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Babak Mokhlesi

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMedicine-Pulmonary/Critical Care
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Professor of Medicine
    Department of Medicine
    Section of Pulmonary and Critical Care
    Director, Sleep Disorders Center
    Director, Sleep Medicine Fellowship Program

    Dr. Mokhlesi is a Professor of Medicine and Director of the Sleep Disorders Center at the University of Chicago. His expertise are in pulmonary, critical care and sleep medicine. His clinical practice is centered on critical care medicine and sleep disorders.He has a particular interest in sleep-disordered breathing such as obstructive sleep apnea and obesity hypoventilation syndrome. His clinical research interests include: cardiometabolic impact of obstructive sleep apnea (OSA) and REM-related OSA, adherence to CPAP therapy, positive airway pressure therapy in obesity hypoventilation syndrome, and postoperative risk associated with sleep-disordered breathing. His research is currently funded by NHLBI/NIH.

    Dr. Mokhlesi's NIH Commons ID is bmokhles.

    2001-2006: Assistant Professor, Department of Medicine, Rush University
    2006-2009: Assistant Professor, Department of Medicine, University of Chicago
    2009-2014: Associate Professor, Department of Medicine, University of Chicago
    2014- Professor of Medicine, Department of Medicine, University of Chicago


    Collapse Biography 
    Collapse awards and honors
    2011Fellow, Academy of Distinguished Medical Educators, University of Chicago, University of Chicago Pritzker School of Medicine
    2013 - 2017R01 HL119161: Impact of Sleep in Restoring Insulin Secretion (RISE) Study
    2014Invited Guest Editor of an issue of Sleep Medicine Clinics on “Sleep Hypoventilation Syndrome

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Afshar M, Brozek JL, Soghier I, Tamae Kakazu M, Wilson KC, Masa JF, Mokhlesi B. The Role of Positive Airway Pressure Therapy in Adults with Obesity Hypoventilation Syndrome: A Systematic Review and Meta-Analysis. Ann Am Thorac Soc. 2019 Nov 14. PMID: 31726017.
      View in: PubMed
    2. Masa JF, Mokhlesi B, Benítez I, Mogollon MV, Gomez de Terreros FJ, Sánchez-Quiroga MÁ, Romero A, Caballero-Eraso C, Alonso-Álvarez ML, Ordax-Carbajo E, Gomez-Garcia T, González M, López-Martín S, Marin JM, Martí S, Díaz-Cambriles T, Chiner E, Egea C, Barca J, Vázquez-Polo FJ, Negrín MA, Martel-Escobar M, Barbe F, Corral J. Echocardiographic Changes with Positive Airway Pressure Therapy in Obesity Hypoventilation Syndrome: Long-term Pickwick Randomized Controlled Trial. Am J Respir Crit Care Med. 2019 Nov 04. PMID: 31682462.
      View in: PubMed
    3. Gómez de Terreros FJ, Cooksey JA, Sunwoo BY, Mokhlesi B, Masa JF, Ruminjo JK, Thomson CC. Clinical Practice Guideline Summary for Clinicians: Evaluation and Management of Obesity Hypoventilation Syndrome. Ann Am Thorac Soc. 2019 Oct 29. PMID: 31661315.
      View in: PubMed
    4. Kessler R, Knutson KL, Mokhlesi B, Anderson SL, Shah M, Meltzer DO, Arora VM. Sleep and activity patterns in older patients discharged from the hospital. Sleep. 2019 Oct 21; 42(11). PMID: 31310317.
      View in: PubMed
    5. Soghier I, Brozek JL, Afshar M, Tamae Kakazu M, Wilson KC, Masa JF, Mokhlesi B. Noninvasive Ventilation versus CPAP as Initial Treatment of Obesity Hypoventilation Syndrome. Ann Am Thorac Soc. 2019 10; 16(10):1295-1303. PMID: 31365842.
      View in: PubMed
    6. Mokhlesi B, Temple KA, Tjaden AH, Edelstein SL, Nadeau KJ, Hannon TS, Manchanda S, Sam S, Barengolts E, Utzschneider KM, Ehrmann DA, Van Cauter E. The association of sleep disturbances with glycemia and obesity in youth at risk for or with recently diagnosed type 2 diabetes. Pediatr Diabetes. 2019 Dec; 20(8):1056-1063. PMID: 31486162.
      View in: PubMed
    7. Mokhlesi B, Masa JF, Brozek JL, Gurubhagavatula I, Murphy PB, Piper AJ, Tulaimat A, Afshar M, Balachandran JS, Dweik RA, Grunstein RR, Hart N, Kaw R, Lorenzi-Filho G, Pamidi S, Patel BK, Patil SP, Pépin JL, Soghier I, Tamae Kakazu M, Teodorescu M. Evaluation and Management of Obesity Hypoventilation Syndrome. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2019 Aug 01; 200(3):e6-e24. PMID: 31368798.
      View in: PubMed
    8. Temple KA, Tjaden AH, Atkinson KM, Barengolts E, Hannon TS, Mather KJ, Utzschneider KM, Edelstein SL, Ehrmann DA, Mokhlesi B. Association of Habitual Daily Physical Activity With Glucose Tolerance and ß-Cell Function in Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes From the Restoring Insulin Secretion (RISE) Study. Diabetes Care. 2019 Aug; 42(8):1521-1529. PMID: 31177181.
      View in: PubMed
    9. Carter JR, Fonkoue IT, Greenlund IM, Schwartz CE, Mokhlesi B, Smoot CA. Sympathetic neural responsiveness to sleep deprivation in older adults: sex differences. Am J Physiol Heart Circ Physiol. 2019 Aug 01; 317(2):H315-H322. PMID: 31149842.
