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Jason Maclean

TitleProfessor
InstitutionUniversity of Chicago
DepartmentNeurobiology
AddressChicago IL 60637
Email
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    Collapse Overview 
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    The primary focus of our group is to apply a diversity of analytical tools, including network science approaches to corticalcircuit dynamics in order to: 1) establish the higher-order cellular and synaptic mechanisms that propagate spikes, 2) to build improved encoding and decoding models of single-trial circuit activity in behaving mammals, and 3) to compare and contrast sensory and motor areas of neocortex.
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    Collapse Biography 
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    University of Manitoba, Winnipeg CANADAPhDNeurophysiology

    Collapse Research 
    Collapse research activities and funding
    R01NS121772     (MACLEAN, JASON NEIL)Apr 15, 2021 - Mar 31, 2024
    NIH
    The origins of neuronal correlations in cerebral cortex
    Role: Principal Investigator
    UF1NS115821     (MARGOLIASH, DANIEL)May 1, 2020 - Jun 30, 2023
    NIH
    From ion channels to graph theory in sensorimotor learning
    Role: Co-Principal Investigator
    R21NS104862     (HANSEL, CHRISTIAN ROBERT)Jul 1, 2018 - Jun 30, 2020
    NIH
    Intrinsic activation of dormant neurons: role in learning and neural ensemble dynamics
    Role: Co-Principal Investigator
    R01NS104898     (BRUNEL, NICOLAS ;HATSOPOULOS, NICHOLAS G ;MACLEAN, JASON NEIL)Jan 1, 2018 - Dec 31, 2022
    NIH
    Large-scale, neuronal ensemble recordings in motor cortex of the behaving marmoset
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sundiang M, Hatsopoulos NG, MacLean JN. Dynamic structure of motor cortical neuron coactivity carries behaviorally relevant information. Netw Neurosci. 2023; 7(2):661-678. PMID: 37397877; PMCID: PMC10312288.
      Citations:    
    2. Jabri T, MacLean JN. Large-Scale Algorithmic Search Identifies Stiff and Sloppy Dimensions in Synaptic Architectures Consistent With Murine Neocortical Wiring. Neural Comput. 2022 11 08; 34(12):2347-2373. PMID: 36283042; PMCID: PMC9680536.
      Citations: 1     Fields:    Translation:AnimalsCells
    3. Wang YW, Wreden CC, Levy M, Meng JL, Marshall ZD, MacLean J, Heckscher E. Sequential addition of neuronal stem cell temporal cohorts generates a feed-forward circuit in the Drosophila larval nerve cord. Elife. 2022 06 20; 11. PMID: 35723253; PMCID: PMC9333992.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    4. Moore DD, Walker JD, MacLean JN, Hatsopoulos NG. Validating markerless pose estimation with 3D X-ray radiography. J Exp Biol. 2022 05 01; 225(9). PMID: 35466360; PMCID: PMC9163444.
      Citations: 3     Fields:    Translation:Animals
    5. Walker JD, Pirschel F, Sundiang M, Niekrasz M, MacLean JN, Hatsopoulos NG. Chronic wireless neural population recordings with common marmosets. Cell Rep. 2021 07 13; 36(2):109379. PMID: 34260919; PMCID: PMC8513487.
      Citations: 2     Fields:    Translation:AnimalsCells
    6. Bojanek K, Zhu Y, MacLean J. Cyclic transitions between higher order motifs underlie sustained asynchronous spiking in sparse recurrent networks. PLoS Comput Biol. 2020 09; 16(9):e1007409. PMID: 32997658; PMCID: PMC7549833.
      Citations: 5     Fields:    Translation:AnimalsCells
    7. Levy M, Sporns O, MacLean JN. Network Analysis of Murine Cortical Dynamics Implicates Untuned Neurons in Visual Stimulus Coding. Cell Rep. 2020 04 14; 31(2):107483. PMID: 32294431; PMCID: PMC7218481.
