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Robert Josephs

TitlePROFESSOR
InstitutionUniversity of Chicago
DepartmentMol Gen/Cell Bio
AddressChicago IL 60637
Email
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    Collapse Biography 
    Collapse education and training
    University of Illinois, Urbana, ILB.S6/1959Physical Chemistry
    Hebrew University, Jerusalem, IsraelM.S.6/1962Biophysical Chemistry
    Johns Hopkins University, Baltimore, MDPh.D.6/1966Biology
    Johns Hopkins University, Baltimore MDResearch Assoc.12/1967Biophysical Chemistry
    Medical Research Council, Cambridge, UKResearch Associate7/1970Structural Biology
    Weizmann Institute, Rehovot, IsraelResearch Associate11/1971Structural Biology
    Collapse awards and honors
    1963 - 1966NIH Predoctoral Fellow, Johns Hopkins University
    1966 - 1968National Cystic Fibrosis Foundation Basic Science Fellow, Johns Hopkins University
    1968 - 1970Helen Hay Whitney Foundation Postdoctoral Fellow, Medical Research Council,Cambridge, UK
    1970 - 1971Helen Hay Whitney Foundation Postdoctoral Fellow, Weizmann Institute, Rehovot, Israel
    1978 - 1983NIH Research Career Development Award,, University of Chicago

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. R. Josephs and J. Feitelson. Interactions of Polyelectrolytes: A Turbidmetric Method for the Estimation of Ionized Polymers. J. Pol. Sci. Part A-1, 3385-3394 (1963).
    2. J. Feitelson and R. Josephs. Interaction Between Polyelectrolytes: DEAE-Sephadex- polymethacrylic acid. Biopolymers 1, 331-342 (1963). .
    3. D.A. Bluemke, B. Carragher, R. Josephs and M.J. Potel. Real Space Reconstructions of Non-ideal Helical Particles. J. Elec. Micro. Technique 5, 141-151 (1987).
    4. B. Carragher, D. Bluemke, B. Gabriel, M. Potel and R. Josephs. Structural Analysis of Sickle Cell Hemoglobin Polymers. I. Sickle Hemoglobin Fibers. J. Mol. Biol. 199, 315-332 (1988). .
    5. D. Bluemke, B. Carragher, M. Potel and R. Josephs. Structural Analysis of Sickle Cell Hemoglobin Polymers. II. Sickle Hemoglobin Macrofibers. J. Mol. Biol. 199, 333-350 (1988). .
    6. B. Carragher, D. Bluemke, M. Becker, W. McDade, M.J. Potel and R. Josephs. Structural Analysis of Sickle Cell Hemoglobin Polymers. III.The Structure of Sickle Hemoglobin Fibers within Fascicles. J. Mol. Biol. 199, 383-388 (1988).
    7. D. Bluemke, B. Carragher, I. Geis, M. Potel and R. Josephs. Electron Density Modeling of Polymers of Sickle Hemoglobin. EMSA Bulletin. 54-63 (1987).
    8. D. Bluemke, B. Carragher and R. Josephs. Reconstruction of Helical Particles with Variable Pitch. Ultramicroscopy 26, 255-270 (1988).
    9. R. Josephs. Blood Cells 13, 373-374. A Commentary (1988). .
    10. S.J. Watowich, E.S. Meyer, R. Hagstrom and R. Josephs. A Stable Rapidly Converging Conjugate Gradient Method for Energy Minimization. J. Comp. Chem. 9, 650-661 (1988). .
    11. W.A. McDade, B. Carragher, C.A. Miller and R. Josephs. On the Assembly of Sickle Hemoglobin Fascicles. J. Mol. Biol.. 206, 637-649 (1989) .
    12. S. J. Watowich, L. Gross, and R. Josephs. Intermolecular Contacts within Sickle Hemoglobin Fibers. J. Mol. Biol. 209, 821-828 (1989).
