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Nancy Schwartz

TitleProfessor
InstitutionUniversity of Chicago
DepartmentPediatrics
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    This program has evolved from the basic biochemistry and enzymology of glycoconjugate structure, function, and synthesis to the study of glycoconjugates in cartilage development, including the identification of gene defects in disorders of skeletal development and chondrodystrophies and the underlying pathophysiology of the matrix deficiencies.

    A second major area of interest involves CNS development, and the role of gliogenesis and glial cell function in traumatic brain injury, infection and developmental disorders.

    Collapse Biography 
    Collapse education and training
    University of Pittsburgh, Pittsburgh, PAPhD1971Biochemistry
    University of Chicago, Chicago, ILPostdoc1971-74Biochemistry
    Collapse awards and honors
    Arthritis Foundation Fellowship
    American Heart Association Established Investigatorship
    Research Career Development Award
    NIH Merit Awardee
    NPA Distinguished Service Award
    NIH Mentor of Excellence Award

    Collapse Research 
    Collapse research activities and funding
    T32GM152395     (SCHWARTZ, NANCY B)Feb 1, 2024 - Jan 31, 2029
    NIH
    The University of Chicago Initiative for Maximizing Student Development (IMSD)
    Role: Principal Investigator
    K12GM146658     (SCHWARTZ, NANCY B)Aug 15, 2022 - Jul 31, 2027
    NIH
    IRACDA at the University of Chicago
    Role: Principal Investigator
    R25NS117360     (SCHWARTZ, NANCY B)Jul 1, 2020 - Jun 30, 2025
    NIH
    University of Chicago Neuroscience Early Stage Scientist Training Program
    Role: Principal Investigator
    R25GM109439     (SCHWARTZ, NANCY B)Sep 1, 2014 - Aug 31, 2024
    NIH
    University of Chicago Initiative for Maximizing Student Development (IMSD) - Renewal 01
    Role: Principal Investigator
    R03HD065976     (SCHWARTZ, NANCY B)Sep 13, 2010 - Aug 31, 2011
    NIH
    Microcephaly in an RNAi mouse with reduced sulfation
    Role: Principal Investigator
    P30HD054275     (SCHWARTZ, NANCY B)Sep 15, 2006 - Jun 30, 2013
    NIH
    J.P.Kennedy Mental Retardation and Developmental Disabilities Center
    Role: Principal Investigator
    R25GM066522     (SCHWARTZ, NANCY B)Jul 1, 2002 - Jan 31, 2029
    NIH
    The University of Chicago PREP
    Role: Principal Investigator
    R01HD017332     (SCHWARTZ, NANCY B)Apr 1, 1983 - May 31, 2017
    NIH
    Proteoglycan Synthesis in Mutant Mouse Systems
    Role: Principal Investigator
    R37AR019622     (SCHWARTZ, NANCY B)Aug 1, 1977 - Jul 31, 2001
    NIH
    REGULATION OF BIOSYNTHESIS OF PROTEOGLYCAN
    Role: Principal Investigator
    R01AM019622     (SCHWARTZ, NANCY B)Aug 1, 1977 - Jul 31, 1990
    NIH
    REGULATION OF BIOSYNTHESIS OF PROTEOGLYCAN
    Role: Principal Investigator
    R01AR019622     (SCHWARTZ, NANCY B)Aug 1, 1977 - Jul 31, 1990
    NIH
    REGULATION OF BIOSYNTHESIS OF PROTEOGLYCAN
    Role: Principal Investigator
    T32HD007009     (SCHWARTZ, NANCY B)Jul 1, 1975 - Apr 30, 2028
    NIH
    Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32)
    Role: Principal Investigator
    P01HD009402     (SCHWARTZ, NANCY B)Jun 1, 1975 - Jan 31, 2017
    NIH
    Biological Basis of Mental Retardation
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Schwartz NB, Domowicz MS. Chemistry and Function of Glycosaminoglycans in the Nervous System. Adv Neurobiol. 2023; 29:117-162. PMID: 36255674.
      Citations: 5     Fields:    Translation:Humans
    2. Helling BA, Krishnan S, Risner LE, Walker ND, Schwartz NB, Morin A. Surveying the experience of postdocs in the United States before and during the COVID-19 pandemic. Elife. 2022 07 26; 11. PMID: 35880738; PMCID: PMC9322995.
      Citations: 3     Fields:    Translation:HumansPHPublic Health
    3. Schwartz NB, Domowicz MS. Roles of Chondroitin Sulfate Proteoglycans as Regulators of Skeletal Development. Front Cell Dev Biol. 2022; 10:745372. PMID: 35465334; PMCID: PMC9026158.
      Citations: 2     
    4. Cortes M, Cortes LK, Schwartz NB. Mapping Proteoglycan Function Using Novel Genetic Strategies. Methods Mol Biol. 2022; 2303:731-752. PMID: 34626419.
      Citations: 1     Fields:    
    5. Domowicz MS, Chan WC, Gonzalez T, Schwartz NB, Claudio-Vázquez P. Brain transcriptome analysis of a CLN2 mouse model as a function of disease progression. J Neuroinflammation. 2021 Nov 08; 18(1):262. PMID: 34749772; PMCID: PMC8576919.
      Citations: 7     Fields:    Translation:AnimalsCells
    6. Weber-Main AM, McGee R, Eide Boman K, Hemming J, Hall M, Unold T, Harwood EM, Risner LE, Smith A, Lawson K, Engler J, Steer CJ, Buchwald D, Jones HP, Manson SM, Ofili E, Schwartz NB, Vishwanatha JK, Okuyemi KS. Grant application outcomes for biomedical researchers who participated in the National Research Mentoring Network's Grant Writing Coaching Programs. PLoS One. 2020; 15(11):e0241851. PMID: 33166315; PMCID: PMC7652313.
