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George P. Leser

AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Aggarwal M, Leser GP, Lamb RA. Repurposing Papaverine as an Antiviral Agent against Influenza Viruses and Paramyxoviruses. J Virol. 2020 02 28; 94(6). PMID: 31896588.
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    2. Aggarwal M, Leser GP, Kors CA, Lamb RA. Structure of the Paramyxovirus Parainfluenza Virus 5 Nucleoprotein in Complex with an Amino-Terminal Peptide of the Phosphoprotein. J Virol. 2018 03 01; 92(5). PMID: 29237836.
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    3. Wong JJW, Young TA, Zhang J, Liu S, Leser GP, Komives EA, Lamb RA, Zhou ZH, Salafsky J, Jardetzky TS. Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation. Nat Commun. 2017 10 03; 8(1):781. PMID: 28974687.
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    4. Leser GP, Lamb RA. Lateral Organization of Influenza Virus Proteins in the Budozone Region of the Plasma Membrane. J Virol. 2017 05 01; 91(9). PMID: 28202765.
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    5. Wen X, Pickens J, Mousa JJ, Leser GP, Lamb RA, Crowe JE, Jardetzky TS. A Chimeric Pneumovirus Fusion Protein Carrying Neutralizing Epitopes of Both MPV and RSV. PLoS One. 2016; 11(5):e0155917. PMID: 27224013.
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    6. Alayyoubi M, Leser GP, Kors CA, Lamb RA. Structure of the paramyxovirus parainfluenza virus 5 nucleoprotein-RNA complex. Proc Natl Acad Sci U S A. 2015 Apr 07; 112(14):E1792-9. PMID: 25831513.
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    7. Kanteti R, Dhanasingh I, Kawada I, Lennon FE, Arif Q, Bueno R, Hasina R, Husain AN, Vigneswaran W, Seiwert T, Kindler HL, Salgia R. MET and PI3K/mTOR as a potential combinatorial therapeutic target in malignant pleural mesothelioma. PLoS One. 2014; 9(9):e105919. PMID: 25221930.
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    8. Welch BD, Paduch M, Leser GP, Bergman Z, Kors CA, Paterson RG, Jardetzky TS, Kossiakoff AA, Lamb RA. Probing the functions of the paramyxovirus glycoproteins F and HN with a panel of synthetic antibodies. J Virol. 2014 Oct; 88(20):11713-25. PMID: 25122782.
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    9. Bruns AM, Leser GP, Lamb RA, Horvath CM. The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly. Mol Cell. 2014 Sep 04; 55(5):771-81. PMID: 25127512.
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    10. Poor TA, Jones LM, Sood A, Leser GP, Plasencia MD, Rempel DL, Jardetzky TS, Woods RJ, Gross ML, Lamb RA. Probing the paramyxovirus fusion (F) protein-refolding event from pre- to postfusion by oxidative footprinting. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):E2596-605. PMID: 24927585.
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    11. Rolle CE, Kanteti R, Surati M, Nandi S, Dhanasingh I, Yala S, Tretiakova M, Arif Q, Hembrough T, Brand TM, Wheeler DL, Husain AN, Vokes EE, Bharti A, Salgia R. Combined MET inhibition and topoisomerase I inhibition block cell growth of small cell lung cancer. . 2014 Mar; 13(3):576-84. PMID: 24327519.
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    12. Kawada I, Hasina R, Arif Q, Mueller J, Smithberger E, Husain AN, Vokes EE, Salgia R. Dramatic antitumor effects of the dual MET/RON small-molecule inhibitor LY2801653 in non-small cell lung cancer. Cancer Res. 2014 Feb 01; 74(3):884-95. PMID: 24305878.
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    13. Hasina R, Surati M, Kawada I, Arif Q, Carey GB, Kanteti R, Husain AN, Ferguson MK, Vokes EE, Villaflor VM, Salgia R. O-6-methylguanine-deoxyribonucleic acid methyltransferase methylation enhances response to temozolomide treatment in esophageal cancer. J Carcinog. 2013; 12:20. PMID: 24319345.
