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David M. Frim

TitleProfessor
InstitutionUniversity of Chicago
DepartmentSurgery-Neurosurgery
AddressChicago IL 60637
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    Collapse Biography 
    Collapse education and training
    Boston Children's HospitalFellowship
    Massachusetts General HospitalResidency
    Massachusetts General HospitalInternship
    Harvard Medical SchoolMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Madsen JR, Boyle TP, Neuman MI, Park EH, Tamber MS, Hickey RW, Heuer GG, Zorc JJ, Leonard JR, Leonard JC, Keating R, Chamberlain JM, Frim DM, Zakrzewski P, Klinge P, Merck LH, Piatt J, Bennett JE, Sandberg DI, Boop FA, Hameed MQ. Diagnostic Accuracy of Non-Invasive Thermal Evaluation of Ventriculoperitoneal Shunt Flow in Shunt Malfunction: A Prospective, Multi-Site, Operator-Blinded Study. Neurosurgery. 2020 Oct 15; 87(5):939-948. PMID: 32459841.
      View in: PubMed
    2. Towle VL, Pytel P, Lane F, Plass J, Frim DM, Troyk PR. Postmortem investigation of a human cortical visual prosthesis that was implanted for 36 years. J Neural Eng. 2020 07 24; 17(4):045010. PMID: 32541097.
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    3. Nwotchouang BST, Eppelheimer MS, Ibrahimy A, Houston JR, Biswas D, Labuda R, Bapuraj JR, Allen PA, Frim D, Loth F. Clivus length distinguishes between asymptomatic healthy controls and symptomatic adult women with Chiari malformation type I. Neuroradiology. 2020 Nov; 62(11):1389-1400. PMID: 32418026.
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    4. Polster SP, Dougherty MC, Zeineddine HA, Lyne SB, Smith HL, MacKenzie C, Pytel P, Yang CW, Tonsgard JH, Warnke PC, Frim DM. Dural Ectasia in Neurofibromatosis 1: Case Series, Management, and Review. Neurosurgery. 2020 05 01; 86(5):646-655. PMID: 31350851.
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    5. Coulter IC, Kulkarni AV, Sgouros S, Constantini S. Cranial and ventricular size following shunting or endoscopic third ventriculostomy (ETV) in infants with aqueductal stenosis: further insights from the International Infant Hydrocephalus Study (IIHS). Childs Nerv Syst. 2020 Jul; 36(7):1407-1414. PMID: 31965292.
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    6. Koueik J, Sandoval-Garcia C, Kestle JRW, Rocque BG, Frim DM, Grant GA, Keating RF, Muh CR, Oakes WJ, Pollack IF, Selden NR, Tubbs RS, Tuite GF, Warf B, Rajamanickam V, Broman AT, Haughton V, Rebsamen S, George TM, Iskandar BJ. Outcomes in children undergoing posterior fossa decompression and duraplasty with and without tonsillar reduction for Chiari malformation type I and syringomyelia: a pilot prospective multicenter cohort study. J Neurosurg Pediatr. 2019 Oct 18; 1-9. PMID: 31628281.
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    7. McLone D, Frim D, Penn R, Swisher CN, Heydemann P, Boyer KM, Noble AG, Rabiah PK, Withers S, Wroblewski K, Karrison T, Hutson S, Wheeler K, Cohen W, Lykins J, McLeod R. Outcomes of hydrocephalus secondary to congenital toxoplasmosis. J Neurosurg Pediatr. 2019 Sep 06; 1-8. PMID: 31491752.
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    8. Nwotchouang BST, Eppelheimer MS, Bishop P, Biswas D, Andronowski JM, Bapuraj JR, Frim D, Labuda R, Amini R, Loth F. Three-Dimensional CT Morphometric Image Analysis of the Clivus and Sphenoid Sinus in Chiari Malformation Type I. Ann Biomed Eng. 2019 Nov; 47(11):2284-2295. PMID: 31187348.
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    9. Eppelheimer MS, Biswas D, Braun AM, Houston JR, Allen PA, Bapuraj JR, Labuda R, Loth DM, Frim D, Loth F. Quantification of changes in brain morphology following posterior fossa decompression surgery in women treated for Chiari malformation type 1. Neuroradiology. 2019 Sep; 61(9):1011-1022. PMID: 31119343.
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    10. Lacy M, Parikh S, Costello R, Bolton C, Frim DM. Neurocognitive Functioning in Unoperated Adults with Chiari Malformation Type I. World Neurosurg. 2019 Jun; 126:e641-e645. PMID: 30831298.
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    11. Biswas D, Eppelheimer MS, Houston JR, Ibrahimy A, Bapuraj JR, Labuda R, Allen PA, Frim D, Loth F. Quantification of Cerebellar Crowding in Type I Chiari Malformation. Ann Biomed Eng. 2019 Mar; 47(3):731-743. PMID: 30535814.
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    12. Lacy M, DeDios-Stern S, Fredrickson S, Parikh S, Nader T, Frim DM. Prevalence of Psychiatric Diagnoses in Pediatric Chiari Malformation Type 1. Pediatr Neurosurg. 2018; 53(6):371-378. PMID: 30149388.