      Citations: 18     Fields:    Translation:Humans
    7. Nandadasa S, Szafron JM, Pathak V, Murtada SI, Kraft CM, O'Donnell A, Norvik C, Hughes C, Caterson B, Domowicz MS, Schwartz NB, Tran-Lundmark K, Veigl M, Sedwick D, Philipson EH, Humphrey JD, Apte SS. Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth. Elife. 2020 09 10; 9. PMID: 32909945; PMCID: PMC7529456.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    8. Risner LE, Morin XK, Erenrich ES, Clifford PS, Franke J, Hurley I, Schwartz NB. Leveraging a collaborative consortium model of mentee/mentor training to foster career progression of underrepresented postdoctoral researchers and promote institutional diversity and inclusion. PLoS One. 2020; 15(9):e0238518. PMID: 32870930; PMCID: PMC7462290.
      Citations: 5     Fields:    Translation:Humans
    9. Schwartz NB, Risner LE, Domowicz M, Freedman VH. Comparisons and Approaches of PREP Programs at Different Stages of Maturity: Challenges, Best Practices and Benefits. Ethn Dis. 2020; 30(1):55-64. PMID: 31969784; PMCID: PMC6970524.
      Citations: 4     Fields:    Translation:Humans
    10. Jo SY, Domowicz MS, Henry JG, Schwartz NB. The Role of Dot1l in Prenatal and Postnatal Murine Chondrocytes and Trabecular Bone. JBMR Plus. 2020 Feb; 4(2):e10254. PMID: 32083237; PMCID: PMC7017886.
      Citations: 9     
    11. Domowicz MS, Chan WC, Henry JG, Ware CB, Andrade J, Dawson G, Schwartz NB, Claudio-Vázquez P. Global Brain Transcriptome Analysis of a Tpp1 Neuronal Ceroid Lipofuscinoses Mouse Model. ASN Neuro. 2019 Jan-Dec; 11:1759091419843393. PMID: 31003587; PMCID: PMC6475859.
      Citations: 10     Fields:    Translation:AnimalsCells
    12. McConnell SC, Westerman EL, Pierre JF, Heckler EJ, Schwartz NB. United States National Postdoc Survey results and the interaction of gender, career choice and mentor impact. Elife. 2018 12 18; 7. PMID: 30561332; PMCID: PMC6298783.
      Citations: 27     Fields:    Translation:Humans
    13. Schwartz NB, Domowicz MS. Proteoglycans in brain development and pathogenesis. FEBS Lett. 2018 12; 592(23):3791-3805. PMID: 29513405.
      Citations: 43     Fields:    Translation:HumansAnimals
    14. Domowicz M, Wadlington NL, Henry JG, Diaz K, Munoz MJ, Schwartz NB. Glial cell responses in a murine multifactorial perinatal brain injury model. Brain Res. 2018 02 15; 1681:52-63. PMID: 29274879; PMCID: PMC5780221.
      Citations: 7     Fields:    Translation:AnimalsCells
    15. Hitchcock P, Mathur A, Bennett J, Cameron P, Chow C, Clifford P, Duvoisin R, Feig A, Finneran K, Klotz DM, McGee R, O'Riordan M, Pfund C, Pickett C, Schwartz N, Street NE, Watkins E, Wiest J, Engelke D. The future of graduate and postdoctoral training in the biosciences. Elife. 2017 10 19; 6. PMID: 29049023; PMCID: PMC5648525.
      Citations: 27     Fields:    Translation:Humans
    16. Agarwal R, Domowicz MS, Schwartz NB, Henry J, Medintz I, Delehanty JB, Stewart MH, Susumu K, Huston AL, Deschamps JR, Dawson PE, Palomo V, Dawson G. Delivery and tracking of quantum dot peptide bioconjugates in an intact developing avian brain. ACS Chem Neurosci. 2015 Mar 18; 6(3):494-504. PMID: 25688887; PMCID: PMC5056627.
      Citations: 22     Fields:    Translation:Animals
    17. Foxley S, Domowicz M, Karczmar GS, Schwartz N. 3D high spectral and spatial resolution imaging of ex vivo mouse brain. Med Phys. 2015 Mar; 42(3):1463-72. PMID: 25735299; PMCID: PMC5148176.
      Citations: 6     Fields:    Translation:Animals
    18. Cortes M, Cortes LK, Schwartz NB. Mapping proteoglycan functions with glycosidases. Methods Mol Biol. 2015; 1229:443-55. PMID: 25325971.
      Citations:    Fields:    Translation:AnimalsCells
    19. Lauing KL, Cortes M, Domowicz MS, Henry JG, Baria AT, Schwartz NB. Aggrecan is required for growth plate cytoarchitecture and differentiation. Dev Biol. 2014 Dec 15; 396(2):224-36. PMID: 25446537; PMCID: PMC4261049.
      Citations: 43     Fields:    Translation:AnimalsCells
    20. Schwartz NB, Domowicz MS. Chemistry and function of glycosaminoglycans in the nervous system. Adv Neurobiol. 2014; 9:89-115. PMID: 25151376.
      Citations: 9     Fields:    
    21. Mis EK, Liem KF, Kong Y, Schwartz NB, Domowicz M, Weatherbee SD. Forward genetics defines Xylt1 as a key, conserved regulator of early chondrocyte maturation and skeletal length. Dev Biol. 2014 Jan 01; 385(1):67-82. PMID: 24161523; PMCID: PMC3895954.
      Citations: 27     Fields:    Translation:AnimalsCells
    22. Qin J, Berdyshev E, Poirer C, Schwartz NB, Dawson G. Neutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of Hyaluronan synthase 2 through decreased ceramide production and activation of Akt. J Biol Chem. 2012 Apr 20; 287(17):13620-32. PMID: 22383528; PMCID: PMC3340193.
      Citations: 31     Fields:    Translation:AnimalsCells
    23. Cortes M, Mensch JR, Domowicz M, Schwartz NB. Proteoglycans: gene cloning. Methods Mol Biol. 2012; 836:3-21. PMID: 22252624.