      View in: PubMed
    10. Mokhlesi B, Temple KA, Tjaden AH, Edelstein SL, Utzschneider KM, Nadeau KJ, Hannon TS, Sam S, Barengolts E, Manchanda S, Ehrmann DA, Van Cauter E. Association of Self-Reported Sleep and Circadian Measures With Glycemia in Adults With Prediabetes or Recently Diagnosed Untreated Type 2 Diabetes. Diabetes Care. 2019 Jul; 42(7):1326-1332. PMID: 31048411.
      View in: PubMed
    11. Masa JF, Mokhlesi B, Benítez I, Gomez de Terreros FJ, Sánchez-Quiroga MÁ, Romero A, Caballero-Eraso C, Terán-Santos J, Alonso-Álvarez ML, Troncoso MF, González M, López-Martín S, Marin JM, Martí S, Díaz-Cambriles T, Chiner E, Egea C, Barca J, Vázquez-Polo FJ, Negrín MA, Martel-Escobar M, Barbe F, Corral J. Long-term clinical effectiveness of continuous positive airway pressure therapy versus non-invasive ventilation therapy in patients with obesity hypoventilation syndrome: a multicentre, open-label, randomised controlled trial. Lancet. 2019 04 27; 393(10182):1721-1732. PMID: 30935737.
      View in: PubMed
    12. Ip MSM, Mokhlesi B. Activating Leptin Receptors in the Central Nervous System Using Intranasal Leptin. A Novel Therapeutic Target for Sleep-disordered Breathing. Am J Respir Crit Care Med. 2019 Mar 15; 199(6):689-691. PMID: 30365343.
      View in: PubMed
    13. Masa JF, Pépin JL, Borel JC, Mokhlesi B, Murphy PB, Sánchez-Quiroga MÁ. Obesity hypoventilation syndrome. Eur Respir Rev. 2019 Mar 31; 28(151). PMID: 30872398.
      View in: PubMed
    14. Arora VM, Machado N, Anderson SL, Desai N, Marsack W, Blossomgame S, Tuvilleja A, Ramos J, Francisco MA, LaFond C, Leung EK, Valencia A, Martin SK, Meltzer DO, Farnan JM, Balachandran J, Knutson KL, Mokhlesi B. Effectiveness of SIESTA on Objective and Subjective Metrics of Nighttime Hospital Sleep Disruptors. J Hosp Med. 2019 01; 14(1):38-41. PMID: 30667409.
      View in: PubMed
    15. Schulman DA, Piquette CA, Alikhan MM, Freedman N, Kumar S, McCallister J, Mokhlesi B, Santamauro J, Singas E, Stern E, Strohl KP, Casey KR. A Sleep Medicine Curriculum for Pulmonary and Pulmonary/Critical Care Fellowship Programs: A Multisociety Expert Panel Report. Chest. 2019 Mar; 155(3):554-564. PMID: 30392792.
      View in: PubMed
    16. Suen C, Ryan CM, Mubashir T, Ayas NT, Abrahamyan L, Wong J, Mokhlesi B, Chung F. Sleep Study and Oximetry Parameters for Predicting Postoperative Complications in Patients With OSA. Chest. 2019 Apr; 155(4):855-867. PMID: 30359618.
      View in: PubMed
    17. Xiang AH, Trigo E, Martinez M, Katkhouda N, Beale E, Wang X, Wu J, Chow T, Montgomery C, Nayak KS, Hendee F, Buchanan TA. Impact of Gastric Banding Versus Metformin on ß-Cell Function in Adults With Impaired Glucose Tolerance or Mild Type 2 Diabetes. Diabetes Care. 2018 12; 41(12):2544-2551. PMID: 30282699.
      View in: PubMed
    18. Varga AW, Mokhlesi B. REM obstructive sleep apnea: risk for adverse health outcomes and novel treatments. Sleep Breath. 2019 Jun; 23(2):413-423. PMID: 30232681.
      View in: PubMed
    19. Sunwoo BY, Mokhlesi B. Obesity Hypoventilation Syndrome: Will Early Detection and Effective Therapy Improve Long-Term Outcomes? J Clin Sleep Med. 2018 09 15; 14(9):1455-1457. PMID: 30176983.
      View in: PubMed
    20. Carter JR, Grimaldi D, Fonkoue IT, Medalie L, Mokhlesi B, Van Cauter E. Assessment of sympathetic neural activity in chronic insomnia: evidence for elevated cardiovascular risk. Sleep. 2018 09 01; 41(9). PMID: 29992317.
      View in: PubMed
    21. Morselli LL, Temple KA, Leproult R, Ehrmann DA, Van Cauter E, Mokhlesi B. Determinants of Slow-Wave Activity in Overweight and Obese Adults: Roles of Sex, Obstructive Sleep Apnea and Testosterone Levels. Front Endocrinol (Lausanne). 2018; 9:377. PMID: 30050500.
      View in: PubMed
    22. Temple KA, Leproult R, Morselli L, Ehrmann DA, Van Cauter E, Mokhlesi B. Sex Differences in the Impact of Obstructive Sleep Apnea on Glucose Metabolism. Front Endocrinol (Lausanne). 2018; 9:376. PMID: 30042734.
      View in: PubMed
    23. Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: II. Observations Using the Oral Glucose Tolerance Test. Diabetes Care. 2018 08; 41(8):1707-1716. PMID: 29941498.
      View in: PubMed
    24. Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: I. Observations Using the Hyperglycemic Clamp. Diabetes Care. 2018 08; 41(8):1696-1706. PMID: 29941497.
      View in: PubMed
    25. Impact of Insulin and Metformin Versus Metformin Alone on ß-Cell Function in Youth With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes. Diabetes Care. 2018 08; 41(8):1717-1725. PMID: 29941500.
      View in: PubMed
    26. Carter JR, Grimaldi D, Fonkoue IT, Medalie L, Mokhlesi B, Cauter EV. Assessment of sympathetic neural activity in chronic insomnia: evidence for elevated cardiovascular risk. Sleep. 2018 06 01; 41(6). PMID: 29522186.