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    13. Rocque BG, Agee BS, Thompson EM, Piedra M, Baird LC, Selden NR, Greene S, Deibert CP, Hankinson TC, Lew SM, Iskandar BJ, Bragg TM, Frim D, Grant G, Gupta N, Auguste KI, Nikas DC, Vassilyadi M, Muh CR, Wetjen NM, Lam SK. Complications following pediatric cranioplasty after decompressive craniectomy: a multicenter retrospective study. J Neurosurg Pediatr. 2018 09; 22(3):225-232. PMID: 29882736.
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    14. Polster SP, Dougherty MC, Zeineddine HA, Lee SK, Frim D. A Report of 2 Cases of Brainstem Hemorrhage After Suboccipital Craniectomy for Chiari Decompression. Oper Neurosurg (Hagerstown). 2018 05 01; 14(5):598. PMID: 28973347.
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    15. Sane A, Tangen K, Frim D, Singh MR, Linninger A. Cellular Obstruction Clearance in Proximal Ventricular Catheters Using Low-Voltage Joule Heating. IEEE Trans Biomed Eng. 2018 11; 65(11):2503-2511. PMID: 29993486.
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    16. Lyon SM, Mayampurath A, Song D, Ye J, Januszyk M, Rogers MR, Ralston A, Frim DM, He TC, Reid RR. Whole-Proteome Analysis of Human Craniosynostotic Tissue Suggests a Link between Inflammatory Signaling and Osteoclast Activation in Human Cranial Suture Patency. Plast Reconstr Surg. 2018 02; 141(2):250e-260e. PMID: 29369995.
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    17. Stamates MM, Frim DM, Yang CW, Katzman GL, Ali S. Magnetic resonance imaging in the prone position and the diagnosis of tethered spinal cord. J Neurosurg Pediatr. 2018 01; 21(1):4-10. PMID: 29076793.
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    18. Ralston A, Johnson A, Ziemer G, Frim DM. Transcardiac migration of ventriculoperitoneal shunt requiring open cardiac surgery: case report and review of the literature. Childs Nerv Syst. 2017 Apr; 33(4):703-707. PMID: 28032181.
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    19. Ralston A, Ogden P, Kohrman MH, Frim DM. In situ repair of vagus nerve stimulator lead damage: technical note. J Neurosurg Pediatr. 2016 Dec; 25(6):679-682. PMID: 27611900.
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    20. Trovk PR, Frim D, Roitberg B, Towle VL, Takahashi K, Suh S, Bak M, Bredeson S. Implantation and testing of WFMA stimulators in macaque. Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug; 2016:4499-4502. PMID: 28269277.
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    21. Lacy M, Ellefson SE, DeDios-Stern S, Frim DM. Parent-Reported Executive Dysfunction in Children and Adolescents with Chiari Malformation Type 1. Pediatr Neurosurg. 2016; 51(5):236-43. PMID: 27225878.
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    22. Eissa TL, Tryba AK, Marcuccilli CJ, Ben-Mabrouk F, Smith EH, Lew SM, Goodman RR, McKhann GM, Frim DM, Pesce LL, Kohrman MH, Emerson RG, Schevon CA, van Drongelen W. Multiscale Aspects of Generation of High-Gamma Activity during Seizures in Human Neocortex. eNeuro. 2016 Mar-Apr; 3(2). PMID: 27257623.
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    23. Ginat DT, Reid R, Frim DM. Imaging Assessment of Re-Exploratory Repair of an Occipital Bone Defect-Associated Tectocerebellar Dysraphism via Hybrid Cranioplasty. Pediatr Neurosurg. 2016; 51(3):164-6. PMID: 26978789.
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    24. Awad IA, Hekmatpanah J, Frim D. Obituary: John F. Mullan, MD, 1925-2015: neurosurgery's modern statesman. J Neurosurg. 2016 09; 125(3):771-4. PMID: 26824372.
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    25. Rozenfeld M, Frim DM, Katzman GL, Ginat DT. MRI Findings After Surgery for Chiari Malformation Type I. AJR Am J Roentgenol. 2015 Nov; 205(5):1086-93. PMID: 26496557.
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    26. Hutson SL, Wheeler KM, McLone D, Frim D, Penn R, Swisher CN, Heydemann PT, Boyer KM, Noble AG, Rabiah P, Withers S, Montoya JG, Wroblewski K, Karrison T, Grigg ME, McLeod R. Patterns of Hydrocephalus Caused by Congenital Toxoplasma gondii Infection Associate With Parasite Genetics. Clin Infect Dis. 2015 Dec 15; 61(12):1831-4. PMID: 26405147.
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    27. Ali S, Frim DM. Extradural spinal cavernous malformation presenting with radiculopathy. Spine J. 2016 Feb; 16(2):e29-30. PMID: 26386177.
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    28. Basati S, Tangen K, Hsu Y, Lin H, Frim D, Linninger A. Impedance Changes Indicate Proximal Ventriculoperitoneal Shunt Obstruction In Vitro. IEEE Trans Biomed Eng. 2015 Dec; 62(12):2787-93. PMID: 25014951.
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    29. Butz DR, Seitz IA, Frim DM, Reid RR, Gottlieb LJ. A ten-year review of myelodysplastic defect management and use of a novel closure technique with V-Y crescentic rotation advancement flaps. J Plast Reconstr Aesthet Surg. 2014 Apr; 67(4):533-9. PMID: 24429299.