      Citations: 1     Fields:    Translation:Animals
    24. Domowicz MS, Henry JG, Wadlington N, Navarro A, Kraig RP, Schwartz NB. Astrocyte precursor response to embryonic brain injury. Brain Res. 2011 May 10; 1389:35-49. PMID: 21396923; PMCID: PMC3097075.
      Citations: 13     Fields:    
    25. Cortes M, Baria AT, Schwartz NB. Sulfation of chondroitin sulfate proteoglycans is necessary for proper Indian hedgehog signaling in the developing growth plate. Development. 2009 May; 136(10):1697-706. PMID: 19369399; PMCID: PMC2673757.
      Citations: 67     Fields:    Translation:AnimalsCells
    26. Domowicz MS, Cortes M, Henry JG, Schwartz NB. Aggrecan modulation of growth plate morphogenesis. Dev Biol. 2009 May 15; 329(2):242-57. PMID: 19268444; PMCID: PMC2810547.
      Citations: 45     Fields:    
    27. Bradley ME, Rest JS, Li WH, Schwartz NB. Sulfate activation enzymes: phylogeny and association with pyrophosphatase. J Mol Evol. 2009 Jan; 68(1):1-13. PMID: 19067028.
      Citations: 8     Fields:    Translation:Cells
    28. King LA, Schwartz NB, Domowicz MS. Glial migratory streams in the developing hindbrain: a slice culture approach. J Neurosci Methods. 2009 Feb 15; 177(1):30-43. PMID: 18948137; PMCID: PMC2677068.
      Citations: 1     Fields:    
    29. Domowicz MS, Sanders TA, Ragsdale CW, Schwartz NB. Aggrecan is expressed by embryonic brain glia and regulates astrocyte development. Dev Biol. 2008 Mar 01; 315(1):114-24. PMID: 18207138; PMCID: PMC2408532.
      Citations: 21     Fields:    
    30. Schwartz NB, Cortes M, King LA. Got sulfate? Luring axons this way and that. Chem Biol. 2007 Feb; 14(2):119-20. PMID: 17317565.
      Citations:    Fields:    Translation:AnimalsCells
    31. Pirok EW, Domowicz MS, Henry J, Wang Y, Santore M, Mueller MM, Schwartz NB. APBP-1, a DNA/RNA-binding protein, interacts with the chick aggrecan regulatory region. J Biol Chem. 2005 Oct 21; 280(42):35606-16. PMID: 16100116.
      Citations: 2     Fields:    Translation:AnimalsCells
    32. Schwartz NB, Domowicz M. Proteoglycans in brain development. Glycoconj J. 2004; 21(6):329-41. PMID: 15514481.
      Citations: 25     Fields:    Translation:Animals
    33. Domowicz MS, Mangoura D, Schwartz NB. Aggrecan regulates telencephalic neuronal aggregation in culture. Brain Res Dev Brain Res. 2003 Jul 12; 143(2):207-16. PMID: 12855192.
      Citations: 3     Fields:    Translation:AnimalsCells
    34. Domowicz MS, Mueller MM, Novak TE, Schwartz LE, Schwartz NB. Developmental expression of the HNK-1 carbohydrate epitope on aggrecan during chondrogenesis. Dev Dyn. 2003 Jan; 226(1):42-50. PMID: 12508223.
      Citations: 9     Fields:    Translation:AnimalsCells
    35. Singh B, Schwartz NB. Identification and functional characterization of the novel BM-motif in the murine phosphoadenosine phosphosulfate (PAPS) synthetase. J Biol Chem. 2003 Jan 03; 278(1):71-5. PMID: 12414806.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    36. Schwartz NB, Domowicz M. Chondrodysplasias due to proteoglycan defects. Glycobiology. 2002 Apr; 12(4):57R-68R. PMID: 12042245.
      Citations: 40     Fields:    Translation:Animals
    37. Pirok EW, Henry J, Schwartz NB. cis elements that control the expression of chick aggrecan. J Biol Chem. 2001 May 18; 276(20):16894-903. PMID: 11350977.
      Citations: 1     Fields:    Translation:AnimalsCells
    38. Krueger RC, Santore MT, Dawson G, Schwartz NB. Increased extracellular magnesium modulates proliferation in fetal neural cells in culture. Brain Res Dev Brain Res. 2001 Apr 30; 127(2):99-109. PMID: 11334997.
      Citations: 3     Fields:    Translation:AnimalsCells
    39. Domowicz MS, Pirok EW, Novak TE, Schwartz NB. Role of the C-terminal G3 domain in sorting and secretion of aggrecan core protein and ubiquitin-mediated degradation of accumulated mutant precursors. J Biol Chem. 2000 Nov 10; 275(45):35098-105. PMID: 11063750.
      Citations: 8     Fields:    Translation:AnimalsCells
    40. Domowicz M, Mangoura D, Schwartz NB. Cell specific-chondroitin sulfate proteoglycan expression during CNS morphogenesis in the chick embryo. Int J Dev Neurosci. 2000 Nov; 18(7):629-41. PMID: 10978841.
      Citations: 8     Fields:    Translation:AnimalsCells
    41. Schwartz N. Biosynthesis and regulation of expression of proteoglycans. Front Biosci. 2000 Jul 01; 5:D649-55. PMID: 10877997.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    42. Krueger RC, Kurima K, Schwartz NB. Completion of the mouse aggrecan gene structure and identification of the defect in the cmd-Bc mouse as a near complete deletion of the murine aggrecan gene. Mamm Genome. 1999 Dec; 10(12):1119-25. PMID: 10594233.