      View in: PubMed
    27. Bhattacharjee R, Khalyfa A, Khalyfa AA, Mokhlesi B, Kheirandish-Gozal L, Almendros I, Peris E, Malhotra A, Gozal D. Exosomal Cargo Properties, Endothelial Function and Treatment of Obesity Hypoventilation Syndrome: A Proof of Concept Study. J Clin Sleep Med. 2018 05 15; 14(5):797-807. PMID: 29734990.
      View in: PubMed
    28. Mokhlesi B, Varga AW. Obstructive Sleep Apnea and Cardiovascular Disease. REM Sleep Matters! Am J Respir Crit Care Med. 2018 03 01; 197(5):554-556. PMID: 29141154.
      View in: PubMed
    29. Ayas NT, Laratta CR, Coleman JM, Doufas AG, Eikermann M, Gay PC, Gottlieb DJ, Gurubhagavatula I, Hillman DR, Kaw R, Malhotra A, Mokhlesi B, Morgenthaler TI, Parthasarathy S, Ramachandran SK, Strohl KP, Strollo PJ, Twery MJ, Zee PC, Chung FF. Knowledge Gaps in the Perioperative Management of Adults with Obstructive Sleep Apnea and Obesity Hypoventilation Syndrome. An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2018 02; 15(2):117-126. PMID: 29388810.
      View in: PubMed
    30. Mokhlesi B, Cifu AS. Diagnostic Testing for Obstructive Sleep Apnea in Adults. JAMA. 2017 Nov 28; 318(20):2035-2036. PMID: 29183053.
      View in: PubMed
    31. Corral J, Mogollon MV, Sánchez-Quiroga MÁ, Gómez de Terreros J, Romero A, Caballero C, Teran-Santos J, Alonso-Álvarez ML, Gómez-García T, González M, López-Martínez S, de Lucas P, Marin JM, Romero O, Díaz-Cambriles T, Chiner E, Egea C, Lang RM, Mokhlesi B, Masa JF. Echocardiographic changes with non-invasive ventilation and CPAP in obesity hypoventilation syndrome. Thorax. 2018 04; 73(4):361-368. PMID: 29146865.
      View in: PubMed
    32. Carter JR, Mokhlesi B. Sex Differences in the Risk of Incident Hypertension With Sleep Apnea: Does Postmenopausal Status Matter? Chest. 2017 10; 152(4):695-697. PMID: 28991540.
      View in: PubMed
    33. Guralnick AS, Balachandran JS, Szutenbach S, Adley K, Emami L, Mohammadi M, Farnan JM, Arora VM, Mokhlesi B. Educational video to improve CPAP use in patients with obstructive sleep apnoea at risk for poor adherence: a randomised controlled trial. Thorax. 2017 12; 72(12):1132-1139. PMID: 28667231.
      View in: PubMed
    34. Lyons PG, Snyder A, Sokol S, Edelson DP, Mokhlesi B, Churpek MM. Association Between Opioid and Benzodiazepine Use and Clinical Deterioration in Ward Patients. J Hosp Med. 2017 06; 12(6):428-434. PMID: 28574532.
      View in: PubMed
    35. Reutrakul S, Mokhlesi B. Obstructive Sleep Apnea and Diabetes: A State of the Art Review. Chest. 2017 11; 152(5):1070-1086. PMID: 28527878.
      View in: PubMed
    36. Kaur A, Mokhlesi B. The Effect of OSA Therapy on Glucose Metabolism: It's All about CPAP Adherence! J Clin Sleep Med. 2017 03 15; 13(3):365-367. PMID: 28212697.
      View in: PubMed
    37. Grossman MN, Anderson SL, Worku A, Marsack W, Desai N, Tuvilleja A, Ramos J, Francisco MA, Lafond C, Balachandran JS, Mokhlesi B, Farnan JM, Meltzer DO, Arora VM. Awakenings? Patient and Hospital Staff Perceptions of Nighttime Disruptions and Their Effect on Patient Sleep. J Clin Sleep Med. 2017 Feb 15; 13(2):301-306. PMID: 27923432.
      View in: PubMed
    38. Noda JR, Masa JF, Mokhlesi B. CPAP or non-invasive ventilation in obesity hypoventilation syndrome: does it matter which one you start with? Thorax. 2017 05; 72(5):398-399. PMID: 28130492.
      View in: PubMed
    39. Mokhlesi B, Sam S, Ehrmann DA. Obstructive sleep apnea and polycystic ovary syndrome: cause or association? Sleep Med. 2017 08; 36:170-171. PMID: 28238552.
      View in: PubMed
    40. Mokhlesi B, Grimaldi D, Beccuti G, Van Cauter E. Effect of one week of CPAP treatment of obstructive sleep apnoea on 24-hour profiles of glucose, insulin and counter-regulatory hormones in type 2 diabetes. Diabetes Obes Metab. 2017 03; 19(3):452-456. PMID: 27860160.
      View in: PubMed
    41. Masa JF, Corral J, Gómez-de-Terreros J, Sánchez-Quiroga MÁ, Mokhlesi B. Response. Chest. 2016 12; 150(6):1406-1407. PMID: 27938746.
      View in: PubMed
    42. Masa JF, Corral J, Gómez-de-Terreros J, Sánchez-Quiroga MÁ, Mokhlesi B. Response. Chest. 2016 12; 150(6):1408. PMID: 27938749.
      View in: PubMed
    43. Masa JF, Corral J, Gómez-de-Terreros J, Sánchez-Quiroga MÁ, Mokhlesi B. Response. Chest. 2016 12; 150(6):1409-1410. PMID: 27938751.
      View in: PubMed
    44. Masa JF, Corral J, Gómez-de-Terreros J, Sánchez-Quiroga MÁ, Mokhlesi B. Response. Chest. 2016 12; 150(6):1411. PMID: 27938753.