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    30. Kearns JT, Esposito D, Dooley B, Frim D, Gundeti MS. Urodynamic studies in spinal cord tethering. Childs Nerv Syst. 2013 Sep; 29(9):1589-600. PMID: 24013329.
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    31. Mansour N, deSouza RM, Sikorski C, Kahana M, Frim D. Role of barbiturate coma in the management of focally induced, severe cerebral edema in children. J Neurosurg Pediatr. 2013 Jul; 12(1):37-43. PMID: 23641961.
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    32. Dawson EC, Montgomery CP, Frim D, Koogler T. Is repeat head computed tomography necessary in children admitted with mild head injury and normal neurological exam? Pediatr Neurosurg. 2012; 48(4):221-4. PMID: 23548857.
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    33. Yudkowsky R, Luciano C, Banerjee P, Schwartz A, Alaraj A, Lemole GM, Charbel F, Smith K, Rizzi S, Byrne R, Bendok B, Frim D. Practice on an augmented reality/haptic simulator and library of virtual brains improves residents' ability to perform a ventriculostomy. Simul Healthc. 2013 Feb; 8(1):25-31. PMID: 23117306.
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    34. Dangle PP, Razmaria AA, Towle VL, Frim DM, Gundeti MS. Is pelvic plexus nerve documentation feasible during robotic assisted laparoscopic ureteral reimplantation with extravesical approach? J Pediatr Urol. 2013 Aug; 9(4):442-7. PMID: 23218755.
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    35. Lacy M, Baldassarre M, Nader T, Frim D. Parent ratings of executive functioning in children with shunted hydrocephalus. Pediatr Neurosurg. 2012; 48(2):73-9. PMID: 23037887.
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    36. Hekman KE, Aliaga L, Straus D, Luther A, Chen J, Sampat A, Frim D. Positive and negative predictors for good outcome after decompressive surgery for Chiari malformation type 1 as scored on the Chicago Chiari Outcome Scale. Neurol Res. 2012 Sep; 34(7):694-700. PMID: 22781921.
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    37. Aliaga L, Hekman KE, Yassari R, Straus D, Luther G, Chen J, Sampat A, Frim D. A novel scoring system for assessing Chiari malformation type I treatment outcomes. Neurosurgery. 2012 Mar; 70(3):656-64; discussion 664-5. PMID: 21849925.
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    38. Anitescu M, DaSilva AN, Frim DM. Intrapleural migration of a spinal catheter in a patient with arachnoiditis and extensive epidural scarring after tethered cord release: a case report and review of literature. Neuromodulation. 2012 May-Jun; 15(3):200-3; discussion 203. PMID: 22329419.
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    39. Gullo R, Zoccali M, Frim DM, Skelly C, Fichera A. A large pelvic mass in a 39-year-old man. Updates Surg. 2011 Dec; 63(4):293-6. PMID: 21461748.
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    40. deSouza RM, Zador Z, Frim DM. Chiari malformation type I: related conditions. Neurol Res. 2011 Apr; 33(3):278-84. PMID: 21513648.
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    41. Othman A, Frim DM, Polak P, Vujicic S, Arnason BG, Boullerne AI. Olig1 is expressed in human oligodendrocytes during maturation and regeneration. Glia. 2011 Jun; 59(6):914-26. PMID: 21446039.
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    42. Tao JX, Chen XJ, Baldwin M, Yung I, Rose S, Frim D, Hawes-Ebersole S, Ebersole JS. Interictal regional delta slowing is an EEG marker of epileptic network in temporal lobe epilepsy. Epilepsia. 2011 Mar; 52(3):467-76. PMID: 21204828.
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    43. Martell A, Dwyer J, Koch H, Zanella S, Kohrman M, Frim D, Ramirez JM, van Drongelen W. N-methyl-D-aspartate-induced oscillatory properties in neocortical pyramidal neurons from patients with epilepsy. J Clin Neurophysiol. 2010 Dec; 27(6):398-405. PMID: 21076319.
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    44. Theyel BB, Kohrman MH, Frim DM, van Drongelen W. Network variability across human tissue samples in vitro: the problem and a solution. J Clin Neurophysiol. 2010 Dec; 27(6):412-7. PMID: 21076332.
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    45. Marcuccilli CJ, Tryba AK, van Drongelen W, Koch H, Viemari JC, Peña-Ortega F, Doren EL, Pytel P, Chevalier M, Mrejeru A, Kohrman MH, Lasky RE, Lew SM, Frim DM, Ramirez JM. Neuronal bursting properties in focal and parafocal regions in pediatric neocortical epilepsy stratified by histology. J Clin Neurophysiol. 2010 Dec; 27(6):387-97. PMID: 21076335.
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    46. Holleman J, Johnson A, Frim DM. The impact of a 'resident replacement' nurse practitioner on an Academic Pediatric Neurosurgical service. Pediatr Neurosurg. 2010; 46(3):177-81. PMID: 20962549.
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    47. Gluncic V, Turner M, Burrowes D, Frim D. Concurrent Chiari decompression and spinal cord untethering in children: feasibility in a small case series. Acta Neurochir (Wien). 2011 Jan; 153(1):109-14; discussion 114. PMID: 20886245.