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    14. Wilson RA, Teng L, Bachmeyer KM, Bissonnette ML, Husain AN, Parham DM, Triche TJ, Wing MR, Gastier-Foster JM, Barr FG, Hawkins DS, Anderson JR, Skapek SX, Volchenboum SL. A novel algorithm for simplification of complex gene classifiers in cancer. Cancer Res. 2013 Sep 15; 73(18):5625-32. PMID: 23913937.
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    15. Roberts KL, Leser GP, Ma C, Lamb RA. The amphipathic helix of influenza A virus M2 protein is required for filamentous bud formation and scission of filamentous and spherical particles. J Virol. 2013 Sep; 87(18):9973-82. PMID: 23843641.
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    16. Doeing DC, Husain AN, Naureckas ET, White SR, Hogarth DK. Bronchial thermoplasty failure in severe persistent asthma: a case report. J Asthma. 2013 Sep; 50(7):799-801. PMID: 23651158.
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    17. Kawada I, Hasina R, Lennon FE, Bindokas VP, Usatyuk P, Tan YH, Krishnaswamy S, Arif Q, Carey G, Hseu RD, Robinson M, Tretiakova M, Brand TM, Iida M, Ferguson MK, Wheeler DL, Husain AN, Natarajan V, Vokes EE, Singleton PA, Salgia R. Paxillin mutations affect focal adhesions and lead to altered mitochondrial dynamics: relevance to lung cancer. . 2013 Jul; 14(7):679-91. PMID: 23792636.
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    18. Welch BD, Liu Y, Kors CA, Leser GP, Jardetzky TS, Lamb RA. Structure of the cleavage-activated prefusion form of the parainfluenza virus 5 fusion protein. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):16672-7. PMID: 23012473.
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    19. Bose S, Zokarkar A, Welch BD, Leser GP, Jardetzky TS, Lamb RA. Fusion activation by a headless parainfluenza virus 5 hemagglutinin-neuraminidase stalk suggests a modular mechanism for triggering. Proc Natl Acad Sci U S A. 2012 Sep 25; 109(39):E2625-34. PMID: 22949640.
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    20. Yuan P, Paterson RG, Leser GP, Lamb RA, Jardetzky TS. Structure of the ulster strain newcastle disease virus hemagglutinin-neuraminidase reveals auto-inhibitory interactions associated with low virulence. PLoS Pathog. 2012; 8(8):e1002855. PMID: 22912577.
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    21. Rossman JS, Leser GP, Lamb RA. Filamentous influenza virus enters cells via macropinocytosis. J Virol. 2012 Oct; 86(20):10950-60. PMID: 22875971.
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    22. Wen X, Krause JC, Leser GP, Cox RG, Lamb RA, Williams JV, Crowe JE, Jardetzky TS. Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site. Nat Struct Mol Biol. 2012 Mar 04; 19(4):461-3. PMID: 22388735.
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    23. Kim YH, Donald JE, Grigoryan G, Leser GP, Fadeev AY, Lamb RA, DeGrado WF. Capture and imaging of a prehairpin fusion intermediate of the paramyxovirus PIV5. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):20992-7. PMID: 22178759.
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    24. Yuan P, Swanson KA, Leser GP, Paterson RG, Lamb RA, Jardetzky TS. Structure of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk. Proc Natl Acad Sci U S A. 2011 Sep 06; 108(36):14920-5. PMID: 21873198.
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    25. Watanabe R, Leser GP, Lamb RA. Influenza virus is not restricted by tetherin whereas influenza VLP production is restricted by tetherin. Virology. 2011 Aug 15; 417(1):50-6. PMID: 21621240.
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    26. Rossman JS, Jing X, Leser GP, Lamb RA. Influenza virus M2 protein mediates ESCRT-independent membrane scission. Cell. 2010 Sep 17; 142(6):902-13. PMID: 20850012.
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    27. Ravid D, Leser GP, Lamb RA. A role for caveolin 1 in assembly and budding of the paramyxovirus parainfluenza virus 5. J Virol. 2010 Oct; 84(19):9749-59. PMID: 20631121.
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    28. Swanson K, Wen X, Leser GP, Paterson RG, Lamb RA, Jardetzky TS. Structure of the Newcastle disease virus F protein in the post-fusion conformation. Virology. 2010 Jul 05; 402(2):372-9. PMID: 20439109.