      Citations: 6     Fields:    Translation:AnimalsCells
    8. Walker JD, Pirschel F, Gidmark N, MacLean JN, Hatsopoulos NG. A platform for semiautomated voluntary training of common marmosets for behavioral neuroscience. J Neurophysiol. 2020 04 01; 123(4):1420-1426. PMID: 32130092; PMCID: PMC7191516.
      Citations: 9     Fields:    Translation:Animals
    9. Kotekal S, MacLean JN. Recurrent interactions can explain the variance in single trial responses. PLoS Comput Biol. 2020 01; 16(1):e1007591. PMID: 31999693; PMCID: PMC7012453.
      Citations: 4     Fields:    Translation:AnimalsCells
    10. Dechery JB, MacLean JN. Functional triplet motifs underlie accurate predictions of single-trial responses in populations of tuned and untuned V1 neurons. PLoS Comput Biol. 2018 05; 14(5):e1006153. PMID: 29727448; PMCID: PMC5955581.
      Citations: 16     Fields:    Translation:AnimalsCells
    11. Imaizumi K, Ruthazer ES, MacLean JN, Lee CC. Editorial: Spontaneous Activity in Sensory Systems. Front Neural Circuits. 2018; 12:27. PMID: 29651239; PMCID: PMC5885770.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    12. Chambers B, Levy M, Dechery JB, MacLean JN. Ensemble stacking mitigates biases in inference of synaptic connectivity. Netw Neurosci. 2018; 2(1):60-85. PMID: 29911678; PMCID: PMC5989998.
      Citations: 2     
    13. Sederberg AJ, MacLean JN, Palmer SE. Learning to make external sensory stimulus predictions using internal correlations in populations of neurons. Proc Natl Acad Sci U S A. 2018 01 30; 115(5):1105-1110. PMID: 29348208; PMCID: PMC5798322.
      Citations: 12     Fields:    Translation:AnimalsCells
    14. Dechery JB, MacLean JN. Emergent cortical circuit dynamics contain dense, interwoven ensembles of spike sequences. J Neurophysiol. 2017 09 01; 118(3):1914-1925. PMID: 28724786; PMCID: PMC5599669.
      Citations: 3     Fields:    Translation:AnimalsCells
    15. Walker J, MacLean J, Hatsopoulos NG. The marmoset as a model system for studying voluntary motor control. Dev Neurobiol. 2017 03; 77(3):273-285. PMID: 27739220.
      Citations: 18     Fields:    Translation:Animals
    16. Chambers B, MacLean JN. Higher-Order Synaptic Interactions Coordinate Dynamics in Recurrent Networks. PLoS Comput Biol. 2016 08; 12(8):e1005078. PMID: 27542093; PMCID: PMC4991791.
      Citations: 16     Fields:    Translation:AnimalsCells
    17. Frye CG, MacLean JN. Spontaneous activations follow a common developmental course across primary sensory areas in mouse neocortex. J Neurophysiol. 2016 08 01; 116(2):431-7. PMID: 27146981; PMCID: PMC4976123.
      Citations: 5     Fields:    Translation:AnimalsCells
    18. Chambers B, MacLean JN. Multineuronal activity patterns identify selective synaptic connections under realistic experimental constraints. J Neurophysiol. 2015 Sep; 114(3):1837-49. PMID: 26203109; PMCID: PMC4575977.
      Citations: 6     Fields:    Translation:AnimalsCells
    19. Sederberg AJ, Palmer SE, MacLean JN. Decoding thalamic afferent input using microcircuit spiking activity. J Neurophysiol. 2015 Apr 01; 113(7):2921-33. PMID: 25695647; PMCID: PMC4416628.
      Citations: 2     Fields:    Translation:AnimalsCells
    20. Neubauer FB, Sederberg A, MacLean JN. Local changes in neocortical circuit dynamics coincide with the spread of seizures to thalamus in a model of epilepsy. Front Neural Circuits. 2014; 8:101. PMID: 25232306; PMCID: PMC4153318.