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    48. Gluncic V, Turner M, Kranzler L, Frim D. Timely recognition of traumatic atlanto-occipital dislocation in a child based on occipital condyle-C1 interval analysis: excellent neurological recovery. J Neurosurg Pediatr. 2010 May; 5(5):465-9. PMID: 20433259.
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    49. Straus D, Foster K, Zimmerman F, Frim D. Chiari drop attacks: surgical decompression and the role of tilt table testing. Pediatr Neurosurg. 2009; 45(5):384-9. PMID: 19940537.
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    50. Lacy M, Pyykkonen BA, Hunter SJ, Do T, Oliveira M, Austria E, Mottlow D, Larson E, Frim D. Intellectual functioning in children with early shunted posthemorrhagic hydrocephalus. Pediatr Neurosurg. 2008; 44(5):376-81. PMID: 18703883.
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    51. Towle VL, Yoon HA, Castelle M, Edgar JC, Biassou NM, Frim DM, Spire JP, Kohrman MH. ECoG gamma activity during a language task: differentiating expressive and receptive speech areas. Brain. 2008 Aug; 131(Pt 8):2013-27. PMID: 18669510.
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    52. Foster KA, Frim DM, McKinnon M. Recurrence of synostosis following surgical repair of craniosynostosis. Plast Reconstr Surg. 2008 Mar; 121(3):70e-76e. PMID: 18317088.
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    53. Bhayani MK, MacCracken E, Frim D, Baroody FM. Prolonged cricopharyngeal muscle spasm after resection of the cervical vagus nerve in a 15-year-old. Pediatr Neurosurg. 2008; 44(1):71-4. PMID: 18097197.
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    54. Williams MA, McAllister JP, Walker ML, Kranz DA, Bergsneider M, Del Bigio MR, Fleming L, Frim DM, Gwinn K, Kestle JR, Luciano MG, Madsen JR, Oster-Granite ML, Spinella G. Priorities for hydrocephalus research: report from a National Institutes of Health-sponsored workshop. J Neurosurg. 2007 Nov; 107(5 Suppl):345-57. PMID: 18459897.
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    55. Ferguson SD, Michael N, Frim DM. Observations regarding failure of cerebrospinal fluid shunts early after implantation. Neurosurg Focus. 2007 Apr 15; 22(4):E7. PMID: 17613196.
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    56. Lee HC, van Drongelen W, McGee AB, Frim DM, Kohrman MH. Comparison of seizure detection algorithms in continuously monitored pediatric patients. J Clin Neurophysiol. 2007 Apr; 24(2):137-46. PMID: 17414969.
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    57. Towle VL, Hunter JD, Edgar JC, Chkhenkeli SA, Castelle MC, Frim DM, Kohrman M, Hecox KE. Frequency domain analysis of human subdural recordings. J Clin Neurophysiol. 2007 Apr; 24(2):205-13. PMID: 17414977.
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    58. Kushen MC, Frim D. Placement of subdural electrode grids for seizure focus localization in patients with a large arachnoid cyst. Technical note. Neurosurg Focus. 2007 Feb 15; 22(2):E5. PMID: 17608348.
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    59. Sikorski CW, Rosen DS, Frim DM. Adjustable shunt valve reprogramming at home: safety and feasibility. Neurosurgery. 2007 Feb; 60(2):333-6; discussion 336-7. PMID: 17290184.
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    60. Lai Y, van Drongelen W, Hecox K, Frim D, Kohrman M, He B. Cortical activation mapping of epileptiform activity derived from interictal ECoG spikes. Epilepsia. 2007 Feb; 48(2):305-14. PMID: 17295624.
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    61. Sikorski CW, Iteld L, McKinnon M, Yamini B, Frim DM. Correction of sagittal craniosynostosis using a novel parietal bone fixation technique: results over a 10-year period. Pediatr Neurosurg. 2007; 43(1):19-24. PMID: 17190983.
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    62. Cadichon SB, Le Hoang M, Wright DA, Curry DJ, Kang U, Frim DM. Neuroprotective effect of the surfactant poloxamer 188 in a model of intracranial hemorrhage in rats. J Neurosurg. 2007 Jan; 106(1 Suppl):36-40. PMID: 17233310.
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    63. Frim DM, Hecox K, Kohrman M, Marcucilli C, Turner M. Is Multifocal Seizure Resection in Children Reasonable? 863. Neurosurgery. 2006 Aug 01; 59(2):475. PMID: 28180681.
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    64. Lacy M, Pyykkonen B, Mottlow D, Do T, Hunter S, Frim DM. Shunting versus Endoscopic Third Ventriculostomy: Long-term Cognitive Outcome 871. Neurosurgery. 2006 Aug 01; 59(2):477-478. PMID: 28180714.
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    65. Foster KA, McKinnon M, Frim DM. Recurrence of Synostosis after Surgical Repair of Craniosynostosis 876. Neurosurgery. 2006 Aug 01; 59(2):479. PMID: 28180736.
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    66. Chkhenkeli SA, Towle VL, Lortkipanidze GS, Spire JP, Bregvadze ESh, Hunter JD, Kohrman M, Frim DM. Mutually suppressive interrelations of symmetric epileptic foci in bitemporal epilepsy and their inhibitory stimulation. Clin Neurol Neurosurg. 2007 Jan; 109(1):7-22. PMID: 16707211.
