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Hania A. Al-Hallaq

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentRadiation & Cellular Oncology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Dr. Hania Al-Hallaq is an Associate Professor at the University of Chicago in the Department of Radiation & Cellular Oncology. She received her Ph.D. from the University of Chicago Medical Physics program in 1994 after studying the oxygenation status of tumors using BOLD MRI in Greg Karczmar’s laboratory. Hania was also the first resident in Therapeutic Physics at The University of Chicago graduating in 2002.

    After a couple of years as a clinical physicist at a large hospital system in the Chicago suburbs, she returned as faculty in Radiation Oncology at the University of Chicago in 2004. She is currently Associate Director of the Graduate Program in Medical Physics and Director of the Medical Physics Certificate Program. Her research focuses on the use of medical imaging to guide treatment positioning and assess treatment response following radiotherapy. She has developed expertise in both x-ray and 3D surface imaging modalities for breast cancer treatments and is chair of TG-302: Surface image-guided radiotherapy. She has published on the use of CT radiomics to predict which patients might later develop RT-induced pneumonitis.

    Currently, she serves as Physics PI for several national protocols studying the safety and efficacy of SBRT for metastatic disease (NRG-BR001, NRG-BR002, ALLIANCE-A091505). She is an associate physics editor for the International Journal of Radiation Oncology, Biology, Physics.


    Collapse Biography 
    Collapse education and training
    American Board of Radiology, Tuscon, AZ06/2003Therapeutic Physics Certification
    The University of Chicago , Chicago, IL08/2002Therapeutic Physics Residency
    The University of Chicago, Chicago, ILPh.D.08/2000Medical Physics
    Bryn Mawr College, Bryn Mawr, PAA.B.05/1994Physics
    Collapse awards and honors
    2006Kurt Rossmann Award for Excellence in Medical Physics Graduate Teaching, The University of Chicago
    2009Franca Kuchnir Award for Excellence in Physics Residency Teaching, The University of Chicago
    2017NRG Oncology Outstanding Manuscript, NRG Oncology Clinical Trials
    2017Kurt Rossmann Award for Excellence in Medical Physics Graduate Teaching, The University of Chicago

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Al-Hallaq H, Cao M, Kruse J, Klein E. Cured in a FLASH: Reducing Normal Tissue Toxicities Using Ultra-High-Dose Rates. Int J Radiat Oncol Biol Phys. 2019 Jun 01; 104(2):257-260. PMID: 31047621.
      View in: PubMed
    2. Ni L, Koshy M, Connell P, Pitroda S, Golden DW, Al-Hallaq H, Hubert G, Kauffman G, McCall A, Malik R. Heart V5 predicts cardiac events in unresectable lung cancer patients undergoing chemoradiation. J Thorac Dis. 2019 Jun; 11(6):2229-2239. PMID: 31372260.
      View in: PubMed
    3. El Naqa I, Irrer J, Ritter TA, DeMarco J, Al-Hallaq H, Booth J, Kim G, Alkhatib A, Popple R, Perez M, Farrey K, Moran JM. Machine learning for automated quality assurance in radiotherapy: A proof of principle using EPID data description. Med Phys. 2019 Apr; 46(4):1914-1921. PMID: 30734324.
      View in: PubMed
    4. Nie K, Al-Hallaq H, Li XA, Benedict SH, Sohn JW, Moran JM, Fan Y, Huang M, Knopp MV, Michalski JM, Monroe J, Obcemea C, Tsien CI, Solberg T, Wu J, Xia P, Xiao Y, El Naqa I. NCTN Assessment on Current Applications of Radiomics in Oncology. Int J Radiat Oncol Biol Phys. 2019 Jun 01; 104(2):302-315. PMID: 30711529.
      View in: PubMed
    5. Davis AM, Pearson EA, Pan X, Pelizzari CA, Al-Hallaq H. Collision-avoiding imaging trajectories for linac mounted cone-beam CT. J Xray Sci Technol. 2019; 27(1):1-16. PMID: 30400125.