      Citations: 5     Fields:    Translation:AnimalsCells
    21. Gururangan SS, Sadovsky AJ, MacLean JN. Analysis of graph invariants in functional neocortical circuitry reveals generalized features common to three areas of sensory cortex. PLoS Comput Biol. 2014 Jul; 10(7):e1003710. PMID: 25010654; PMCID: PMC4091703.
      Citations: 11     Fields:    Translation:AnimalsCells
    22. Sadovsky AJ, MacLean JN. Mouse visual neocortex supports multiple stereotyped patterns of microcircuit activity. J Neurosci. 2014 Jun 04; 34(23):7769-77. PMID: 24899701; PMCID: PMC4044243.
      Citations: 18     Fields:    Translation:AnimalsCells
    23. Runfeldt MJ, Sadovsky AJ, MacLean JN. Acetylcholine functionally reorganizes neocortical microcircuits. J Neurophysiol. 2014 Sep 01; 112(5):1205-16. PMID: 24872527; PMCID: PMC4122727.
      Citations: 24     Fields:    Translation:AnimalsCells
    24. Sadovsky AJ, MacLean JN. Scaling of topologically similar functional modules defines mouse primary auditory and somatosensory microcircuitry. J Neurosci. 2013 Aug 28; 33(35):14048-60, 14060a. PMID: 23986241; PMCID: PMC3756753.
      Citations: 25     Fields:    Translation:AnimalsCells
    25. Piochon C, Kruskal P, Maclean J, Hansel C. Non-Hebbian spike-timing-dependent plasticity in cerebellar circuits. Front Neural Circuits. 2012; 6:124. PMID: 23335888; PMCID: PMC3542521.
      Citations: 16     Fields:    
    26. Kruskal PB, Li L, MacLean JN. Circuit reactivation dynamically regulates synaptic plasticity in neocortex. Nat Commun. 2013; 4:2574. PMID: 24108320.
      Citations: 18     Fields:    Translation:AnimalsCells
    27. Luczak A, Maclean JN. Default activity patterns at the neocortical microcircuit level. Front Integr Neurosci. 2012; 6:30. PMID: 22701405; PMCID: PMC3373160.
      Citations: 37     
    28. Yuste R, MacLean J, Vogelstein J, Paninski L. Imaging action potentials with calcium indicators. Cold Spring Harb Protoc. 2011 Aug 01; 2011(8):985-9. PMID: 21807854.
      Citations: 17     Fields:    Translation:Cells
    29. Sadovsky AJ, Kruskal PB, Kimmel JM, Ostmeyer J, Neubauer FB, MacLean JN. Heuristically optimal path scanning for high-speed multiphoton circuit imaging. J Neurophysiol. 2011 Sep; 106(3):1591-8. PMID: 21715667; PMCID: PMC3174822.
      Citations: 24     Fields:    Translation:AnimalsCells
    30. MacLean JN, Yuste R. Imaging action potentials with calcium indicators. Cold Spring Harb Protoc. 2009 Nov; 2009(11):pdb.prot5316. PMID: 20150055.
      Citations: 13     Fields:    Translation:Animals
    31. Watson BO, MacLean JN, Yuste R. UP states protect ongoing cortical activity from thalamic inputs. PLoS One. 2008; 3(12):e3971. PMID: 19092994; PMCID: PMC2597736.
      Citations: 33     Fields:    Translation:AnimalsCells
    32. Hoffman KL, Battaglia FP, Harris K, MacLean JN, Marshall L, Mehta MR. The upshot of up states in the neocortex: from slow oscillations to memory formation. J Neurosci. 2007 Oct 31; 27(44):11838-41. PMID: 17978020; PMCID: PMC6673366.
      Citations: 29     Fields:    Translation:HumansAnimals
    33. MacLean JN, Fenstermaker V, Watson BO, Yuste R. A visual thalamocortical slice. Nat Methods. 2006 Feb; 3(2):129-34. PMID: 16432523.