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    67. Zhang Y, Ding L, van Drongelen W, Hecox K, Frim DM, He B. A cortical potential imaging study from simultaneous extra- and intracranial electrical recordings by means of the finite element method. Neuroimage. 2006 Jul 15; 31(4):1513-24. PMID: 16631381.
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    68. Fagan LH, Ferguson S, Yassari R, Frim DM. The Chiari pseudotumor cerebri syndrome: symptom recurrence after decompressive surgery for Chiari malformation type I. Pediatr Neurosurg. 2006; 42(1):14-9. PMID: 16357496.
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    69. Musleh W, Yassari R, Hecox K, Kohrman M, Chico M, Frim D. Low incidence of subdural grid-related complications in prolonged pediatric EEG monitoring. Pediatr Neurosurg. 2006; 42(5):284-7. PMID: 16902339.
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    70. Frim DM, Do T, Mottlow D, Hunter S, Lacy M. Neurocognitive Performance after Shunting for Hydrocephalus: Effects of Shunt Valve Type. Neurosurgery. 2005 Aug 01; 57(2):436. PMID: 28184837.
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    71. Lai Y, van Drongelen W, Ding L, Hecox KE, Towle VL, Frim DM, He B. Estimation of in vivo human brain-to-skull conductivity ratio from simultaneous extra- and intra-cranial electrical potential recordings. Clin Neurophysiol. 2005 Feb; 116(2):456-65. PMID: 15661122.
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    72. Khorasani L, Sikorski CW, Frim DM. Lumbar CSF shunting preferentially drains the cerebral subarachnoid over the ventricular spaces: implications for the treatment of slit ventricle syndrome. Pediatr Neurosurg. 2004 Nov-Dec; 40(6):270-6. PMID: 15821357.
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    73. Lee MC, Yamini B, Frim DM. Pseudotumor cerebri patients with shunts from the cisterna magna: clinical course and telemetric intracranial pressure data. Neurosurgery. 2004 Nov; 55(5):1094-9. PMID: 15509316.
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    74. Curry DJ, Wright DA, Lee RC, Kang UJ, Frim DM. Poloxamer 188 volumetrically decreases neuronal loss in the rat in a time-dependent manner. Neurosurgery. 2004 Oct; 55(4):943-8; discussion 948-9. PMID: 15458603.
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    75. Curry DJ, Wright DA, Lee RC, Kang UJ, Frim DM. Surfactant poloxamer 188-related decreases in inflammation and tissue damage after experimental brain injury in rats. J Neurosurg. 2004 Aug; 101(1 Suppl):91-6. PMID: 16206978.
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    76. Yamini B, Refai D, Rubin CM, Frim DM. Initial endoscopic management of pineal region tumors and associated hydrocephalus: clinical series and literature review. J Neurosurg. 2004 May; 100(5 Suppl Pediatrics):437-41. PMID: 15287451.
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    77. Yassari R, Frim D. Evaluation and management of the Chiari malformation type 1 for the primary care pediatrician. Pediatr Clin North Am. 2004 Apr; 51(2):477-90. PMID: 15062680.
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    78. Sikorski CW, Yamini B, Frim DM. Endoscopic cyst fenestration outcomes in children one year of age or less. Pediatr Neurosurg. 2004 Mar-Apr; 40(2):59-63. PMID: 15292634.
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    79. Frim DM, Wright DA, Curry DJ, Cromie W, Lee R, Kang UJ. The surfactant poloxamer-188 protects against glutamate toxicity in the rat brain. Neuroreport. 2004 Jan 19; 15(1):171-4. PMID: 15106852.
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    80. Zhang X, van Drongelen W, Hecox KE, Towle VL, Frim DM, McGee AB, He B. High-resolution EEG: cortical potential imaging of interictal spikes. Clin Neurophysiol. 2003 Oct; 114(10):1963-73. PMID: 14499758.
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    81. van Drongelen W, Nayak S, Frim DM, Kohrman MH, Towle VL, Lee HC, McGee AB, Chico MS, Hecox KE. Seizure anticipation in pediatric epilepsy: use of Kolmogorov entropy. Pediatr Neurol. 2003 Sep; 29(3):207-13. PMID: 14629902.
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    82. Macdonald RL, Amidei C, Baron J, Weir B, Brown F, Erickson RK, Hekmatpanah J, Frim D. Randomized, pilot study of intermittent pneumatic compression devices plus dalteparin versus intermittent pneumatic compression devices plus heparin for prevention of venous thromboembolism in patients undergoing craniotomy. Surg Neurol. 2003 May; 59(5):363-72; discussion 372-4. PMID: 12765806.
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    83. Lee MC, Frank JI, Kahana M, Tonsgard JH, Frim DM. Decompressive hemicraniectomy in a 6-year-old male after unilateral hemispheric stroke. Case report and review. Pediatr Neurosurg. 2003 Apr; 38(4):181-5. PMID: 12646736.
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    84. Rosen DS, Wollman R, Frim DM. Recurrence of symptoms after Chiari decompression and duraplasty with nonautologous graft material. Pediatr Neurosurg. 2003 Apr; 38(4):186-90. PMID: 12646737.