    13. R. W. Briehl, E. S. Mann, and R. Josephs. Length Distributions of Hemoglobin S Fibers. J. Mol. Biol. 211, 693-698 (1990).
    14. A. McGough, and R. Josephs. On the Structure of Erythrocyte Spectrin in Partially Expanded Membrane Skeletons. PNAS 87, 5208-5212 (1990).
    15. Stanley J. Watowich, Leon J. Gross, and Robert Josephs. Intermolecular Contacts within Sickle Hemoglobin Fibers. SPIE Proceedings. 1396, 316 323 (1991).
    16. M. R. Lewis, L. J. Gross, and R. Josephs. Variable Pitch in Frozen Hydrated Sickle Hemoglobin Fibers: An Image Analysis Model Study. Ultramicroscopy, 56, 303-317 (1994). .
    17. Leon J. Gross, Stanley J. Watowich, and Robert Josephs. Contacts Stabilizing Sickle Hemoglobin Fibers An Analysis of Competing Models:A Rebuttal. J Structural Biology 111,172-179 (1993). .
    18. Barbara Gabriel and Robert Josephs. On the Stability of Sickle Hemoglobin Macrofibers: Isolated Layers of Antiparallel Double Strands. J. Structural Biology . 110, 122-126 (1993). .
    19. William A. McDade and Robert Josephs. On the Formation and Crystallization of Sickle Hemoglobin Macrofibers. J. Structural Biology 110, 90 - 97 (1993).
    20. Michael R. Lewis, Leon J. Gross, and Robert Josephs. Cryo-Electron Microscopy of Deoxy-Sickle Hemoglobin Fibers. Microscopy Research and Technique . 27, 459 - 467 (1994). .
    21. M. Potel, T.E. Wellems, B. Deer, R. Vassar and R. Josephs. Macrofiber Structure and the Dynamics of Sickle Hemoglobin Crystallization. J Mol. Biol. 177, 819-839 (1984). .
    22. B. Shen, R. Josephs and T. Steck. Ultrastructure of Unit Fragments of the Human Erythrocyte Membrane. J. Cell Biol. 99, 810-821 (1984).
    23. B. Shen, R. Josephs and T. Steck. Ultrastructure of the Intact Skeleton of the Human Erythrocyte Membrane. J. Cell Biol. 102, 997-1006 (1986). .
    24. B. Carragher, D.A. Bluemke, M.J. Potel and R. Josephs. The Restoration of Electron Micrographs Obscured by Drift and Rotation. Proteins: Structure, Function and Genetics 1, 176-187 (1986). .
    25. M. L. Lewis, T. E. Lee and Robert Josephs. The Hand of the Helix of Sickle Hemoglobin Fibers. J. Structural Biology 107 196 - 199 (1991).
    26. Stanley J. Watowich, Leon J. Gross and Robert Josephs Analysis of the Intermolecular Contacts within Sickle Hemoglobin Fibers: Effect of Site-Specific Substitutions, Fiber Pitch and Double Strand Disorder. J Structural Biology 111,161-171 (1993).
    27. E. Reisler, M. Burke, R. Josephs and W.F. Harrington. Crosslinking of Myosin and Myosin Filaments. J. Mechanochem. and Cell Motility 2, 163-179 (1973).
    28. R. Josephs. An Analysis of Mechanism of Crystallization of Glutamic Dehydrogenase. J. Mol. Biol. 97, 127-130 (1975). .
    29. A. Amsterdam, R. Josephs, M.E. Lieberman and H. Lindner. A Freeze Fracture Study of Granulosa Cells and the Organization of Intercellular Junctional Elements on the Preovulatory Follicle of the Rat. J. Cell Sci. 21, 93-105 (1976).
    30. R. Josephs, H. Jarosch and S.J. Edelstein. Polymorphism of Sickle Cell Hemoglobin Fibers. J. Mol. Biol. 102, 409-426 (1976).
    31. R. Smith, U. Aebi, R. Josephs and M. Kessel. The Three-dimensional Structure of T4 Bacteriophage Tail. J. Mol. Biol. 106, 243-271 (1976). .