      View in: PubMed
    6. Foy JJ, Robinson KR, Li H, Giger ML, Al-Hallaq H, Armato SG. Variation in algorithm implementation across radiomics software. J Med Imaging (Bellingham). 2018 Oct; 5(4):044505. PMID: 30840747.
      View in: PubMed
    7. Xiao A, Crosby J, Malin M, Kang H, Washington M, Hasan Y, Chmura SJ, Al-Hallaq HA. Single-institution report of setup margins of voluntary deep-inspiration breath-hold (DIBH) whole breast radiotherapy implemented with real-time surface imaging. J Appl Clin Med Phys. 2018 Jul; 19(4):205-213. PMID: 29935001.
      View in: PubMed
    8. Kharouta M, Malin M, Son C, Al-Hallaq H, Hasan Y. Initial experience using superflab as intravaginal packing during interstitial brachytherapy for advanced gynecologic cancer. J Contemp Brachytherapy. 2018 Jun; 10(3):218-224. PMID: 30038641.
      View in: PubMed
    9. Luke JJ, Lemons JM, Karrison TG, Pitroda SP, Melotek JM, Zha Y, Al-Hallaq HA, Arina A, Khodarev NN, Janisch L, Chang P, Patel JD, Fleming GF, Moroney J, Sharma MR, White JR, Ratain MJ, Gajewski TF, Weichselbaum RR, Chmura SJ. Safety and Clinical Activity of Pembrolizumab and Multisite Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors. J Clin Oncol. 2018 06 01; 36(16):1611-1618. PMID: 29437535.
      View in: PubMed
    10. AN Gutierrez, HA Al-Hallaq, DN Stanley. Image Guidance in Radiation Therapy: Techniques, Accuracy, and Limitations edited by P Alaei and G Ding. Surface Image-guided Radiotherapy: Overview and Quality Assurance. 2018; 279-308.
    11. HA Al-Hallaq, AN Gutierrez, L Padilla. Image Guidance in Radiation Therapy: Techniques, Accuracy, and Limitations (edited by P Alaei and G Ding). Surface Image-guided Radiotherapy: Clinical Applications and Motion Management. 2018; 309-345.
    12. Kang H, Padilla L, Hasan Y, Al-Hallaq H. Automated calculation of point A coordinates for CT-based high-dose-rate brachytherapy of cervical cancer. J Contemp Brachytherapy. 2017 Aug; 9(4):354-358. PMID: 28951755.
      View in: PubMed
    13. Anthony GJ, Cunliffe A, Castillo R, Pham N, Guerrero T, Armato SG, Al-Hallaq HA. Incorporation of pre-therapy 18 F-FDG uptake data with CT texture features into a radiomics model for radiation pneumonitis diagnosis. Med Phys. 2017 Jul; 44(7):3686-3694. PMID: 28422299.
      View in: PubMed
    14. Kauffmann G, Wu T, Al-Hallaq H, Hasan Y. Triple-tandem high-dose-rate brachytherapy for early-stage medically inoperable endometrial cancer: Initial report on acute toxicity and dosimetric comparison to stereotactic body radiation therapy. Brachytherapy. 2017 Jan - Feb; 16(1):141-146. PMID: 27866953.
      View in: PubMed
    15. Al-Hallaq HA, Chmura SJ, Salama JK, Lowenstein JR, McNulty S, Galvin JM, Followill DS, Robinson CG, Pisansky TM, Winter KA, White JR, Xiao Y, Matuszak MM. Benchmark Credentialing Results for NRG-BR001: The First National Cancer Institute-Sponsored Trial of Stereotactic Body Radiation Therapy for Multiple Metastases. Int J Radiat Oncol Biol Phys. 2017 01 01; 97(1):155-163. PMID: 27843033.