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    85. Curry DJ, Wright DA, Lee RC, Kang UJ, Frim DM. Synthes Award for Resident Research in Brain and Craniofacial Injury: poloxamer 188 volumetrically decreases neuron loss in the rat model of excitotoxicity in a time-dependent manner. Clin Neurosurg. 2003; 50:374-81. PMID: 14677453.
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    86. Le H, Yamini B, Frim DM. Lumboperitoneal shunting as a treatment for slit ventricle syndrome. Pediatr Neurosurg. 2002 Apr; 36(4):178-82. PMID: 12006752.
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    87. Jackson CC, Chwals WJ, Frim DM. A single-incision laparoscopic technique for retrieval and replacement of disconnected ventriculoperitoneal shunt tubing found in the peritoneum. Pediatr Neurosurg. 2002 Apr; 36(4):175-7. PMID: 12006751.
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    88. Le H, Chico M, Hecox K, Frim D. Interscapular placement of a vagal nerve stimulator pulse generator for prevention of wound tampering. Technical note. Pediatr Neurosurg. 2002 Mar; 36(3):164-6. PMID: 11919454.
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    89. Piatt JH, Frim D. Glutaric aciduria type 1 and nonaccidental head injury. Pediatrics. 2002 Mar; 109(3):554. PMID: 11875161.
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    90. Le HN, Frim DM. Gene therapy for Parkinson's disease. Expert Opin Biol Ther. 2002 Feb; 2(2):151-61. PMID: 11849115.
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    91. Frim DM, Munshi I, Goumnerova L. Measurements of intraventricular pressure in a patient shunted from the ventricle to the internal jugular vein against the direction of blood flow (the El-Shafei shunt). Childs Nerv Syst. 2001 Jun; 17(7):379-81. PMID: 11465789.
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    92. Frim DM, Lathrop D, Chwals WJ. Intraventricular pressure dynamics in ventriculocholecystic shunting: a telemetric study. Pediatr Neurosurg. 2001 Feb; 34(2):73-6. PMID: 11287806.
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    93. Frim DM, Lathrop D. Telemetric assessment of intracranial pressure changes consequent to manipulations of the Codman-Medos programmable shunt valve. Pediatr Neurosurg. 2000 Nov; 33(5):237-242. PMID: 11155059.
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    94. Papasian NC, Frim DM. A theoretical model of benign external hydrocephalus that predicts a predisposition towards extra-axial hemorrhage after minor head trauma. Pediatr Neurosurg. 2000 Oct; 33(4):188-93. PMID: 11124635.
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    95. Nakamura K, Bindokas VP, Marks JD, Wright DA, Frim DM, Miller RJ, Kang UJ. The selective toxicity of 1-methyl-4-phenylpyridinium to dopaminergic neurons: the role of mitochondrial complex I and reactive oxygen species revisited. Mol Pharmacol. 2000 Aug; 58(2):271-8. PMID: 10908294.
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    96. Frim DM, Goumnerova LC, Lathrop D. 831 Intraventricular Pressure Changes after Third Ventriculo-cisternostomy for Aqueductal Stenosis. Neurosurgery. 2000 Aug 01; 47(2):537-538. PMID: 28201644.
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    97. Munshi I, Frim D, Stine-Reyes R, Weir BK, Hekmatpanah J, Brown F. Effects of posterior fossa decompression with and without duraplasty on Chiari malformation-associated hydromyelia. Neurosurgery. 2000 Jun; 46(6):1384-9; discussion 1389-90. PMID: 10834643.
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    98. Frim DM, Goumnerova LC. In vivo intracranial pressure dynamics in patients with hydrocephalus treated by shunt placement. J Neurosurg. 2000 Jun; 92(6):927-32. PMID: 10839251.
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    99. Nadig M, Munshi I, Short MP, Tonsgard JH, Sullivan C, Frim DM. A child with neurofibromatosis-1 and a lumbar epidural arteriovenous malformation. J Child Neurol. 2000 Apr; 15(4):273-5. PMID: 10805199.
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    100. Curry DJ, Frim DM. Delayed repair of open depressed skull fracture. Pediatr Neurosurg. 1999 Dec; 31(6):294-7. PMID: 10702728.
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    101. Yamini B, Goumnerova LC, Frim DM. Endoscopic approach to noncommunicating fluid spaces in the shunted patient. Pediatr Neurosurg. 1999 Nov; 31(5):237-41. PMID: 10681677.
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    102. Frim DM, Scott RM. Management of cavernous malformations in the pediatric population. Neurosurg Clin N Am. 1999 Jul; 10(3):513-8. PMID: 10419575.
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    103. Citow JS, Munshi I, Chang-Stroman T, Sullivan C, Frim DM. C2/3 instability in a child with Down's syndrome . case report and discussion. Pediatr Neurosurg. 1998 Mar; 28(3):143-6. PMID: 9705592.
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    104. Munshi I, Lathrop D, Madsen JR, Frim DM. Intraventricular pressure dynamics in patients with ventriculopleural shunts: a telemetric study. Pediatr Neurosurg. 1998 Feb; 28(2):67-9. PMID: 9693334.
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    105. Frim DM, Scott RM, Madsen JR. Surgical management of neonatal hydrocephalus. Neurosurg Clin N Am. 1998 Jan; 9(1):105-10. PMID: 9405768.
