labro AJ, Raes AL, Bellens I, Ottschytsch N, Snyders DJ. Gating of shaker-type channels requires the flexibility of S6 caused by prolines. J Biol Chem. 2003 Dec 12; 278(50):50724-31. PMID: 13679372.
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