      View in: PubMed
    45. Alzoubaidi M, Mokhlesi B. Obstructive sleep apnea during rapid eye movement sleep: clinical relevance and therapeutic implications. Curr Opin Pulm Med. 2016 11; 22(6):545-54. PMID: 27583667.
      View in: PubMed
    46. Masa JF, Corral J, Romero A, Caballero C, Terán-Santos J, Alonso-Álvarez ML, Gomez-Garcia T, González M, López-Martínez S, De Lucas P, Marin JM, Marti S, Díaz-Cambriles T, Chiner E, Merchan M, Egea C, Obeso A, Mokhlesi B. The Effect of Supplemental Oxygen in Obesity Hypoventilation Syndrome. J Clin Sleep Med. 2016 10 15; 12(10):1379-1388. PMID: 27568890.
      View in: PubMed
    47. Mokhlesi B, Carter JR. Growing Evidence Linking OSA During Rapid Eye Movement Sleep to Systemic Hypertension. Chest. 2016 09; 150(3):475-7. PMID: 27613971.
      View in: PubMed
    48. Mokhlesi B, Ayas NT. Cardiovascular Events in Obstructive Sleep Apnea - Can CPAP Therapy SAVE Lives? N Engl J Med. 2016 Sep 08; 375(10):994-6. PMID: 27571490.
      View in: PubMed
    49. Khalyfa A, Almendros I, Gileles-Hillel A, Akbarpour M, Trzepizur W, Mokhlesi B, Huang L, Andrade J, Farré R, Gozal D. Circulating exosomes potentiate tumor malignant properties in a mouse model of chronic sleep fragmentation. Oncotarget. 2016 Aug 23; 7(34):54676-54690. PMID: 27419627.
      View in: PubMed
    50. Mokhlesi B, Grimaldi D, Beccuti G, Abraham V, Whitmore H, Delebecque F, Van Cauter E. Effect of One Week of 8-Hour Nightly Continuous Positive Airway Pressure Treatment of Obstructive Sleep Apnea on Glycemic Control in Type 2 Diabetes: A Proof-of-Concept Study. Am J Respir Crit Care Med. 2016 08 15; 194(4):516-9. PMID: 27525461.
      View in: PubMed
    51. Chung F, Memtsoudis SG, Ramachandran SK, Nagappa M, Opperer M, Cozowicz C, Patrawala S, Lam D, Kumar A, Joshi GP, Fleetham J, Ayas N, Collop N, Doufas AG, Eikermann M, Englesakis M, Gali B, Gay P, Hernandez AV, Kaw R, Kezirian EJ, Malhotra A, Mokhlesi B, Parthasarathy S, Stierer T, Wappler F, Hillman DR, Auckley D. Society of Anesthesia and Sleep Medicine Guidelines on Preoperative Screening and Assessment of Adult Patients With Obstructive Sleep Apnea. Anesth Analg. 2016 08; 123(2):452-73. PMID: 27442772.
      View in: PubMed
    52. Gozal D, Ham SA, Mokhlesi B. Sleep Apnea and Cancer: Analysis of a Nationwide Population Sample. Sleep. 2016 Aug 01; 39(8):1493-500. PMID: 27166241.
      View in: PubMed
    53. Masa JF, Corral J, Caballero C, Barrot E, Terán-Santos J, Alonso-Álvarez ML, Gomez-Garcia T, González M, López-Martín S, De Lucas P, Marin JM, Marti S, Díaz-Cambriles T, Chiner E, Egea C, Miranda E, Mokhlesi B. Non-invasive ventilation in obesity hypoventilation syndrome without severe obstructive sleep apnoea. Thorax. 2016 Oct; 71(10):899-906. PMID: 27406165.
      View in: PubMed
    54. Mokhlesi B, Carter JR. Efficacy of CPAP modalities in lowering blood pressure in OSA: does the method used to measure blood pressure matter? Thorax. 2016 08; 71(8):677-8. PMID: 27301973.
      View in: PubMed
    55. Poeran J, Cozowicz C, Chung F, Mokhlesi B, Ramachandran SK, Memtsoudis SG. Suboptimal Diagnostic Accuracy of Obstructive Sleep Apnea in One Database Does Not Invalidate Previous Observational Studies. Anesthesiology. 2016 May; 124(5):1192-3. PMID: 27093655.
      View in: PubMed
    56. Opperer M, Cozowicz C, Bugada D, Mokhlesi B, Kaw R, Auckley D, Chung F, Memtsoudis SG. Does Obstructive Sleep Apnea Influence Perioperative Outcome? A Qualitative Systematic Review for the Society of Anesthesia and Sleep Medicine Task Force on Preoperative Preparation of Patients with Sleep-Disordered Breathing. Anesth Analg. 2016 May; 122(5):1321-34. PMID: 27101493.
      View in: PubMed
    57. Mudambi L, Spiegelman A, Geron D, Hirshkowitz M, Mokhlesi B, Shaib Y, Velamuri S, Lan CO, Sharafkhaneh A. Obstructive Sleep Apnea Is Not Associated with Higher Health Care Use after Colonoscopy under Conscious Sedation. Ann Am Thorac Soc. 2016 Mar; 13(3):419-24. PMID: 26871998.
      View in: PubMed
    58. Masa JF, Corral J, Romero A, Caballero C, Terán-Santos J, Alonso-Álvarez ML, Gomez-Garcia T, González M, López-Martín S, De Lucas P, Marin JM, Marti S, Díaz-Cambriles T, Chiner E, Merchan M, Egea C, Obeso A, Mokhlesi B. Protective Cardiovascular Effect of Sleep Apnea Severity in Obesity Hypoventilation Syndrome. Chest. 2016 Jul; 150(1):68-79. PMID: 26923627.
      View in: PubMed
    59. Cortese R, Zhang C, Bao R, Andrade J, Khalyfa A, Mokhlesi B, Gozal D. DNA Methylation Profiling of Blood Monocytes in Patients With Obesity Hypoventilation Syndrome: Effect of Positive Airway Pressure Treatment. Chest. 2016 07; 150(1):91-101. PMID: 26923628.