    32. H. Schmitt, R. Josephs and E. Reisler. Regulation of Microtubule Assembly: A Search for in vivo Factors. Nature 265, 653-655 (1977).
    33. Moshe Bar-Josef, R. Josephs, and J. Cohen. Carnation Yellow Fleck Virus in vivo: A Structural Analysis. Virology 81, 144-151 (1977). .
    34. R. Josephs and W.F. Harrington. Studies on the Formation and Physical Chemical Properties of Synthetic Myosin Filaments. Biochemistry 5, 3477-3487 (1966).
    35. R. Josephs, H. Eisenberg and E. Reisler. Some Properties of Cross-linked Polymers of Glutamic Dehydrogenase. Biochemistry 12, 4060-4067 (1973). .
    36. R. Josephs and G. Borisy. Self-assembly of Glutamic Dehydrogenase into Ordered Superstructures: Multichain Tubes Formed by Association of Single Molecules. J. Mol. Biol. 65, 127-155 (1972). .
    37. T. Wellems and R. Josephs. Crystallization of Sickle Cell Hemoglobin by Fiber Alignment and Fusion. J. Mol. Biol. 135, 651 (1979).
    38. T. Wellems and R. Josephs. Helical Crystals of Sickle Cell Hemoglobin. J. Mol. Biol. 137, 443 (1980). .
    39. T. Wellems, R. Vassar and R. Josephs. Polymorphic Assemblies of Double Strands of Sickle Cell Hemoglobin: Manifold Pathways of Deoxyhemoglobin S Crystallization. J. Mol. Biol. 153, 1011-1026 (1981). .
    40. R. Vassar, M. Potel and R. Josephs. Studies on the Fiber-to-Crystal Transition of Sickle Cell Hemoglobin in Polyethylene Glycol. J. Mol. Biol. 157, 395-412.(1982).
    41. Gunjan Agarwal , Jiang Cheng Wang , Suzanna Kwong , Scott Cohen , Frank A. Ferrone ,Robert Josephs & Robin W. Briehl. Sickle Hemoglobin Fibers: Mechanisms of Depolymerization J Mol. Biol. 322 395 - 412 (2002). .
    42. Jiang C. Wang, Matthew S. Turner, Gunjan Agarwal, Suzanna Kwong, Robert Josephs, Frank A. Ferrone and Robin W. Briehl. Micromechanics of Isolated Sickle Cell Hemoglobin Fibers: Bending Moduli and Persistence Lengths. J. Mol. Biol. 315 601 - 612 (2002). .
    43. Xianfeng Li, Robin W. Briehl, Robert M. Bookchin, Robert Josephs, Baoyang Wei James M. Manning, and Frank A. Ferrone. Sickle Hemoglobin Polymer Stability Probed by Triple and Quadruple Mutant Hybrids. J. Biol. Chem. 277 13479-13487 (2002). .
    44. Maria Ivanova, Ravi Jasuja, Lada Krasnosselskaia, Robert Josephs, Zhiping Wang, Min Ding, Kazumi Horiuchi, Kazuhiko Adachi, and Frank A. Ferrone. Flexibility and Nucleation in Sickle Hemoglobin. J Mol. Biol. 314,851-861 (2001).
    45. Wang, Z., Kishchenko, G., Chen, Y., and R. Josephs. Polymerization of Deoxy-Sickle Hemoglobin in High Phosphate Buffer. J. Structural Biology 131, 197 - 209 (2000).
    46. R. H. Fairclough, G. M. Twaddle, E. Gudipati, R. S. Stone, D. Richman, D. Burkwall and R. Josephs. Mapping the mAb 383C Epitope to a2(187-199) of the Torpedo Acetylcholine Receptor on the Three Dimensional Model. J. Mol. Biol. 282 301 - 315 (1998). .