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    106. Frim DM, Goumnerova LC. Telemetric intraventricular pressure measurements after third ventriculocisternostomy in a patient with noncommunicating hydrocephalus. Neurosurgery. 1997 Dec; 41(6):1425-8; discussion 1428-30. PMID: 9402598.
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    107. Ovsiew F, Frim DM. Neurosurgery for psychiatric disorders. J Neurol Neurosurg Psychiatry. 1997 Dec; 63(6):701-5. PMID: 9416800.
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    108. Park JK, Frim DM, Schwartz MS, Reidy P, Farley JA, Black PM, Scott RM, Goumnerova LC, Madsen JR. The use of clinical practice guidelines (CPGs) to evaluate practice and control costs in ventriculoperitoneal shunt management. Surg Neurol. 1997 Dec; 48(6):536-41. PMID: 9400633.
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    109. Goumnerova LC, Frim DM. Treatment of hydrocephalus with third ventriculocisternostomy: outcome and CSF flow patterns. Pediatr Neurosurg. 1997 Sep; 27(3):149-52. PMID: 9548525.
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    110. Rodgers WB, Frim DM, Emans JB. Surgery of the spine in myelodysplasia. An overview. Clin Orthop Relat Res. 1997 May; (338):19-35. PMID: 9170359.
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    111. Eskandar EN, Weller SJ, Frim DM. Hydrocephalus requiring urgent external ventricular drainage in a patient with diabetic ketoacidosis and cerebral edema: case report. Neurosurgery. 1997 Apr; 40(4):836-8; discussion 838-9. PMID: 9092859.
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    112. Frim DM, Wollman L, Evans AB, Ojemann RG. Acute pulmonary edema after low-level air embolism during craniotomy. Case report. J Neurosurg. 1996 Nov; 85(5):937-40. PMID: 8893735.
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    113. Frim DM, Zec N, Golden J, Scott RM. Immunohistochemically identifiable tissue plasminogen activator in cavernous angioma: mechanism for re-hemorrhage and lesion growth. Pediatr Neurosurg. 1996 Sep; 25(3):137-41; discussion 141-2. PMID: 9144712.
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    114. Galpern WR, Frim DM, Tatter SB, Altar CA, Beal MF, Isacson O. Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP+ rat model of substantia nigra degeneration. Cell Transplant. 1996 Mar-Apr; 5(2):225-32. PMID: 8689033.
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    115. Frim DM, Padwa B, Buckley D, Crowell RM, Ogilvy CS. Mandibular subluxation as an adjunct to exposure of the distal internal carotid artery in endarterectomy surgery. Technical note. J Neurosurg. 1995 Nov; 83(5):926-8. PMID: 7472568.
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    116. Yoshimoto Y, Lin Q, Collier TJ, Frim DM, Breakefield XO, Bohn MC. Astrocytes retrovirally transduced with BDNF elicit behavioral improvement in a rat model of Parkinson's disease. Brain Res. 1995 Sep 11; 691(1-2):25-36. PMID: 8590062.
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    117. Chapman PH, Frim DM. Symptomatic syringomyelia following surgery to treat retethering of lipomyelomeningoceles. J Neurosurg. 1995 May; 82(5):752-5. PMID: 7714598.
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    118. Frim DM, Ogilvy CS. Mutism and cerebellar dysarthria after brain stem surgery: case report. Neurosurgery. 1995 Apr; 36(4):854-7. PMID: 7596521.
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    119. Isacson O, Frim DM, Galpern WR, Tatter SB, Breakefield XO, Schumacher JM. Cell-mediated delivery of neurotrophic factors and neuroprotection in the neostriatum and substantia nigra. Restor Neurol Neurosci. 1995 Jan 01; 8(1):59-61. PMID: 21551807.
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    120. Andersen JK, Frim DM, Isacson O, Beal MF, Breakefield XO. Elevation of neuronal MAO-B activity in a transgenic mouse model does not increase sensitivity to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Brain Res. 1994 Sep 05; 656(1):108-14. PMID: 7804823.
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    121. Frim DM, Wüllner U, Beal MF, Isacson O. Implanted NGF-producing fibroblasts induce catalase and modify ATP levels but do not affect glutamate receptor binding or NMDA receptor expression in the rat striatum. Exp Neurol. 1994 Aug; 128(2):172-80. PMID: 8076661.
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    122. Castillo B, del Cerro M, Breakefield XO, Frim DM, Barnstable CJ, Dean DO, Bohn MC. Retinal ganglion cell survival is promoted by genetically modified astrocytes designed to secrete brain-derived neurotrophic factor (BDNF). Brain Res. 1994 May 30; 647(1):30-6. PMID: 8069702.
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    123. Frim DM, Uhler TA, Galpern WR, Beal MF, Breakefield XO, Isacson O. Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):5104-8. PMID: 8197193.
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    124. Brownell AL, Hantraye P, Wullner U, Hamberg L, Shoup T, Elmaleh DR, Frim DM, Madras BK, Brownell GL, Rosen BR, et al. PET- and MRI-based assessment of glucose utilization, dopamine receptor binding, and hemodynamic changes after lesions to the caudate-putamen in primates. Exp Neurol. 1994 Jan; 125(1):41-51. PMID: 7905836.