      Citations: 22     Fields:    Translation:AnimalsCells
    43. Kurima K, Singh B, Schwartz NB. Genomic organization of the mouse and human genes encoding the ATP sulfurylase/adenosine 5'-phosphosulfate kinase isoform SK2. J Biol Chem. 1999 Nov 19; 274(47):33306-12. PMID: 10559207.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    44. Deyrup AT, Singh B, Krishnan S, Lyle S, Schwartz NB. Chemical modification and site-directed mutagenesis of conserved HXXH and PP-loop motif arginines and histidines in the murine bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase. J Biol Chem. 1999 Oct 08; 274(41):28929-36. PMID: 10506138.
      Citations: 4     Fields:    Translation:AnimalsCells
    45. Deyrup AT, Krishnan S, Singh B, Schwartz NB. Activity and stability of recombinant bifunctional rearranged and monofunctional domains of ATP-sulfurylase and adenosine 5'-phosphosulfate kinase. J Biol Chem. 1999 Apr 16; 274(16):10751-7. PMID: 10196147.
      Citations: 3     Fields:    Translation:AnimalsCells
    46. Schwartz NB, Pirok EW, Mensch JR, Domowicz MS. Domain organization, genomic structure, evolution, and regulation of expression of the aggrecan gene family. Prog Nucleic Acid Res Mol Biol. 1999; 62:177-225. PMID: 9932455.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    47. Kurima K, Warman ML, Krishnan S, Domowicz M, Krueger RC, Deyrup A, Schwartz NB. A member of a family of sulfate-activating enzymes causes murine brachymorphism. Proc Natl Acad Sci U S A. 1998 Jul 21; 95(15):8681-5. PMID: 9671738; PMCID: PMC21136.
      Citations: 33     Fields:    Translation:AnimalsCells
    48. Deyrup AT, Krishnan S, Cockburn BN, Schwartz NB. Deletion and site-directed mutagenesis of the ATP-binding motif (P-loop) in the bifunctional murine ATP-sulfurylase/adenosine 5'-phosphosulfate kinase enzyme. J Biol Chem. 1998 Apr 17; 273(16):9450-6. PMID: 9545271.
      Citations: 25     Fields:    Translation:AnimalsCells
    49. Immergluck LC, Domowicz MS, Schwartz NB, Herold BC. Viral and cellular requirements for entry of herpes simplex virus type 1 into primary neuronal cells. J Gen Virol. 1998 Mar; 79 ( Pt 3):549-59. PMID: 9519833.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    50. Schwartz NB, Lyle S, Ozeran JD, Li H, Deyrup A, Ng K, Westley J. Sulfate activation and transport in mammals: system components and mechanisms. Chem Biol Interact. 1998 Feb 20; 109(1-3):143-51. PMID: 9566742.
      Citations: 9     Fields:    Translation:Animals
    51. Pirok EW, Li H, Mensch JR, Henry J, Schwartz NB. Structural and functional analysis of the chick chondroitin sulfate proteoglycan (aggrecan) promoter and enhancer region. J Biol Chem. 1997 Apr 25; 272(17):11566-74. PMID: 9111072.
      Citations: 3     Fields:    Translation:AnimalsCells
    52. Domowicz M, Krueger RC, Li H, Mangoura D, Vertel BM, Schwartz NB. The nanomelic mutation in the aggrecan gene is expressed in chick chondrocytes and neurons. Int J Dev Neurosci. 1996 Jun; 14(3):191-201. PMID: 8842798.
      Citations: 3     Fields:    Translation:AnimalsCells
    53. Pettway Z, Domowicz M, Schwartz NB, Bronner-Fraser M. Age-dependent inhibition of neural crest migration by the notochord correlates with alterations in the S103L chondroitin sulfate proteoglycan. Exp Cell Res. 1996 May 25; 225(1):195-206. PMID: 8635512.
      Citations: 9     Fields:    Translation:Animals
    54. Ozeran JD, Westley J, Schwartz NB. Kinetics of PAPS translocase: evidence for an antiport mechanism. Biochemistry. 1996 Mar 26; 35(12):3685-94. PMID: 8619988.
      Citations: 6     Fields:    Translation:AnimalsCells
    55. Ozeran JD, Westley J, Schwartz NB. Identification and partial purification of PAPS translocase. Biochemistry. 1996 Mar 26; 35(12):3695-703. PMID: 8619989.
      Citations: 5     Fields:    Translation:AnimalsCells
    56. Li H, Domowicz M, Hennig A, Schwartz NB. S103L reactive chondroitin sulfate proteoglycan (aggrecan) mRNA expressed in developing chick brain and cartilage is encoded by a single gene. Brain Res Mol Brain Res. 1996 Mar; 36(2):309-21. PMID: 8965652.
      Citations: 5     Fields:    Translation:Animals
    57. Szabo M, Knox KL, Ringstrom SJ, Perlyn CA, Sutandi S, Schwartz NB. Mechanism of the inhibitory action of RU486 on the secondary follicle-stimulating hormone surge. Endocrinology. 1996 Jan; 137(1):85-9. PMID: 8536646.
      Citations: 6     Fields:    Translation:Animals
    58. Schwartz NB, Domowicz M, Krueger RC, Li H, Mangoura D. Brain aggrecan. Perspect Dev Neurobiol. 1996; 3(4):291-306. PMID: 9117261.
      Citations: 10     Fields:    Translation:HumansAnimals
    59. Li H, Deyrup A, Mensch JR, Domowicz M, Konstantinidis AK, Schwartz NB. The isolation and characterization of cDNA encoding the mouse bifunctional ATP sulfurylase-adenosine 5'-phosphosulfate kinase. J Biol Chem. 1995 Dec 08; 270(49):29453-9. PMID: 7493984.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    60. Juul SE, Krueger RC, Scofield L, Hershenson MB, Schwartz NB. Hyperoxia alone causes changes in lung proteoglycans and hyaluronan in neonatal rat pups. Am J Respir Cell Mol Biol. 1995 Dec; 13(6):629-38. PMID: 7576700.