    47. R. M. Bookchin, T. Balazs, Z. Wang, R. Josephs, and V. Lew. Polymer Structure and Solubility of Deoxyhemoglobin S in the Presence of High Concentrations of Volume Excluding 70-kDa Dextran. J. Biol. Chem. 274 6689-6697 ( 1999). .
    48. A. Joachimiak, Quaite-Randall, E, Tollaksen, S., Mai, X., Adams, M. W. W., Josephs, R. and Giometti, C. Purification of Chaperonins from Thermophilic Bacteria and Archaea. Journal of Chromatography A. 773 131 - 138 (1997).
    49. Quaite-Randall, E. , J. Trent, R. Josephs and A. Joachimiak. Conformational Cycle of the Archaeosome, A TCP1-likeChaperonon from Sulfolobus shibatae. J. Biol. Chem. 270 28818 - 28823 (1995). .
    50. Khodadad, J. K. R. Waugh, J. Podalski, R. Josephs, and T. Steck Remodeling the Shape of the Skeleton in the Intact Red Cell. Biophysical J 70 1036 - 1044 (1996).
    51. R. Josephs and W.F. Harrington. An Unusual Pressure Dependence for a Reversibly Associating Protein System: Sedimentation Studies on Myosin. Proc. Natl. Acad. Sci. USA 58, 1587-1594 (1967). .
    52. H. Eisenberg, R. Josephs, E. Reisler and J. Schellman. Scattering Correction to the Absorbance, Wavelength Dependence of the Refractive Index Increment, and the Molecular Weight of the Bovine Liver Dehydrogenase, Oligomer and Subunit. Biopolymers 16, 2773-2783 (1977).
    53. Z. Kam, R. Josephs, H. Eisenberg and B. Gratzer. Structural Study of Spectrin from Human Erythrocyte Membranes. Biochemistry 16, 5563-5572 (1977).
    54. R. Josephs and W.F. Harrington. On the Stability of Myosin Filaments. Biochemistry 7, 2834-2847 (1968). .
    55. R. Josephs and A. Minton. Measurement of the Isothermal Piezooptic Coefficient with the Ultracentrifuge. J. Phys. Chem. 75, 716-718 (1971).
    56. R. Josephs. Electron Microscope Studies on Glutamic Dehydrogenase: Subunit Structure of Individual Molecules and Linear Associates. J. Mol. Biol. 55, 147-153 (1971).
    57. Nooney, R.I., Dhanasekaran, T., Chen, Y., Josephs, R. and Ostafin,) Self-assembled highly ordered spherical mesoporous silica/gold nanocomposites. A.E. Adv. Mater. 14(7), 529-532 (2002). .
    58. Nooney, R., Dhanasekaran, T., Chen, Y., Josephs, R., Ostafin, A., Controlling Mesoporous Silicate Nanoparticle Size with Co-solvent. Chemistry of Materials, 14, 4721-4728 (2002).
    59. M. S. Turner, R. W. Briehl, F.A. Ferrone and R. Josephs.. Twisted protein aggregates and disease; the stability of sickle hemoglobin Fibers. Physical Review Letters 90, 128103(1 - 4) (2003). .
    60. Nooney, R.; Dhanasekaran, T,. Ostafin, A.E,. Chen, Y, and Josephs, R; "Self Assembly of Supermicro- and Meso-porous Silica and Silica/gold Nanoparticles using Double Chained Surfactants." Microporous and Mesoporous Materials 75 183-193 (2004).
    61. M.S. Turner, R.W. Briehl, J.C. Wang,F.A. Ferrone and R. Josephs. Anisotropy in Sickle Hemoglobin Fibers from Variations in Bending and Twist. J. Mol. Biol. 357 1422 - 1427 (2006). .
    62. M.S. Turner, J.C. Wang, C.W. Jones, F.A. Ferrone, R. Josephs and R.W. Briehl. Fluctations in Self Assembled Sickle Cell Hemoglobin Fibers. Langmuir 18 7182 - 7187 (2002).
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