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    29. Rossman JS, Jing X, Leser GP, Balannik V, Pinto LH, Lamb RA. Influenza virus m2 ion channel protein is necessary for filamentous virion formation. J Virol. 2010 May; 84(10):5078-88. PMID: 20219914.
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    30. Connolly SA, Leser GP, Jardetzky TS, Lamb RA. Bimolecular complementation of paramyxovirus fusion and hemagglutinin-neuraminidase proteins enhances fusion: implications for the mechanism of fusion triggering. J Virol. 2009 Nov; 83(21):10857-68. PMID: 19710150.
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    31. Chen BJ, Leser GP, Jackson D, Lamb RA. The influenza virus M2 protein cytoplasmic tail interacts with the M1 protein and influences virus assembly at the site of virus budding. J Virol. 2008 Oct; 82(20):10059-70. PMID: 18701586.
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    32. Yuan P, Leser GP, Demeler B, Lamb RA, Jardetzky TS. Domain architecture and oligomerization properties of the paramyxovirus PIV 5 hemagglutinin-neuraminidase (HN) protein. Virology. 2008 Sep 01; 378(2):282-91. PMID: 18597807.
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    33. Backovic M, Leser GP, Lamb RA, Longnecker R, Jardetzky TS. Characterization of EBV gB indicates properties of both class I and class II viral fusion proteins. Virology. 2007 Nov 10; 368(1):102-13. PMID: 17655906.
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    34. Chen BJ, Leser GP, Morita E, Lamb RA. Influenza virus hemagglutinin and neuraminidase, but not the matrix protein, are required for assembly and budding of plasmid-derived virus-like particles. J Virol. 2007 Jul; 81(13):7111-23. PMID: 17475660.
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    35. Tompkins SM, Lin Y, Leser GP, Kramer KA, Haas DL, Howerth EW, Xu J, Kennett MJ, Durbin RK, Durbin JE, Tripp R, Lamb RA, He B. Recombinant parainfluenza virus 5 (PIV5) expressing the influenza A virus hemagglutinin provides immunity in mice to influenza A virus challenge. Virology. 2007 May 25; 362(1):139-50. PMID: 17254623.
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    36. Connolly SA, Leser GP, Yin HS, Jardetzky TS, Lamb RA. Refolding of a paramyxovirus F protein from prefusion to postfusion conformations observed by liposome binding and electron microscopy. Proc Natl Acad Sci U S A. 2006 Nov 21; 103(47):17903-8. PMID: 17093041.
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    37. Leser GP, Lamb RA. Influenza virus assembly and budding in raft-derived microdomains: a quantitative analysis of the surface distribution of HA, NA and M2 proteins. Virology. 2005 Nov 25; 342(2):215-27. PMID: 16249012.
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    38. Schmitt AP, Leser GP, Morita E, Sundquist WI, Lamb RA. Evidence for a new viral late-domain core sequence, FPIV, necessary for budding of a paramyxovirus. J Virol. 2005 Mar; 79(5):2988-97. PMID: 15709019.
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    39. Takeda M, Leser GP, Russell CJ, Lamb RA. Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):14610-7. PMID: 14561897.
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    40. Waning DL, Schmitt AP, Leser GP, Lamb RA. Roles for the cytoplasmic tails of the fusion and hemagglutinin-neuraminidase proteins in budding of the paramyxovirus simian virus 5. J Virol. 2002 Sep; 76(18):9284-97. PMID: 12186912.
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    41. Schmitt AP, Leser GP, Waning DL, Lamb RA. Requirements for budding of paramyxovirus simian virus 5 virus-like particles. J Virol. 2002 Apr; 76(8):3952-64. PMID: 11907235.
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    42. Andersson H, Palm S, Lindegren S, Bäck T, Jacobsson L, Leser G, Horvath G. Comparison of the therapeutic efficacy of 211At- and 131I-labelled monoclonal antibody MOv18 in nude mice with intraperitoneal growth of human ovarian cancer. Anticancer Res. 2001 Jan-Feb; 21(1A):409-12. PMID: 11299770.
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    43. Zhang J, Leser GP, Pekosz A, Lamb RA. The cytoplasmic tails of the influenza virus spike glycoproteins are required for normal genome packaging. Virology. 2000 Apr 10; 269(2):325-34. PMID: 10753711.