      Citations: 5     Fields:    Translation:Animals
    61. Li H, Schwartz NB. Gene structure of chick cartilage chondroitin sulfate proteoglycan (aggrecan) core protein. J Mol Evol. 1995 Dec; 41(6):878-85. PMID: 8587132.
      Citations: 2     Fields:    Translation:AnimalsCells
    62. Domowicz M, Li H, Hennig A, Henry J, Vertel BM, Schwartz NB. The biochemically and immunologically distinct CSPG of notochord is a product of the aggrecan gene. Dev Biol. 1995 Oct; 171(2):655-64. PMID: 7556944.
      Citations: 14     Fields:    Translation:AnimalsCells
    63. Lyle S, Stanczak JD, Westley J, Schwartz NB. Sulfate-activating enzymes in normal and brachymorphic mice: evidence for a channeling defect. Biochemistry. 1995 Jan 24; 34(3):940-5. PMID: 7827052.
      Citations: 3     Fields:    Translation:Animals
    64. Lyle S, Geller DH, Ng K, Stanczak J, Westley J, Schwartz NB. Kinetic mechanism of adenosine 5'-phosphosulphate kinase from rat chondrosarcoma. Biochem J. 1994 Jul 15; 301 ( Pt 2):355-9. PMID: 8042977; PMCID: PMC1137087.
      Citations: 3     Fields:    Translation:AnimalsCells
    65. Lyle S, Geller DH, Ng K, Westley J, Schwartz NB. Kinetic mechanism of ATP-sulphurylase from rat chondrosarcoma. Biochem J. 1994 Jul 15; 301 ( Pt 2):349-54. PMID: 8042976; PMCID: PMC1137086.
      Citations: 5     Fields:    Translation:AnimalsCells
    66. Vertel BM, Grier BL, Li H, Schwartz NB. The chondrodystrophy, nanomelia: biosynthesis and processing of the defective aggrecan precursor. Biochem J. 1994 Jul 01; 301 ( Pt 1):211-6. PMID: 8037674; PMCID: PMC1137164.
      Citations: 15     Fields:    Translation:AnimalsCells
    67. Lyle S, Ozeran JD, Stanczak J, Westley J, Schwartz NB. Intermediate channeling between ATP sulfurylase and adenosine 5'-phosphosulfate kinase from rat chondrosarcoma. Biochemistry. 1994 Jun 07; 33(22):6822-7. PMID: 8204616.
      Citations: 8     Fields:    Translation:Animals
    68. Lyle S, Stanczak J, Ng K, Schwartz NB. Rat chondrosarcoma ATP sulfurylase and adenosine 5'-phosphosulfate kinase reside on a single bifunctional protein. Biochemistry. 1994 May 17; 33(19):5920-5. PMID: 8180221.
      Citations: 8     Fields:    Translation:AnimalsCells
    69. Li H, Schwartz NB, Vertel BM. cDNA cloning of chick cartilage chondroitin sulfate (aggrecan) core protein and identification of a stop codon in the aggrecan gene associated with the chondrodystrophy, nanomelia. J Biol Chem. 1993 Nov 05; 268(31):23504-11. PMID: 8226878.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    70. Hennig AK, Mangoura D, Schwartz NB. Large chondroitin sulfate proteoglycans of developing chick CNS are expressed in cerebral hemisphere neuronal cultures. Brain Res Dev Brain Res. 1993 Jun 08; 73(2):261-72. PMID: 8353936.
      Citations: 5     Fields:    Translation:AnimalsCells
    71. Kearns AE, Vertel BM, Schwartz NB. Topography of glycosylation and UDP-xylose production. J Biol Chem. 1993 May 25; 268(15):11097-104. PMID: 8496172.
      Citations: 18     Fields:    Translation:AnimalsCells
    72. Vertel BM, Walters LM, Flay N, Kearns AE, Schwartz NB. Xylosylation is an endoplasmic reticulum to Golgi event. J Biol Chem. 1993 May 25; 268(15):11105-12. PMID: 8496173.
      Citations: 20     Fields:    Translation:AnimalsCells
    73. Schwartz NB, Hennig AK, Krueger RC, Krzystolik M, Li H, Mangoura D. Developmental expression of S103L cross-reacting proteoglycans in embryonic chick. Prog Clin Biol Res. 1993; 383B:505-14. PMID: 8115367.
      Citations: 4     Fields:    Translation:Animals
    74. Hennig A, Krueger R, Mangoura D, Schwartz NB. Chondroitin sulfate proteoglycan expression during neuronal development. Cell Mol Biol (Noisy-le-grand). 1992 Aug-Sep; 38(5-6):585-93. PMID: 1282844.
      Citations: 6     Fields:    Translation:AnimalsCells
    75. Krueger RC, Hennig AK, Schwartz NB. Two immunologically and developmentally distinct chondroitin sulfate proteolglycans in embryonic chick brain. J Biol Chem. 1992 Jun 15; 267(17):12149-61. PMID: 1601881.
      Citations: 8     Fields:    Translation:Animals
    76. Ng K, D'Souza M, Callahan L, Geller DH, Kearns AE, Lyle S, Schwartz NB. Synthesis and utilization of a nonhydrolyzable phosphoadenosine phosphosulfate analog. Anal Biochem. 1991 Oct; 198(1):60-7. PMID: 1665019.
      Citations: 1     Fields:    Translation:AnimalsCells
    77. Callahan L, Schwartz N, Ng K. Dibasic amines as competitive ions improve the resolution between polyanionic nucleotides. Anal Biochem. 1991 Aug 01; 196(2):229-33. PMID: 1842909.
      Citations:    Fields:    Translation:Cells
    78. Kearns AE, Campbell SC, Westley J, Schwartz NB. Initiation of chondroitin sulfate biosynthesis: a kinetic analysis of UDP-D-xylose: core protein beta-D-xylosyltransferase. Biochemistry. 1991 Jul 30; 30(30):7477-83. PMID: 1906743.