      View in: PubMed
    16. Feng CH, Hasan Y, Kopec M, Al-Hallaq HA. Simultaneously integrated boost (SIB) spares OAR and reduces treatment time in locally advanced cervical cancer. J Appl Clin Med Phys. 2016 09 08; 17(5):76-89. PMID: 27685108.
      View in: PubMed
    17. Feng CH, Hasan Y, Kopec M, Al-Hallaq HA. Simultaneously integrated boost (SIB) spares OAR and reduces treatment time in locally advanced cervical cancer. J Appl Clin Med Phys. 2016 Sep; 17(5):1-12. PMID: 28297436.
      View in: PubMed
    18. Al-Hallaq HA, Chmura S, Salama JK, Winter KA, Robinson CG, Pisansky TM, Borges V, Lowenstein JR, McNulty S, Galvin JM, Followill DS, Timmerman RD, White JR, Xiao Y, Matuszak MM. Rationale of technical requirements for NRG-BR001: The first NCI-sponsored trial of SBRT for the treatment of multiple metastases. Pract Radiat Oncol. 2016 Nov - Dec; 6(6):e291-e298. PMID: 27345129.
      View in: PubMed
    19. Cunliffe AR, White B, Justusson J, Straus C, Malik R, Al-Hallaq HA, Armato SG. Comparison of Two Deformable Registration Algorithms in the Presence of Radiologic Change Between Serial Lung CT Scans. J Digit Imaging. 2015 Dec; 28(6):755-60. PMID: 25822396.
      View in: PubMed
    20. Eckhause T, Al-Hallaq H, Ritter T, DeMarco J, Farrey K, Pawlicki T, Kim GY, Popple R, Sharma V, Perez M, Park S, Booth JT, Thorwarth R, Moran JM. Automating linear accelerator quality assurance. Med Phys. 2015 Oct; 42(10):6074-83. PMID: 26429282.
      View in: PubMed
    21. Han X, Pearson E, Pelizzari C, Al-Hallaq H, Sidky EY, Bian J, Pan X. Algorithm-enabled exploration of image-quality potential of cone-beam CT in image-guided radiation therapy. Phys Med Biol. 2015 Jun 21; 60(12):4601-33. PMID: 26020490.
      View in: PubMed
    22. Cunliffe A, Armato SG, Castillo R, Pham N, Guerrero T, Al-Hallaq HA. Lung texture in serial thoracic computed tomography scans: correlation of radiomics-based features with radiation therapy dose and radiation pneumonitis development. Int J Radiat Oncol Biol Phys. 2015 Apr 01; 91(5):1048-56. PMID: 25670540.
      View in: PubMed
    23. Cunliffe AR, Contee C, Armato SG, White B, Justusson J, Malik R, Al-Hallaq HA. Effect of deformable registration on the dose calculated in radiation therapy planning CT scans of lung cancer patients. Med Phys. 2015 Jan; 42(1):391-9. PMID: 25563279.
      View in: PubMed
    24. Feng CH, Gerry E, Chmura SJ, Hasan Y, Al-Hallaq HA. An image-guided study of setup reproducibility of postmastectomy breast cancer patients treated with inverse-planned intensity modulated radiation therapy. Int J Radiat Oncol Biol Phys. 2015 Jan 01; 91(1):58-64. PMID: 25442344.
      View in: PubMed
    25. Padilla L, Kang H, Washington M, Hasan Y, Chmura SJ, Al-Hallaq H. Assessment of interfractional variation of the breast surface following conventional patient positioning for whole-breast radiotherapy. J Appl Clin Med Phys. 2014 Sep 08; 15(5):4921. PMID: 25207578.
      View in: PubMed
    26. Cunliffe AR, Armato SG, Straus C, Malik R, Al-Hallaq HA. Lung texture in serial thoracic CT scans: correlation with radiologist-defined severity of acute changes following radiation therapy. Phys Med Biol. 2014 Sep 21; 59(18):5387-98. PMID: 25157625.