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    44. Horvath G, Leser G, Hahlin M, Henriksson M. Exon deletions and variants of human estrogen receptor mRNA in endometrial hyperplasia and adenocarcinoma. Int J Gynecol Cancer. 2000 Mar; 10(2):128-136. PMID: 11240664.
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    45. Andersson H, Lindegren S, Back T, Jacobsson L, Leser G, Horvath G. Radioimmunotherapy of nude mice with intraperitoneally growing ovarian cancer xenograft utilizing 211At-labelled monoclonal antibody MOv18. Anticancer Res. 2000 Jan-Feb; 20(1A):459-62. PMID: 10769696.
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    46. Andersson H, Lindegren S, Bäck T, Jacobsson L, Leser G, Horvath G. The curative and palliative potential of the monoclonal antibody MOv18 labelled with 211At in nude mice with intraperitoneally growing ovarian cancer xenografts--a long-term study. Acta Oncol. 2000; 39(6):741-5. PMID: 11130014.
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    47. Leser GP, Ector KJ, Ng DT, Shaughnessy MA, Lamb RA. The signal for clathrin-mediated endocytosis of the paramyxovirus SV5 HN protein resides at the transmembrane domain-ectodomain boundary region. Virology. 1999 Sep 15; 262(1):79-92. PMID: 10489343.
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    48. Dutch RE, Leser GP, Lamb RA. Paramyxovirus fusion protein: characterization of the core trimer, a rod-shaped complex with helices in anti-parallel orientation. Virology. 1999 Feb 01; 254(1):147-59. PMID: 9927582.
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    49. Andersson H, Lindegren S, Bäck T, Jacobsson L, Leser G, Horvath G. Biokinetics of the monoclonal antibodies MOv 18, OV 185 and OV 197 labelled with 125I according to the m-MeATE method or the Iodogen method in nude mice with ovarian cancer xenografts. Acta Oncol. 1999; 38(3):323-8. PMID: 10380823.
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    50. He B, Leser GP, Paterson RG, Lamb RA. The paramyxovirus SV5 small hydrophobic (SH) protein is not essential for virus growth in tissue culture cells. Virology. 1998 Oct 10; 250(1):30-40. PMID: 9770417.
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    51. Karlsson L, Leser G, Ryd W, Horvath G. Estradiol induces DNA fragmentation in a human endometrial adenocarcinoma with estradiol-inhibited growth phenotype. Anticancer Res. 1997 Sep-Oct; 17(5A):3259-63. PMID: 9413157.
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    52. Jin H, Leser GP, Zhang J, Lamb RA. Influenza virus hemagglutinin and neuraminidase cytoplasmic tails control particle shape. EMBO J. 1997 Mar 17; 16(6):1236-47. PMID: 9135140.
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    53. Karlsson L, Leser G, Delle U, Horvath G. Tumour growth and cell kinetics in variants of a human endometrial adenocarcinoma expressing either wild-type or mutant p53. Acta Oncol. 1997; 36(7):729-33. PMID: 9490092.
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    54. Horvath G, Leser G, Karlsson L, Delle U. Estradiol regulates tumor growth by influencing p53 and bcl-2 expression in human endometrial adenocarcinomas grown in nude mice. In Vivo. 1996 Jul-Aug; 10(4):411-6. PMID: 8839787.
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    55. Karlsson L, Leser G, Ryd W, Delle U, Köpf I, Horvath G. Characterisation of a human endometrial adenocarcinoma established in vivo and in vitro. In Vivo. 1996 Jul-Aug; 10(4):421-8. PMID: 8839789.
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    56. Brassard DL, Leser GP, Lamb RA. Influenza B virus NB glycoprotein is a component of the virion. Virology. 1996 Jun 15; 220(2):350-60. PMID: 8661386.
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    57. Sakaguchi T, Leser GP, Lamb RA. The ion channel activity of the influenza virus M2 protein affects transport through the Golgi apparatus. J Cell Biol. 1996 May; 133(4):733-47. PMID: 8666660.
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    58. Jin H, Subbarao K, Bagai S, Leser GP, Murphy BR, Lamb RA. Palmitylation of the influenza virus hemagglutinin (H3) is not essential for virus assembly or infectivity. J Virol. 1996 Mar; 70(3):1406-14. PMID: 8627657.