      Citations: 20     Fields:    Translation:AnimalsCells
    79. Dennis JE, Carrino DA, Schwartz NB, Caplan AI. Ultrastructural characterization of embryonic chick cartilage proteoglycan core protein and the mapping of a monoclonal antibody epitope. J Biol Chem. 1990 Jul 15; 265(20):12098-103. PMID: 1694854.
      Citations: 6     Fields:    Translation:AnimalsCells
    80. Krueger RC, Fields TA, Hildreth J, Schwartz NB. Chick cartilage chondroitin sulfate proteoglycan core protein. I. Generation and characterization of peptides and specificity for glycosaminoglycan attachment. J Biol Chem. 1990 Jul 15; 265(20):12075-87. PMID: 2365711.
      Citations: 15     Fields:    Translation:AnimalsCells
    81. Krueger RC, Fields TA, Mensch JR, Schwartz NB. Chick cartilage chondroitin sulfate proteoglycan core protein. II. Nucleotide sequence of cDNA clone and localization of the S103L epitope. J Biol Chem. 1990 Jul 15; 265(20):12088-97. PMID: 1694853.
      Citations: 10     Fields:    Translation:AnimalsCells
    82. Campbell SC, Krueger RC, Schwartz NB. Deglycosylation of chondroitin sulfate proteoglycan and derived peptides. Biochemistry. 1990 Jan 30; 29(4):907-14. PMID: 2340282.
      Citations:    Fields:    Translation:AnimalsCells
    83. Ng KF, Schwartz NB. Solubilization and partial purification of hyaluronate synthetase from oligodendroglioma cells. J Biol Chem. 1989 Jul 15; 264(20):11776-83. PMID: 2501297.
      Citations: 15     Fields:    Translation:AnimalsCells
    84. Callahan L, Ng K, Geller DH, Agarwal K, Schwartz NB. Synthesis and properties of a nonhydrolyzable adenosine phosphosulfate analog. Anal Biochem. 1989 Feb 15; 177(1):67-71. PMID: 2545117.
      Citations: 2     Fields:    Translation:Animals
    85. Zaruba ME, Schwartz NB, Tennekoon GI. Reconstitution of adenosine 3'-phosphate 5'-phosphosulfate transporter from rat brain. Biochem Biophys Res Commun. 1988 Sep 30; 155(3):1271-7. PMID: 3178808.
      Citations: 2     Fields:    Translation:AnimalsCells
    86. Campbell SC, Schwartz NB. Kinetics of intracellular processing of chondroitin sulfate proteoglycan core protein and other matrix components. J Cell Biol. 1988 Jun; 106(6):2191-202. PMID: 3133380; PMCID: PMC2115125.
      Citations: 8     Fields:    Translation:AnimalsCells
    87. Melvin T, Schwartz NB. Biochemical correlations in animal models of chondrodysplasias. Pathol Immunopathol Res. 1988; 7(1-2):68-72. PMID: 3065768.
      Citations: 2     Fields:    Translation:Animals
    88. Krueger RC, Schwartz NB. An improved method of sequential alcian blue and ammoniacal silver staining of chondroitin sulfate proteoglycan in polyacrylamide gels. Anal Biochem. 1987 Dec; 167(2):295-300. PMID: 2450484.
      Citations: 12     Fields:    
    89. Smalheiser NR, Schwartz NB. Cranin: a laminin-binding protein of cell membranes. Proc Natl Acad Sci U S A. 1987 Sep; 84(18):6457-61. PMID: 2957695; PMCID: PMC299096.
      Citations: 43     Fields:    Translation:AnimalsCells
    90. Smalheiser NR, Schwartz NB. Kinetic analysis of 'rapid onset' neurite formation in NG108-15 cells reveals a dual role for substratum-bound laminin. Brain Res. 1987 Jul; 431(1):111-21. PMID: 3620981.
      Citations: 7     Fields:    Translation:Cells
    91. Vernillo AT, Schwartz NB. The effects of phenytoin (5,5-diphenylhydantoin) on human gingival fibroblasts in culture. J Periodontal Res. 1987 Jul; 22(4):307-12. PMID: 2957484.
      Citations: 3     Fields:    Translation:HumansCells
    92. Geller DH, Henry JG, Belch J, Schwartz NB. Co-purification and characterization of ATP-sulfurylase and adenosine-5'-phosphosulfate kinase from rat chondrosarcoma. J Biol Chem. 1987 May 25; 262(15):7374-82. PMID: 3034891.
      Citations: 7     Fields:    Translation:Animals
    93. Bourdon MA, Krusius T, Campbell S, Schwartz NB, Ruoslahti E. Identification and synthesis of a recognition signal for the attachment of glycosaminoglycans to proteins. Proc Natl Acad Sci U S A. 1987 May; 84(10):3194-8. PMID: 3472204; PMCID: PMC304835.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    94. Bird TA, Schwartz NB, Peterkofsky B. Mechanism for the decreased biosynthesis of cartilage proteoglycan in the scorbutic guinea pig. J Biol Chem. 1986 Aug 25; 261(24):11166-72. PMID: 3733750.
      Citations: 3     Fields:    Translation:Animals
    95. Vernillo AT, Schwartz NB. Stimulation of collagen and glycosaminoglycan production by phenytoin 5,5-diphenylhydantoin in monolayer cultures of mesenchymal cells derived from embryonic chick sternae. Arch Oral Biol. 1986; 31(12):819-23. PMID: 3479956.
      Citations:    Fields:    Translation:AnimalsCells
    96. Philipson LH, Westley J, Schwartz NB. Effect of hyaluronidase treatment of intact cells on hyaluronate synthetase activity. Biochemistry. 1985 Dec 31; 24(27):7899-906. PMID: 3937551.
      Citations: 15     Fields:    Translation:AnimalsCells
    97. Olson CA, Krueger R, Schwartz NB. Deglycosylation of chondroitin sulfate proteoglycan by hydrogen fluoride in pyridine. Anal Biochem. 1985 Apr; 146(1):232-7. PMID: 3993934.