      View in: PubMed
    27. Corbin KS, Dorn PL, Jain SK, Al-Hallaq HA, Hasan Y, Chmura SJ. Hypofractionated radiotherapy does not increase acute toxicity in large-breasted women: results from a prospectively collected series. Am J Clin Oncol. 2014 Aug; 37(4):322-6. PMID: 23357972.
      View in: PubMed
    28. Rudra S, Al-Hallaq HA, Feng C, Chmura SJ, Hasan Y. Effect of RTOG breast/chest wall guidelines on dose-volume histogram parameters. J Appl Clin Med Phys. 2014 Mar 06; 15(2):4547. PMID: 24710440.
      View in: PubMed
    29. Cunliffe AR, Armato SG, Fei XM, Tuohy RE, Al-Hallaq HA. Lung texture in serial thoracic CT scans: registration-based methods to compare anatomically matched regions. Med Phys. 2013 Jun; 40(6):061906. PMID: 23718597.
      View in: PubMed
    30. Wood AM, Medved M, Bacchus ID, Al-Hallaq HA, Shimauchi A, Newstead GM, Olopade OI, Venkataraman SS, Ivancevic MK, Karczmar GS. Classification of breast lesions pre-contrast injection using water resonance lineshape analysis. NMR Biomed. 2013 May; 26(5):569-77. PMID: 23165988.
      View in: PubMed
    31. Cunliffe AR, Al-Hallaq HA, Labby ZE, Pelizzari CA, Straus C, Sensakovic WF, Ludwig M, Armato SG. Lung texture in serial thoracic CT scans: assessment of change introduced by image registration. Med Phys. 2012 Aug; 39(8):4679-90. PMID: 22894392.
      View in: PubMed
    32. Dorn PL, Al-Hallaq HA, Haq F, Goldberg M, Abe H, Hasan Y, Chmura SJ. A prospective study of the utility of magnetic resonance imaging in determining candidacy for partial breast irradiation. Int J Radiat Oncol Biol Phys. 2013 Mar 01; 85(3):615-22. PMID: 22836047.
      View in: PubMed
    33. Li J, Wiersma RD, Stepaniak CJ, Farrey KJ, Al-Hallaq HA. Improvements in dose accuracy delivered with static-MLC IMRT on an integrated linear accelerator control system. Med Phys. 2012 May; 39(5):2456-62. PMID: 22559616.
      View in: PubMed
    34. Dorn PL, Corbin KS, Al-Hallaq H, Hasan Y, Chmura SJ. Feasibility and acute toxicity of hypofractionated radiation in large-breasted patients. Int J Radiat Oncol Biol Phys. 2012 May 01; 83(1):79-83. PMID: 22035661.
      View in: PubMed
    35. Liauw SL, Weichselbaum RR, Rash C, Correa D, Al-Hallaq HA, Pelizzari CA, Jani AB. Biochemical control and toxicity after intensity-modulated radiation therapy for prostate cancer. Technol Cancer Res Treat. 2009 Jun; 8(3):201-6. PMID: 19445537.
      View in: PubMed
    36. Al-Hallaq HA, Mell LK, Bradley JA, Chen LF, Ali AN, Weichselbaum RR, Newstead GM, Chmura SJ. Magnetic resonance imaging identifies multifocal and multicentric disease in breast cancer patients who are eligible for partial breast irradiation. Cancer. 2008 Nov 01; 113(9):2408-14. PMID: 18823018.
      View in: PubMed
    37. Al-Hallaq HA, Reft CS, Roeske JC. The dosimetric effects of tissue heterogeneities in intensity-modulated radiation therapy (IMRT) of the head and neck. Phys Med Biol. 2006 Mar 07; 51(5):1145-56. PMID: 16481684.