      Citations: 28     Fields:    Translation:AnimalsCells
    34. MacLean JN, Watson BO, Aaron GB, Yuste R. Internal dynamics determine the cortical response to thalamic stimulation. Neuron. 2005 Dec 08; 48(5):811-23. PMID: 16337918.
      Citations: 194     Fields:    Translation:AnimalsCells
    35. Cowley KC, Zaporozhets E, Maclean JN, Schmidt BJ. Is NMDA receptor activation essential for the production of locomotor-like activity in the neonatal rat spinal cord? J Neurophysiol. 2005 Dec; 94(6):3805-14. PMID: 16120672.
      Citations: 19     Fields:    Translation:AnimalsCells
    36. MacLean JN, Zhang Y, Goeritz ML, Casey R, Oliva R, Guckenheimer J, Harris-Warrick RM. Activity-independent coregulation of IA and Ih in rhythmically active neurons. J Neurophysiol. 2005 Nov; 94(5):3601-17. PMID: 16049145.
      Citations: 80     Fields:    Translation:AnimalsCells
    37. Yuste R, MacLean JN, Smith J, Lansner A. The cortex as a central pattern generator. Nat Rev Neurosci. 2005 Jun; 6(6):477-83. PMID: 15928717.
      Citations: 101     Fields:    Translation:HumansAnimals
    38. MacLean JN, Zhang Y, Johnson BR, Harris-Warrick RM. Activity-independent homeostasis in rhythmically active neurons. Neuron. 2003 Jan 09; 37(1):109-20. PMID: 12526777.
      Citations: 148     Fields:    Translation:AnimalsCells
    39. Zhang Y, MacLean JN, An WF, Lanning CC, Harris-Warrick RM. KChIP1 and frequenin modify shal-evoked potassium currents in pyloric neurons in the lobster stomatogastric ganglion. J Neurophysiol. 2003 Apr; 89(4):1902-9. PMID: 12612050.
      Citations: 7     Fields:    Translation:AnimalsCells
    40. MacLean JN, Schmidt BJ, MacLean JN, Schmidt BJ. Voltage-sensitivity of motoneuron NMDA receptor channels is modulated by serotonin in the neonatal rat spinal cord. J Neurophysiol. 2001 Sep; 86(3):1131-8. PMID: 11535663.
      Citations: 17     Fields:    Translation:AnimalsCells
    41. Schmidt BJ, Hochman S, MacLean JN. NMDA receptor-mediated oscillatory properties: potential role in rhythm generation in the mammalian spinal cord. Ann N Y Acad Sci. 1998 Nov 16; 860:189-202. PMID: 9928312.
      Citations: 23     Fields:    Translation:AnimalsCells
    42. MacLean JN, Cowley KC, Schmidt BJ. NMDA receptor-mediated oscillatory activity in the neonatal rat spinal cord is serotonin dependent. J Neurophysiol. 1998 May; 79(5):2804-8. PMID: 9582246.
      Citations: 25     Fields:    Translation:AnimalsCells
    43. MacLean JN, Schmidt BJ, Hochman S. NMDA receptor activation triggers voltage oscillations, plateau potentials and bursting in neonatal rat lumbar motoneurons in vitro. Eur J Neurosci. 1997 Dec; 9(12):2702-11. PMID: 9517475.
      Citations: 22     Fields:    Translation:AnimalsCells
    44. MacLean JN, Hochman S, Magnuson DS. Lamina VII neurons are rhythmically active during locomotor-like activity in the neonatal rat spinal cord. Neurosci Lett. 1995 Sep 01; 197(1):9-12. PMID: 8545064.
      Citations: 15     Fields:    Translation:AnimalsCells
    45. Magnuson DS, Schramm MJ, MacLean JN. Long-duration, frequency-dependent motor responses evoked by ventrolateral funiculus stimulation in the neonatal rat spinal cord. Neurosci Lett. 1995 Jun 09; 192(2):97-100. PMID: 7675330.
      Citations: 5     Fields:    Translation:Animals
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