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    59. Leser GP, Ector KJ, Lamb RA. The paramyxovirus simian virus 5 hemagglutinin-neuraminidase glycoprotein, but not the fusion glycoprotein, is internalized via coated pits and enters the endocytic pathway. Mol Biol Cell. 1996 Jan; 7(1):155-72. PMID: 8741847.
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    60. Horvath G, Leser G, Delle U. Estradiol influences p53 expression in a human endometrial adenocarcinoma heterotransplanted into nude mice. In Vivo. 1996 Jan-Feb; 10(1):29-32. PMID: 8726808.
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    61. Paterson RG, Leser GP, Shaughnessy MA, Lamb RA. The paramyxovirus SV5 V protein binds two atoms of zinc and is a structural component of virions. Virology. 1995 Apr 01; 208(1):121-31. PMID: 11831692.
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    62. Horvath G, Leser G, Delle U. Protein expression of p53 and Rb suppressor genes during the first passages of human endometrial adenocarcinomas heterotransplanted into nude mice. In Vivo. 1995 Jan-Feb; 9(1):41-8. PMID: 7669947.
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    63. Jin H, Leser GP, Lamb RA. The influenza virus hemagglutinin cytoplasmic tail is not essential for virus assembly or infectivity. EMBO J. 1994 Nov 15; 13(22):5504-15. PMID: 7957116.
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    64. Horvath G, Andersson H, Mellqvist L, Leser G, Delle U. Tumor volume growth and cell proliferation in an estradiol resistant human endometrial adenocarcinoma growing in nude mice. In Vivo. 1994 Mar-Apr; 8(2):259-62. PMID: 7919131.
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    65. Kopecný V, Fakan S, Pavlok A, Pivko J, Grafenau P, Biggiogera M, Leser G, Martin TE. Immunoelectron microscopic localization of small nuclear ribonucleoproteins during bovine early embryogenesis. Mol Reprod Dev. 1991 Jul; 29(3):209-19. PMID: 1834097.
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    66. Leser GP, Nicoll DA, Applebury ML. Distinctive properties of the purified Na-Ca exchanger from rod outer segments. Ann N Y Acad Sci. 1991; 639:222-33. PMID: 1785848.
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    67. Biggiogera M, Fakan S, Leser G, Martin TE, Gordon J. Immunoelectron microscopical visualization of ribonucleoproteins in the chromatoid body of mouse spermatids. Mol Reprod Dev. 1990 Jun; 26(2):150-8. PMID: 2142601.
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    68. Leser GP, Fakan S, Martin TE. Ultrastructural distribution of ribonucleoprotein complexes during mitosis. snRNP antigens are contained in mitotic granule clusters. Eur J Cell Biol. 1989 Dec; 50(2):376-89. PMID: 2534076.
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    69. Leser GP, Martin TE. Changes in heterogeneous nuclear RNP core polypeptide complements during the cell cycle. J Cell Biol. 1987 Nov; 105(5):2083-94. PMID: 3316247.
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    70. Martin TE, Barghusen SC, Leser GP, Spear PG. Redistribution of nuclear ribonucleoprotein antigens during herpes simplex virus infection. J Cell Biol. 1987 Nov; 105(5):2069-82. PMID: 2824525.
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    71. Fakan S, Leser G, Martin TE. Immunoelectron microscope visualization of nuclear ribonucleoprotein antigens within spread transcription complexes. J Cell Biol. 1986 Oct; 103(4):1153-7. PMID: 2945824.
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    72. Leser GP, Escara-Wilke J, Martin TE. Monoclonal antibodies to heterogeneous nuclear RNA-protein complexes. The core proteins comprise a conserved group of related polypeptides. J Biol Chem. 1984 Feb 10; 259(3):1827-33. PMID: 6363416.
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    73. Fakan S, Leser G, Martin TE. Ultrastructural distribution of nuclear ribonucleoproteins as visualized by immunocytochemistry on thin sections. J Cell Biol. 1984 Jan; 98(1):358-63. PMID: 6231300.
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    74. Leser G. [Not Available]. Rev Alsace. 1984; 110:155-68. PMID: 11635625.
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