      View in: PubMed
    60. Carter JR, Fonkoue IT, Grimaldi D, Emami L, Gozal D, Sullivan CE, Mokhlesi B. Positive airway pressure improves nocturnal beat-to-beat blood pressure surges in obesity hypoventilation syndrome with obstructive sleep apnea. Am J Physiol Regul Integr Comp Physiol. 2016 Apr 01; 310(7):R602-11. PMID: 26818059.
      View in: PubMed
    61. Valencia-Flores M, Mokhlesi B, Santiago-Ayala V, Reséndiz-García M, Castaño-Meneses A, Meza-Vargas MS, Mendoza A, Orea-Tejeda A, García-Ramos G, Aguilar-Salinas C, Bliwise DL. Intermittent hypoxemia and sleep fragmentation: associations with daytime alertness in obese sleep apnea patients living at moderate altitude. Sleep Med. 2016 04; 20:103-9. PMID: 27318233.
      View in: PubMed
    62. Mokhlesi B, Ham SA, Gozal D. The effect of sex and age on the comorbidity burden of OSA: an observational analysis from a large nationwide US health claims database. Eur Respir J. 2016 Apr; 47(4):1162-9. PMID: 26797029.
      View in: PubMed
    63. Chung F, Nagappa M, Singh M, Mokhlesi B. CPAP in the Perioperative Setting: Evidence of Support. Chest. 2016 Feb; 149(2):586-597. PMID: 26469321.
      View in: PubMed
    64. Cooksey J, Mokhlesi B. Postoperative Complications in Obesity Hypoventilation Syndrome and Hypercapnic OSA: CO2 Levels Matter! Chest. 2016 Jan; 149(1):11-3. PMID: 26757283.
      View in: PubMed
    65. Manthous CA, Mokhlesi B. Avoiding Management Errors in Patients with Obesity Hypoventilation Syndrome. Ann Am Thorac Soc. 2016 Jan; 13(1):109-14. PMID: 26512908.
      View in: PubMed
    66. Nagappa M, Liao P, Wong J, Auckley D, Ramachandran SK, Memtsoudis S, Mokhlesi B, Chung F. Validation of the STOP-Bang Questionnaire as a Screening Tool for Obstructive Sleep Apnea among Different Populations: A Systematic Review and Meta-Analysis. PLoS One. 2015; 10(12):e0143697. PMID: 26658438.
      View in: PubMed
    67. Lyons PG, Zadravecz FJ, Edelson DP, Mokhlesi B, Churpek MM. In response to "Obstructive sleep apnea and adverse outcomes in surgical and nonsurgical patients on the wards". J Hosp Med. 2016 Feb; 11(2):157. PMID: 26606686.
      View in: PubMed
    68. Schwartz NG, Rattner A, Schwartz AR, Mokhlesi B, Gilman RH, Bernabe-Ortiz A, Miranda JJ, Checkley W. Sleep Disordered Breathing in Four Resource-Limited Settings in Peru: Prevalence, Risk Factors, and Association with Chronic Diseases. Sleep. 2015 Sep 01; 38(9):1451-9. PMID: 25845694.
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    69. Mokhlesi B, Hagen EW, Finn LA, Hla KM, Carter JR, Peppard PE. Obstructive sleep apnoea during REM sleep and incident non-dipping of nocturnal blood pressure: a longitudinal analysis of the Wisconsin Sleep Cohort. Thorax. 2015 Nov; 70(11):1062-9. PMID: 26307037.
      View in: PubMed
    70. Gera A, Jacobsen J, Mokhlesi B, Rezania K. Bilateral pneumothorax: A rare complication of central venous catheter placement for plasmapheresis years after thymectomy. J Clin Apher. 2016 Aug; 31(4):405-6. PMID: 26123595.
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    71. Lyons PG, Zadravecz FJ, Edelson DP, Mokhlesi B, Churpek MM. Obstructive sleep apnea and adverse outcomes in surgical and nonsurgical patients on the wards. J Hosp Med. 2015 Sep; 10(9):592-8. PMID: 26073058.
      View in: PubMed
    72. Chung F, Liao P, Yang Y, Andrawes M, Kang W, Mokhlesi B, Shapiro CM. Postoperative sleep-disordered breathing in patients without preoperative sleep apnea. Anesth Analg. 2015 Jun; 120(6):1214-24. PMID: 25988633.
      View in: PubMed
    73. Nagappa M, Mokhlesi B, Wong J, Wong DT, Kaw R, Chung F. The Effects of Continuous Positive Airway Pressure on Postoperative Outcomes in Obstructive Sleep Apnea Patients Undergoing Surgery: A Systematic Review and Meta-analysis. Anesth Analg. 2015 May; 120(5):1013-23. PMID: 25899270.
      View in: PubMed
    74. Wu X, Lv S, Yu X, Yao L, Mokhlesi B, Wei Y. Treatment of OSA reduces the risk of repeat revascularization after percutaneous coronary intervention. Chest. 2015 Mar; 147(3):708-718. PMID: 25412159.
      View in: PubMed
    75. Koren D, O'Sullivan KL, Mokhlesi B. Metabolic and glycemic sequelae of sleep disturbances in children and adults. Curr Diab Rep. 2015 Jan; 15(1):562. PMID: 25398202.
      View in: PubMed
    76. Mokhlesi B, Finn LA, Hagen EW, Young T, Hla KM, Van Cauter E, Peppard PE. Obstructive sleep apnea during REM sleep and hypertension. results of the Wisconsin Sleep Cohort. Am J Respir Crit Care Med. 2014 Nov 15; 190(10):1158-67. PMID: 25295854.