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    125. Uhler TA, Frim DM, Pakzaban P, Isacson O. The effects of megadose methylprednisolone and U-78517F on toxicity mediated by glutamate receptors in the rat neostriatum. Neurosurgery. 1994 Jan; 34(1):122-7; discussion 127-8. PMID: 7907169.
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    126. Golden J, Frim DM, Chapman PH, Vonsattel JP. Marked tissue eosinophilia within organizing chronic subdural hematoma membranes. Clin Neuropathol. 1994 Jan-Feb; 13(1):12-6. PMID: 8033456.
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    127. Andersen JK, Frim DM, Isacson O, Breakefield XO. Herpesvirus-mediated gene delivery into the rat brain: specificity and efficiency of the neuron-specific enolase promoter. Cell Mol Neurobiol. 1993 Oct; 13(5):503-15. PMID: 8111822.
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    128. Frim DM, Simpson J, Uhler TA, Short MP, Bossi SR, Breakefield XO, Isacson O. Striatal degeneration induced by mitochondrial blockade is prevented by biologically delivered NGF. J Neurosci Res. 1993 Jul 01; 35(4):452-8. PMID: 8103116.
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    129. Frim DM, Yee WM, Isacson O. NGF reduces striatal excitotoxic neuronal loss without affecting concurrent neuronal stress. Neuroreport. 1993 Jun; 4(6):655-8. PMID: 7688588.
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    130. Frim DM, Uhler TA, Short MP, Ezzedine ZD, Klagsbrun M, Breakefield XO, Isacson O. Effects of biologically delivered NGF, BDNF and bFGF on striatal excitotoxic lesions. Neuroreport. 1993 Apr; 4(4):367-70. PMID: 8098961.
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    131. Frim DM, Short MP, Rosenberg WS, Simpson J, Breakefield XO, Isacson O. Local protective effects of nerve growth factor-secreting fibroblasts against excitotoxic lesions in the rat striatum. J Neurosurg. 1993 Feb; 78(2):267-73. PMID: 8421209.
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    132. Yee WM, Frim DM, Isacson O. Relationships between stress protein induction and NMDA-mediated neuronal death in the entorhinal cortex. Exp Brain Res. 1993; 94(2):193-202. PMID: 8395405.
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    133. Frim DM, Barker FG, Poletti CE, Hamilton AJ. Postoperative low-dose heparin decreases thromboembolic complications in neurosurgical patients. Neurosurgery. 1992 Jun; 30(6):830-2; discussion 832-3. PMID: 1614582.
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    134. Frim DM, Ogilvy CS, Vonsattal JP, Chapman PH. Is intracerebral schwannoma a developmental tumor of children and young adults? Case report and review. Pediatr Neurosurg. 1992; 18(4):190-4. PMID: 1472431.
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    135. Adler GK, Smas CM, Fiandaca M, Frim DM, Majzoub JA. Regulated expression of the human corticotropin releasing hormone gene by cyclic AMP. Mol Cell Endocrinol. 1990 Apr 17; 70(2):165-74. PMID: 2161364.
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    136. Frim DM, Robinson BG, Pasieka KB, Majzoub JA. Differential regulation of corticotropin-releasing hormone mRNA in rat brain. Am J Physiol. 1990 Apr; 258(4 Pt 1):E686-92. PMID: 2333962.
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    137. Frim DM, Jones D, Goumnerova L. Development of symptomatic Chiari malformation in a child with craniofacial dysmorphism. Pediatr Neurosurg. 1990-1991; 16(4-5):228-31. PMID: 2135192.
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    138. Boulos Z, Frim DM, Dewey LK, Moore-Ede MC. Effects of restricted feeding schedules on circadian organization in squirrel monkeys. Physiol Behav. 1989 Mar; 45(3):507-15. PMID: 2756042.
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    139. Robinson BG, Frim DM, Schwartz WJ, Majzoub JA. Vasopressin mRNA in the suprachiasmatic nuclei: daily regulation of polyadenylate tail length. Science. 1988 Jul 15; 241(4863):342-4. PMID: 3388044.
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    140. Robinson BG, Emanuel RL, Frim DM, Majzoub JA. Glucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta. Proc Natl Acad Sci U S A. 1988 Jul; 85(14):5244-8. PMID: 2839838.
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    141. Frim DM, Emanuel RL, Robinson BG, Smas CM, Adler GK, Majzoub JA. Characterization and gestational regulation of corticotropin-releasing hormone messenger RNA in human placenta. J Clin Invest. 1988 Jul; 82(1):287-92. PMID: 3260606.
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    142. Codington JF, Deak MR, Frim DM, Jeanloz RW. Evidence for the presence of an N-acetyllactosamine-type chain in epiglycanin. Arch Biochem Biophys. 1986 Nov 15; 251(1):47-54. PMID: 3789744.
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    143. Apelgren KN, Frim DM, Harling-Berg CJ, Gander PH, Moore-Ede MC. Effectiveness of cyclic intragastric feeding as a circadian zeitgeber in the squirrel monkey. Physiol Behav. 1985 Mar; 34(3):335-40. PMID: 3925471.
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    144. Codington JF, Frim DM. Cell-surface macromolecular and morphological changes related to allotransplantability in the TA3 tumor. Biomembranes. 1983; 11:207-58. PMID: 6338947.
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