      Citations: 5     Fields:    Translation:Animals
    98. Koerner T, Olson C, Schwartz NB, Rodén L. Mechanisms of chain initiation in the biosynthesis of connective tissue polysaccharides. Fed Proc. 1985 Feb; 44(2):373-80. PMID: 3917944.
      Citations: 14     Fields:    Translation:AnimalsCells
    99. Schwartz NB, Habib G, Campbell S, D'Elvlyn D, Gartner M, Krueger R, Olson C, Philipson L. Synthesis and structure of proteoglycan core protein. Fed Proc. 1985 Feb; 44(2):369-72. PMID: 3917943.
      Citations: 4     Fields:    Translation:AnimalsCells
    100. Geetha-Habib M, Campbell SC, Schwartz NB. Subcellular localization of the synthesis and glycosylation of chondroitin sulfate proteoglycan core protein. J Biol Chem. 1984 Jun 10; 259(11):7300-10. PMID: 6725288.
      Citations: 13     Fields:    Translation:AnimalsCells
    101. Philipson LH, Schwartz NB. Subcellular localization of hyaluronate synthetase in oligodendroglioma cells. J Biol Chem. 1984 Apr 25; 259(8):5017-23. PMID: 6425282.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    102. Hoffmann HP, Schwartz NB, Prockop DJ, Rodén L. Location of xylosyltransferase in the cisternae of the rough endoplasmic reticulum of embryonic cartilage cells. Connect Tissue Res. 1984; 12(2):151-63. PMID: 6426856.
      Citations: 11     Fields:    Translation:AnimalsCells
    103. Brennan MJ, Oldberg A, Ruoslahti E, Brown K, Schwartz N. Immunological evidence for two distinct chondroitin sulfate proteoglycan core proteins: differential expression in cartilage matrix deficient mice. Dev Biol. 1983 Jul; 98(1):139-47. PMID: 6407883.
      Citations: 5     Fields:    Translation:Animals
    104. Conway WF, Schwartz NB, Dorfman A. The irreversible effect of bromodeoxyuridine on chick chondrocytes. Exp Cell Res. 1982 May; 139(1):79-86. PMID: 7084318.
      Citations: 1     Fields:    Translation:AnimalsCells
    105. Sugahara K, Schwartz NB. Defect in 3'-phosphoadenosine 5'-phosphosulfate synthesis in brachymorphic mice. II. Tissue distribution of the defect. Arch Biochem Biophys. 1982 Apr 01; 214(2):602-9. PMID: 6284030.
      Citations: 15     Fields:    Translation:Animals
    106. Sugahara K, Schwartz NB. Defect in 3'-phosphoadenosine 5'-phosphosulfate synthesis in brachymorphic mice. I. Characterization of the defect. Arch Biochem Biophys. 1982 Apr 01; 214(2):589-601. PMID: 6284029.
      Citations: 16     Fields:    Translation:Animals
    107. Schwartz NB. Role of ovarian inhibin (folliculostatin) in regulating FSH secretion in the female rat. Adv Exp Med Biol. 1982; 147:15-36. PMID: 6817602.
      Citations: 1     Fields:    Translation:Animals
    108. Schwartz NB. Defect in proteoglycan synthesis in brachymorphic mice. Prog Clin Biol Res. 1982; 110 Pt B:97-103. PMID: 7167591.
      Citations:    Fields:    Translation:Animals
    109. Schwartz NB. Synthesis of cartilage proteoglycans. Ala J Med Sci. 1981 Jan; 18(1):41-5. PMID: 7235185.
      Citations:    Fields:    Translation:Animals
    110. Campbell CS, Schwartz NB. The impact of constant light on the estrous cycle of the rat. Endocrinology. 1980 Apr; 106(4):1230-8. PMID: 7188901.
      Citations: 4     Fields:    Translation:Animals
    111. Coudron C, Ellis K, Philipson L, Schwartz NB. Preliminary characterization of a xylose acceptor prepared by hydrogen fluoride treatment of proteoglycan core protein. Biochem Biophys Res Commun. 1980 Jan 29; 92(2):618-23. PMID: 7356486.
      Citations: 4     Fields:    Translation:Animals
    112. Dorfman A, Vertel BM, Schwartz NB. Immunological methods in the study of chondroitin sulfate proteoglycans. Curr Top Dev Biol. 1980; 14(Pt 2):169-98. PMID: 6161752.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    113. Sugahara K, Schwartz NB. Defect in 3'-phosphoadenosine 5'-phosphosulfate formation in brachymorphic mice. Proc Natl Acad Sci U S A. 1979 Dec; 76(12):6615-8. PMID: 230515; PMCID: PMC411917.
      Citations: 25     Fields:    Translation:Animals
    114. Sugahara K, Schwartz NB, Dorfman A. Biosynthesis of hyaluronic acid by Streptococcus. J Biol Chem. 1979 Jul 25; 254(14):6252-61. PMID: 376529.
      Citations: 20     Fields:    Translation:Cells
    115. Schwartz NB. Synthesis and secretion of an altered chondroitin sulfate proteoglycan. J Biol Chem. 1979 Apr 10; 254(7):2271-7. PMID: 570971.
      Citations: 9     Fields:    Translation:AnimalsCells
    116. Schwartz NB, Ostrowski V, Brown KS, Pratt RM. Defective PAPS-synthesis in epiphyseal cartilage from brachymorphic mice. Biochem Biophys Res Commun. 1978 May 15; 82(1):173-8. PMID: 666832.
      Citations: 9     Fields:    Translation:Animals
    117. John KV, Schwartz NB, Ankel H. UDP-glucuronate carboxy-lyase in cultured chondrocytes. J Biol Chem. 1977 Oct 10; 252(19):6707-10. PMID: 197101.