      View in: PubMed
    77. Bhattacharjee R, Choi BH, Gozal D, Mokhlesi B. Association of adenotonsillectomy with asthma outcomes in children: a longitudinal database analysis. PLoS Med. 2014 Nov; 11(11):e1001753. PMID: 25369282.
      View in: PubMed
    78. Lyons PG, Mokhlesi B. Diagnosis and management of obstructive sleep apnea in the perioperative setting. Semin Respir Crit Care Med. 2014 Oct; 35(5):571-81. PMID: 25353102.
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    79. Shear TC, Balachandran JS, Mokhlesi B, Spampinato LM, Knutson KL, Meltzer DO, Arora VM. Risk of sleep apnea in hospitalized older patients. J Clin Sleep Med. 2014 Oct 15; 10(10):1061-6. PMID: 25317085.
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    80. Mokhlesi B. Sleep Hypoventilation: A State-of-the-Art Overview. Sleep Med Clin. 2014 Sep 01; 9(3):xv-xvi. PMID: 25309154.
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    81. Balachandran JS, Masa JF, Mokhlesi B. Obesity Hypoventilation Syndrome Epidemiology and Diagnosis. Sleep Med Clin. 2014 Sep; 9(3):341-347. PMID: 25360072.
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    82. Hart N, Mandal S, Manuel A, Mokhlesi B, Pepin JL, Piper A, Stradling J. Rebuttal: 'Obesity hypoventilation syndrome (OHS): does the current definition need revisiting?'. Thorax. 2014 Oct; 69(10):955. PMID: 24858324.
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    83. Chung F, Mokhlesi B. Postoperative complications associated with obstructive sleep apnea: time to wake up! Anesth Analg. 2014 Feb; 118(2):251-3. PMID: 24445625.
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    84. Mokhlesi B, Grimaldi D, Van Cauter E. Response to comment on Grimaldi et al. Association of obstructive sleep apnea in rapid eye movement sleep with reduced glycemic control in type 2 diabetes: therapeutic implications. Diabetes Care 2014;37:355-363. Diabetes Care. 2014; 37(3):e60-1. PMID: 24558089.
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    85. Patterson KC, Mokhlesi B. Response. Chest. 2013 Dec; 144(6):1977. PMID: 24297144.
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    86. Restoring Insulin Secretion (RISE): design of studies of ß-cell preservation in prediabetes and early type 2 diabetes across the life span. Diabetes Care. 2014; 37(3):780-8. PMID: 24194506.
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    87. Mokhlesi B, Hovda MD, Vekhter B, Arora VM, Chung F, Meltzer DO. Sleep-disordered breathing and postoperative outcomes after bariatric surgery: analysis of the nationwide inpatient sample. Obes Surg. 2013 Nov; 23(11):1842-51. PMID: 23690272.
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    88. Grimaldi D, Beccuti G, Touma C, Van Cauter E, Mokhlesi B. Association of obstructive sleep apnea in rapid eye movement sleep with reduced glycemic control in type 2 diabetes: therapeutic implications. Diabetes Care. 2014 Feb; 37(2):355-63. PMID: 24101701.
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    89. Mokhlesi B. Response. Chest. 2013 Oct; 144(4):1422. PMID: 24081364.
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    90. Mokhlesi B, Hovda MD, Vekhter B, Arora VM, Chung F, Meltzer DO. Sleep-disordered breathing and postoperative outcomes after elective surgery: analysis of the nationwide inpatient sample. Chest. 2013 Sep; 144(3):903-914. PMID: 23538745.
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    91. Hart N, Mandal S, Manuel A, Mokhlesi B, Pépin JL, Piper A, Stradling JR. Obesity hypoventilation syndrome: does the current definition need revisiting? Thorax. 2014 Jan; 69(1):83-4. PMID: 23986390.
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    92. Mokhlesi B, Guralnick AS. CPAP adherence during the perioperative period. J Clin Sleep Med. 2013 Jul 15; 9(7):733-4. PMID: 23853572.
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    93. Mokhlesi B. Empiric postoperative autotitrating positive airway pressure therapy: generating evidence in the perioperative care of patients at risk for obstructive sleep apnea. Chest. 2013 Jul; 144(1):5-7. PMID: 23880670.
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    94. Patterson KC, Huang F, Oldham JM, Bhardwaj N, Hogarth DK, Mokhlesi B. Excessive daytime sleepiness and obstructive sleep apnea in patients with sarcoidosis. Chest. 2013 Jun; 143(6):1562-1568. PMID: 23258454.
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    95. Kaw R, Mokhlesi B, Chung F, Gay P, Bolden N, Hillman D. Society of anesthesia and sleep medicine: proceedings of 2012 annual meeting. Sleep Breath. 2013 Dec; 17(4):1333-9. PMID: 23673871.
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    96. Chung F, Chau E, Yang Y, Liao P, Hall R, Mokhlesi B. Serum bicarbonate level improves specificity of STOP-Bang screening for obstructive sleep apnea. Chest. 2013 May; 143(5):1284-1293. PMID: 23238577.
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    97. Balachandran JS, Yu X, Wroblewski K, Mokhlesi B. A brief survey of patients' first impression after CPAP titration predicts future CPAP adherence: a pilot study. J Clin Sleep Med. 2013 Mar 15; 9(3):199-205. PMID: 23493772.
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    98. Chau EH, Mokhlesi B, Chung F. Obesity Hypoventilation Syndrome and Anesthesia. Sleep Med Clin. 2013 Mar; 8(1):135-147. PMID: 23503584.
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    99. Guralnick AS, Pant M, Minhaj M, Sweitzer BJ, Mokhlesi B. CPAP adherence in patients with newly diagnosed obstructive sleep apnea prior to elective surgery. J Clin Sleep Med. 2012 Oct 15; 8(5):501-6. PMID: 23066360.
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    100. Morselli LL, Knutson KL, Mokhlesi B. Sleep and insulin resistance in adolescents. Sleep. 2012 Oct 01; 35(10):1313-4. PMID: 23024425.