      View in: PubMed
    38. Singh R, Al-Hallaq H, Pelizzari CA, Zagaja GP, Chen A, Jani AB. Dosimetric quality endpoints for low-dose-rate prostate brachytherapy using biological effective dose (BED) vs. conventional dose. Med Dosim. 2003; 28(4):255-9. PMID: 14684190.
      View in: PubMed
    39. al-Hallaq HA, Zamora MA, Fish BL, Halpern HJ, Moulder JE, Karczmar GS. Using high spectral and spatial resolution bold MRI to choose the optimal oxygenating treatment for individual cancer patients. Adv Exp Med Biol. 2003; 530:433-40. PMID: 14562738.
      View in: PubMed
    40. Fan X, River JN, Zamora M, Al-Hallaq HA, Karczmar GS. Effect of carbogen on tumor oxygenation: combined fluorine-19 and proton MRI measurements. Int J Radiat Oncol Biol Phys. 2002 Nov 15; 54(4):1202-9. PMID: 12419449.
      View in: PubMed
    41. Karczmar GS, Fan X, Al-Hallaq H, River JN, Tarlo K, Kellar KE, Zamora M, Rinker-Schaeffer C, Lipton MJ. Functional and anatomic imaging of tumor vasculature: high-resolution MR spectroscopic imaging combined with a superparamagnetic contrast agent. Acad Radiol. 2002 May; 9 Suppl 1:S115-8. PMID: 12019844.
      View in: PubMed
    42. Al-Hallaq HA, Fan X, Zamora M, River JN, Moulder JE, Karczmar GS. Spectrally inhomogeneous BOLD contrast changes detected in rodent tumors with high spectral and spatial resolution MRI. NMR Biomed. 2002 Feb; 15(1):28-36. PMID: 11840550.
      View in: PubMed
    43. Karczmar GS, Fan X, Al-Hallaq HA, Zamora M, River JN, Rinker-Schaeffer C, Zaucha M, Tarlo K, Kellar K. Uptake of a superparamagnetic contrast agent imaged by MR with high spectral and spatial resolution. Magn Reson Med. 2000 May; 43(5):633-9. PMID: 10800026.
      View in: PubMed
    44. Al-Hallaq HA, Zamora M, Fish BL, Farrell A, Moulder JE, Karczmar GS. MRI measurements correctly predict the relative effects of tumor oxygenating agents on hypoxic fraction in rodent BA1112 tumors. Int J Radiat Oncol Biol Phys. 2000 May 01; 47(2):481-8. PMID: 10802376.
      View in: PubMed
    45. ML Giger, HA Al-Hallaq, DE Wolverton, U Bick. U.S. Patent # 5,984,870. Method and system for the automated analysis of lesions in ultrasound images. 1999.
    46. Giger ML, Al-Hallaq H, Huo Z, Moran C, Wolverton DE, Chan CW, Zhong W. Computerized analysis of lesions in US images of the breast. Acad Radiol. 1999 Nov; 6(11):665-74. PMID: 10894069.
      View in: PubMed
    47. Al-Hallaq HA, River JN, Zamora M, Oikawa H, Karczmar GS. Correlation of magnetic resonance and oxygen microelectrode measurements of carbogen-induced changes in tumor oxygenation. Int J Radiat Oncol Biol Phys. 1998 Apr 01; 41(1):151-9. PMID: 9588930.
      View in: PubMed
    48. Kovar DA, Al-Hallaq HA, Zamora MA, River JN, Karczmar GS. Fast spectroscopic imaging of water and fat resonances to improve the quality of MR images. Acad Radiol. 1998 Apr; 5(4):269-75. PMID: 9561260.
      View in: PubMed
    49. Oikawa H, al-Hallaq HA, Lewis MZ, River JN, Kovar DA, Karczmar GS. Spectroscopic imaging of the water resonance with short repetition time to study tumor response to hyperoxia. Magn Reson Med. 1997 Jul; 38(1):27-32. PMID: 9211376.
      View in: PubMed
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