      Citations: 9     Fields:    Translation:AnimalsCells
    118. Schwartz NB. Regulation of chondroitin sulfate synthesis. Effect of beta-xylosides on synthesis of chondroitin sulfate proteoglycan, chondroitin sulfate chains, and core protein. J Biol Chem. 1977 Sep 25; 252(18):6316-21. PMID: 561070.
      Citations: 48     Fields:    Translation:AnimalsCells
    119. Campbell CS, Schwartz NB. Steroid feedback regulation of luteinizing hormone and follicle-stimulating hormone secretion rates in male and female rats. J Toxicol Environ Health. 1977 Sep; 3(1-2):61-95. PMID: 336902.
      Citations: 4     Fields:    Translation:Animals
    120. Campbell CS, Schwartz NB, Firlit MG. The role of adrenal and ovarian steroids in the control of serum LH and FSH. Endocrinology. 1977 Jul; 101(1):162-72. PMID: 558875.
      Citations: 9     Fields:    Translation:Animals
    121. Schwartz NB, Justo SN. Acute changes in serum gonadotrophins and steroids following orchidectomy in the rat: role of the adrenal gland. Endocrinology. 1977 Jun; 100(6):1550-6. PMID: 870306.
      Citations: 3     Fields:    Translation:Animals
    122. Schwartz NB. Regulation of synthesis of chondroitin sulfate proteoglycan. Ups J Med Sci. 1977; 82(2):76-7. PMID: 20078284.
      Citations: 1     Fields:    Translation:AnimalsCells
    123. Schwartz NB, Ho PL, Dorfman A. Effect of beta-xylosides on synthesis of cartilage-specific proteoglycan in chondrocyte cultures. Biochem Biophys Res Commun. 1976 Aug 09; 71(3):851-6. PMID: 134712.
      Citations: 4     Fields:    Translation:AnimalsCells
    124. Schwartz NB. Chondroitin sulfate glycosyltransferases in cultured chondrocytes. Turnover, oscillatory change during growth, and suppression by 5-bromodeoxyuridine. J Biol Chem. 1976 Jun 10; 251(11):3346-51. PMID: 945267.
      Citations: 4     Fields:    Translation:AnimalsCells
    125. Schwartz NB. Biosynthesis of chondroitin sulfate. Role of phospholipids in the activity of UDP-D-galactose: D-xylose galactosyltransferase. J Biol Chem. 1976 Jan 25; 251(2):285-91. PMID: 942716.
      Citations: 4     Fields:    Translation:Animals
    126. Schwartz NB, Dorfman A. Purification of rat chondrosarcoma xylosyltransferase. Arch Biochem Biophys. 1975 Nov; 171(1):136-44. PMID: 811171.
      Citations: 5     Fields:    Translation:AnimalsCells
    127. Stoolmiller AC, Schwartz NB, Dorfman A. Biosynthesis of chondroitin 4-sulfate-proteoglycan by a transplantable rat chondrosarcoma. Arch Biochem Biophys. 1975 Nov; 171(1):124-35. PMID: 242267.
      Citations: 2     Fields:    Translation:Animals
    128. Galligani L, Hopwood J, Schwartz NB, Dorfman A. Stimulation of synthesis of free chondroitin sulfate chains by beta-D-xylosides in cultured cells. J Biol Chem. 1975 Jul 25; 250(14):5400-6. PMID: 167013.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    129. Schwartz NB, Rodén L. Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltrans. J Biol Chem. 1975 Jul 10; 250(13):5200-7. PMID: 1150655.
      Citations: 14     Fields:    Translation:Animals
    130. Schwartz NB. Biosynthesis of chondroitin sulfate: immunoprecipitation of interacting xylosyltransferase and galactosyltransferase. FEBS Lett. 1975 Jan 01; 49(3):342-5. PMID: 1167359.
      Citations: 9     Fields:    Translation:Animals
    131. Schwartz NB, Dorfman A. Stimulation of chondroitin sulfate proteoglycan production by chondrocytes in monolayer. Connect Tissue Res. 1975; 3(2):115-22. PMID: 126838.
      Citations: 9     Fields:    Translation:Animals
    132. Schwartz NB, Rodén L. Biosynthesis of chondroitin sulfate. Purification of UDP-D-xylose:core protein beta-D-xylosyltransferase by affinity chromatography. Carbohydr Res. 1974 Oct; 37(1):167-80. PMID: 4214614.
      Citations: 8     Fields:    Translation:AnimalsCells
    133. Schwartz NB, Galligani L, Ho PL, Dorfman A. Stimulation of synthesis of free chondroitin sulfate chains by beta-D-xylosides in cultured cells. Proc Natl Acad Sci U S A. 1974 Oct; 71(10):4047-51. PMID: 4372604; PMCID: PMC434325.
      Citations: 39     Fields:    Translation:AnimalsCells
    134. Schwartz NB, Abram D, Feingold DS. L-Rhamnulose 1-phosphate aldolase of Escherichia coli. The role of metal in enzyme structure. Biochemistry. 1974 Apr 09; 13(8):1726-30. PMID: 4208690.
      Citations: 5     Fields:    Translation:AnimalsCells
    135. Schwartz NB, Dorfman A, Rodén L. Biosynthesis of chondroitin sulfate: interaction between xylosyltransferase and galactosyltransferase. Biochem Biophys Res Commun. 1974 Feb 04; 56(3):717-24. PMID: 4857056.
      Citations: 15     Fields:    Translation:AnimalsCells
    136. . Matrix Biology: Gradients and patterns within the extracellular matrix. In "Mimicking the Extracellular Matrix: The Intersection of Matrix Biology and Biomaterials" Royal Society of Chemistry Publishing. (Chapter 2; pp 31-64).
    137. . Chapter 03764: Chondrodysplasias, 2018 in Reference Module in Biomedical Sciences, Ed. M.Kaplan, Elsevier Ltd., Oxford, UK.
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