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    101. Kaw R, Mokhlesi B. Aspects of acute care in Sleep Medicine. Sleep Breath. 2013 May; 17(2):459-60. PMID: 23014930.
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    102. Chau EH, Lam D, Wong J, Mokhlesi B, Chung F. Obesity hypoventilation syndrome: a review of epidemiology, pathophysiology, and perioperative considerations. Anesthesiology. 2012 Jul; 117(1):188-205. PMID: 22614131.
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    103. Jacobsen JH, Shi L, Mokhlesi B. Factors associated with excessive daytime sleepiness in patients with severe obstructive sleep apnea. Sleep Breath. 2013 May; 17(2):629-35. PMID: 22733531.
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    104. Mokhlesi B. REM-related obstructive sleep apnea: to treat or not to treat? J Clin Sleep Med. 2012 Jun 15; 8(3):249-50. PMID: 22701380.
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    105. Carr GE, Mokhlesi B, Gehlbach BK. Acute cardiopulmonary failure from sleep-disordered breathing. Chest. 2012 Mar; 141(3):798-808. PMID: 22396567.
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    106. Mokhlesi B, Scoccia B, Mazzone T, Sam S. Risk of obstructive sleep apnea in obese and nonobese women with polycystic ovary syndrome and healthy reproductively normal women. Fertil Steril. 2012 Mar; 97(3):786-91. PMID: 22264851.
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    107. Mokhlesi B, Punjabi NM. "REM-related" obstructive sleep apnea: an epiphenomenon or a clinically important entity? Sleep. 2012 Jan 01; 35(1):5-7. PMID: 22215911.
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    108. Mokhlesi B, Gozal D. In the fight against advanced glycation end-products (AGEs), you should treat OSA, shouldn't you? Sleep Med. 2012 Jan; 13(1):5-6. PMID: 22137112.
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    109. Pamidi S, Knutson KL, Ghods F, Mokhlesi B. Depressive symptoms and obesity as predictors of sleepiness and quality of life in patients with REM-related obstructive sleep apnea: cross-sectional analysis of a large clinical population. Sleep Med. 2011 Oct; 12(9):827-31. PMID: 21978724.
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    110. Mokhlesi B, Pannain S, Ghods F, Knutson KL. Predictors of slow-wave sleep in a clinic-based sample. J Sleep Res. 2012 Apr; 21(2):170-5. PMID: 21955220.
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    111. Pamidi S, Knutson KL, Ghods F, Mokhlesi B. The impact of sleep consultation prior to a diagnostic polysomnogram on continuous positive airway pressure adherence. Chest. 2012 Jan; 141(1):51-57. PMID: 21700685.
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    112. Mokhlesi B, Gozal D. Update in sleep medicine 2010. Am J Respir Crit Care Med. 2011 Jun 01; 183(11):1472-6. PMID: 21642256.
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    113. Conwell W, Patel B, Doeing D, Pamidi S, Knutson KL, Ghods F, Mokhlesi B. Prevalence, clinical features, and CPAP adherence in REM-related sleep-disordered breathing: a cross-sectional analysis of a large clinical population. Sleep Breath. 2012 Jun; 16(2):519-26. PMID: 21614575.
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    114. Mokhlesi B, Tulaimat A, Parthasarathy S. Oxygen for obesity hypoventilation syndrome: a double-edged sword? Chest. 2011 May; 139(5):975-977. PMID: 21540211.
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    115. Mokhlesi B, Pamidi S, Yaggi HK. Sleep disordered breathing and subjective sleepiness in the elderly: a deadly combination? Sleep. 2011 Apr 01; 34(4):413-5. PMID: 21461318.
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    116. Tulaimat A, Mokhlesi B. Accuracy and reliability of extubation decisions by intensivists. Respir Care. 2011 Jul; 56(7):920-7. PMID: 21310114.
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    117. Mokhlesi B. Obesity hypoventilation syndrome: a state-of-the-art review. Respir Care. 2010 Oct; 55(10):1347-62; discussion 1363-5. PMID: 20875161.
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    118. Pannain S, Mokhlesi B. Bariatric surgery and its impact on sleep architecture, sleep-disordered breathing, and metabolism. Best Pract Res Clin Endocrinol Metab. 2010 Oct; 24(5):745-61. PMID: 21112023.
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    119. Mokhlesi B, Gozal D. Update in sleep medicine 2009. Am J Respir Crit Care Med. 2010 Mar 15; 181(6):545-9. PMID: 20208040.
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    120. Mokhlesi B, Saager L, Kaw R. Q: Should we routinely screen for hypercapnia in sleep apnea patients before elective noncardiac surgery? Cleve Clin J Med. 2010 Jan; 77(1):60-1. PMID: 20048031.
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    121. Littleton SW, Mokhlesi B. The pickwickian syndrome-obesity hypoventilation syndrome. Clin Chest Med. 2009 Sep; 30(3):467-78, vii-viii. PMID: 19700045.
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    122. Mokhlesi B, Khan M. Nail-gun narcolepsy. Lancet. 2009 Jul 18; 374(9685):238. PMID: 19616721.
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    123. Kaw R, Hernandez AV, Walker E, Aboussouan L, Mokhlesi B. Determinants of hypercapnia in obese patients with obstructive sleep apnea: a systematic review and metaanalysis of cohort studies. Chest. 2009 Sep; 136(3):787-796. PMID: 19567489.
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    124. Lee WY, Mokhlesi B. Diagnosis and management of obesity hypoventilation syndrome in the ICU. Crit Care Clin. 2008 Jul; 24(3):533-49, vii. PMID: 18538199.
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    125. Lee W, Nagubadi S, Kryger MH, Mokhlesi B. Epidemiology of Obstructive Sleep Apnea: a Population-based Perspective. Expert Rev Respir Med. 2008 Jun 01; 2(3):349-364. PMID: 19690624.
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    126. Mokhlesi B, Kryger MH, Grunstein RR. Assessment and management of patients with obesity hypoventilation syndrome. Proc Am Thorac Soc. 2008 Feb 15; 5(2):218-25. PMID: 18250215.
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    127. Mokhlesi B, Gozal D. Adult and pediatric sleep-disordered breathing: a virtual symposium. Introduction. Proc Am Thorac Soc. 2008 Feb 15; 5(2):135. PMID: 18250204.
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    128. Tasali E, Mokhlesi B, Van Cauter E. Obstructive sleep apnea and type 2 diabetes: interacting epidemics. Chest. 2008 Feb; 133(2):496-506. PMID: 18252916.
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    129. Mokhlesi B, Tulaimat A, Gluckman TJ, Wang Y, Evans AT, Corbridge TC. Predicting extubation failure after successful completion of a spontaneous breathing trial. Respir Care. 2007 Dec; 52(12):1710-7. PMID: 18028561.
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    130. Mokhlesi B, Tulaimat A. Recent advances in obesity hypoventilation syndrome. Chest. 2007 Oct; 132(4):1322-36. PMID: 17934118.
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    131. Mokhlesi B, Angulo-Zereceda D, Yaghmai V. False-positive FDG-PET scan secondary to lipoid pneumonia mimicking a solid pulmonary nodule. Ann Nucl Med. 2007 Sep; 21(7):411-4. PMID: 17876555.
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    132. Mokhlesi B. Positive airway pressure titration in obesity hypoventilation syndrome: continuous positive airway pressure or bilevel positive airway pressure. Chest. 2007 Jun; 131(6):1624-6. PMID: 17565013.
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    133. Mokhlesi B, Tulaimat A, Faibussowitsch I, Wang Y, Evans AT. Obesity hypoventilation syndrome: prevalence and predictors in patients with obstructive sleep apnea. Sleep Breath. 2007 Jun; 11(2):117-24. PMID: 17187265.
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    134. Ip M, Mokhlesi B. Sleep and Glucose Intolerance/Diabetes Mellitus. Sleep Med Clin. 2007; 2(1):19-29. PMID: 19536352.
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    135. Mokhlesi B, Tulaimat A, Evans AT, Wang Y, Itani AA, Hassaballa HA, Herdegen JJ, Stepanski EJ. Impact of adherence with positive airway pressure therapy on hypercapnia in obstructive sleep apnea. J Clin Sleep Med. 2006 Jan 15; 2(1):57-62. PMID: 17557438.
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    136. Hassaballa HA, Tulaimat A, Herdegen JJ, Mokhlesi B. The effect of continuous positive airway pressure on glucose control in diabetic patients with severe obstructive sleep apnea. Sleep Breath. 2005 Dec; 9(4):176-80. PMID: 16283228.
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    137. Tulaimat A, Mokhlesi B. Noninvasive ventilation for persistent weaning failure. Am J Respir Crit Care Med. 2004 May 01; 169(9):1073; author reply 1073-4. PMID: 15107307.
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    138. Mokhlesi B, Garimella PS, Joffe A, Velho V. Street drug abuse leading to critical illness. Intensive Care Med. 2004 Aug; 30(8):1526-36. PMID: 14999443.
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    139. Sam S, Corbridge TC, Mokhlesi B, Comellas AP, Molitch ME. Cortisol levels and mortality in severe sepsis. Clin Endocrinol (Oxf). 2004 Jan; 60(1):29-35. PMID: 14678284.
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    140. Mokhlesi B, Shulzhenko O, Garimella PS, Kuma L, Monti C. Pulmonary Strongyloidiasis: The Varied Clinical Presentations. Clin Pulm Med. 2004 Jan; 11(1):6-13. PMID: 20111672.
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    141. Mokhlesi B, Corbridge T. Toxicology in the critically ill patient. Clin Chest Med. 2003 Dec; 24(4):689-711. PMID: 14710698.
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    142. Tulaimat A, Mokhlesi B, Stevens D. Continuous positive airway pressure in patients with heart failure. N Engl J Med. 2003 Jul 03; 349(1):93-5; author reply 93-5. PMID: 12840100.
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    143. Mokhlesi B, Leikin JB, Murray P, Corbridge TC. Adult toxicology in critical care: Part II: specific poisonings. Chest. 2003 Mar; 123(3):897-922. PMID: 12628894.
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    144. Mokhlesi B, Leiken JB, Murray P, Corbridge TC. Adult toxicology in critical care: part I: general approach to the intoxicated patient. Chest. 2003 Feb; 123(2):577-92. PMID: 12576382.
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    145. Mokhlesi B. Clinical implications of gastroesophageal reflux disease and swallowing dysfunction in COPD. Am J Respir Med. 2003; 2(2):117-21. PMID: 14720011.
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    146. Mokhlesi B. Corticosteroids for patients with septic shock. JAMA. 2003 Jan 01; 289(1):43; author reply 43-4. PMID: 12503964.
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    147. Mokhlesi B, Ansaarie I, Bader M, Tareen M, Boatman J. Coronary artery air embolism complicating a CT-guided transthoracic needle biopsy of the lung. Chest. 2002 Mar; 121(3):993-6. PMID: 11888990.
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    148. Mokhlesi B, Logemann JA, Rademaker AW, Stangl CA, Corbridge TC. Oropharyngeal deglutition in stable COPD. Chest. 2002 Feb; 121(2):361-9. PMID: 11834644.
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    149. Mokhlesi B, Morris AL, Huang CF, Curcio AJ, Barrett TA, Kamp DW. Increased prevalence of gastroesophageal reflux symptoms in patients with COPD. Chest. 2001 Apr; 119(4):1043-8. PMID: 11296167.
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    150. Mokhlesi B, Jain M. Pulmonary manifestations of POEMS syndrome: case report and literature review. Chest. 1999 Jun; 115(6):1740-2. PMID: 10378577.
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